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Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第8期30卷 919-942页

作者： Ren-Yong Wang jia.Ling Yang Ning Xu jia.Xu Shao-Hua Yang Dao-Ming Liang jin-Ze Li Hong Zhu Second Affiliated Hospital of Kunming Medical University Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Center Wuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of *** influence of lipid metabolism disruption on the development of HCC has been demonstrated in published *** To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in *** Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed *** real-time polymerase chain reaction analysis was used to evaluate the expression of *** red staining was employed to observe intracellular lipid *** interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP *** Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk ***,proliferation,migration,and invasion were reduced by RP11-817I4.1 *** increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY *** LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

关键词： Hepatocellular carcinoma Lipid metabolism Immune microenvironment Prognostic markers Metabolic reprogramming

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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 945-967页

作者： jia.Li Hu Mei-jin Huang Halike Halina Kun Qiao Zhi-Yuan Wang jia.Jie Lu Cheng-Liang Yin Feng Gao Department of Gastroenterology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Xinjia.g Clinical Research Center for Digestive Disease Urumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Oncology 920th Hospital of PLA Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination *** is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of *** also affects the prognosis of GC *** reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour ***,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still *** To investigate inflammatory-related biomarkers in predicting the prognosis of GC *** constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO *** patients from the GSE26253 cohort were used for *** and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was *** calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the *** decision curve analysis results were plotted to quantify and assess the clinical value of the *** set enrichment analysis was performed to explore the potential regulatory pathways *** relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and ***,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy *** A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was *** prognostic analysis revealed that the risk score was a separate prognostic factor in GC *** to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group ha

关键词： Gastric cancer Inflammation Immune infiltration Prognosis signature Subt

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Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids:A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 731-739页

作者： Xiao-Wen Sun jing-Yi Xu Chang-Zhen Zhu Si-jia.Li Lu-jia.jin Zhi-Dong Zhu Department of Gastrointestinal Surgery Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China Surgical Department Tsinghua University Affiliated Beijing Tsinghua Changgeng HospitalBeijing 102218China

BACKGROUND Hemorrhoids are among the most common and frequently encountered chronic anorectal diseases in anorectal *** are venous clusters formed by con-gestion,expansion,and flexion of the venous plexus in the lower part of the *** hemorrhoids bleed easily and recurrently,and this can result in severe ***,they may have a negative effect on the health of the patient and surgical treatment is ***-Morgan hemorrhoidectomy has been widely used since 1937 for the treatment of grade III and IV ***-ever,most patients experience different degrees of postoperative pain that may cause *** mixed hemorrhoids *** The clinical data of patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy were collected *** basic character-istics of the enrolled patients with mixed hemorrhoids were recorded,and based on the Goligher clinical grading system,the hemorrhoids were classified as grades III or *** endpoint of this study was the disappearance of pain in all *** data were presented as mean±SD,such as age,pain score,and QoL ***’s t-test was used to compare the *** A total of 164 patients were *** distribution of the visual analog scale pain scores of all patients at 3,7,14 and 28 d after surgery showed that post-surgery pain was significantly reduced with the passage of *** days after the operation,the pain had completely disappeared in some ***-eight days after the surgery,none of the patients experienced any *** the World Health Or-ganization Quality of Life-BREF self-reporting questionnaire scores of patients between 14 and 28 d after surgery,we observed that the quality-of-life scores of the patients post-surgery had significantly *** were six items that were compared at 14-and 28-d *** mean QoL score 28 d after surgery(4.79±0.46)was higher than that at 14 d p

关键词： Hemorrhoids Mixed hemorrhoids Milligan organ hemorrhoidectomy Postoperative pain Quality of life Anesthesia mode

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Annotated survey and perspectives on rail transport energy system RAMS evaluation technology

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Green Energy and Intelligent Transportation 2024年第3期3卷 75-90页

作者： Ruifeng Shi Lingzhi Zhang Feng Lin jin Ning Limin jia.Kwang Y.Lee School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China China Institute of Energy and Transportation Integrated Development Beijing 102206China State Key Lab of Rail Traffic Control&Safety Beijing Jiaotong UniversityBeijing 100044China Department of Electrical and Computer Engineering Baylor UniversityWacoTX 76798USA

