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Cell responses and hemocompatibility of g-HA/PLA composites

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Science China(Life Sciences) 2011年第4期54卷 366-371页

作者： LI jia ZHENg Wei ZHENg YuFeng LOU Xia Center for Biomedical Materials and Engineering Harbin Engineering University Harbin 150001 China School of Chemistry and Environmental Engineering Harbin University of Science and Technology Harbin 150040 China Department of Advanced Materials and Nanotechnology College of Engineering Peking University Beijing 100871 China Nanochemistry Research Institute Department of Chemical Engineering Curtin University of Technology Bentley WA 9102 Australia

The objective of this study was to investigate the hemocompatibility and cell responses to some novel poly（L-lactide）（PLA） composites containing surface modified hydroxyapatite particles for potential applications as a bone substitute material. The surface of hydroxyapatite （HA） particles was first grafted with L-lactic acid oligomers to form grafted HA （g-HA） particles. The g-HA particles were further blended with PLA to prepare g-HA/PLA composites. Our previous study has shown signifi- cant improvement in tensile properties of these materials due to the enhanced interracial adhesion between the polymer matrix and HA particles. To further investigate the potential applications of these composites in bone repair and other orthopedic sur- geries, a series of in vitro and in vivo experiments were conducted to examine the cell responses and hemocompatibility of the materials. In vitro experiments showed that the g-HA/PLA composites were well tolerated by the L-929 cells. Hemolysis of the composites was lower than that of pure PLA. Subcutaneous implantation demonstrated that the g-HA/PLA composites were more favorable than the control materials for soft tissue responses. The results suggested that the g-HA/PLA composites are promising and safe materials with potential applications in tissue engineering.

关键词： polylactide hydroxyapatite composites biocompatibility cytotoxicity

SELECTIVE COPPER REMOVAL FROM CUPRIFEROUS gOLD CONCENTRATE

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中国有色金属学会会刊：英文版 1995年第1期5卷 36-41页

作者： Deng Tong(Institute of Chemical Metallurgy, Academia Sinica, Beijing 100080) Muir David(School of MPS , Murdoch University, wa 6150, Australia) ACAD SINICA INST CHEM METBEIJING 100080PEOPLES R CHINA MURDOCH UNIV SCH MATH & PHYS SCIMURDOCHWA 6150AUSTRALIA

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ＳＥＬＥＣＴＩＶＥＣＯＰＰＥＲＲＥＭＯＶＡＬＦＲＯＭＣＵＰＲＩＦＥＲＯＵＳＧＯＬＤＣＯＮＣＥＮＴＲＡＴＥＤｅｎｇ；Ｔｏｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＭｅｔａｌｌｕｒｇｙ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂｅｉｊｉｎｇ１０００８０）Ｍｕｉｒ...

关键词： copper selective leaching cupriferous gold concentate

A survey of image-based computational learning techniques for frost detection in plants

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Information Processing in Agriculture 2023年第2期10卷 164-191页

作者： Sayma Shammi Ferdous Sohel Dean Diepeveen Sebastian Zander Michael g.K.Jones Discipline of Information Technology Murdoch UniversityMurdochWA 6150Australia Centre for Crop and Food Innovation Food Futures InstituteMurdoch UniversityMurdochWA 6150Australia Department of Primary Industries and Regional Development Western AustraliaSouth PerthWA 6151Australia

Frost damage is one of the major concerns for crop growers as it can impact the growth of the plants and hence,*** detection of frost can help farmers mitigating its *** the past,frost detection was a manual or visual ***-based techniques are increasingly being used to understand frost development in plants and automatic assessment of damage resulting from *** research presents a comprehensive survey of the state-of the-art methods applied to detect and analyse frost stress in *** identify three broad computational learning approaches i.e.,statistical,traditional machine learning and deep learning,applied to images to detect and analyse frost in *** propose a novel taxonomy to classify the existing studies based on several *** taxonomy has been developed to classify the major characteristics of a significant body of published *** this survey,we profile 80 relevant papers based on the proposed *** thoroughly analyse and discuss the techniques used in the various approaches,i.e.,data acquisition,data preparation,feature extraction,computational learning,and *** summarise the current challenges and discuss the opportunities for future research and development in this area including in-field advanced artificial intelligence systems for real-time frost monitoring.

