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Bullous pemphigoid associated with acquired hemophilia A: A case report

World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-jia Hao Xu-ya Chai Pei-Sai Li ya.g Liu Li-Xia Liu Ying Xu Pan-Pan ya.g Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKgROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： ya-Xin Xu Xiao-Xuan Niu Wen-Chang jia Jing Wen Xue-Lin Cheng yan Han Ming-Hui Peng Jing Zhou yao Liu Sun-Fang jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of general Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKgROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region global Burden of Disease Risk factors Disability-adjusted life years

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Rational design and synthesis of advanced metal-organic frameworks for electrocatalytic water splitting

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Science China Chemistry 2023年第4期66卷 943-965页

作者： Yu-jia Tang ya-Qian Lan School of Chemistry and Materials Science Institute of Advanced Materials and Flexible Electronics(IAMFE)Nanjing University of Information Science and TechnologyNanjing 210044China School of Chemistry South China Normal UniversityGuangzhou 510006China

As a promising and significant technology for hydrogen production,electrocatalytic water splitting is a research hotspot in the energy conversion field for alleviating the global energy crisis and achieving carbon neutrality ***-organic frameworks(MOFs)have been widely investigated as catalyst candidates with remarkable activity and long-term electrocatalysis durability owing to their precise and tailorable structures:tunable pore channels in the range of micropore/mesopore promote the mass/electron transfer;high specific surface areas expose abundant active species;modified metal nodes can serve as active sites;versatile organic ligands can be functionalized to further enhance the electrocatalytic *** this review,recent advances in the rational design and synthesis of advanced MOF electrocatalysts for water splitting are presented in the following ***,we analyze the design concepts of MOF electrocatalysts from the perspective of their distinct and modifiable ***,three common synthesis techniques of MOF electrocatalysts are briefly ***,we focus on the classification of different MOFs for robust electrocatalytic water splitting,including pristine MOFs,mixed-metallic MOFs,MOF nanosheets,electrically conductive MOFs,MOFs on substrates,and polyoxometalate-based ***,summary and outlook are proposed to uncover the next generation of advanced MOFs for electrochemical energy conversion applications.

关键词： metal-organic frameworks water splitting electrocatalysis hydrogen evolution reaction oxygen evolution reaction polyoxometalates

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Influence of the gaussian colored noise and electromagnetic radiation on the propagation of subthreshold signals in feedforward neural networks

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Science China(Technological Sciences) 2021年第4期64卷 847-857页

作者： gE Mengyan WANg guoWei jia ya Department of Physics Central China Normal UniversityWuhan 430079China

Iterative methods are used to simulate the in vitro feedforward neural networks in physiological *** can be propagated to a minimum of ten ***,the discharge activity of each group will be more *** feedforward neural networks have a wide range of applications in machine learning,and the weight of synapses considerably influences the propagation of weak ***,we investigated the effect of gaussian colored noise and electromagnetic radiation on the propagation of the subthreshold excitatory postsynaptic current signals in the input layer of the multilayer Izhikevich neural feedforward *** the absence of electromagnetic radiation,the excitatory postsynaptic current signal is stably propagated and amplified in multilayer feedforward neural networks under the optimal gaussian colored noise strength or correlation time in the output layer of the *** with the case in which there is no electromagnetic radiation,the presence of electromagnetic radiation slightly reduces the propagation of weak ***,the time required to propagate the excitatory postsynaptic current signal to the output layer increases with the increasing feedback *** feedforward neural network considered in this study is a considerably simple *** complex structures,such as backward connection and delayed feedback,can be observed in real biological ***,the next step will be to study more complex neural models with neuron models based on the physiological experimental data and compare them with real biological ***,the study of neural networks can be combined with an experimental study about the auditory nervous system of bats to understand the biological mechanism associated with the auditory system function of bats from two perspectives.

关键词： feedforward neural network colored noise electromagnetic radiation signal propagation

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Influence of Random Potentials on the Current of the Molecular Motor Model

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Chinese Physics Letters 2001年第11期18卷 1431-1434页

作者： jia ya LI jia-rong Department of Physics Huazhong Normal UniversityWuhan 430079 Institute of Particle Physics:Huazhong Normal University Wuhan 430079

The current of the molecular motor model disturbed by random potentials, which involve the dichotomous and Ornstein-Uhlenbeck potentials, is studied using a finite-space correlation function. It is found that: (i) the amplitude and the correlation length of random potentials play opposing roles in the transport of the molecular motor model;(ii) a random potential with small amplitude and large correlation length is very useful in the molecular motor system.

