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Perturbation of autophagy pathways in murine alveolar macrophage by 2D TMDCs is chalcogen-dependent

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Journal of Environmental Sciences 2024年第1期135卷 97-107页

作者： Xiaofei Zhou Weitao jin Rui Zhang Xuan Mao jia.bo jia.Hongyu Zhou College of Science&Technology Hebei Agricultural UniversityHuanghua 061100China Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China

Increasing risks of incidental and occupational exposures to two-dimensional transition metal dichalcogenides(2D TMDCs)due to their broad application in various areas raised their public health *** the composition-dependent cytotoxicity of 2D TMDCs has been well-recognized,how the outer chalcogenide atoms and inner transition metal atoms differentially contribute to their perturbation on cell homeostasis at non-lethal doses remains to be *** the present work,we compared the autophagy induction and related mechanisms in response to WS_(2),NbS_(2),WSe_(2)and Nb Se_(2)nanosheets exposures in MH-S murine alveolar *** these 2D TMDCs had comparable physicochemical properties,overall cytotoxicity and capability in triggering autophagy in MH-S cells,but showed outer chalcogen-dependent subcellular localization and activation of autophagy ***,WS_(2)and NbS_(2)nanosheets adhered on the cell surface and internalized in the lysosomes,and triggered m TOR-dependent activation of ***,WSe_(2)and Nb Se_(2)nanosheets had extensive distribution in cytoplasm of MH-S cells and induced autophagy in an m TOR-independent ***,the 2D TMDCs-induced perturbation on autophagy aggravated the cytotoxicity of respirable benzo[a]*** findings provide a deeper insight into the potential health risk of environmental 2D TMDCs from the perspective of homeostasis perturbation.

关键词： Chalcogen group Autophagy pathway Cell function Endosomal escape Inhalation toxicity

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Hepatic function of glucagon-like peptide-1 and its based diabetes drugs

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Medical Review 2024年第4期4卷 312-325页

作者： jia.Nuo Feng Tianru jin Division of Advanced Diagnostics Toronto General Research InstituteUniversity Health NetworkTorontoONCanada Department of Physiology Temerty Faculty of MedicineUniversity of TorontoTorontoONCanada Banting and Best Diabetes Centre Temerty Faculty of MedicineUniversity of TorontoTorontoONCanada Division of Advanced Diagnostics Toronto General Research InstituteUniversity Health NetworkTorontoON M5G 1L7Canada Department of Physiology Temerty Faculty of MedicineUniversity of TorontoTorontoON M5G 1L7Canada Banting and Best Diabetes Centre Temerty Faculty of MedicineUniversity of TorontoTorontoONM5G 1L7Canada

Incretins are gut-produced peptide-hormones that potentiate insulin secretion,especially after food *** concept of incretin was formed more than 100 years ago,even before insulin was isolated and utilized in the treatment of subjects with type 1 *** first incretin,glucose-dependent insulinotropic polypeptide(GIP),was identified during later 1960’s and early 1970’s;while the second one,known as glucagon-like peptide-1(GLP-1),was recognized during 1980’***,GLP-1-based therapeutic agents[also known as GLP-1 receptor(GLP-1R)agonists,GLP-1RAs]are among the first line drugs for type 2 *** addition to serving as incretin,extra-pancreatic functions of GLP-1RAs have been broadly recognized,including those in the liver,despite the absence of GLP-1R in hepatic *** existence of insulin-independent or gut-pancreas-liver axis-independent hepatic function of GLP-1RAs explains why those therapeutic agents are effective in subjects with insulin resistance and their profound effect on lipid *** a brief review on the discovery of GLP-1,we reviewed literature on the exploration of hepatic function of GLP-1 and GLP-1RAs and discussed recent studies on the role of hepatic hormone fibroblast growth factor 21(FGF21)in mediating function of GLP-1RAs in animal *** was followed by presenting our perspective views.

