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Curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation

Chinese Journal of Integrative Medicine 2024年第7期30卷 600-607页

作者： xu Ben ZHANG jia-en YE Lin YUAN Chang-wei Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis(RIF)progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18(ADAMTS18)*** NRK-49F cells RIF model were induced with transforming growth factorβ1(TGF-β1).Effects of different concentrations of curcumin(0,10,20,and 30μmol/L)on cell proliferation,cell cycle,cell apoptosis as well as cyclin D1 expression were analyzed by cell counting kit-8,flow cytometry and Western blot,***18 methylation levels were determined by methylation-specific polymerase chain ***18,fibronectin(FN),type I collagen(Col-I)and alpha-smooth muscle actin(α-SMA)mRNA and protein expressions were analyzed by real-time PCR(RT-PCR)and Western blot,***,cells were treated with 50 mmol/L 5-aza-2′-deoxycytidine(5-aza-dC,demethylation agent)for 72 *** of curcumin on extracellular matrix(ECM)deposition was evaluated by immunochemical staining and Western ***-49F cells were transfected with ADAMTS18 small interfering RNA and grouped into a normal control,ADAMTS18-knock-out(KO),and ADAMTS18-KO+30μmol/L curcumin groups,and whether curcumin can reverse the effect of ADAMTS18 knockdown on RIF was *** Compared with the control group,TGF-β1 significantly inhibited the proliferation of NRK-49F cells,blocked the G1/G0 phase,promoted cell apoptosis and inhibited cyclin D1 expression(P<0.01).Among the different concentrations of curcumin,30μmol/L curcumin significantly reversed these processes(P<0.01).Immunochemical staining and Western blot results showed that curcumin significantly inhibited the deposition of FN,Col-I andα-SMA(P<0.01).Curcumin and 5-zaz-dC had synergistic effects,promoting ADAMTS18 expression,removing ADAMTS18 methylation,and reducing ECM ***18 knockdown promoted ECM accumulation,and curcumin reversed this process(P<0.01).Conclusion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal fibrosis curcumin Chinese medicine ADAMTS18 methylation modification

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Impact of frailty on postoperative outcomes after hepatectomy:A systematic review and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2319-2328页

作者： Yao-jia Lv Guang-Xing xu jia-Rong Lan Day Surgery Ward Huzhou Central HospitalThe Affiliated Central Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Medicine Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND The impact of frailty on postoperative outcomes in patients undergoing hepatectomy is still *** To study the influence of frailty on postoperative outcomes,such as mortality,rate of complications,and length of hospitalization,following *** PubMed,EMBASE,and Scopus databases were searched for observational studies with adult(≥18 years)patients after planned/elective hepatectomy.A randomeffects model was used for all analyses,and the results are expressed as weighted mean difference(WMD),relative risk(RR),or hazards ratio(HR)with 95%confidence interval(CI).RESULTS Analysis of the 13 included studies showed a significant association of frailty with elevated risk of in-hospital mortality(RR=2.76,95%CI:2.10-3.64),mortality at 30 d(RR=4.60,95%CI:1.85-11.40),and mortality at 90 d(RR=2.52,95%CI:1.70-3.75)in the postoperative *** patients had a poorer long-term survival(HR=2.89,95%CI:1.84-4.53)and higher incidence of“any”complications(RR=1.69,95%CI:1.40-2.03)and major(grade III or higher on the Clavien-Dindo scale)complications(RR=2.69,95%CI:1.85-3.92).Frailty was correlated with markedly lengthier hospital stay(WMD=3.65,95%CI:1.45-5.85).CONCLUSION Frailty correlates with elevated risks of mortality,complications,and prolonged hospitalization,which need to be considered in surgical *** research is essential to formulate strategies for improved outcomes in this vulnerable cohort.

关键词： Frailty Frail adults Hepatic resection Hepatectomy Complications Mortality Survival Clinical outcomes Meta-analysis

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Tuning Synaptic Connections Instead of Weights by Genetic Algorithm in Spiking Policy Network

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Machine Intelligence Research 2024年第5期21卷 906-918页

作者： Duzhen Zhang Tielin Zhang Shuncheng jia Qingyu Wang Bo xu School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Institute of Automation Chinese Academy of Sciences(CAS)Beijing100190China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences(CAS)Shanghai200031China

Learning from interaction is the primary way that biological agents acquire knowledge about their environment and *** deep reinforcement learning(DRL)explores a computational approach to learning from interaction and has made significant progress in solving various ***,despite its power,DRL still falls short of biological agents in terms of energy *** the underlying mechanisms are not fully understood,we believe that the integration of spiking communication between neurons and biologically-plausible synaptic plasticity plays a prominent role in achieving greater energy *** this biological intuition,we optimized a spiking policy network(SPN)using a genetic algorithm as an energy-efficient alternative to *** SPN mimics the sensorimotor neuron pathway of insects and communicates through event-based *** by biological research showing that the brain forms memories by creating new synaptic connections and rewiring these connections based on new experiences,we tuned the synaptic connections instead of weights in the SPN to solve given *** results on several robotic control tasks demonstrate that our method can achieve the same level of performance as mainstream DRL methods while exhibiting significantly higher energy efficiency.

