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Frontiers of Chemical Science and Engineering 2023年第12期17卷 2014-2024页

作者： Xiao Yong Pengfei sha.Jinghui Peng Mengdi liu Qian Zhang jianhua yu liyan yu lifeng Dong College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Department of Physics Hamline UniversitySaint PaulMN 55104USA

Capacitive deionization can alleviate water shortage and water environmental pollution, but performances are greatly determined by the electrochemical and desalination properties of its electrode materials. In this work, B and N co-doped porous carbon with micro-mesoporous structures is derived from sodium alginate by a carbonization, activation, and hydrothermal doping process, which exhibits large specific surface area (2587 m^(2)·g^(‒1)) and high specific capacitance (190.7 F·g^(‒1)) for adsorption of salt ions and heavy metal ions. Furthermore, the materials provide a desalination capacity of 26.9 mg·g−1 at 1.2 V in 500 mg·l^(‒1) NaCl solution as well as a high removal capacity (239.6 mg·g^(‒1)) and adsorption rate (7.99 mg·g^(‒1)·min^(‒1)) for Pb2+ with an excellent cycle stability. This work can pave the way to design low-cost porous carbon with high-performances for removal of salt ions and heavy metal ions.

关键词： capacitance deionization porous carbon B N co-doping heavy metal ions water purification

lncRNA UCA1在急性髓系白血病患者中的表达及其临床意义

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中国实验血液学杂志 2024年第4期32卷 999-1004页

作者：白雪伍燕平李忠玉陈晓奉王蒙李佳佳蚌埠医学院第一附属医院血液科安徽蚌埠233003

目的:检测急性髓系白血病(AMl)患者骨髓中尿路上皮癌胚抗原1(lncRNA UCA1)的表达水平,并探讨lnc RNA UCA1表达水平在AMl患者中的临床意义。方法:收集50例AMl患者骨髓标本作为实验组和20例缺铁性贫血(IDA)患者骨髓标本作为对照组,并收集... 详细信息

目的:检测急性髓系白血病(AMl)患者骨髓中尿路上皮癌胚抗原1(lncRNA UCA1)的表达水平,并探讨lnc RNA UCA1表达水平在AMl患者中的临床意义。方法:收集50例AMl患者骨髓标本作为实验组和20例缺铁性贫血(IDA)患者骨髓标本作为对照组,并收集AMl患者的相关临床病理特征资料。采用实时荧光定量PCR(q RT-PCR)检测lnc RNA UCA1在实验组和对照组中的表达水平,并分析lnc RNA UCA1在AMl患者中的表达水平与临床病理特征及预后的关系。采用Kaplan-Meier曲线分析lnc RNA UCA1表达水平对AMl患者总体生存时间(OS)的影响;采用Cox风险回归模型分析影响AMl患者预后的因素。结果:与对照组相比,lnc RNA UCA1表达水平在AMl患者中明显升高(Plnc RNA UCA1高表达组中血红蛋白低于90 g/l的患者占比明显高于低表达组(P=0.004);lnc RNA UCA1在M1、M2和M4型AMl患者中表达水平较高,而在M0、M5型AMl患者中表达水平较低,差异具有统计学意义(P=0.009)。lnc RNA UCA1高表达组患者与低表达组患者的性别、年龄、WBC计数、PlT计数、骨髓原始细胞比例、化疗方案及疗效、核型、基因突变及预后风险分层的差异均无统计学意义(均P>0.05);lnc RNA UCA1高表达组患者的OS较低表达组患者显著缩短(P=0.0229)。结论:lnc RNA UCA1表达水平在AMl患者中明显上调,其高表达与较差的临床病理特征及不良预后相关,可作为判断AMl患者预后的指标和潜在的治疗靶点。

关键词：急性髓系白血病 lncRNA UCA1 预后临床意义

不同类型多糖对羊皮明胶凝胶性质及结构的影响

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食品与发酵工业 2024年第10期50卷 112-118,126页

作者：王敏赵以宁余群力韩玲罗进贾培程强甘肃农业大学食品科学与工程学院甘肃兰州730070 泾川县旭康食品有限责任公司甘肃平凉744000

为探究2种不同类型的多糖对羊皮明胶凝胶特性和结构的影响,利用卡拉胶与魔芋胶复配,银耳多糖作为安全性改性剂,研究羊皮明胶凝胶强度、质构、色泽、熔化温度及结构的变化。结果表明,卡拉胶与魔芋胶复配可显著提高羊皮明胶凝胶的凝胶强... 详细信息

