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Individual virome analysis reveals the general co-infection of mammal-associated viruses with SARS-related coronaviruses in bats

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Virologica Sinica 2024年第4期39卷 565-573页

作者： Hao-Rui Si Ke Wu jia Su Tian-Yi Dong Yan Zhu Bei Li Ying Chen Yang Li Zheng-Li Shi peng Zhou Wuhan Institute of Virology Chinese Academy of SciencesWuhan 43000China guangzhou National Laboratory Guangzhou International Bio IslandGuangzhou 510005China University of Chinese Academy of Sciences Beijing 100000China State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical SchoolGuangzhou 510005China

Bats are the natural reservoir hosts for SARS-related coronavirus(SARSr-CoV)and other highly pathogenic ***,it is conceivable that an individual bat may harbor multiple ***,there is limited knowledge on the overall co-circulation of microorganisms in ***,we conducted a 16-year monitoring of bat viruses in south and central China and identified 238 SARSr-CoV positive samples across nine bat species from ten provinces or administrative *** these,76 individual samples were selected for further metagenomics *** found a complex microenvironment characterized by the general cocirculation of microbes from two different sources:mammal-associated viruses or environment-associated *** later includes commensal bacteria,enterobacteria-related phages,and insect or fungal viruses of food *** showed that 25%(19/76)of the samples contained at least one another mammal-associated virus,notably alphacoronaviruses(13/76)such as AlphaCoV/YN2012,HKU2-related CoV and AlphaCoV/Rf-HuB2013,along with viruses from other ***,we observed three viruses co-circulating within a single bat,comprising two coronavirus species and one *** analysis also revealed the potential presence of pathogenic bacteria or fungi in ***,we obtained 25 viral genomes from the 76 bat SARSr-CoV positive samples,some of which formed new evolutionary ***,our study reveals the complex microenvironment of bat microbiome,facilitating deeper investigations into their pathogenic potential and the likelihood of cross-species transmission.

关键词： Bat Microbiome SARS-related coronavirus Co-infection Alphacoronavirus

Natural product chlorogenic acid achieves pharmacological activity and health protection via regulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Ke Fu Shu Dai Yafang Zhang jia.gong Cheng Wang Chenhao Yao Shenglin Zhang Cheng peng Yunxia Li State Key Laboratory of Southwestern Chinese Medicine Resources， Key Laboratory of Standardization for Chinese Herbal Medicine， Ministry of Education， School of Pharmacy， Chengdu University of Traditional Chinese Medicine College of Enology， Northwest A&F University

Chlorogenic acid (CA) is a natural plant-derived polyphenol compound that is widely present in beverages (coffee and tea)， fruits (blueberry， apple， and mulberry)， and medicinal plants (Lonicera japonica， Eucommia ulmoides， and Cichorium intybus). In recent years， CA has attracted extensive attention due to its various health benefits， such as anti-inflammatory， immunomodulatory， anti-obesity， anti-diabetes mellitus， and neuroprotection activities. Interestingly， the low bioavailability of CA corresponds to high bioactivity， which raises a key scientific question of how low bioavailability CA can achieve high biological activity. In this review， we highlight the gut microbiota as a key target for connecting the two by summarizing a large amount of evidence. Specifically， the composition and abundance of gut microbiota， its metabolites， intestinal immunity， barrier function and so on were all changed under different pathological conditions such as inflammatory bowel disease， liver disease， kidney disease， cardiovascular disease， diabetes mellitus， obesity， etc. Conversely， these changes could be reversed by CA. In a word， CA could achieve pharmacological activity as well as health-protective effects by modulating intestinal immune and barrier function， gut microbiota composition， gut microbiota metabolites， and signaling pathways. This review provides new targets for the prevention and treatment of diseases by CA. Meanwhile， regulating the composition of the gut microbiota through natural products may be a potential strategy to achieve health protection.

