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Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-Ying Meng lin-Zhu Lu Qian-Qian Guo Chang-Jun lv Nian-Hua Tan Zhe Deng Jun-Yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si Mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment

指向“科学态度与社会责任”的单元复习教学——以“含氮化合物的合理使用”为例

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化学教学 2024年第2期 47-52页

作者：孙换男吕琳袁林新沂市高级中学江苏徐州221400 扬州大学化学化工学院江苏扬州225000 新沂市教师发展中心江苏徐州221400

以“尿素的合成与合理使用”为情境主线,以“感受尿素合成的新方法”到“感知尿素之功”及“感知尿素之过”再到“感悟尿素的环保价值”四个逐层递进的教学环节,展开“含氮化合物的合理使用”单元复习,让学生感受化学知识的价值和化学... 详细信息

以“尿素的合成与合理使用”为情境主线,以“感受尿素合成的新方法”到“感知尿素之功”及“感知尿素之过”再到“感悟尿素的环保价值”四个逐层递进的教学环节,展开“含氮化合物的合理使用”单元复习,让学生感受化学知识的价值和化学对人类生产生活做出的巨大贡献,形成合理使用化学品的意识和绿色化学观念,以此促进学生“科学态度与社会责任”学科核心素养的发展。

关键词：高中化学科学态度与社会责任学科核心素养单元复习含氮化合物的合理使用

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柴达木地区人工防护林建设探析

青海农林科技 2024年第2期 37-40,60页

作者：吕嘉海西州林业站青海德令哈817099

人工防护林建设是柴达木地区生态环境保护的重要组成部分,为当地经济社会高质量发展提供良好的生态保障。本文从柴达木地区自然条件出发,在分析人工防护林建设现状和问题,从退化林修复及防护林营造的角度,提出了防护林建设的指导思想、... 详细信息

人工防护林建设是柴达木地区生态环境保护的重要组成部分,为当地经济社会高质量发展提供良好的生态保障。本文从柴达木地区自然条件出发,在分析人工防护林建设现状和问题,从退化林修复及防护林营造的角度,提出了防护林建设的指导思想、建设原则、建设重点、建设策略,以求能更好地推动柴达木地区人工防护林建设的发展。

关键词：柴达木地区人工防护林建设

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电气化铁路接触网地震作用与抗震性能分析

铁道工程学报 2024年第8期41卷 91-96页

作者：杨佳陈奋飞贾传果吕峻逸邢挺张家玮中铁二院工程集团有限责任公司成都610031 重庆大学重庆400045 中国铁路青藏集团有限公司西宁810006

研究目的:高地震烈度区域电气化铁路沿线途经多条地震断裂带,接触网系统在地震作用下易出现损坏,影响列车的正常运行。本文结合高地震烈度区电气化铁路,基于接触网系统服役特性,开展了4柱3跨原型足尺振动台试验,建立并验证地震响应下的... 详细信息

研究目的:高地震烈度区域电气化铁路沿线途经多条地震断裂带,接触网系统在地震作用下易出现损坏,影响列车的正常运行。本文结合高地震烈度区电气化铁路,基于接触网系统服役特性,开展了4柱3跨原型足尺振动台试验,建立并验证地震响应下的接触网系统有限元模型,开展地震作用下接触网系统的地震响应仿真计算,对比分析接触网导线、腕臂、定位器、支柱等关键装备的抗震性能,并比较分析不同的接触网导线工作张力、跨距以及锚段长度对接触网系统抗震性能的影响,提出高地震烈度区接触网系统的抗震设计原则及措施,全面分析与研究地震作用下接触网系统响应规律和抗震性能。本文提出的关于接触网系统抗震性能分析数据及研究结论,能有效补充和完善接触网抗震设计规范及标准,有力支撑铁路工程建设,提升电气化铁路防灾抗灾能力。研究结论:(1)地震激励对接触网腕臂装置的影响较小,定位器出现受压,导致钩环结构易脱落;(2)地震激励对接触网支柱、接触线具有十分明显的影响,可造成支柱柱底应力增大和接触线跨中位移增大;(3)锚段长度对抗震性能无明显影响,适当增大接触线工作张力、减小跨距可有效降低接触网系统的地震响应;(4)本研究成果可为轨道交通领域防灾减灾设计提供指导。

关键词：接触网高地震烈度地震响应抗震设计性能

多孔玻璃粉原位生长高纯绿色发光CsPbBr_(3)量子点

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硅酸盐学报 2024年第8期52卷 2615-2622页