为探究2种不同类型的多糖对羊皮明胶凝胶特性和结构的影响,利用卡拉胶与魔芋胶复配,银耳多糖作为安全性改性剂,研究羊皮明胶凝胶强度、质构、色泽、熔化温度及结构的变化。结果表明,卡拉胶与魔芋胶复配可显著提高羊皮明胶凝胶的凝胶强度和质构特性,在复配胶质量比为2∶1时,凝胶强度和硬度最大,分别为(625.75±5.28)g、(172.26±0.5)g。同时,熔化温度提高至30℃以上。加入银耳多糖后,增强了复合凝胶的粘连性。l^(*)值无显著变化,而a^(*)值和b^(*)值显著提高。红外光谱图表明,亲水胶体减少了明胶凝胶分子内氢键的形成。添加银耳多糖使羰基向高波数移动。加入多糖后羊皮明胶衍射峰逐渐变得平坦,三股螺旋和左螺旋的生成被破坏。扫描电镜(scanning electron microscope,SEM)结果表明添加适量多糖后,改善了复合凝胶的网络结构,使得网络结构更加均匀致密。综上所述,卡拉胶与魔芋胶复配主要改善羊皮明胶的质构特性和熔化温度,银耳多糖主要影响明胶凝胶的色泽和粘连性、回弹力。2种多糖都对羊皮明胶的特性产生了积极的影响,这可为以后羊皮明胶在食品上的应用提供理论依据和技术指导。

关键词：羊皮明胶复配胶凝胶强度质构特性

Functional identification of C-type lectin in the diamondback moth,Plutella xylostella(l.)innate immunity

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Journal of Integrative Agriculture 2021年第12期20卷 3240-3255页

作者： lI Jin-yang lIN Jun-han g.Mandela FERNANDEZ-gRANDON ZHANg jia-yu YOU Min-sheng XIA Xiao-feng State Key laboratory of Ecological Pest Control for Fujian and Taiwan Crops Institute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China Joint International Research laboratory of Ecological Pest Control Ministry of EducationFuzhou 350002P.R.China Key laboratory of Integrated Pest Management for Fujian-Taiwan Crops Ministry of Agriculture and Rural AffairsFuzhou 350002P.R.China Fujian Vocational College of Bioengineering Fuzhou 350002P.R.China Natural Resources Institute University of GreenwichKent ME44TBUK

C-type lectins(CTls)are a superfamily of Ca^(2+)-dependent carbohydrate-recognition proteins,and an important pattern recognition receptor(PRR)in insect innate immunity which can mediate humoral and cellular immunity in *** this study,we report a novel dual carbohydrate-recognition domain(CRD)CTl from Plutella xylostella which we designate *** is a protein with a 969 bp open reading frame(ORF)encoding 322 amino acids,containing a signal peptide and a dual-CRD with EPN(glu_(124)-Pro_(125)-Asn_(126))and QPD(gln_(274)-Pro_(275)-Asp_(276))*** expression of PxIMl mRNA in the fat body was significantly higher than in hemocytes and *** relative expression levels of PxIMl in the whole insect and the fat body were significantly inhibited after infection with Bacillus thuringiensis 8010(Bt8010)at 18 h,while they were significantly upregulated after infection with Serratia marcescens IAE6 or Pichia *** recombinant PxIMl(rPxIMl)protein could bind to the tested pathogen-associated molecular patterns(PAMPs),and the bacteria of Enterobacter ***5,*** IAE6,Staphylococcus aureus,Escherichia coli Bl21,and Bt8010 in a Ca^(2+)-dependent manner,however,it showed limited binding to the fungus,*** rPxIMl exhibited strong activity in the presence of Ca^(2+) to agglutinate Bt8010,Enterobacter ***5 and ***,but it only weakly agglutinated with *** Bl21,and could not agglutinate with *** IAE6 or ***,the rPxIMl could bind to hemocytes,promote the adsorption of hemocytes to beads,and enhance the phenoloxidase(PO)activity and melanization of *** results suggest that PxIMl plays an important role in pathogen recognition and in mediating subsequent humoral and cellular immunity of ***.

