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A visual photothermal paper sensor for H_2S recognition through rational modulation LSPR wavelength of plasmonics

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Science China Chemistry 2018年第3期61卷 368-374页

作者： Hui Wang jiabin cui Anila Arshad Suying Xu Leyu Wang State Key Laboratory of Chemical Resource Engineering School of Science Beijing University of Chemical Technology

It is known that the localized surface plasmon resonance(LSPR) wavelength of plasmonics is highly dependent on compositions and geometry of plasmonics as well as the surrounding environments. Here, monodispersed Au@Ag core-shell nanoparticles(Au@Ag NPs) were prepared by carefully optimizing the shell thickness of Au@Ag NPs, and the presence of hydrogen sulfide(H_2 S) would significantly alter the LSPR wavelength. On the basis of this, a photothermal paper sensor for on-site recognition of H_2 S was constructed with a visual detection limit of 12.8 ng/L.

关键词： localized surface plasmon resonance Au@Ag NPs H2S detection photothermal paper sensor

A Pretargeting Strategy Enabled by Bioorthogonal Reactions Towards Advanced Nuclear Medicines: Application and Perspective

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Chemical Research in Chinese Universities 2021年第4期37卷 870-879页

作者： GAO Yun CHEN Lei GE Jianxian cui jiabin ZENG Jianfeng GAO Mingyuan Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123P.R.China

Pretargeting is an innovative and promising approach in nuclear medicine for targeted-imaging/therapy through the following bioorthogonal *** requires two reactive participants,one of which is a targeting vector and the other is a small radiolabeled probe capable of specifically coupling through bioorthogonal reactions with the targeting vector accumulated in the disease *** to the conventional direct targeting approach,such a two-step scheme conceptually can achieve a higher imaging contrast and an improved therapeutic effect owing to the suppressed non-specific *** this review,we will first give a brief introduction on pretargeting systems and the history of bioorthogonal reactions,and then focus on some important works about radionuclide delivering through the bioorthogonal reaction based pretargeting ***,we will discuss the steps forward in respect to the future clinical translation and truly hope that this methodology would continue to make contributions to nuclear medicines.

关键词： Pretargeting Bioorthogonal reaction Nuclear medicine

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大规模预训练模型在信息安全领域的应用研究

网络空间安全 2024年第3期15卷 68-71页

作者：田雄军崔佳斌袁礼杨凯锋国家电子计算机质量检验检测中心北京经济管理职业学院中国电子信息产业集团公司第六研究所

[目的/意义]探讨大规模预训练模型在信息安全领域的应用研究。[方法/过程]阐述大规模预训练模型的基本原理，结合实际分析大规模预训练模型在信息安全中的优势和面临的挑战，由此展现信息安全中运用大规模训练模型在上下文理解语义分析... 详细信息

[目的/意义]探讨大规模预训练模型在信息安全领域的应用研究。[方法/过程]阐述大规模预训练模型的基本原理，结合实际分析大规模预训练模型在信息安全中的优势和面临的挑战，由此展现信息安全中运用大规模训练模型在上下文理解语义分析能力、集成多模态数据能力等方面的优势，以及在隐私与安全性、数据偏差和样本不平衡方面存在的问题。[结果/结论]重点针对自然语言处理、网络安全和入侵检测等信息安全任务，探讨了大规模预训练模型的应用实践，为信息安全领域预训练模型的合理、有效的运用，提供一些思路和理论基础，以期通过预训练模型的运用，在一定程度上提高信息安全管理水平。

关键词：预训练模型信息安全自然语言处理网络安全应用研究

Development of NIR-II fluorescence image-guided and pH-responsive nanocapsules for cocktail drug delivery

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Nano Research 2015年第6期8卷 1932-1943页

作者： Sheng Huang Shan Peng Yuanbao Li jiabin cui Hongli Chen Leyu Wang State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Environmentally Harmful Chemical AnalysisBeijing University of Chemical Technology Beijing 100029 China

Nanocapsule-based targeted delivery and stimulus-responsive release can increase drug effectiveness, while reducing the side effects of the drug. However, difficulties in the scale-up synthesis, fast burst release, and low degradability, could hamper the translation of drug nanocapsules from lab to clinic. Here we have controllably functionalized the biodegradable and widely available polysuccinimide, in order to obtain an amphiphilic poly（amino acid）. Using this polymer, we designed nanocapsules （〈 100 nm） for hydrophobic drug delivery, which could facilitate tumor targeting, hydrogen bond-based pH-responsive release, and real-time fluorescence tracking, in the second near-infrared region. This method is versatile, eco-friendly, and easy to scale up at low costs. In addition, this system can carry a cocktail of drugs, obtained by loading multiple anticancer drugs to the same vehicle. Our nanocapsules were observed to be stable in blood vessels （pH = 7.4）, and the pH-responsive release （pH = 5.0 in lysosome） was sustained. The chemotherapy results in tumor-xenografted mice suggested that our nanocapsule was safe and efficient, and may be a useful tool for drug delivery.