关键词： Spiking neural networks genetic evolution bio-inspired learning agent&cognitive architectures robotic control

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Preparation and characterization of Rb-doped TiO_(2) powders for photocatalytic applications

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Rare Metals 2024年第2期43卷 555-561页

作者： Lu jia Li-Mei Yang Wei Wang Song-Tao Huang Zheng xu National Engineering Laboratory of Biohydrometallurgy General Research Institute for Nonferrous MetalsBeijing100088China

TiO_(2)nanoparticles doped with different concentrations of Rb were prepared by sol–gel *** crystal structures of samples were characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM).It was confirmed by the Rietveld refinement method that the as-prepared samples crystallize in anatase phase and Rb doping induces expansion and distortion of the crystal *** with the pure TiO_(2),the Rb-doped nanoparticles have smaller crystal size and better *** rate of methylene blue was used to evaluate the photocatalytic activity of Rb–TiO_(2).It indicated that doping Rb into TiO_(2)can effectively improve the photocatalytic activity of TiO_(2)and the mechanisms were discussed in *** using the sample doped with 0.20%Rb,methylene blue degraded with the fastest rate(97%within 60 min).

关键词： Rb doping TiO_(2) Photocatalysis Sol-gel

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Adaptive detection of range-spread targets in homogeneous and partially homogeneous clutter plus subspace interference

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Journal of Systems Engineering and Electronics 2024年第1期35卷 43-54页

作者： jiaN Tao HE jia WANG Bencai LIU Yu xu Congan XIE Zikeng Research Institute of Information Fusion Naval Aviation UniversityYantai 264001China Air Force Early Warning Academy Wuhan 430019China

Adaptive detection of range-spread targets is considered in the presence of subspace interference plus Gaussian clutter with unknown covariance *** target signal and interference are supposed to lie in two linearly independent subspaces with deterministic but unknown *** on the two-step criteria,two adaptive detectors based on Gradient tests are proposed,in homogeneous and partially homogeneous clutter plus subspace interference,*** of the proposed detectors exhibit theoretically constant false alarm rate property against unknown clutter covariance matrix as well as the power *** results show that,the proposed detectors have better performance than their existing counterparts,especially for mismatches in the signal steering vectors.

关键词： adaptive detection subspace interference constant false alarm rate Gradient test partially homogeneous environment

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Noninvasive Detection of Cerebral Blood Flow and Blood Oxygen Based on Inductive Sensing Technology and Near Infrared Spectroscopy

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Journal of Beijing Institute of Technology 2024年第3期33卷 204-212页

作者： Cheng Zhou Zexiang Lyu Maoting Zhang Xin Zou Liang Wei feng Wang Mingxin Qin jia xu jian Sun College of Biomedical Engineering Army Medical UniversityChongqing 400038China School of Pharmacy and Bioengineering Chongqing University of TechnologyChongqing 400054China Department of Medical Engineering Xinqiao HospitalChongqing 400037China

The synchronous monitoring of cerebral blood flow and blood oxygen levels plays a pivotal role in the prevention,diagnosis,and treatment of cerebrovascular *** study introduces a novel noninvasive device utilizing inductive sensing and near-infrared spectroscopy technology to facilitate simultaneous monitoring of cerebral blood flow and blood oxygen *** device consists of modules for cerebral blood flow monitoring,cerebral blood oxygen monitoring,control,communication,and a host *** experiments conducted on healthy subjects,it was confirmed that the device can effectively achieve synchronous monitoring and recording of cerebral blood flow and blood oxygen *** results demonstrate the device’s capability to accurately measure these signals *** technology enables dynamic monitoring of cerebral blood flow and blood oxygen signals with potential clinical applications in preventing,diagnosing,treating cerebrovascular diseases while reducing their associated harm.