关键词： diamondback moth humoral and cellular immunity C-type lectin pattern recognition receptors carbohydrate-recognition domain

独活寄生汤对TNF-α诱导的类风湿性关节炎成纤维样滑膜细胞增殖、凋亡和炎症的影响

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中国药理学通报 2024年第9期40卷 1665-1673页

作者：吴婧若步亚男岳进茹陈佳王桂宇张育敏山西中医药大学基础医学院山西晋中030619

目的探究独活寄生汤含药血清对肿瘤坏死因子-α(TNF-α)诱导的类风湿性关节炎(RA)成纤维样滑膜细胞(FlS)增殖、凋亡和炎症的影响及作用机制。方法将MH7A细胞分为正常组(10%空白血清)、模型组(10μg·l^(-1) TNF-α+10%空白血清)、独活... 详细信息

目的探究独活寄生汤含药血清对肿瘤坏死因子-α(TNF-α)诱导的类风湿性关节炎(RA)成纤维样滑膜细胞(FlS)增殖、凋亡和炎症的影响及作用机制。方法将MH7A细胞分为正常组(10%空白血清)、模型组(10μg·l^(-1) TNF-α+10%空白血清)、独活寄生汤低(10μg·l^(-1) TNF-α+2.5%含药血清+7.5%空白血清)、中(10μg·l^(-1) TNF-α+5%含药血清+5%空白血清)、高(10μg·l^(-1) TNF-α+10%含药血清)剂量组共5组;MTT法筛选独活寄生汤含药血清给药浓度;EdU染色检测细胞增殖情况;免疫荧光染色检测增殖标志物Ki67表达情况;流式细胞仪检测细胞凋亡率;ElISA法检测细胞中IFN-γ、Il-4、Il-6和Il-10的含量;RT-qPCR和Western blot检测Bax、Bcl-2、caspase-3及TlR4/MyD88/NF-κB信号通路mRNA和蛋白的表达情况。结果与正常组比较,模型组细胞增殖水平明显上升,凋亡水平明显减弱,IFN-γ和Il-6的含量升高,Il-4和Il-10的含量减少,TlR4/MyD88/NF-κB信号通路被激活;经独活寄生汤含药血清低、中、高剂量组干预后,均能有效改善细胞异常增殖情况,增强细胞凋亡,抑制炎性反应和TlR4/MyD88/NF-κB信号通路的激活。结论独活寄生汤含药血清能够抑制TNF-α诱导的RA-FlS异常增殖和促炎因子的分泌,增强细胞凋亡和抗炎水平,其作用机制可能与调控TlR4/MyD88/NF-κB信号通路有关。

关键词：独活寄生汤类风湿性关节炎成纤维样滑膜细胞增殖凋亡炎症因子 TlR4/MyD88/NF-κB信号通路

Antibacterial,antioxidant and antiproliferation activities of essential oils and ethanolic extracts from Chinese mugwort(Artemisia vulgaris l.)leaf in sha.xi

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Traditional Medicine Research 2024年第1期9卷 47-56页

作者： Hu-Tan-Xian Zhang Feng-Ru lyu jia-Tong He Chen-yu liu Zheng-Yang Zhou Rui-Jie Wu Zi-Qing Zhao He li School of Chemistry and Chemical Engineering North University of ChinaTaiyuan 030051China sha.xi Jinshuo Biomedical Technology Co. Ltd.Jinzhong 030600China

Background:Artemisia vulgaris,a medicinal aromatic plant,is widely used as a food item,tonic pharmaceutical,and cosmetic industry additive owing to its antibacterial,antihypertensive,hepatoprotective,antioxidant,and antispasmodic *** the effect of different geographic locations on the chemical composition and bioactivities of its extracts is ***:Biological activities of essential oils and ethanol extracts of three varieties of Artemisia vulgaris leaves,which are grown in sha.xi province China,were ***:gas chromatography-mass spectrometry analysis revealed that the main components of essential oils were terpenes and *** oils and ethanol extract of Artemisia vulgaris leaves possessed good antioxidant activities,and their half maximal inhibitory concentrations determined using 1,1-diphenyl-2-picrylhydrazyl and 2,2’-azinobis-(3-ethylbenzthiazoline-6-sulphonate)assays were 57.0 and 22.9μg/ml,*** essential oils also exhibited remarkable antibacterial activity against three foodborne pathogenic bacterial *** ethanol extract presented a high anticancer activity against the MgC-803 human gastric cancer cell ***:These biological activities were well correlated with the composition of the extract and EOs,which in turn is affected by the genetic composition of Artemisia vulgaris and geographic location and diverse climatic condition under which it is *** findings demonstrate the remarkable potential of Artemisia vulgaris as a valuable source of antioxidant,antibacterial,and anticancer agents.