作者：林航吕雪杰高鹏王元生中国科学院福建物质结构研究所中国科学院光电材料化学与物理院重点实验室福州350002

钙钛矿量子点玻璃兼具量子点优异的发光特性和玻璃的物化稳定性,受到广泛关注,但其制备过程中存在组分挥发严重、晶粒尺寸和分布难以调控等问题,实验重复性往往较差。本工作中,以多孔玻璃为模板,基于原位生长的方法,制备了CsPbBr_(3)量... 详细信息

钙钛矿量子点玻璃兼具量子点优异的发光特性和玻璃的物化稳定性,受到广泛关注,但其制备过程中存在组分挥发严重、晶粒尺寸和分布难以调控等问题,实验重复性往往较差。本工作中,以多孔玻璃为模板,基于原位生长的方法,制备了CsPbBr_(3)量子点-多孔玻璃(简称为CPB-PG)复合材料。由于量子点生长受限于多孔玻璃的孔道,因此复合材料的组分/结构具有较好的可控性。改变多孔玻璃的热处理分相、酸浸析和碱洗工艺条件,可调控CPB-PG中析出的CsPbBr_(3)量子点的粒径分布。多孔玻璃粉浸渍于卤化物盐溶液时,Cs^(+)、Pb^(2+)、Br^(–)会吸附于孔道中;烘干溶剂后,CsPbBr_(3)析出;升温至CsPbBr_(3)熔点温度之上煅烧时,CsPbBr_(3)熔融,并在降温过程中于玻璃孔道中原位重结晶。光谱测试分析表明,随着量子点尺寸增大,样品发射峰红移;晶体缺陷有所增加,相应荧光量子效率下降;制得CPB-PG的半峰宽最窄仅为18 nm,实现了对于宽色域背光显示至关重要的高纯绿光发射(色坐标接近Rec.2020标准)。耦合绿光CPB-PG、红光K_(0.42)Cs_(0.58)Pb(Br_(1.5)I_(1.5))量子点玻璃粉、以及InGaN蓝光芯片,构建白光发光二极管(LED)原型器件;在20 mA电流驱动下,白光LED的光效30 lm/W,色温7710 K,显色指数75.8,可以覆盖约96%的Rec.2020标准色域。

关键词：钙钛矿量子点玻璃陶瓷晶化白光发光二极管发光

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铸牢中华民族共同体意识的高校时代新人培养

新疆大学学报（哲学社会科学版） 2024年第4期52卷 1-7页

作者：刘琼豪吕嘉欣广西师范大学马克思主义学院广西桂林541000

中华民族共同体意识是我国近代以来中华民族共同体追逐民族复兴梦想的生动反映和能动自觉。铸牢中华民族共同体意识具有鲜明的育人价值,在高校时代新人培养中有助于引导大学生坚定理想信念、激发使命担当精神、增强民族团结意识。这在... 详细信息

中华民族共同体意识是我国近代以来中华民族共同体追逐民族复兴梦想的生动反映和能动自觉。铸牢中华民族共同体意识具有鲜明的育人价值,在高校时代新人培养中有助于引导大学生坚定理想信念、激发使命担当精神、增强民族团结意识。这在我国近代以来高校新人培养中得到了实践验证,体现为以中华民族学说激发高校学生的新民蜕变、以独立自主为核心的民族精神激励无产阶级革命新人及“又红又专”新人养成、以锐意进取精神塑造“四有”新人。进入新时代,我国铸牢高校学生的中华民族共同体意识,需优化高校时代新人培养路径,即遵循为社会主义服务的育人价值,重点开展“四史”教育;以担当精神丰富育人目标,着重增强自信自强意识培育;以民族团结意识拓宽育人路径,着力加强社会主义核心价值观教育。

关键词：铸牢中华民族共同体意识高校时代新人培养

Chain Elongation Using Native Soil Inocula:Exceptional n-Caproate Biosynthesis Performance and Microbial Mechanisms

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Engineering 2024年第8期39卷 262-272页

作者： lin Deng Yang lv Tian Lan Qing-Lian Wu Wei-Tong Ren Hua-Zhe Wang Bing-Jie Ni Wan-Qian Guo State Key Laboratory of Urban Water Resource and the Environment Harbin Institute of TechnologyHarbin 150090China Centre for Technology in Water and Wastewater&School of Civil and Environmental Engineering University of Technology SydneySydneyNSW 2007Australia