关键词： function. disturbed Molecular

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Identification of nonlinear process described by neural fuzzy Hammerstein-Wiener model using multi-signal processing

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Advances in Manufacturing 2023年第4期11卷 694-707页

作者： Feng Li Li jia ya.gu College of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001JiangsuPeople’s Republic of China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai200444People’s Republic of China School of Electrical Engineering and Automation Changshu Institute of TechnologyChangshu215500JiangsuPeople’s Republic of China

In this study,a novel approach for nonlinear process identification via neural fuzzy-based Hammerstein-Wiener model with process disturbance by means of multi-signal processing is *** Hammerstein-Wiener model consists of three blocks where a dynamic linear block is sandwiched between two static nonlinear ***-signal sources are designed for achieving identification separation of the Hammerstein-Wiener *** correlation analysis theory is utilized for estimating unknown parameters of output nonlinearity and linear block using separable signals,thus the interference of process disturbance is ***,the immeasurable intermediate variable and immeasurable noise term in identification model is taken over by auxiliary model output and estimate residuals,and then auxiliary model-based recursive extended least squares parameter estimation algorithm is derived to calculate parameters of the input nonlinearity and noise ***,convergence analysis of the suggested identification scheme is derived using stochastic process *** simulation results indicate that proposed identification approach yields high identification accuracy and has good robustness.

关键词： Nonlinear process Parameter identification Hammerstein-Wiener model Neural fuzzy model Multiple signal processing

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Can a Correlation Ratchet Operate Under Spatial Symmetry and Temporal Symmetry ?

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Chinese Physics Letters 1998年第5期15卷 315-317页

作者： jia ya LI jia-rong Department of Physics Huazhong Normal UniversityWuhan 430079 Institute of Particle Physics Huazhong Normal UniversityWuhan 430079

The simplest imaginable ratchet system which cantains two noises correlated with each other is *** is found that(1)the correlation between noises can induce transport,even when the ratchet potential is completely symmetric in space and the driving forcing is symmetric in time,and(2)the system can exhibit a current in either direction,and the direction can be controlled by the intensity of the correlation between noises.

关键词： symmetric system intensity

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Constraints on axion-like particles with different magnetic field models from the PKS 2155–304 energy spectrum

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Research in Astronomy and Astrophysics 2019年第10期19卷 152-158页

作者： jia Bu ya-Ping Li Department of Astronomy Xiamen University Xiamen 361005 China Shanghai Astronomical Observatory Shanghai 200030 China

Axion-like particles(ALPs) are a promising kind of dark matter candidate particle that are predicted to couple with photons in the presence of magnetic fields. The oscillations between photons and ALPs traveling in the magnetic fields have been used to constrain ALP properties. In this work, we obtain some new constraints on the ALP mass ma and the photon-ALP coupling constant g with two different magnetic field models through TeV photons from PKS 2155–304. The first is the discrete-Φ model in which the magnetic field has the orientation angle Φ that changes discretely and randomly from one coherent domain to the next, and the second is the linearly-continuous-Φ model in which the magnetic field orientation angle Φ varies continuously across neighboring coherent domains. For the discrete-Φ model, we can obtain the best constraints on the ALP mass m1 = ma/(1 neV)= 0.1 and on the photon-ALP coupling constant g11= g/(10^-11 geV^-1)= 5. The reasonable range of the ALP mass m1 is 0.08 ~ 0.2 when g11 = 5,and the only reasonable value of the photon-ALP coupling constant is g11 = 5 when m1 = 0.1. For the linearly-continuous-Φ model, we can obtain the best constraints on the ALP mass m1 = 0.1 and on the photon-ALP coupling constant g11 = 0.7. The reasonable range of the ALP mass m1 is 0.05 ~ 0.4 when g11= 0.7, and the reasonable range of the photon-ALP coupling constant g11 is 0.5 ~ 1 when m1 = *** of the results are consistent with the upper bound(g geV^-1, i.e., g11 < 6.6) set by the CAST experiment.

关键词： cosmology dark matter-gamma rays general-galaxies magnetic fields

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Detection of electron-phonon coupling in two-dimensional materials by light scattering

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Nano Research 2021年第6期14卷 1711-1733页

作者： jia-Min Lai ya-Ru Xie Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China CAS Center of Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing101408China Beijing Academy of Quantum Information Science Beijing100193China

Electron-phonon coupling affects the properties of two-dimensional(2D)materials significantly,leading to a series of novel *** light scattering provides a powerful experimental tool to explore electron-phonon interaction in 2D *** review gives an overview of the basic theory and experimental advances of electron-phonon coupling in 2D materials detected by Raman and Brillouin scattering,*** the Raman scattering part,we review Raman spectroscopy studies of electron-phonon coupling in graphene,transition metal disulfide compounds,van der Waals heterostructures,strongly correlated systems,and 2D magnetic *** the Brillouin scattering part,we extensively introduce Brillouin spectroscopy in non-van der Waals 2D structures,including temperature sensors for phonons and magnons,interfacial Dzyaloshinsky-Moriya interaction and spin torque in multilayer magnetic structures,as well as exciton-polariton in semiconductor quantum well.

关键词： electron-phonon coupling Raman scattering Brillouin scattering two-dimensional(2D)materials

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From Chinese Science Bulletin to Science Bulletin: celebrate the coming 50th birthday

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Science Bulletin 2015年第24期60卷 2145-2150页

作者： Xuming jia Rui An Xiao-ya Chen Science China Press Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

As the only multidisciplinary journal supervised by Chinese Academy of Sciences and the National Natural Science Foundation of China,Science Bulletin will usher in its50th anniversary in 2016.A fifty-year history for a journal is always ***,the more important reason to celebrate besides the great age is:the fifty-year old journal continues to be vigorous and influential.

关键词：下线服务迁移

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