关键词： Artemisia vulgaris essential oils ethanol extracts antioxidant antiproliferation

Regional location of lymph node metastases predicts survival in patients with de novo metastatic prostate cancer

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Asian Journal of Andrology 2023年第4期25卷 462-467页

作者： Zhi-Peng Wang Jun-Ru Chen Jin-ge Zhao sha.Zhu Xing-Ming Zhang jia-yu l.a.g Ben He yu-Chao Ni guang-Xi Sun Peng-Fei Shen Hao Zeng Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology The Third People’s Hospital of ChengduChengdu 610031China

To report the regional locations of metastases and to estimate the prognostic value of the pattern of regional metastases inmen with metastatic hormone-sensitive prostate cancer (mHSPC), we retrospectively analyzed 870 mHSPC patients betweenNovember 28, 2009, and February 4, 2021, from West China Hospital in Chengdu, China. The patients were initially classifiedinto 5 subgroups according to metastatic patterns as follows: simple bone metastases (g1), concomitant bone and regional lymphnode (lN) metastases (g2), concomitant bone and nonregional lN (NRlN) metastases (g3), lung metastases (g4), and livermetastases (g5). In addition, patients in the g3 group were subclassified as g3a and g3b based on the lN metastatic plane(below or above the diaphragm, respectively). The associations of different metastatic patterns with castration-resistant prostatecancer-free survival (CFS) and overall survival (OS) were analyzed by univariate and multivariate analyses. The results showedthat patients in g1 and g2 had relatively favorable clinical outcomes, patients in g3a and g4 had intermediate prognoses, andpatients in g3b and g5 had the worst survival outcomes. We observed that patients in g3b had outcomes comparable to those ing5 but had a significantly worse prognosis than patients in g3a (median CFS: 8.2 months vs 14.3 months, P = 0.015;medianOS: 38.1 months vs 45.8 months, P = 0.038). In conclusion, metastatic site can predict the prognosis of patients with mHSPC,and the presence of concomitant bone and NRlN metastases is a valuable prognostic factor. Furthermore, our findings indicatethat the farther the NRlNs are located, the more aggressive the disease is.

关键词： lymph node metastases metastatic hormone-sensitive prostate cancer metastatic pattern metastatic site nonregional lymph node metastases staging

基于X射线荧光光谱的温稠密物质离化分布实验方法研究

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物理学报 2024年第1期73卷 241-247页

作者：张志宇赵阳青波张继彦林成亮杨国洪韦敏习熊刚吕敏黄成武朱托宋天明赵妍张玉雪张璐李丽灵杜华冰车兴森黎宇坤詹夏宇杨家敏中国工程物理研究院激光聚变研究中心绵阳621900 北京应用物理与计算数学研究所北京100088

受温度及密度等环境效应影响,温稠密物质的电子结构发生显著变化,其理论描述非常复杂,精密实验测量亦极其困难.本文发展了基于X射线荧光光谱研究温稠密物质离化分布的实验方法,结合理论研究有助于深入理解温稠密物质的电子结构变化.在... 详细信息

受温度及密度等环境效应影响,温稠密物质的电子结构发生显著变化,其理论描述非常复杂,精密实验测量亦极其困难.本文发展了基于X射线荧光光谱研究温稠密物质离化分布的实验方法,结合理论研究有助于深入理解温稠密物质的电子结构变化.在万焦耳激光装置上,设计特殊构型黑腔复合加载产生数十eV、近固体密度的稠密Ti物质,利用激光辐照V产生的热发射线泵浦Ti的荧光,并采用晶体谱仪诊断样品的X射线荧光光谱.实验中获得冷样品和加载样品的荧光光谱,观测到加载样品K_(α)及K_(β)荧光谱线相对于冷样品光谱在高能侧的显著变化,结合理论计算解释了加载样品荧光谱线的变化主要来源于其温度上升后离化分布的改变,建立了基于X射线荧光光谱的温稠密物质离化分布实验研究能力.