The rail transit system plays a crucial role in modern *** the increasing demand for clean and green energy in the transport sector,its energy system is expected to achieve low-carbon and highly efficient energy utilization in rail ***,the gradual development of the rail transport energy system has led to an increase in its complexity,and the rising difficulty of system assessment has faced the limitations of traditional assessment ***,it is essential to develop effective assessment *** paper begins by providing a systematic review of the development status of Reliability,Availability,Maintainability and Safety(RAMS)assessment and analyzing the shortcomings of traditional RAMS assessment technology in the context of rail transit energy ***,based on the four fundamental properties of RAMS,it summarizes the current state of key assessment technologies in the field of rail ***,the paper delves into the challenges and potential solutions concerning the implementation of RAMS assessment technology for rail transit energy ***,the paper offers an outlook on the future development of RAMS assessment for rail transport energy *** comprehensively analyzing these aspects,the paper aims to contribute valuable insights into optimizing the rail transit energy system,promoting its sustainable and efficient operation in the context of clean and green energy utilization.

关键词： Integration of energy and transportation RAMS evaluation Rail transit energy system

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3D Road Network Modeling and Road Structure Recognition in Internet of Vehicles

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1365-1384页

作者： Dun Cao jia.Ru jia. Qin Amr Tolba jin Wang Min Zhu College of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China Department of Computer Science Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia College of Information Science and Technology Zhejiang Shuren UniversityHangzhou310015China

Internet of Vehicles (IoV) is a new system that enables individual vehicles to connect with nearby vehicles,people, transportation infrastructure, and networks, thereby realizing amore intelligent and efficient transportationsystem. The movement of vehicles and the three-dimensional (3D) nature of the road network cause the topologicalstructure of IoV to have the high space and time *** modeling and structure recognition for 3Droads can benefit the description of topological changes for IoV. This paper proposes a 3Dgeneral roadmodel basedon discrete points of roads obtained from GIS. First, the constraints imposed by 3D roads on moving vehicles areanalyzed. Then the effects of road curvature radius (Ra), longitudinal slope (Slo), and length (Len) on speed andacceleration are studied. Finally, a general 3D road network model based on road section features is *** paper also presents intersection and road section recognition methods based on the structural features ofthe 3D road network model and the road features. Real GIS data from a specific region of Beijing is adopted tocreate the simulation scenario, and the simulation results validate the general 3D road network model and therecognitionmethod. Therefore, thiswork makes contributions to the field of intelligent transportation by providinga comprehensive approach tomodeling the 3Droad network and its topological changes in achieving efficient trafficflowand improved road safety.

关键词： Internet of vehicles road networks 3D road model structure recognition GIS

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An efficient and mild recycling of waste melamine formaldehyde foams by alkaline hydrolysis

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Green Energy & Environment 2024年第5期9卷 919-926页

作者： Shaodi Wu Ning Zhang Chizhou Wang Xianglin Hou Jie Zhao Shiyu jia.jia.cheng Zhao Xiaojing Cui Haibo jin Tiansheng Deng Shanxi Engineering Research Center of Biorefinery Institute of Coal ChemistryChinese Academy of Sciences27 South Taoyuan RoadTaiyuan030001China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Department of Chemistry and Chemical Engineering Taiyuan Institute of TechnologyTaiyuanShanxi030008China Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology/College of New Materials and Chemical Engineering Beijing Institute of Petrochemical TechnologyBeijing102617China

Melamine formaldehyde foam(MFF)generates many poisonous chemicals through the traditional recycling methods for organic resin ***,a high MFF degradation ratio of ca.97 wt.%was achieved under the mild conditions(160℃)in a NaOH–H2O system with ammelide and ammeline as the main degradation *** alkaline solvent had an obvious corrosion effect for MFF,as indicated by scanning electron microscopy(SEM).The reaction process and products distribution were studied by Fourier-transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS),and ^(13)C nuclear magnetic resonance(NMR).Besides,the MFF degradation products that have the similar chemical structures and bonding performances to those of melamine can be directly used as the raw material for synthesis of melamine urea-formaldehyde resins(MUFs).Moreover,the degradation system demonstrated here showed the high degradation efﬁciency after reusing for 7 *** degradation process generated few harmful pollutants and no pre-or post-treatments were required,which proves its feasibility in the safe removal or recovery of waste MFF.

