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Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU jia.Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi WU Zhi-Ming WU Mei-En ZHAN Yan-Qing WANG De-Feng PAN Fei ye Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

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Systematic review and network meta-analysis of different nonsteroidal anti-inflammatory drugs for juvenile idiopathic arthritis

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World Journal of Clinical Cases 2024年第12期12卷 2056-2064页

作者： Tao Zeng jia.-Zhong ye Hui Qin Qian-Qian Xu College of Medicine Jingchu University of Technology JingmenJingmen 448000Hubei ProvinceChina

BACKGROUND Various non-steroidal anti-inflammatory drugs(NSAIDs)have been used for juvenile idiopathic arthritis(jia..However,the optimal method for jia.has not yet been *** To perform a systematic review and network meta-analysis to determine the optimal *** We searched for randomized controlled trials(RCTs)from PubMed,EMBASE,Google Scholar,CNKI,and Wanfang without restriction for publication date or language at August,*** RCTs that comparing the effectiveness of NSAIDs with each other or placebo for jia.were included in this network *** surface under the cumulative ranking curve(SUCRA)analysis was used to rank the treatments.P value less than 0.05 was identified as statistically *** We included 8 RCTs(1127 patients)comparing 8 different instructions including meloxicam(0.125 qd and 0.250 qd),Celecoxib(3 mg/kg bid and 6 mg/kg bid),piroxicam,Naproxen(5.0 mg/kg/d,7.5 mg/kg/d and 12.5 mg/kg/d),inuprofen(30-40 mg/kg/d),Aspirin(60-80 mg/kg/d,75 mg/kg/d,and 55 mg/kg/d),Tolmetin(15 mg/kg/d),Rofecoxib,and *** were no significant differences between any two NSAIDs regarding ACR Pedi 30 *** SUCRA shows that celecoxib(6 mg/kg bid)ranked first(SUCRA,88.9%),rofecoxib ranked second(SUCRA,68.1%),Celecoxib(3 mg/kg bid)ranked third(SUCRA,51.0%).There were no significant differences between any two NSAIDs regarding adverse *** SUCRA shows that placebo ranked first(SUCRA,88.2%),piroxicam ranked second(SUCRA,60.5%),rofecoxib(0.6 mg/kg qd)ranked third(SUCRA,56.1%),meloxicam(0.125 mg/kg qd)ranked fourth(SUCRA,56.1%),and rofecoxib(0.3 mg/kg qd)ranked fifth(SUCRA,56.1%).CONCLUSION In summary,celecoxib(6 mg/kg bid)was found to be the most effective NSAID for treating ***,piroxicam,and meloxicam may be safer options,but further research is needed to confirm these findings in larger trials with higher quality studies.

关键词： Non-steroidal anti-inflammatory drugs Juvenile idiopathic arthritis Network meta-analysis Systematic review

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慢性心力衰竭合并缺血性脑卒中患者再发脑卒中的危险因素分析

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中华老年心脑血管病杂志 2024年第6期26卷 653-656页

作者：张清洋刘佳尤佳朱业江苏省苏北人民医院心血管内科扬州225001 江苏省苏北人民医院药学部扬州225001 扬州市妇幼保健院内科

目的探讨慢性心力衰竭(CHF)合并缺血性脑卒中(IS)患者再发脑卒中的相关危险因素。方法选取2021年1月至2023年1月在江苏省苏北人民医院就诊的老年CHF合并IS患者235例,根据左心室射血分数(LVEF)分型分为射血分数减低的心力衰竭(HFrEF)组80... 详细信息

目的探讨慢性心力衰竭(CHF)合并缺血性脑卒中(IS)患者再发脑卒中的相关危险因素。方法选取2021年1月至2023年1月在江苏省苏北人民医院就诊的老年CHF合并IS患者235例,根据左心室射血分数(LVEF)分型分为射血分数减低的心力衰竭(HFrEF)组80例(LVEF0.05)。结论糖尿病和LAD是老年CHF合并IS患者再发IS的独立危险因素。

关键词：心力衰竭卒中复发危险因素 logistic模型

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米粉品质改良剂研究进展

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食品与发酵工业 2024年第7期50卷 346-353页