关键词：温稠密物质电子结构离化分布 X射线荧光光谱

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P(N-MAAm)水凝胶吸附剂的制备及其对亚甲基蓝染料吸附性能的研究

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现代化工 2024年第S01期44卷 166-171页

作者：韩志成贾伟娜王璇于世超刘奕含于良民中国海洋大学三亚海洋研究院海南三亚572025 中国海洋大学化学化工学院山东青岛266100

将N-羟甲基丙烯酰胺引入聚丙烯酸-丙烯酰胺体系,采用“一锅煮”法合成了P(N-MAAm)水凝胶。结果显示,当n(AM)∶n(AA)为1∶4、中和度为60%、交联剂用量为0.4%、n(AM)∶n(N-MA)=9.5∶0.5时,P(N-MAAm)对亚甲基蓝(MB)的实测最大吸附量可达160... 详细信息

将N-羟甲基丙烯酰胺引入聚丙烯酸-丙烯酰胺体系,采用“一锅煮”法合成了P(N-MAAm)水凝胶。结果显示,当n(AM)∶n(AA)为1∶4、中和度为60%、交联剂用量为0.4%、n(AM)∶n(N-MA)=9.5∶0.5时,P(N-MAAm)对亚甲基蓝(MB)的实测最大吸附量可达1603.77 mg/g;降低环境温度、盐度,提高pH有利于P(N-MAAm)水凝胶吸附MB;吸附动力学曲线符合准一级动力学模型(R_(1)>0.999),吸附等温线更符合langmuir模型(R_(l)>0.981),P(N-MAAm)水凝胶对MB的吸附过程更倾向于是物理吸附,并且可能是多分子层吸附。P(N-MAAm)水凝胶通过langmuir模型拟合计算得到理论最大吸附量为3170.27 mg/g;具有良好的可重复利用性能,5次吸附-解吸循环后对MB的去除率仍高于95%。

关键词：水凝胶 N-羟甲基丙烯酰胺聚丙烯酰胺丙烯酸亚甲基蓝

生姜青枯病菌拮抗芽孢杆菌的筛选、鉴定及发酵条件优化

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南方农业学报 2024年第2期55卷 468-478页

作者：崔文艳张佳佳俞伶俐张贵云王文佳彭玲罗喜燕何朋杰贵州中医药大学贵州贵阳550025 贵州大学绿色农药与农业生物工程教育部重点实验室贵州贵阳550025

【目的】筛选出对生姜青枯病病原菌具有较好拮抗效果的芽孢杆菌,并优化其发酵条件,旨在为丰富生姜青枯病的生防芽孢杆菌菌种资源及生防制剂的进一步开发应用打下理论基础。【方法】以生姜根际土壤为研究对象,以生姜青枯病菌为靶标,通过... 详细信息

【目的】筛选出对生姜青枯病病原菌具有较好拮抗效果的芽孢杆菌,并优化其发酵条件,旨在为丰富生姜青枯病的生防芽孢杆菌菌种资源及生防制剂的进一步开发应用打下理论基础。【方法】以生姜根际土壤为研究对象,以生姜青枯病菌为靶标,通过稀释涂布法和抑菌圈法从中分离并筛选出能高效拮抗生姜青枯病菌的芽孢杆菌;通过形态学观察、生理生化测定和分子生物学鉴定,确定拮抗菌株的分类地位;采用牛津杯法测定拮抗菌株对生姜青枯病菌的抑菌活性,并结合单因素和正交试验对其发酵条件进行优化。【结果】从生姜根际土壤中分离出1株对生姜青枯病菌具有较强拮抗作用的菌株HC-5,其抑菌圈直径达0.71 cm。综合形态学特征、生理生化特性及分子鉴定结果,将菌株HC-5鉴定为贝莱斯芽孢杆菌(Bacillusvelezensis)。单因素和正交试验结果显示,菌株HC-5的最适发酵培养基组分为糯米粉5.0 g/l、酵母浸粉7.0 g/l、硫酸锌11.0 g/l,最适发酵条件为培养温度35℃、培养时间36 h、接种量1.0%、转速180 r/min、初始pH 5.5、装液量100 m l。优化后菌株HC-5无菌上清液对生姜青枯病菌的抑菌圈直径增大至3.03 cm,相比于lB和发酵培养基条件下分别增大76.2%和62.9%。【结论】菌株HC-5对生姜青枯病菌具有良好的拮抗效果,经发酵条件优化后其无菌上清液对生姜青枯病菌的抑菌活性显著增强。菌株HC-5具有开发成生姜青枯病生防菌剂的潜力。

关键词：生姜青枯病贝莱斯芽孢杆菌拮抗活性正交试验发酵条件