关键词： FGF21 GLP-1 GLP-1R GLP-1RA

Carbon felt electrode coated with WS2 enables a high-performance polysulfide/ferricyanide flow battery

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Rare Metals 2024年第10期43卷 5039-5047页

作者： Liang-Yu Li Su Yan Ying-jia.Huang Fang-Fang Zhong jin-Chao Cao Mei Ding Chuan-Kun jia College of Materials Science and Engineering Changsha University of Science and Technology Institute of Energy Storage Technology College of Energy and Power EngineeringChangsha University of Science and Technology Binzhou Institute of Technology Weiqiao-UCAS Science and Technology Park

Polysulfide/ferricyanide flow batteries （S/Fe RFBs）,with the advantages of abundant earth reservation low cost,high safety,and environmental friendliness,have attracted significant interest and demonstrated noteworthy potential for practical ***,the battery performance,including the energy efficiency （EE）,voltage efficiency （VE）,and power density of the S/Fe RFBs remains low owing to the slow redox kinetics of polysulfide *** address these concerns,WS2was selected as the booster and deposited on a commercial carbon felt electrode （WS2–CF） to stimulate the redox reactions of polysulfide *** better hydrophilicity and smaller charge-transfer resistance,WS2–CF exhibits enhanced electrochemical activity toward polysulfide redox ***,the battery performance of S/Fe RFB with WS2–CF as the anode has been improved,with EE of 84%,VE of 84%,and a peak power density of 175.7 mW·cm-2,which are all higher than the cell only with the bare carbon felt （CF） as electrodes (76%,77% and 155.8 mW·cm-2,respectively).Furthermore,the cycling life of the S/Fe RFB with WS2–CF has been prolonged to 2200 cycles with a capacity retention of 96% a 40 mA·cm-2because of the good stability of WS2–CF as the ***,under the same conditions,the S/Fe RFB without WS2–CF terminated after 1500 cycles with a fast capacity *** successful utilization of WS2as a booster on an electrode provides an efficient strategy for obtaining advanced S/Fe RFBs for practical applications.

关键词： Carbon felt Energy storage Polysulfide/ferricyanide flow battery Tungsten disulfide

Directional amine-based solvent extraction for simultaneous enhanced water recovery,salt separation and effective descaling from hypersaline brines

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 83-92页

作者： Yuyao Zhang Litao jia.jin Zhao Xuming Liu Shuyu Dong Chuanyang Liu Yuanyuan Cui Shougang Research Institute of Technology Beijing 100043China Research Center of Environmental Technology in Water Pollution Source Identification and Precise Supervision School of EnvironmentTsinghua UniversityBeijing 100084China

The feasibility of simultaneous water recovery,salt separation and effective descaling of hypersaline brine was investigated by diisopropylamine(DIPA)-based directional solvent extraction(DSE),using diluted/concentrated seawater with initial saline concentration range of 12–237 g/L at extraction temperatures of 5 and 15℃,*** water recovery shows an obvious boundary at saline concentration of 115 g/L under dual effect of specific water extraction efficiency and extraction *** Cl^(–) ion concentration in product water is in sharp contrast to the nearly complete removal of SO_(4)^(2–)and hardness ions,indicating that DIPA-based DSE process indeed achieved efficient separation and purification of Cl^(–) ion from hypersaline ***,the radical precipitation of Mg^(2+)and Ca^(2+)ions in form of Mg(OH)_(2)and CaCO_(3)demonstrates effective descaling potential,although it leads to more DIPA residues in dewatered raffinate than product ***,an exponential correlation between the Cl^(–) removal efficiency and specific water extraction efficiency further reveals the intrinsic relationship of water extraction process and transfer of Cl^(–) ion to the product ***,the study provides a novel approach for integrating the water recovery and separation of Cl^(–) ion from ultra-high-salinity brines with radical precipitation of Mg^(2+)and Ca^(2+) ions in one step.

