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不锈钢薄板圆盘剪分切过程有限元仿真研究

机械工程学报 2013年第9期49卷 190-198页

作者：路家斌潘嘉强阎秋生广东工业大学机电工程学院广州510006

针对金属板材圆盘剪精密分切工艺,应用DEFORM-2D仿真软件建立金属板材的圆盘剪分切模型,采用Oyane韧性断裂准则分析304不锈钢板材在圆盘剪分切加工中的弹塑性变形、断裂过程,研究裂纹的产生与扩展、材料断裂分离机理及断面形貌特征。根... 详细信息

针对金属板材圆盘剪精密分切工艺,应用DEFORM-2D仿真软件建立金属板材的圆盘剪分切模型,采用Oyane韧性断裂准则分析304不锈钢板材在圆盘剪分切加工中的弹塑性变形、断裂过程,研究裂纹的产生与扩展、材料断裂分离机理及断面形貌特征。根据板材在分切过程中的静水应力变化,提出用塌角区出现最大拉应力时的切入时间t1、分切区出现拉应力时的切入时间t2及t1之间的时间差t来简便直观地判断分切断面的塌角高度和剪切带高度的变化趋势,t1和t越小,最后形成的塌角和剪切带高度越小。揭示圆盘剪轴向间隙对分切断面形貌的影响规律,随着轴向间隙的增大,塌角高度和撕裂角逐渐增大,剪切带高度逐渐减小,而毛刺高度则先略微减小再急剧增大。有限元仿真结果与实际圆盘剪分切试验结果具有良好的一致性。

关键词：圆盘剪分切有限元模拟轴向间隙静水应力断面形貌

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磁流变即效微细砂轮精细加工研究

金刚石与磨料磨具工程 2007年第1期27卷 74-77页

作者：余娟阎秋生路家斌广东工业大学机电工程学院广州510090

在对磁流变液特性分析的基础上,提出了基于磁流变效应即效微细砂轮研抛的新工艺方法。磁流变液与金刚石微粉磨料均匀混合形成的抛光液,在外加磁场作用下形成粘弹性的准固体磨粒球团构成的微细砂轮,以普通玻璃为工件材料,基础试验证明本... 详细信息

在对磁流变液特性分析的基础上,提出了基于磁流变效应即效微细砂轮研抛的新工艺方法。磁流变液与金刚石微粉磨料均匀混合形成的抛光液,在外加磁场作用下形成粘弹性的准固体磨粒球团构成的微细砂轮,以普通玻璃为工件材料,基础试验证明本加工方法在加工玻璃材料时可行和有效。试验结果表明,磁流变即效微细砂轮在加工玻璃过程中加工表面呈现塑性去除特征,加工工具无进给时加工痕迹表面有中间突边缘圆环凹陷的形状,工具尖端与加工表面越接近其材料去除率越高。

关键词：磁流变效应微细砂轮精细加工抛光

A matched cohort study of laparoscopy-assisted and open total gastrectomy for advanced proximal gastric cancer without serosa invasion

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Chinese Medical Journal 2014年第3期127卷 403-407页

作者： Lin Jianxian Huang Changming Zheng Chaohui Li Ping Xie Jianwei Wang jiabin lu Jun Department of Gastric Surgery Fujian Medical University Union Hospital Fuzhou Fujian 350001 China

Background Little is known about the feasibility and safety of laparoscopy-assisted total gastrectomy （LATG） with extended lymphadenectomy in patients with advanced gastric cancer （AGC）.This study compared the technical feasibility,safety,and oncologic efficacy of LATG with open total gastrectomy （OTG） for AGC without serosa *** From January 2009 to December 2011,235 patients underwent LATG and 153 patients underwent OTG for AGC without serosa ***,gender,and depth of invasion （pT2 and pT3） were matched by propensity scoring,and 116 patients （58 LATG and 58 OTG） were selected for *** clinicopathologic characteristics,postoperative outcomes,and survival were *** There was no significant difference in clinicopathologic characteristics between the two propensity-matched *** number of lymph nodes per patient was 29,and the mean number of retrieved lymph nodes was similar in the LATG and OTG groups （30.8±10.2 vs.29.0±8.3）.Peri-operative characteristics,operation time,number of transfused units per patient,and time to resumption of activities were similar in the two groups; while blood loss,times to first flatus and resumption of soft diet,and post-operative stay were significantly lower in the LATG group （P ＜0.05,respectively）.Rates of post-operative complications （12.1％ vs.15.5％） and postoperative mortality （0％ vs.1.7％）,as well as cumulative survival rates,were *** LATG with D2 lymphadenectomy is a safe and feasible procedure for AGC patients without serosa ***,randomized trials are needed to confirm the efficacy of LATG in this patient population.