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Converting intercalation-type cathode in spent lithium-ion batteries into conversion-type cathode

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Nano Research 2024年第5期17卷 4602-4609页

作者： Dingding Zhu Yong Su Jingzhao Chen Xiangze Ou Xuedong Zhang Wen Xie Yuyan Zhou Yunna guo Qiushi Dai peng jia Jitong Yan Lin geng Baiyu guo Liqiang Zhang Yongfu Tang Qiao Huang jianyu Huang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066000China

The widespread applications of lithium-ion batteries(LIBs)generate tons of spent ***,recycling LIBs is of paramount importance in protecting the environment and saving the *** commercialized LIBs mostly adopt layered oxides such as LiCoO_(2)(LCO)or LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)(NMC)as the cathode *** the intercalation-type spent oxides into conversion-type cathodes(such as metal fluorides(MFs))offers a valid recycling strategy and provides substantially improved energy densities for ***,two typical Co-based cathodes,LCO and LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NMC622),in spent LIBs were successfully converted to CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) cathodes by a reduction and fluorination *** as converted CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) delivered cell energy densities of 650 and 700 Wh/kg,*** atomic-level electron microscopy revealed that the used LCO and NMC622 were converted to highly phase pure Co metal and Ni_(0.6)Co_(0.2)Mn_(0.2) alloys in the used graphite-assisted reduction roasting,simultaneously producing the important product of Li_(2)CO_(3) using only environment friendly *** study provided a versatile strategy to convert the intercalation-type Co-based cathode in the spent LIBs into conversion-type MFs cathodes,which offers a new avenue to recycle the spent LIBs and substantially increase the energy densities of next generation LIBs.

关键词： spent lithium-ion batteries recycling energy densities conversion-type cathode

Weatherability and heat resistance enhanced by interaction between Ag25 and Mg/AI-LDH

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Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang Xiang-Cui Liu Yu-Chao Wang Huan-Ran Zheng Jin-Xian Wang jia-Yi Zheng Meng-Jie Liu Dan-Ni Deng Yu Bai Ying-Bi Chen Tong Zhang Zhi-Ming Liu Yong-peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(Ag25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of Ag25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and Ag25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

Nanodiamond:a promising metal-free nanoscale material in photocatalysis and electrocatalysis

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Rare Metals 2024年第8期43卷 3501-3552页

作者： Xiao-Wu gao Zi-Wei Zhao Yang He Sai-Fei Fan Ke-Ran jiao Si-Yu Lou Xin-Yue Han peng-Fei Song Rong Cai Zhun Hu Zhong-Jie jia.g Yong-Jie Wang jia-Qi Zhu guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems School of ScienceHarbin Institute of TechnologyShenzhen 518055China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150080China School of Advanced Technology Xi'an Jiaotong-Liverpool UniversitySuzhou215000China Department of Biosciences Rice UniversityHoustonTX 77251USA Institute of Industrial Catalysis School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China guangzhou Key Laboratory for Surface Chemistry of Energy Materials New Energy Research Institute&Guangdong Engineering and Technology Research Center for Surface Chemistry of Energy MaterialsCollege of Environment and EnergySouth China University of TechnologyGuangzhou 510006China

Benefiting from its surface-rich functional groups,eco-friendliness,impressive electrochemical properties,excellent light absorption,structural tunability at the atomic/morphological level,and ultra-high stability under harsh conditions,nanodiamond has emerged as a promising carbon-based non-metallic material in the field of energy conversion such as electrocatalysis and ***,nanodiamond,as a new generation of green catalysts,can overcome the poisoning of catalysts by complex pollutants in advanced oxidation processes,thus effectively removing organic matter from water,which is unparalleled in reducing the cost of water purification and avoiding secondary cross-contamination of water by traditional heavy metal-based ***,we review the research and development of nanodiamonds as major electrocatalysts and photocatalysts for energy conversion and for air/water treatment for environmental *** relevant properties,trimming strategy,mechanistic understanding,and design principles of nanodiamond as a catalyst are described,as well as the challenges and prospects of this emerging field.

关键词： Carbon materials Nanodiamond Electrocatalysis Photocatalysis Energy conversion Pollutant treatment

中央土地督察对地方土地出让的影响效应及作用机制研究——基于例行督察的准实验研究

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公共管理与政策评论 2024年第3期13卷 93-115页

作者：刘佳朱珊彭佳陕西师范大学国家安全学院(政法与公共管理学院) 电子科技大学公共管理学院

作为土地管理的一项重要制度创新,土地督察制度通过硬化土地利用的制度约束,规范地方政府土地出让,从而限制土地出让规模。本研究以土地例行督察政策为准自然实验,采用中国281个地级市的面板数据,运用多期DID方法实证检验了土地例行督... 详细信息

