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Xanthones from garcinia pedunculata and garcinia nujia.gensis and their anti-inflammatory activity

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Chinese Journal of Natural Medicines 2025年第2期23卷 225-233页

作者： Xiaojie Fan Yufeng jia.jia.in guo Jinyuan ya.g Dahong Li Huiming hua Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education and School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

Ten novel xanthones,garpedunxanthones A-g（1-5,6a/6b,7a/7b） and nujia.gxanthone Q（8）,along with sixteen known analogs（9-24）,were isolated from garcinia pedunculata and *** structures were elucidated through high-resolution electrospray ionization mass spectrometry（HR-ESI-MS） data,comprehensive nuclear magnetic resonance（NMR） spectroscopic analyses,and electronic circular dichroism（ECD） *** compounds without cytotoxicity were assessed for anti-inflammatory properties by measuring the inhibition of nitric oxide（NO） production in lipopolysaccharide（LPS）-induced ***-activity relationships are also *** 7b,19,and 21 exhibited significant anti-inflammatory activity with IC50values of 16.44±0.69,14.28±0.78,and 10.67±3.28 μmol·L-1,***-linked immunosorbent assay（ELISA） demonstrated that compounds 7b,19,and 21 inhibited the expression of pro-inflammatory cytokines TNF-α and IL-6 in a dose-dependent *** inhibitory effect of compo und 21 on IL-6 at 20 μmol·L-1was comparable to that of the positive *** network pharmacology studies,potential targets of compounds and inflammation were identified from PharmMapper and geneCards *** Ontology（gO） and Kyoto Encyclopedia of genes and genomes（KEgg） enrichment analysis revealed that the overlapped targets were intricately associated with major pathogenic processes linked to inflammation,including positive regulation of mitogen-activated protein kinase（MAPK） cascade,protein kinase activity,NO synthase regulator activity,MAPK signaling pathway,and EgFR tyrosine kinase inhibitor resistance.

关键词： Anti-inflammation garcinia nujia.gensis garcinia pedunculata Network pharmacology Xanthones

RgS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-yao Wang Bang Liu ya.g-Pu jia.Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-jia.yan Wei-hua.Fu Feng Zhu Department of general Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of general Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKgROUND Regulator of g protein signaling(RgS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric g *** speci-fic effect of RgS,particularly RgS4,on the progression of gastric cancer(gC)is not yet *** To explore the role and underlying mechanisms of action of RgS4 in gC *** The prognostic significance of RgS4 in gC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RgS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RgS4 on gC growth in *** RgS4 was highly expressed in gC tissues compared with matched adjacent normal *** RgS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RgS4 knockdown suppressed gC cell proliferation,migration and ***,xenograft experiments confirmed that RgS4 silencing significantly inhibited tumor ***,RgS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RgS4 expression in gC indicates a worse prognosis and RgS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： gastric cancer Prognosis Regulator of g protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis:A 48-Week,Multicentre,Randomized,Double-Blind,and Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2025年第2期31卷 99-107页

作者： jia.Qing-yun WANg Yi-ru SUN Da-wei MAO jia.-chun XUE Luan gU Xiao-hua.YU Xiang PIAO Xue-mei XU Hao LIANg Qian-qian Spine Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200032)China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai(200032)China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai(201203)China Department of Orthopedics Linyi People's HospitalLinyiShandong Province(273000)China Department of Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200437)China Department of Orthopedics the Seventh People's Hospital of Shanghai University of Traditional Chinese MedicineShanghai(200137)China

Objective:To explore the efficacy and safety of Juan Bi Pill(JBP)in treatment of active rheumatoid arthritis(RA).Methods:From February 2017 to May 2018,115 participants from 4 centers were randomly divided into JBP group(57 cases)and placebo group(58 cases)in a 1:1 ratio using a random number table *** received a dose of JBP(4 g,twice a day,orally)combined with methotrexate(MTX,10 mg per week)or placebo(4 g,twice a day,orally)combined with MTX for 12 *** were required with follow-up visits at 24 and 48 weeks,attending 7 assessment *** were undergo disease activity assessment 7 times(at baseline and 2,4,8,12,24,48 weeks)and safety assessments 6 times(at baseline and 4,8,12,24,48 weeks).The primary endpoint was 28-joint Disease Activity Score(DAS28-ESR and DAS28-CRP).The secondary endpoints included American College of Rheumatology(ACR)criteria for 20%and 50%improvement(ACR20/50),Health Assessment Questionnaire Disability Index(HAQ-DI),clinical disease activity index(CDAI),visual analog scale(VAS),Short Form-36(SF-36)score,Medial Outcomes Study(MOS)sleep scale score,serum erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),tender joint count,swollen joint count,and morning *** adverse reactions were observed during the ***:After 12 weeks of treatment,DAS28-ESR and DAS28-CRP scores in both groups were lower than before treatment(both Pgroup were higher than those in the placebo group(both Pg to placebo(all Pglobal VAS change of RA patients and physicians,the serum ESR and CRP levels,and the number of tenderness and swelling joints were lower than before treatment at 4,8,12,24,48 weeks in both groups(P<0.05 or P<0.01),while the reduction of above indices in