关键词： Hypersaline brines Directional solvent extraction Salt separation Ca^(2+)and Mg^(2+)descaling

Construction of biomimetic proton transport channels in metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 513-517页

作者： Xiao-Min Li Junchao jia.Danting Yang jia.i jin Junkuo Gao School of Materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejia.g Key Laboratory of Pathophysiology School of Public HealthSchool of MedicineNingbo UniversityNingbo 315211China

Construction of proton transport channels in metal-organic frameworks(MOFs)with simple synthesis processes,high proton conductivities and good performance stabilities has been of great interest for proton exchange membrane fuel cell(PEMFC).Herein,we mimic the proton transport behavior of amino acid residues in bacteriorhodopsin,select UiO-66-COOH as the host,glycine and aspartic acid as the functional guest molecules,and then functionalize the MOF framework with amino acids to obtain biomimetic proton transport *** strategy endows UiO-66-COOH-Asp a high proton conductivity of 1.19×10^(-2)S/cm at 70℃and 98%RH,excellent cycle stability of performances and performance durability,which can be comparable to the reported MOFs-based proton ***,the proton conduction mechanism in UiO-66-COOH-Asp is elaborated in detail due to its visual structure,which is also one of the advantages of adopting MOFs as research platform,making it possible to optimize the structure-activity relationship of advanced ***,this strategy has clear objectives and simple synthesis,which has made certain contributions to both theoretical research and future industrial production of proton conductors.

关键词： MOF Amino acids Biomimetic proton transport channels Synergistic effect Proton conduction mechanism

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Local resonance metamaterial-based integrated design for suppressing longitudinal and transverse waves in fluid-conveying pipes

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Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1821-1840页

作者： Donghai HAN Qi jia.Yuanyu GAO Qiduo jin Xin FANG Jihong WEN Dianlong YU Laboratory of Science and Technology on Integrated Logistics Support National University of Defense TechnologyChangsha 410073China College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China

To solve the problem of low broadband multi-directional vibration control of fluid-conveying pipes,a novel metamaterial periodic structure with multi-directional wide bandgaps is ***,an integrated design method is proposed for the longitudinal and transverse wave control of fluid-conveying pipes,and a novel periodic structure unit model is constructed for vibration *** on the bandgap vibration reduction mechanism of the acoustic metamaterial periodic structure,the material parameters,structural parameters,and the arrangement interval of the periodic structure unit are *** finite element method(FEM)is used to predict the vibration transmission characteristics of the fluid-conveying pipe installed with the vibration reduction periodic ***,the wave/spectrum element method(WSEM)and experimental test are used to verify the calculated results ***,the vibration attenuation characteristics of the structure under different conditions,such as rubber material parameters,mass ring material,and fluid-structure coupling effect,are *** results show that the structure can produce a complete bandgap of 46 Hz-75 Hz in the low-frequency band below 100 Hz,which can effectively suppress the low broadband vibration of the fluidconveying *** addition,a high damping rubber material is used in the design of the periodic structure unit,which realizes the effective suppression of each formant peak of the pipe,and improves the vibration reduction effect of the fluid-conveying ***,the structure has the effect of suppressing both bending vibration and longitudinal vibration,and effectively inhibits the transmission of transverse waves and longitudinal waves in the *** research results provide a reference for the application of acoustic metamaterials in the multi-directional vibration control of fluid-conveying pipes.

关键词： fluid-conveying pipe acoustic metamaterial multi-directional vibration reduction local resonance

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Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 364-371页

作者： Ji-Chun Tang jia.Wei Ma jin-jin jia. Jie Shen Liang-Liang Cao Department of Anesthesiology The Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Anesthesiology People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture 843599Xinjiang Uygur Autonomous RegionChina Department of Critical Care Medicine Jiangnan University Medical CenterWuxi 214122Jiangsu ProvinceChina Department of Critical Care Medicine People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture843599Xinjiang Uygur Autonomous RegionChina

BACKGROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative *** current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and *** for colo-rectal cancer typically involves general ***,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative *** study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative *** To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal *** Following the inclusion criteria and exclusion criteria,a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research *** data collection,the effects of postoperative analgesia,sedation,and recovery were *** Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(P<0.05).The research group also showed lower Visual analog scale scores at 24 h and 48 h,higher Ramany scores at 6 h and 12 h,and improved cognitive function at 24 h,48 h,and 72 h(P<0.05).Additionally,interleukin-6 and interleukin-10 levels were significantly reduced at various time points in the research group compared to the control group(P<0.05).Levels of CD3+,CD4+,and CD4+/CD8+were also lower in the research group at multiple time points(P<0.05).CONCLUSION For patients with colorectal cancer,g

关键词： Multimodal analgesia Anesthesia Colorectal cancer Postoperative pain

Colonoscopy-assisted removal of an impaction foreign body at the rectosigmoid junction: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1990-1995页

作者： Peng-Fei Zhou jin-Gen Lu jia.Dong Zhang jia.Wen Wang Department of Anorectal Surgery Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200000China

BACKGROUND When an anorectal foreign body is found,its composition and shape should be evaluated,and a timely and effective treatment plan should be developed based on the patient's symptoms to avoid serious complications such as intestinal perforation caused by displacement of the foreign *** SUMMARY A 54-year-old male was admitted to our outpatient clinic on June 3,2023,due to a rectal foreign body that had been embedded for more than 24 *** patient reported using a glass electrode tube to assist in the recovery of prolapsed hemorrhoids,however,the electrode tube was inadvertently inserted into the anus and could not be removed by the *** hospitalization,the patient underwent surgery,and the foreign body was dragged into the rectum with the aid of *** anus was dilated with a comb-type pulling hook and an anal fistula pulling hook to widen the anus and remove the foreign body,and the local anal symptoms were then relieved with topical *** patient was allowed to eat and drink,and an entire abdominal Computed tomography(CT)and colonoscopy were reviewed 3 d after *** revealed no foreign body residue and colonoscopy showed no metal or other residues in the colon and rectum,and no apparent intestinal tract *** The timeliness and rationality of the surgical and therapeutic options for this patient were based on a literature review of the clinical signs and conceivable conditions in such *** type,material and the potential risks of rectal foreign bodies should be considered.

关键词： Foreign body impaction Surgical therapy Rectum-sigmoid colon Colonoscopy Case report

Data Secure Storage Mechanism for IIoT Based on Blockchain

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Computers, Materials & Continua 2024年第3期78卷 4029-4048页

作者： jin Wang Guoshu Huang R.Simon Sherratt Ding Huang jia.Ni School of Computer Science and Mathematics Fujian University of TechnologyFuzhou350118China School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410004China School of Systems Engineering The University of ReadingReadingRG66AYUK School of Computer Nanjing University of Information Science and TechnologyNanjing210044China

With the development of Industry 4.0 and big data technology,the Industrial Internet of Things(IIoT)is hampered by inherent issues such as privacy,security,and fault tolerance,which pose certain challenges to the rapid development of *** technology has immutability,decentralization,and autonomy,which can greatly improve the inherent defects of the *** the traditional blockchain,data is stored in a Merkle *** data continues to grow,the scale of proofs used to validate it grows,threatening the efficiency,security,and reliability of blockchain-based ***,this paper first analyzes the inefficiency of the traditional blockchain structure in verifying the integrity and correctness of *** solve this problem,a new Vector Commitment(VC)structure,Partition Vector Commitment(PVC),is proposed by improving the traditional VC ***,this paper uses PVC instead of the Merkle tree to store big data generated by *** can improve the efficiency of traditional VC in the process of commitment and ***,this paper uses PVC to build a blockchain-based IIoT data security storage mechanism and carries out a comparative analysis of *** mechanism can greatly reduce communication loss and maximize the rational use of storage space,which is of great significance for maintaining the security and stability of blockchain-based IIoT.

关键词： Blockchain IIoT data storage cryptographic commitment