关键词： Frost Cold stress Machine learning Image analysis Crop Plant

未经充分处理将含重金属的废液销售给下游企业的行为如何定性

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人民检察 2024年第14期 37-42页

作者：张辉黄晓亮侯艳芳劳娃韩广强王小飞《人民检察》北京师范大学法学院华东政法大学刑事法学院最高人民检察院普通犯罪检察厅江苏省张家港市人民检察院

实务中,污染环境案件的表现形态复杂多样,在法律适用中多有争议,厘清相关法律问题,正确适用法律,是“高质效办好每一个案件”的题中之义。为此,本刊特述选一起具有典型意义的案件——某企业将未经充分处理的含有重金属的废液销售给下游... 详细信息

实务中,污染环境案件的表现形态复杂多样,在法律适用中多有争议,厘清相关法律问题,正确适用法律,是“高质效办好每一个案件”的题中之义。为此,本刊特述选一起具有典型意义的案件——某企业将未经充分处理的含有重金属的废液销售给下游企业的案件,该案涉及很多法律关系,有探讨价值,值得关注.

关键词：相关法律问题正确适用法律探讨价值下游企业题中之义重金属典型意义表现形态

Auroral substorm response to solar wind pressure shock

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Chinese Science Bulletin 2001年第18期46卷 1547-1551,1587页

作者： HONg Minghua wa.g Xianmin D.Chua g.Parks Institute of geology and geophysics Chinese Academy of SciencesBejing 100101China Institute of Space Medico-Engineering Bejing 100094China geophysics Program University of WashingtonSeattleWA98195USA

Two cases of auroral substorms have been studied with the Polar UVI data, which were associated with solar wind pressure shock arriving at the Earth. The global aurora activities started about 1-2 min after pressure shocks arrived at dayside magnetopause, then nightside auroras intensified rapidly 3-4 min later, with auroral sub-storm onset. The observations in synchronous orbit indicated that the compressing effects on magnetosphere were observed in their corresponding sites about 2 min after the pressure shocks impulse magnetopause. We propose that the auroral intensification and substorm onset possibly result from hydromagnetic wave produced by the pressure shock. The fast-mode wave propagates across the magnetotail lobes with higher local Alfven velocity, magnetotail was compressed rapidly and strong lobe field and cross-tail current were built in about 1-2 min, and furthermore the substorm was triggered due to an instability in current sheet.

关键词： auroral substorm solar wind pressure shock hydro-magnetic wave.

Establishment of a Tumor-bearing Mouse Model Stably Expressing EgFP Labeled Human MUC1 VNTRs

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Chemical Research in Chinese Universities 2008年第4期24卷 505-510页

作者： ZHANg Shu-zi ZHANg Hai-hong ZHANg wa SHI He-liang YU Xiang-hui KONg Wei LI Wei Vaccine Research Center College of Life Science Jilin University Changchun 130012 P R. China

Two eukaryotic vectors expressing 9 tandem repeats of human MUCI（VNTR）, VR1012-VNTR, and pEgFP-VNTR, were constructed by cloning VNTR gene into VR1012 and pEgFP, respectively. VNTR stably expressing murine Lewis lung carcinoma（LLC） cell line（VNTR^＋ LLC） was established by Lipofectamine-mediated transfection of pEgFP-VNTR into LLC cells. The EgFP expression was observed under a fluorescent microscope and VNTR expression in VNTR^＋ LLC cells was confirmed by means of Western blotting. A syngenic graft tumor model was generated by subcutaneous injection of VNTR^＋ LLC cells into C57/BL6 mice and tumor size increased rapidly with time and in a cell qumber dependent manner. VNTR mRNA expression in the tumor formed was confirmed by RT-PCR. After the third immunization mice were challenged subcutaneously with 5×10^5 VNTR^＋ LLC cells, a significant reduction of subcutaneous tumor growth was observed in the groups immunized with VNTR plasmid DNA compared with that in the groups immunized with the vector DNA alone. Thus, the suppression of subcutaneous tumor was antigen-specific. This model is useful for the development of tumor vaccines targeting MUCI VNTRs.

关键词： MUCI VNTR Tumor antigen Tumor model Tumor vaccine

MMPP/M/C queue with congestion-based staffing policy and applications in operations of steel industry

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Journal of Iron and Steel Research International 2019年第7期26卷 659-668页

作者： Yan-he jia Li-xin Tang Zhe george Zhang Xiao-feng Chen Liaoning Key Laboratory of Manufacturing System and Logistics Institute of Industrial and Systems Engineering Northeastern University Shenyang 110819 Liaoning China Beedie School of Business Simon Fraser University Burnaby BC V5A 1S6 Canada Department of Decision Sciences Western Washington University Bellingham WA 98225 USA

A queueing model of the Markov-modulated Poisson process (MMPP) with thresholds was investigated. The customer arrival with various arrival rates in the model was viewed as the MMPP. In contrast to the Poisson, s arrival process, the MMPP can better describe the situation that the arrival rate changes with changing conditions;therefore, the model fits better with reality. The threshold conversion was added to the model based on the general MMPP/M/C model. When the number of customers in the system exceeds a threshold, all servers work to serve;when the number of customers in the system is less than another threshold, some servers are shut down. This is the congestion-based staffing policy with two thresholds. Specifically, the problems in the slab stocking stage of slab production at the Iron and Steel Complex in China were analysed. In the slab production process, because the rate of the upstream steelmaking is not constant, the rate of slab reaching the slab yard is uncertain. The crane service is used to store slabs in a warehouse. Because the slab arrival rate varies, different numbers of cranes in service need to be optimized for cost control. Thus, MMPP was used to describe slab arrival with varied arrival rates. Therefore, an MMPP/M/C queue with thresholds was used to analyse and solve the practical problems, and the optimal number of service cranes was obtained to minimize the cost of slab stocking.