关键词： Chinese medicine Juan Bi Pill methotrexate active rheumatoid arthritis randomized controlled trial

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui jia.Zhenguo gao Xuetao Shi Mukun He hua.guo guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

关节内矢状面复位对胫骨平台骨折治疗的指导意义

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中国骨伤 2025年第1期38卷 100-104页

作者：张家凡龙安华韩大成贾梓超张亚奎首都医科大学附属北京潞河医院北京101149 应急管理部应急总医院北京100020

胫骨平台骨折是累及胫骨近端关节面的骨折,其损伤机制复杂、骨折形态不一,且多伴有不同程度的软组织损伤,诊断治疗难度大。近年来的研究热点集中于解决胫骨平台后侧柱的复位与固定,因为临床上发现胫骨平台骨折术后残留矢状面的复位不足... 详细信息

胫骨平台骨折是累及胫骨近端关节面的骨折,其损伤机制复杂、骨折形态不一,且多伴有不同程度的软组织损伤,诊断治疗难度大。近年来的研究热点集中于解决胫骨平台后侧柱的复位与固定,因为临床上发现胫骨平台骨折术后残留矢状面的复位不足或复位丢失导致膝关节功能障碍。胫骨平台后倾角是描述胫骨矢状面力线的重要参数。在自然状态下,胫骨平台后倾角(posterior tibial slope,PTS)发生改变累及前交叉韧带(anterior cruciate ligament,ACL)、后交叉韧带(posterior cruciate ligament,PCL)等膝关节周围软组织,影响膝关节稳定性。在全膝关节置换(total knee arthroplasty,TKA)中,选择合适的PTS能有效增加假体存留率,提高屈伸膝效能,有利于膝关节稳定。在创伤骨科领域,纠正矢状面畸形同样重要,需遵循“逆损伤机制”原则。定量评价胫骨平台骨折术后的矢状面复位情况,探讨矢状面复位对术后远期效果及并发症的影响,目前认识尚浅,有待进一步的临床和生物力学研究。

关键词：胫骨平台骨折矢状面畸形胫骨平台后倾角前交叉韧带生物力学

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水氮盐耦合对芦竹生长发育及光合作用的影响

节水灌溉 2025年第1期 21-29页

作者：段志文贾亚敏刘淑慧太原理工大学水利科学与工程学院山西太原030024

为探究水氮盐耦合对能源植物芦竹生长发育和光合作用的影响,明确不同盐化程度土壤适宜芦竹生长的水氮条件,基于盆栽试验,设置土壤盐分(S0:非盐化土、S1:轻度盐化土、S2:中度盐化土和S3:重度盐化土)、施纯氮量(N0:0、N1:60、N2:120和N3:1... 详细信息

为探究水氮盐耦合对能源植物芦竹生长发育和光合作用的影响,明确不同盐化程度土壤适宜芦竹生长的水氮条件,基于盆栽试验,设置土壤盐分(S0:非盐化土、S1:轻度盐化土、S2:中度盐化土和S3:重度盐化土)、施纯氮量(N0:0、N1:60、N2:120和N3:180 kg/hm2)、灌溉定额(W0:2850、W1:4275、W2:5700和W3:7125 m^(3)/hm^(2))三因素四水平正交试验。结果表明,水、氮、盐单因素对芦竹株高、茎粗、叶宽、单丛鲜重和干重均有显著影响(P0.05);中度和重度盐化土壤以上特征产生显著差异(Pg和45.90 g;轻度盐化土,中氮低水处理的芦竹可以同时有着较高的生物量积累和水氮利用效率;中度盐化土,中氮中水处理的芦竹可以在水氮利用效率较高的同时达到最优产量;重度盐化土,芦竹生长发育明显受限,水氮利用效率也处于较低水平,需要采取更加综合的土壤改良措施以促进芦竹的生长发育。综上所述,水氮调控能提升芦竹在高盐土壤中的生物量积累。

关键词：水氮盐耦合生长光合作用盐化土壤芦竹

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Effect of confinement on the three-phase equilibrium of water-oil-CO_(2)mixtures in nanopores

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Petroleum Science 2022年第1期19卷 203-210页

作者： Yi-Lei Song Shao-hua.gu Zhao-Jie Song Zhuo-ya Zhang Xu-ya Chang jia.guo State Key Laboratory of Petroleum Resources and Prospecting and Unconventional Petroleum Research Institute China University of Petroleum-BeijingBeijing102249China Sinopec Petroleum Exploration and Production Research Institute Beijing100083China

Accurate characterization of fluid phase behavior is an important aspect of CO_(2) enhanced shale oil *** far,however,there has been little discussion about the nanopore confinement effect,including adsorption and capillarity on the phase equilibrium of water-oil-CO_(2) *** this study,an improved three-phase flash algorithm is proposed for calculating the phase behavior of water-oil-gas mixture on the basis of an extended Young-Laplace equation and a newly developed fugacity calculation *** fugacity model can consider the effect of water-oil-gas adsorption on phase equilibrium.A water-Bakken oil-CO_(2) mixture is utilized to verify the accuracy of the flash algorithm and investigate the confinement *** show that the confinement effect promotes the transfer of all components in the vapor phase to other phases,while the transfer of water,CO_(2),and lighter hydrocarbons is more *** leads to a large decrease,a large increase,and a small increase in the mole fraction of the vapor,oleic,and aqueous phases,*** the confinement effect is considered,the density difference of vaporoleic phases decreases,and the interfacial tension of vapor-oleic phases decreases;however,the density difference of vapor-aqueous phases increases,the interfacial tension of vapor-aqueous phases still decreases.