作者：梁蕊叶发银陈嘉赵国华西南大学食品科学学院重庆400715 川渝共建特色食品重庆市重点实验室重庆400715

米粉是我国传统经典主食之一,深受消费者青睐,但此类产品经常会存在易断条、蒸煮损失大、贮藏过程品质易劣变等问题。因此,改善米粉的品质具有重要的实际意义,其中使用品质改良剂是一个简单有效的途径。为此,该文在广泛查阅文献的基础上... 详细信息

米粉是我国传统经典主食之一,深受消费者青睐,但此类产品经常会存在易断条、蒸煮损失大、贮藏过程品质易劣变等问题。因此,改善米粉的品质具有重要的实际意义,其中使用品质改良剂是一个简单有效的途径。为此,该文在广泛查阅文献的基础上,对淀粉(包括淀粉、变性淀粉和含淀粉辅料)、食用胶、无机盐、乳化剂、酶制剂、小分子糖等米粉品质改良剂的实际效果、工作机理等进行了系统总结。论文数据及结论对选用适当品质改良剂提升米粉品质有较好的参考价值,并对未来米粉品质改良剂的研究重点进行了展望。

关键词：大米淀粉凝胶质构品质蒸煮品质改良剂

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战略性新兴产业赋能长江经济带绿色转型:理论分析与机制检验

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经济体制改革 2024年第3期 44-52页

作者：叶堂林郭佳钦阳杨首都经济贸易大学城市经济与公共管理学院北京100070 首都经济贸易大学经济学院北京100070

基于2010~2021年长江经济带城市面板数据,全面考察战略性新兴产业对绿色发展的影响。结果显示:战略性新兴产业发展能够显著减轻环境污染,有利于长江经济带实现绿色发展,且在上游、中游、下游地区以及成渝城市群、长江中游城市群、长三... 详细信息

基于2010~2021年长江经济带城市面板数据,全面考察战略性新兴产业对绿色发展的影响。结果显示:战略性新兴产业发展能够显著减轻环境污染,有利于长江经济带实现绿色发展,且在上游、中游、下游地区以及成渝城市群、长江中游城市群、长三角城市群之间存在异质性影响。战略性新兴产业通过提高经济集聚、人才集聚、技术集聚促进区域绿色转型发展,且战略性新兴产业对绿色发展的影响存在基于自身规模大小的门槛效应,在跨越门槛值后,其对节能降耗、绿色发展的促进作用会进一步减弱。同时,战略性新兴产业发展水平较高的地方,人才集聚及技术集聚的绿色溢出效应更明显,且经济集聚带来的规模经济效应能够在一定程度上弱化其产生的“拥挤效应”和“搭便车”等资源浪费、效率低下现象。鉴于此,应注重人才集聚的创新溢出效应,加快实现技术集聚,提高战略性新兴产业集聚区的准入门槛,并适度扩张战略性新兴产业的发展规模。

关键词：战略性新兴产业绿色发展要素集聚长江经济带

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前提性反思:中国式现代化研究无法回避的问题

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内蒙古社会科学 2024年第4期45卷 17-23页

作者：贾丽民宋叶恒天津师范大学马克思主义学院天津300387

何以进一步推进和深化中国式现代化研究,是当今学术界无法回避的重大课题。对此,要想做出有力回应、在已有研究成果的基础上实现进一步突破,就需要把中国式现代化拉入到整个人类社会现代化发展的大坐标系中,对其进行整体性审视和前提性... 详细信息

何以进一步推进和深化中国式现代化研究,是当今学术界无法回避的重大课题。对此,要想做出有力回应、在已有研究成果的基础上实现进一步突破,就需要把中国式现代化拉入到整个人类社会现代化发展的大坐标系中,对其进行整体性审视和前提性反思,而不是做简单的重复性阐释。从整个人类社会现代化发展的历史进程、具体呈现、未来趋势看,在“一元”与“多元”、“本土”与“外来”、“进行时”与“完成时”的辩证关系中思考和把握中国式现代化,是对中国式现代化研究进行前提性反思的关键所在。惟其如此,才能以客观、辩证、历史的立场研析中国式现代化问题,将中国式现代化研究向纵深推进。