关键词： near IR fluorescence pH responsive cocktail drug delivery

Monolayer MoS_2 decorated Cu_7S_4-Au nanocatalysts for sensitive and selective detection of mercury(Ⅱ)

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Science China Materials 2017年第4期60卷 352-360页

作者： jiabin cui State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Environmentally Harmful Chemical Analysis Beijing University of Chemical Technology (BUCT) Beijing 100029 China

Sensitive and selective detection of Hg（II） contamination is of great importance with concern of public health. Herein, we successfully fabricated monolayer MoS2 （S-MoS2） decorated Cu7S4-Au （Cu7S4-Au@S-MoS2） nanocomposite modified electrode for the sensitive and selective detection of Hg（II） via anodic stripping voltammetric technique. Due to the excellent electrocatalytic reduction performance arisen from the abundant active edge sites of small monolayer MoS2 and good affinity of Au toward Hg, the current method displayed high sensitivity （LOD = 190 nmol L-l） and enhanced selectivity. As control, nanostructures including Cu7S4-Au, Cu7S4@S-MoS2 and Cu7S4-Au@M-MoS2 （M： multilayer） were also investigated, but showed low re- sponse to Hg（Ⅱ）, suggesting that both Au domains and active edge sites of monolayer MoS2 have crucial synergistic effects on the high-performance for recognition of Hg（Ⅱ）. Moreover, the developed method displays satisfied performance for the detection of Hg（Ⅱ） in real samples, which indicates its potentials in practical applications.

关键词： CuyS4-Au nanocatalysts MoS2 square wave anodicstripping voltammetry mercury(Ⅱ)

Surface active-site engineering in hierarchical PtNi nanocatalysts for efficient triiodide reduction reaction

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Nano Research 2021年第12期14卷 4714-4718页

作者： jiabin cui Pin Ma Weidan Li Rui Jiang Lirong Zheng Yuan Lin Chang Guo Xiong Yin Leyu Wang State Key Laboratory of Chemical Resource Engineering Innovation Centre for Soft Matter Science and EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing100029China Beijing National Laboratory for Molecular Sciences Key Laboratory of PhotochemistryCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing100190China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Pillar of Engineering Product Development Singapore University of Technology and DesignSingapore487372Singapore

Hierarchical Pt-alloys enriched with active sites are highly desirable for efficient catalysis,but their syntheses generally need time-consuming and elaborate annealing treatment at high *** herein report a surface active-site engineering strategy for constructing the hierarchical PtNi nanocatalysts with an atomic Pt-skin layer(PtNi@Pt-SL)towards efficient triiodide reduction reaction(TRR)via an acid-dealloying *** facile acid-dealloying process promotes the formation of surface Pt active sites on the hierarchical Pt-alloys,and thus results in good catalytic performance towards *** calculation reveals that the enhanced catalytic property stems from the moderate energy barriers for iodide atoms on the surface Pt *** surface active-site engineering strategy paves a new way for the design of active and durable electrocatalysts.

关键词： surface active-site engineering Pt skin-layer hierarchical structure dealloying triiodide reduction reaction

Smart CU1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release

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Nano Research 2015年第12期8卷 4038-4047页

作者： Sheng Huang Jing Liu Qian He Hongli Chen jiabin cui Suying Xu Yuliang Zhao Chunying Chen Leyu Wang State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Environmentally Harmful Chemical Analysis Beijing University of Chemical Technology Beijing 100029 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China and Institute of High Energy Physics Chinese Academy of Sciences Beijing 100190 China

Thermosensitive drug delivery systems （DDSs） face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near- infrared （NIR） photothermal Cu175S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine （DOX） loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions （pH = 7.4, 37 ~C） for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous long- term NIR irradiation. Based on the stable and high photothermal efficiency （55.8%）, pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstratin~ remote and noninvasive control.

关键词： copper sulfides near infrared light phothermal therapy drug release

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大容量锂电池模组过充热失控分析

时代汽车 2024年第6期 135-137,148页

作者：宋毓聪郭跃崔佳斌宋冬冬杨洪宇中汽研汽车检验中心(常州)有限公司江苏省常州市213000

为提高动力电池的安全性,降低热失控的风险,以某款标称容量为166Ah的大容量锂电池模组作为研究对象,在常温25℃试验环境下,利用充放电测试系统以1/5C恒流对电池模组进行过充电热失控试验,研究其过充电热失控的反应特点和行为特性。结果... 详细信息

为提高动力电池的安全性,降低热失控的风险,以某款标称容量为166Ah的大容量锂电池模组作为研究对象,在常温25℃试验环境下,利用充放电测试系统以1/5C恒流对电池模组进行过充电热失控试验,研究其过充电热失控的反应特点和行为特性。结果表明:在常温25℃试验环境下,该电池模组充电至154%SOC,发生热失控行为。过充热失控反应存在明显的演变过程,热失控发生前电芯一致性变差,内部电压的下降时间超前于模组的热失控异常升温时间,对热失控进行预警。

关键词：锂电池模组过充电反应特点行为特性

In-situ wet tearing based subnanometer MoSeS for efficient hydrogen evolution

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Science China Materials 2017年第10期60卷 929-936页

作者： Wenli Lu jiabin cui Rui Jiang Yueguang Chen Leyu Wang State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Environmentally Harmful Chemical Analysis Beijing University of Chemical Technology （BUCT） Beijing 100029 China

The development of ultrasmall transition-metal dichalcogenide（such as MoS_2,MoSe_2） nanostructures is an efficient strategy to increase the active edge sites and overall performance for hydrogen evolution reaction. Here,we report an in-situ tearing strategy to produce the carbon nanotube supported subnanometer ternary MoSeS（denoted as CNTs@NiSe@MoSeS） for efficient hydrogen evolution. Large（18.3 ± 1.1nm in length） multilayer MoS_2 sheets grown on Ni（OH）_2 thin film are torn into subnanometer（5.2 ± 0.7 nm in length） MoSeS via a subsequent selenization progress,along with the transformation of Ni（OH）_2 thin film into small Ni Se nanoplates. The resulting nanocomposite exhibits abundant active edge sites,outstanding 10,000-cycle stability and ultrahigh activity with a low overpotential of 189 mV at a high current density of 200 mA cm^（-2） toward hydrogen evolution.

关键词： subnanometer transition-metal dichalcogenides insitu tearing hydrogen evolution reaction