This study demonstrates the feasibility and effectiveness of utilizing native soils as a resource for inocula to produce n-caproate through the chain elongation(CE)platform,offering new insights into anaerobic soil *** results reveal that all five of the tested soil types exhibit CE activity when supplied with high concentrations of ethanol and acetate,highlighting the suitability of soil as an ideal source for n-caproate *** with anaerobic sludge and pit mud,the native soil CE system exhibited higher selectivity(60.53%),specificity(82.32%),carbon distribution(60.00%),electron transfer efficiency(165.00%),and conductivity(0.59 ms∙cm^(-1)).Kinetic analysis further confirmed the superiority of soil in terms of a shorter lag time and higher yield.A microbial community analysis indicated a positive correlation between the relative abundances of Pseudomonas,Azotobacter,and Clostridium and n-caproate ***,metagenomics analysis revealed a higher abundance of functional genes in key microbial species,providing direct insights into the pathways involved in n-caproate formation,including in situ CO_(2)utilization,ethanol oxidation,fatty acid biosynthesis(FAB),and reverse beta-oxidation(RBO).The numerous functions in FAB and RBO are primarily associated with Pseudomonas,Clostridium,Rhodococcus,Stenotrophomonas,and Geobacter,suggesting that these genera may play roles that are involved or associated with the CE ***,this innovative inoculation strategy offers an efficient microbial source for n-caproate production,underscoring the importance of considering CE activity in anaerobic soil microbial ecology and holding potential for significant economic and environmental benefits through soil consortia exploration.

关键词： Soil Chain elongation n-caproate Reverse beta-oxidation Fatty acid biosynthesis Metagenomics

Effect of jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

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Current Medical Science 2024年第3期44卷 603-610页

作者： Juan YANG Meng-yuan LIANG Yu LI Hao ZHANG Wei LI Jing lv Li-ping DONG Jing-song JIN Cheng YANG Qing-hong ZHANG Li LONG Rong ZOU Yi GAO Dan SONG Chun-qin PAN Ying YAO Xiao-lin ZHAN Xiao-hui WANG Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First People’s Hospital of GuiyangGuiyang550000China Department of Nephrology The Third Xiangya HospitalCentral South UniversityChangsha410000China Department of Nephrology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Nephrology Wuhan No. 4 HospitalWuhan430033China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430060China Department of Nephrology Central Theater General Hospital of PLAWuhan430064China Department of Nephrology Taihe HospitalShiyan442000China Department of Nephrology Third People’s Hospital of Hubei ProvinceWuhan430033China Department of Nephrology Hubei Province Integrated Traditional Chinese and Western Medicine Hospital of Hubei provinceWuhan430024China Department of Nephrology Xi’an No.3 HospitalAffiliated Hospital of Northwest UniversityXi’an710000China Department of Nephrology Shenzhen Guangming District People’s HospitalShenzhen518000China Department of Nephrology Xiantao First People’s HospitalXiantao433000China Department of Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology Huangshi Central HospitalHuangshi435000China Department of Nephrology The Fifth Hospital of WuhanWuhan430050China

Objective This study aimed to analyze the clinical efficacy of the jianpi Shengxue tablet for treating renal *** A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two *** in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered jianpi Shengxue *** 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two *** After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(Plinical symptom score and total iron binding capacity decreased(Plinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(Pjianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

关键词： jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study

湖北省肿瘤科医护人员安宁疗护实践水平现状及其影响因素分析

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军事护理 2024年第8期41卷 47-51页

作者：贾佳聂小菲吕翻翻李龙倜湖北医药学院护理学院湖北十堰442000 十堰市太和医院服务质量办公室湖北十堰442000

目的了解肿瘤科医护人员安宁疗护实践水平现状并分析其影响因素。方法2023年9-11月,分层随机整群抽样法选取1198名肿瘤科医护人员为研究对象,采用安宁疗护自评实践量表、疼痛评估知识和信心自我感知量表、死亡工作自我能力量表及跨学科... 详细信息

目的了解肿瘤科医护人员安宁疗护实践水平现状并分析其影响因素。方法2023年9-11月,分层随机整群抽样法选取1198名肿瘤科医护人员为研究对象,采用安宁疗护自评实践量表、疼痛评估知识和信心自我感知量表、死亡工作自我能力量表及跨学科合作指数修订量表等对其进行调查。结果肿瘤科医护人员安宁疗护实践水平总分为(67.37±12.77)分,回归分析结果显示,学历、安宁疗护工作喜爱程度、跨学科合作能力、疼痛评估能力及死亡应对能力是其主要影响因素(均P<0.05)。结论肿瘤科医护人员安宁疗护实践水平处于中等水平,受跨学科合作能力、疼痛评估能力及死亡应对能力等多种因素影响;管理者应从相关因素入手,提高医护人员安宁疗护实践水平,进而提高临终患者的生命质量。

关键词：安宁疗护肿瘤科医护人员实践水平影响因素