关键词：中国式现代化前提性反思辩证关系

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Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution:Prospective single-centre trial

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World Journal of Gastrointestinal Endoscopy 2024年第5期16卷 259-272页

作者： Yuan Gao Lian-Song ye Xu Li Bin Yu Ke Liao jia.Xie jia.g Du Qiong-Ying Zhang Bing Hu Department of Gastroenterology and Hepatology Digestive Endoscopy Medical Engineering Research LaboratoryWest China HospitalMed-X Center for MaterialsSichuan UniversityChengdu 610041Sichuan ProvinceChina Design Measurement and Evaluation(CBDME)Department of Clinical Research ManagementWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Institute for Disaster Management and Reconstruction Sichuan University-The Hong Kong Polytechnic UniversityChengdu 610065Sichuan ProvinceChina West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610044Sichuan ProvinceChina Precision Medicine Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Esophageal chromoendoscopy with iodine solution is important for detecting early esophageal *** effect of routine treatment for lesions lightly stained with Lugol’s iodine solution is limited,and the addition of natural substances to a regular diet is becoming increasingly *** has antitumor effects as reported in previous *** To evaluate whether vinegar supplementation could improve the prognosis of patients with lightly stained esophageal *** prospective single-centre trial included consecutive patients with lightly stained lesions between June 2020 and April *** in the experimental group received increased amounts of vinegar for 6 *** primary outcome of the study was the clinical therapeutic *** related to vinegar ingestion and adverse events were also recorded in *** A total of 166 patients were included in the final *** was no significant difference in the baseline data between the two ***-to-treat(ITT)analysis demonstrated that the rates at which endoscopic characteristics improved were 33.72%in the experimental group and 20.00%in the conventional group(P=0.007);and the rates at which biopsy pathology improved were 19.77%and 8.75%,respectively(P=0.011).Additional vinegar consumption had a statistically protective effect on the rate at which endoscopic characteristics improved[hazard ratio(HR)_(ITT)=2.183,95%CI:1.183-4.028;HR_(per-protocol(PP))=2.307,95%CI:1.202-4.426]and biopsy pathology improved(HR_(ITT)=2.931,95%CI:1.212-7.089;HR_(PP)=3.320,95%CI:1.295-8.507).No statistically significant effect of increased vinegar consumption on preventing high-grade intraepithelial neoplasia or early cancer was observed(HR_(ITT)=0.382,95%CI:0.079-1.846;HRPP=0.382,95%CI:0.079-1.846).The subgroup analyses indicated that the overall therapeutic improvement of endoscopic characteristics and biopsy pathology seemed more obvious in older(age>60)male patients w

关键词： Chromoendoscopy Esophageal squamous epithelium Vinegar Atypical hyperplasia Prognosis

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《峄山刻石》字库开发的研究

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印刷与数字媒体技术研究 2024年第3期 299-309页

作者：陈业欣何佳峻咸阳职业技术学院信息工程学院咸阳712000

《峄山刻石长安牌》良好地再现了秦统一文字的风貌,其造字规则对后世书法、汉字结构有着深远影响,研究《峄山刻石长安牌》文字的结字特征,能有效地洞察汉字构成规律,开发传统字体。本研究分析《峄山刻石》典型字体元件,找出其潜在的规律... 详细信息

《峄山刻石长安牌》良好地再现了秦统一文字的风貌,其造字规则对后世书法、汉字结构有着深远影响,研究《峄山刻石长安牌》文字的结字特征,能有效地洞察汉字构成规律,开发传统字体。本研究分析《峄山刻石》典型字体元件,找出其潜在的规律,建立可重复使用的基本范式。使用Illustrator中的度量工具对字腔的比例和分布、笔划的粗细、弧度和倾斜角度等进行定量分析,总结造字规范。建立一套方法,控制《峄山刻石》字型的字腔大小与分布,可对字体重心平稳度、结构匀称度、缩放比例等进行排布控制。搭建标准笔划与部首元件库并建立拼字规则。采用此方法可为设计《峄山刻石》字库新字型提供依据,提高开发的准确度和效率。