作为土地管理的一项重要制度创新,土地督察制度通过硬化土地利用的制度约束,规范地方政府土地出让,从而限制土地出让规模。本研究以土地例行督察政策为准自然实验,采用中国281个地级市的面板数据,运用多期DID方法实证检验了土地例行督察对地方政府土地出让规模的长短期抑制效应及作用机制。实证结果显示:(1)土地例行督察能够有效遏制土地出让规模,且此结论具有较强的稳健性;(2)土地例行督察对土地出让规模的抑制作用长期持续且稳定;(3)土地例行督察通过提升产业结构高级化水平,从而消减了地方政府土地出让规模;(4)被督察地区的主政官员是异地莅任,以及被督察地区的财政透明度越高,则土地例行督察对地方政府土地出让规模的抑制效果越优;(5)土地例行督察具有显著的驻地效应,土地督察局驻地地区的土地出让规模比非驻地地区显著减少;(6)土地例行督察的抑制效应存在区域异质性,在东部地区政策效应最强,中部地区次之,西部地区没有影响。最后,本研究提出了加大土地例行督察的实施力度、促进土地例行督察政策与产业政策的协调、强化土地督察局权力和职能、注重土地例行督察效应的区域差异等政策建议。

关键词：土地例行督察土地出让产业结构驻地效应影响机制

基于量子反应均衡的政府与共享单车企业停车管理博弈分析

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控制与决策 2024年第2期39卷 641-648页

作者：张书婧贾顺平彭芃毛保华北京交通大学交通运输学院北京100044 北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044 北京交通大学中国综合交通研究中心北京100044

共享单车停车问题是城市交通治理中最主要的问题之一,其表面为共享单车用户停车行为不规范、共享单车企业管理调度不及时所致,究其本质实为共享单车各利益主体缺乏有效协同治理机制、停车权责划分不清晰、成本分担失衡的结果.考虑政府... 详细信息

共享单车停车问题是城市交通治理中最主要的问题之一,其表面为共享单车用户停车行为不规范、共享单车企业管理调度不及时所致,究其本质实为共享单车各利益主体缺乏有效协同治理机制、停车权责划分不清晰、成本分担失衡的结果.考虑政府与共享单车企业的有限理性,建立扩展式博弈的量子反应均衡(QRE)模型分析双方停车管理博弈机理,并利用gambit软件进行算例仿真分析.研究表明:双方博弈结果随理性程度增加逐渐趋向于基于完全理性的子博弈精炼纳什均衡,政府掌握更多企业运营信息有利于达到社会效用最大化的博弈结果;政府引入有效处罚措施或主导负责停车管理可以降低自身的财政支出和社会总成本,建立量化的处罚标准能够促进企业主动承担停车管理责任;有限理性程度、违停数量、激励机制和科技手段运行效率会影响企业的停车管理策略选择.

关键词：共享单车停车治理研究有限理性量子反应均衡扩展式博弈仿真

3M syndrome patient with a novel mutation:A case rep

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World Journal of Clinical Cases 2024年第8期12卷 1454-1460页

作者： Ming-Ran Luo Si-Ming Dai Yin Li Qian Wang Hao Liu peng gao jia-Yun Liu jian Chen Shu-Jie Zhao guo-Yong Yin Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKgROUND A rare autosomal recessive genetic disorder,3M syndrome,is characterized by severe intrauterine and postnatal growth *** with 3M syndrome typically exhibit short stature,facial deformities,long tubular bones,and high vertebral bodies but generally lack mental abnormalities or other organ *** genes associated with 3M syndrome include CUL7,OBSL1 and *** clinical and molecular characteristics of patient with 3M syn-drome are unique and serve as important diagnostic *** SUMMARY In this case,the patient displayed square shoulders,scoliosis,long slender tubular bones,and normal neurological ***,the patient did not exhibit the typical dysmorphic facial features,relative macrocephaly,or growth retardation commonly observed in individuals with 3M *** exon sequencing revealed a novel heterozygous c.56681+1g>C(Splice-3)variant and a previously reported nonsense heterozygous c.3341g>A(***1114Ter)variant of ***,it is important to note that the clinical features of 3M syndrome may not always be observable,and genetic confirmation is often ***,the identification of the c.5683+1g>C variant in OBSL1 is notewor-thy because it has not been previously reported in public *** Our study identified a new variant(c.5683+1g>C)of OBSL1 that contributes to expanding the molecular profile of 3M syndrome.

关键词： 3M syndrome CUL7 OBSL1 CCDC8 Autosomal recessive Case report

Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

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World Journal of gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-Ling Wang Chen Chen Yi-jia Zhu Wen-Wen Tang Yu-Ji Wang Ze-peng Chen Lin-Hai He Yu-gen Chen Wei Zhang jia.gsu Province Hospital of Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 Clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina jia.gsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina jia.gsu Collaborative Innovation Center of Chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKgROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PgP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress gut microbiota Serum metabolites