关键词： Melamine formaldehyde foam Degradation Alkaline hydrolysis Recycling

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Physics of cavitation near particles

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Journal of Hydrodynamics 2024年第1期36卷 102-118页

作者： jia.xin Yu Xiao-yu Wang Jun-wei Shen jin-sen Hu Xiang-qing Zhang Da-qing He Yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The combined effect of cavitation and silt abrasion presents a great challenge and threat to secure the operation and the efficiency of hydraulic machineries working in sediment-laden *** present paper critically reviews the current research progress on the interaction mechanisms of the bubbles and the ***,the analytical models including boundary treatment methods for predicting the jet dynamics of the bubble collapse near particles are ***,the bubble collapsing dynamics,jet dynamics and shock wave characteristics near particles are revealed both experimentally and ***,the bubble-particle-wall system is investigated with a focus on microjets.

关键词： Cavitation bubble particle jet shock wave

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Stereospecific Assembly of Trisubstituted Alkenes via Photoinduced Nitrogen-Centered Radical-Triggered C—C Bond Cleavage/Functionalization of Oxime Esters

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Chinese Journal of Chemistry 2024年第12期42卷 1399-1406页

作者： Yu Bao Zhi-Jie Song jin-Long Dai Shenghu Yan Yue Zhang jia.Yin Wang Guigen Li School of Pharmacy Changzhou UniversityChangzhouJiangsu 213164China Department of Chemistry and Biochemistry Texas Tech University79409USA

Comprehensive Summary A general and convenient photoredox-catalyzed acylation and alkylcyanation of MBH acetates has been established,enabling the assembly of the C(sp2)–C(sp3)bond by a nitrogen-centered radical strategy for the synthesis of trisubstituted alkenes in moderate to excellent chemical yields(48 examples in total).The reaction of MBH acetates with acyl(indanone)oxime esters afforded trisubstituted alkenes containing 1,4-dicarbonyl ***,the use of Eosin Y as a photocatalyst in the catalytic system resulted in the formation of distal cyano group-anchored trisubstituted alkenes via deconstructive functionalization of cycloketone oxime ***,these resulting 1,4-dicarbonyl compounds could be applied to late-stage transformations,providing important methods for the synthesis of dihydropyridazin-3(2H)-one.

关键词： Photocatalysis Radical reactions MBH acetates Oxime esters Stereoselectivity Acylation Alkylation Green chemistry

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A Bregman-Style Improved ADMM and its Linearized Version in the Nonconvex Setting:Convergence and Rate Analyses

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Journal of the Operations Research Society of China 2024年第2期12卷 298-340页

作者： Peng-Jie Liu jin-Bao jia. Hu Shao Xiao-Quan Wang jia.Wei Xu Xiao-Yu Wu School of Mathematics Jiangsu Center for Applied MathematicsChina University of Mining and TechnologyXuzhou 221116JiangsuChina School of Mathematics and Physics Center for Applied Mathematics of GuangxiGuangxi Minzu UniversityNanning 530006GuangxiChina Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Mathematics and Computational Science Xiangtan UniversityXiangtan 411105HunanChina

This work explores a family of two-block nonconvex optimization problems subject to linear *** first introduce a simple but universal Bregman-style improved alternating direction method of multipliers(ADMM)based on the iteration framework of ADMM and the Bregman ***,we utilize the smooth performance of one of the components to develop a linearized version of *** to the traditional ADMM,both proposed methods integrate a convex combination strategy into the multiplier update *** each proposed method,we demonstrate the convergence of the entire iteration sequence to a unique critical point of the augmented Lagrangian function utilizing the powerful Kurdyka–Łojasiewicz property,and we also derive convergence rates for both the sequence of merit function values and the iteration ***,some numerical results show that the proposed methods are effective and encouraging for the Lasso model.

关键词： Nonconvex optimization Alternating direction method of multipliers Kurdyka-Lojasiewicz property Convergence rate

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Pancreatic cancer with gastrointestinal obstruction as an initial symptom

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 545-547页

作者： jia.Ren Xu Xing-Nan Wu Yong-Qiang Si jin-Pu Yang Xiao-Sun Liu Department of Gastrointestinal Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Gastroenterology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor: Pancreatic cancer is the fourth leading cause of cancer mortality in the United States [ 1, 2 ]. Risk factors of pancreatic cancer include smoking, family history of chronic pancreatitis, advanced age, male, diabetes mellitus, and obesity [1]. Most of patients have no obvious symptoms in the early stage, and are often diagnosed in the late stage and accompanied by invasion of surrounding tissues and distant metastasis, such as local lymph nodes, liver, lung and peritoneum [ 1, 3 ]. Therefore, the prognosis is poor.

关键词： cancer Pancreatic invasion

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