关键词： Markov-modulated Poisson process Matrix geometry Congestion-based staffing policy Threshold conversion Slab Crane

一起东佛里生奶绵羊附红细胞体病流行病学调查、诊疗报告

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畜牧兽医杂志 2024年第3期43卷 62-65页

作者：钱琳娜张帆宋越邵国玉乔蕾杨斌高娃内蒙古自治区农牧业科学院内蒙古呼和浩特010031 科尔沁右翼前旗动物疫病预防控制中心

为探究附红细胞体在内蒙古呼和浩特市托克托县地区的流行情况,接诊呼和浩特托县地区某东佛里生奶绵羊养殖场病例,该场近一周多圈舍出现产奶羊只体温升高、精神沉郁、瘫软、食欲减退或废绝等症状,有出现症状1~2 d迅速死亡病例,也有使用... 详细信息

为探究附红细胞体在内蒙古呼和浩特市托克托县地区的流行情况,接诊呼和浩特托县地区某东佛里生奶绵羊养殖场病例,该场近一周多圈舍出现产奶羊只体温升高、精神沉郁、瘫软、食欲减退或废绝等症状,有出现症状1~2 d迅速死亡病例,也有使用抗生素硫酸庆大霉素-青霉素联用结合补液治疗1周无好转或死亡病例,死亡总数超8只,仍有10余只相似症状正在接受治疗。经现场剖检、圈舍环境调查、样品实验室检测,结合临床诊疗,确诊此次疫情为奶绵羊附红细胞体病,且周边羊养殖场(户)羊只也存在附红细胞体感染。说明附红细胞体在托克托县呈地方性流行。

关键词：奶绵羊附红细胞体流行病学调查诊断治疗

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老年非小细胞肺癌患者术后生活质量的纵向研究

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中华老年多器官疾病杂志 2024年第6期23卷 416-420页

作者：贾琎蕊李晓红胡滨首都医科大学附属北京朝阳医院胸外科北京100020

目的纵向研究老年非小细胞肺癌(NSCLC)患者术后生活质量,并分析其影响因素。方法通过便利抽样法对行根治术治疗的老年NSCLC患者术后1个月行一般情况及生活质量问卷调查,共发放190份问卷,收回有效问卷182份,以术后1个月肺癌患者生活质... 详细信息

目的纵向研究老年非小细胞肺癌(NSCLC)患者术后生活质量,并分析其影响因素。方法通过便利抽样法对行根治术治疗的老年NSCLC患者术后1个月行一般情况及生活质量问卷调查,共发放190份问卷,收回有效问卷182份,以术后1个月肺癌患者生活质量测定量表(FACT-L)总分分组,分为生活质量良好组(≥平均分)及生活质量不良组(gistic回归分析评估老年NSCLC患者术后1个月生活质量不良的影响因素。结果 182例老年NSCLC患者在术后3个月时有3例患者不配合复查或失访,未获得二次生活质量调查,予以剔除,术后6个月时有8例患者失访,获得171份有效问卷。随着术后时间的延长,老年NSCLC患者各维度FACT-L评分及其总分逐渐升高,差异有统计学意义(Pgistic回归分析显示,吸烟史(OR=3.074,95%CI 1.461~6.468)、中转开胸(OR=2.377,95%CI 1.099~5.145)、术后肺部并发症(OR=4.088,95%CI 2.193~7.621)、癌因性疲乏(OR=3.016,95%CI 1.535~5.927)均为老年NSCLC患者术后1个月生活质量不良的危险因素(P<0.05)。171例老年NSCLC患者中,术后1个月有癌因性疲乏者术后6个月FACT-L总分明显低于无癌因性疲乏者(P<0.05)。结论有吸烟史、中转开胸、术后肺部并发症及癌因性疲乏的老年NSCLC患者术后早期生活质量较差,但随着术后时间的延长,患者生活质量可逐渐提升,癌因性疲乏可对患者术后生活质量产生持续不良影响。

关键词：老年人非小细胞肺癌根治术生活质量纵向研究影响因素