关键词： Three-phase behavior Water-oil-CO_(2)mixtures Nanopore confinement CO_(2)enhanced oil recovery Shale reservoirs

The gECAM ground search system for gamma-ray transients

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 161-174页

作者： Ce Cai yan-Qiu Zhang Shao-Lin Xiong Ping Wang jia.-Hui Li Xiao-Bo Li Cheng-Kui Li Yue hua.g Shi-Jie Zheng Li-Ming Song Shuo Xiao Qi-Bin Yi Yi Zhao Sheng-Lun Xie Rui Qiao yan-Qi Du Zhi-Wei guo Wang-Chen Xue Chao Zheng jia.Cong Liu Chen-Wei Wang Wen-Jun Tan Yue Wang Jin-Peng Zhang Chao-ya.g Li guo-Ying Zhao Xiao-Yun Zhao Xiao-Lu Zhang Zhen Zhang Wen-Xi Peng Xiang Ma Jing-yan Shi Dong-ya.guo Jin Wang Xin-Qiao Li Xiang-ya.g Wen Zheng-hua.An Fan Zhang College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang050024China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China University of Chinese Academy of Sciences Beijing100049China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang550001China guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang550001China School of Physics and Optoelectronics Xiangtan UniversityXiangtan411105China School of Computer and Information Dezhou UniversityDezhou253023China Institute of Astrophysics Central China Normal UniversityWuhan430079China

In the era of time-domain,multi-messenger astronomy,the detection of transient events on the high-energy electromagnetic sky has become more important than *** gravitational wave high-energy electromagnetic counterpart all-sky monitor(gECAM)is a dedicated mission to monitor gamma-ray transients,launched in December,2020.A real-time on-board trigger and location software,using the traditional signal-to-noise ratio(SNR)method for blind search,is constrained to relatively bright signals due to the limitations in on-board computing resources and the need for real-time *** this work,we developed a ground-based pipeline for gECAM to search for various transients,especially for weak bursts missed by on-board *** pipeline includes both automatic and manual mode,offering options for blind search and targeted *** targeted search is specifically designed to search for interesting weak bursts,such as gravitational wave-associated gamma-ray bursts(gRBs).From the ground search of the data in the first year,gECAM has been triggered by 54 gRBs and other transients,including soft gamma-ray repeaters,X-ray binaries,solar flares,terrestrial gamma-ray *** report the properties of each type of triggers,such as trigger time and light *** this search pipeline and assuming a soft Band spectrum,the gRB detection sensitivity of gECAM is increased to about 1.1×10^(-8)erg cm^(-2)s^(-1)(10-1000 ke V,burst duration of 20 s).These results demonstrate that the gECAM ground search system(both blind search and targeted search)is a versatile pipeline to recover true astrophysical signals which were too weak to be found in the on-board search.

关键词： gamma-ray sources gravitational waves data analysis gamma-ray telescopes

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α-氨基酮类化合物的合成与表征

化学研究与应用 2025年第1期37卷 224-229页

作者：张飞丁雅丽张华山青海民族大学药学院青海西宁810007 青海民族大学化学与材料科学学院青海西宁810007

α-氨基酮类化合物是重要的药物分子和高活性的反应中间体。以2-苯乙炔基苯甲醛、N-苯甲酰基亚胺前体为原料,噻唑衍生的氮杂环卡宾催化发生氮杂安息香反应,以56~91%的产率合成了8个不同取代的2-苯甲酰胺基-2-苯基-1-(2'-苯乙炔基)苯基乙... 详细信息

α-氨基酮类化合物是重要的药物分子和高活性的反应中间体。以2-苯乙炔基苯甲醛、N-苯甲酰基亚胺前体为原料,噻唑衍生的氮杂环卡宾催化发生氮杂安息香反应,以56~91%的产率合成了8个不同取代的2-苯甲酰胺基-2-苯基-1-(2'-苯乙炔基)苯基乙-1-酮4。采用1HNMR、13CNMR、HRMS对产物4进行结构鉴定。为了验证反应的实用性,对4g的合成进行了放大实验,产率85%。此反应具有条件温和、底物适应范围较广、步骤简单、产率高等特点,可为工业化应用提供一定参考价值。

关键词：氮杂安息香反应 α-氨基酮噻唑衍生的氮杂环卡宾催化