关键词： cerebrovascular disease synchronous monitoring inductive sensing near infrared spec-troscopy(NIRS)

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Design and Implementation of a High-Sensitivity Magnetic Sensing System Based on GMI Effect

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Journal of Beijing Institute of Technology 2024年第3期33卷 237-247页

作者： Wenzhu Wu Ming xu Changlin Han Junquan Tang jia xu Lin xu Mingxin Qin Department of Electronic Engineering Army Medical UniversityChongqing 400038China Chongqing Medical and Pharmaceutical College Chongqing 401331China Department of Intelligence Science and Technology National University of Defense TechnologyChangshaChangsha 410073China Intelligent Game and Decision Lab Beijing 100091China

A high-sensitivity magnetic sensing system based on giant magneto-impedance(GMI)effect is designed and *** system comprises a GMI sensor equipped with a gradient probe and an signal acquisition and processing module.A segmented superposition algorithm is used to increase target signal and reduce the random *** results show that under unshielded,room temperature conditions,the system achieves successful detection of weak magnetic fields down to 2 pT with a notable sensitivity of 1.84×10^(8)V/T(G=1000).By applying 17 overlays,the segmented superposition algorithm increases the power proportion of the target signal at 31 Hz from6.89%to 45.91%,surpassing the power proportion of the 2 Hz low-frequency interference ***,it reduces the power proportion of the 20 Hz random *** segmented superposition process effectively cancels out certain random noise elements,leading to a reduction in their respective power *** high-sensitivity magnetic sensing system features a simple structure,and is easy to operate,making it highly valuable for both practical applications and broader dissemination.

关键词： high-sensitivity magnetic field sensing system GMI effect segmented superposition algorithm

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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI Jie CHEN Ya-feng GAO Lei LI Yi-jie feng Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency catheter ablation

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Journal of Geriatric Cardiology 2024年第2期21卷 200-210页

作者： Qing YAN jia-Qi LIANG Yi-De YUAN Yuan LI jia-Li FAN Wen-Huan WU Pan xu jia-Hong xuE Department of Cardiovascular Medicine the Second Affiliated Hospital of Xi’an Jiaotong UniversityShaanxiChina Department of Cardiovascular Medicine Zichang People’s HospitalShaanxiChina Department of Ultrasound Xijing HospitalAir Force Military Medical UniversityShaanxiChina

BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin *** study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency catheter ablation(RFCA).METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an jiaotong University were included in this *** participants were grouped based on cumulative TyG index values tertiles within 3 months after *** regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF *** predictive value of all risk factors was assessed by receiver operating curve *** There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence increased with increasing cumulative TyG index values *** adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)=4.949,95%CI:1.778–13.778,P=0.002]and the high cumulative TyG index group(HR=8.716,95%CI:3.371–22.536,P<0.001)had a higher risk of AF recurrence than those in the low cumulative TyG index *** restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulative TyG index *** considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)=0.847,95%CI:0.797–0.897,P<0.001].CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after *** longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.

关键词： atrial fibrillation index

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A two-step multi-frequency receiver function inversion method for shallow crustal S-wave velocity structure and its application across the basin-mountain range belts in Northeast China

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Science China Earth Sciences 2024年第3期67卷 687-703页

作者： Ruihao YANG xu WANG Ling CHEN Mingye feng Qifu CHEN State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

A shallow crustal velocity structure(above 10 km depth) is essential for understanding the crustal structures and deformation and assessing the exploration prospect of natural resources, and also provides priori information for imaging deeper crustal and mantle structure. Passive-source seismic methods are cost-effective and advantageous for regional-scale imaging of shallow crustal structures compared to active-source methods. Among these passive methods, techniques utilizing receiver function waveforms and/or body-wave amplitude ratios have recently gained prominence due to their relatively high spatial resolution. However, in basin regions, reverberations caused by near-surface unconsolidated sedimentary layers often introduce strong non-uniqueness and uncertainty, limiting the applicability of such methods. To address these challenges, we propose a two-step inversion method that uses multi-frequency P-RF waveforms and P-RF horizontal-to-vertical amplitude ratios. Synthetic tests indicate that our two-step inversion method can mitigate the non-uniqueness of the inversion and enhance the stability of the results. Applying this method to teleseismic data from a linear seismic array across the sedimentary basins in Northeast China, we obtain a high-resolution image of the shallow crustal S-wave velocity structure along the array. Our results reveal significant differences between the basins and mountains. The identification of low-velocity anomalies(<2.8 km s^(-1)) at depths less than 1.0 km beneath the Erlian Basin and less than 2.5 km beneath the Songliao Basin suggests the existence of sedimentary layers. Moreover, the high-velocity anomalies(~3.4–3.8 km s^(-1)) occurring at depths greater than 7 km in the Songliao Basin may reflect mafic intrusions emplaced during the Early Cretaceous. Velocity anomaly distribution in our imaging result is consistent with the location of the major faults, uplifts, and sedimentary depressions, as well as active-source seismic res

关键词： Receiver function Frequency dependence Two-step inversion Shallow crustal velocity structures Unconsolidated sedimentary basins

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