关键词： laparoscopic surgery total gastrectomy advanced gastric cancer D2 lymphadenectomy matched cohort study

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

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Acta Pharmaceutica Sinica B 2021年第12期11卷 4008-4019页

作者： Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang jiabin lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 310058China Department of Clinical Pharmacology Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou First People’s HospitalCancer CenterZhejiang University School of MedicineHangzhou 310006China Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009China Cancer Center of Zhejiang University Hangzhou 310058China

Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic *** aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA ***,the underpinning mechanism remains poorly ***(DUB)is regarded as a main orchestrator in maintaining protein ***,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent *** depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in *** analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient ***,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients.

关键词： Cholangiocarcinoma Deubiquitinase JOSD2 YAP/TAZ

Early changes to the extracellular space in the hippocampus under simulated microgravity conditions

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Science China(Life Sciences) 2022年第3期65卷 604-617页

作者： Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang jiabin lu Department of Radiology Peking University Third HospitalBeijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Department of Neurology Aerospace Center HospitalPeking University Aerospace Clinical CollegeBeijing 100039China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China NHC Key Laboratory of Medical Immunology Department of ImmunologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Radiology Aerospace Center HospitalPeking University Aerospace Clinical CollegeBeijing 100039China

The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains *** this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 *** tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both *** diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 *** alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 *** findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS.

关键词： brain extracellular space interstitial fluid interstitial system tracer-based magnetic resonance imaging simulated microgravity hindlimb-unloading

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单晶SiC化学机械抛光液的固相催化剂研究

机械工程学报 2017年第21期53卷 167-173页

作者：徐少平路家斌阎秋生宋涛潘继生广东工业大学机电工程学院广州510006

针对单晶Si C化学机械抛光使用的抛光液,研究了产生芬顿反应Fe、Fe O、Fe_2O_3、Fe_3O_4等4种铁系固相催化剂的效果。结果发现当Fe_3O_4作为催化剂时,Si C表面能够产生明显的化学反应,生成较软易去除的Si O_2氧化层,化学机械抛光时材料... 详细信息

针对单晶Si C化学机械抛光使用的抛光液,研究了产生芬顿反应Fe、Fe O、Fe_2O_3、Fe_3O_4等4种铁系固相催化剂的效果。结果发现当Fe_3O_4作为催化剂时,Si C表面能够产生明显的化学反应,生成较软易去除的Si O_2氧化层,化学机械抛光时材料去除率最高达到17.2 mg/h、表面粗糙度最低达到R_a2.5 nm。相比Fe、Fe O、Fe_2O_3等固相催化剂,Fe_3O_4更适宜用作Si C的化学机械抛光。抛光液中Fe^(2+)离子浓度和稳定性是决定芬顿反应速率和稳定性的重要因素,固相催化剂电离自由Fe^(2+)能力的差异直接影响了化学抛光液中的Fe^(2+)浓度,固相催化剂电离Fe^(2+)的能力越强,抛光液中Fe^(2+)浓度就越高,芬顿反应速率越快,与Si C进行化学反应速度越快,材料去除率越高,抛光质量越好。

关键词：碳化硅化学机械抛光芬顿反应固相催化剂去除效率

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集群磁流变变间隙动压平坦化加工试验研究

机械工程学报 2021年第19期57卷 230-238页

作者：阎秋生廖博涛路家斌付有志广东工业大学机电工程学院广州510006

为了提高光电晶片集群磁流变平坦化加工效果,提出集群磁流变变间隙动压平坦化加工方法,探究各工艺参数对加工效果的影响规律。以蓝宝石晶片为研究对象开展了集群磁流变变间隙动压平坦化加工和集群磁流变抛光对比试验,通过检测加工表面... 详细信息