关键词：峄山刻石字库开发设计方法

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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期 500-520页

作者： Kun Zhang Meng-Xia Zhang Xiao-Xiang Meng Jing Zhu jia.Jun Wang Yi-Fan He ye-Hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical Sciences Tianjin Medical University Department of Hepatology and Gastroenterology Tianjin Union Medical Center Tianjin Medical University Tianjin Union Medical Center Affiliated to Nankai University

Background: G-protein coupled receptors（GPCRs） are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liver fibrosis. Here, we aimed to reveal the role of GPR65, a proton-sensing receptor, in liver fibrosis and to elucidate the underlying ***: The expression level of GPR65 was evaluated in both human and mouse fibrotic livers. Furthermore, Gpr65-deficient mice were treated with either bile duct ligation（BDL） for 21 d or carbon tetrachloride（CCl4） for 8 weeks to investigate the role of GPR65 in liver fibrosis. A combination of experimental approaches, including Western blotting, quantitative real-time reverse transcription-polymerase chain reaction（qRT-PCR）, and enzyme-linked immunosorbent assay（ELISA）, confocal microscopy and rescue studies, were used to explore the underlying mechanisms of GPR65's action in liver fibrosis. Additionally, the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***: We found that hepatic macrophage（HM）-enriched GPR65 was upregulated in both human and mouse fibrotic livers. Moreover, knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation, injury and fibrosis in vivo, and mouse bone marrow transplantation（BMT） experiments further demonstrated that the protective effect of Gpr65 knockout is primarily mediated by bone marrow-derived macrophages（BMMs）. Additionally, in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited, while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α（TNF-ivationα）, interleukin-6（IL-6） and transforming growth factor-of hepatic stellate cells（HSCs） and the damage of hepaβ（TGF-tocytes β）, all of which subsequently promoted the act（HCs）. Mechanistically, GPR65 overexpression, the acidic pH and GPR65 exo

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Current state and influencing factors in airbag management among emergency department nurses:A multicenter study

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World Journal of Clinical Cases 2024年第18期12卷 3417-3427页

作者： Xiao-Hui Wei Li-Jin Zhou Rui Li Xin-Yuan Li ye Zhang Hai-Yue Zhang Si-Meng Wang jia.Zhang Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Nursing Emergency Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200335China Department of Neurosurgery Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Bengbu Medical UniversityBengbu 233030Anhui ProvinceChina

BACKGROUND The emergency department(ED)plays a critical role in establishing artificial airways and implementing mechanical *** airbags in the ED presents a prime opportunity to mitigate the risk of ventilator-associated ***,existing research has largely overlooked the understanding,beliefs,and practical dimensions of airway airbag management among ED nurses,with a predominant focus on intensive care unit *** To investigate the current status of ED nurses'knowledge,beliefs,and practical behaviors in airway airbag management and their influencing *** A survey was conducted from July 10th to August 10th,2023,using convenience sampling on 520 ED nurses from 15 tertiary hospitals and 5 sary hospitals in *** analysis was utilized to analyze the influencing *** The scores for ED nurses'airway airbag management knowledge were 60.26±23.00,belief was 88.65±13.36,and behavior was 75.10±*** main influencing factors of airbag management knowledge included participation in specialized nurse or mechanical ventilation training,department,and work experience in the *** factors of airbag management belief comprised knowledge,department,and participation in specialized nurse or mechanical ventilation *** influencing factors of airbag management behavior included knowledge,belief,department,participation in specialized nurse or mechanical ventilation training,and professional *** belief in airbag management among ED nurses acted as a partial mediator between knowledge and behavior,with a total effect value of 0.513,and an indirect effect of 0.085,constituting 16.6%of the total *** ED nurses exhibit a positive attitude toward airbag management with relatively standardized practices,yet there remains room for improvement in their knowledge *** managers should implement interventions tailored to the characteristics of ED nurses'airbag managem

关键词： Artificial airway management Health knowledge Attitudes Practice Airbag management Pathway analysis Nurses

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