为了提高光电晶片集群磁流变平坦化加工效果,提出集群磁流变变间隙动压平坦化加工方法,探究各工艺参数对加工效果的影响规律。以蓝宝石晶片为研究对象开展了集群磁流变变间隙动压平坦化加工和集群磁流变抛光对比试验,通过检测加工表面粗糙度、材料去除率,观测加工表面形貌、集群磁流变抛光垫中磁链串受动态挤压前后形态变化,研究挤压幅值、工件盘转速、挤压频率以及最小加工间隙等工艺参数对加工效果的影响规律。试验结果表明:集群磁流变平坦化加工在施加工件轴向微幅低频振动后,集群磁流变抛光垫中形成的磁链串更粗壮,不但使其沿工件的径向流动实现磨粒动态更新、促使加工界面内有效磨粒数增多,而且在工件与抛光盘之间的加工间隙产生动态抛光压力、使磨粒与加工表面划擦过程柔和微量化,形成了提高材料去除效率、降低加工表面粗糙度的机制。对于2英寸蓝宝石晶电(1英寸=2.54 cm)集群磁流变变间隙动压平坦化加工与集群磁流变抛光加工效果相比,材料去除率提高19.5%,表面粗糙度降低了42.96%,在挤压振动频率1 Hz、最小加工间隙1 mm、挤压幅值0.5 mm、工件盘转速500 r/min的工艺参数下进行抛光可获得表面粗糙度为Ra0.45 nm的超光滑表面,材料去除率达到3.28 nm/min。证明了集群磁流变变间隙动压平坦化加工方法可行有效。

关键词：集群磁流变抛光变间隙动压平坦化加工表面粗糙度材料去除率

High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer

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High density of IL-17-producing cells is associated with imp...

中华医学会第十次全国妇产科学术会议妇科肿瘤会场（妇科肿瘤学组、妇科病理学组）

作者： Chunyan Lan Xin Huang Xialin Su Huiqiang Huang Qichun Cai jiabin lu Jihong Liu State Key Laboratory of Oncology in South China Department of Gynecologic Oncology Sun Yat-sen University Cancer Center Department of Pathology Sun Yat-sen University Cancer Center Department of Medical Oncology Sun Yat-sen University Cancer Center

Objectives:Interleukin(IL)-17 is the signature cytokine of T helper 17 *** role of IL-17 in the tumor microenvironment is still *** studies describing IL-17 expression in ovarian cancer have been reported. In this stu... 详细信息

关键词： High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer

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润滑剂黏度对电工硅钢精密剪切加工影响

润滑与密封 2019年第8期44卷 1-7,22页

作者：阎秋生汤彪路家斌广东工业大学机电工程学院

为研究润滑剂黏度对精密剪切加工断面质量的影响,在不同润滑剂黏度条件下以0. 5 mm厚的无取向电工硅钢为实验材料进行剪切加工实验,对比研究了不同润滑黏度时电工硅钢的剪切断面形貌、加工硬化以及剪切力。通过对比实验发现,电工硅钢精... 详细信息

为研究润滑剂黏度对精密剪切加工断面质量的影响,在不同润滑剂黏度条件下以0. 5 mm厚的无取向电工硅钢为实验材料进行剪切加工实验,对比研究了不同润滑黏度时电工硅钢的剪切断面形貌、加工硬化以及剪切力。通过对比实验发现,电工硅钢精密剪切过程中润滑条件的改善,硅钢剪切断面质量得到提高,剪切带高度增加,塌角高度和毛刺高度减少,加工硬化减少;润滑剂黏度较小时,剪切力明显减小,相应的剪切区域的组织流动区域也明显变小,剪切带高度也明显变大。研究表明,润滑剂黏度的不同直接影响板材剪切过程中刀具与板材间的润滑状态,从而影响剪切力的大小和材料变形状态,进而影响剪切断面组织流动和剪切质量。

关键词：电工硅钢剪切润滑断面形貌剪切力