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Chinese Medical Journal 2014年第8期127卷 1588-1589页

作者： Shi Qiuxia hu Chuanxian Hou Xiaotong jia Ming Xu Zhiwei Xie Jinsheng Center for Cardiac Intensive Care Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China Department of Cardiac Surgery Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China Department of Cardiac Surgery Huaian First People's Hospital Nanjing Medical University Huaian Jiangsu 223000 China Department of Cardiothoracic Surgery the Affiliated Hospital of Hangzhou Normal University Hangzhou Zhejiang 310015 China

For the patients with a relatively slow heart rate, the frequency of opening and closing of biological valves and the number ot impact ot mecnamcai stress upon biological valves were relatively less, so the mechanical wear was reduced. The question is whether this can slow the failure and calcification of the biological valve. A retrospective analysis replacement （MVR） cases was carried out. of 92 biological mitral valve during the period of 1996-2003

关键词： biological valve failure heart rate

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植物物候变化研究进展

生态学杂志 2015年第11期34卷 3237-3243页

作者：翟佳袁凤辉吴家兵中国科学院沈阳应用生态研究所森林与土壤生态国家重点实验室沈阳110016 中国科学院大学北京100049

全球变化背景下,植物物候对气候变暖的响应已经成为研究热点。本文就植物物候对温度、水分、光照等气象因子的响应做了总结,并对国内外物候研究方法进行概述,特别是综合了近年来国内物候变化研究的文献,对我国植物春季物候变化情况作了... 详细信息

全球变化背景下,植物物候对气候变暖的响应已经成为研究热点。本文就植物物候对温度、水分、光照等气象因子的响应做了总结,并对国内外物候研究方法进行概述,特别是综合了近年来国内物候变化研究的文献,对我国植物春季物候变化情况作了统计:全球变化对我国大部分地区植被的影响主要是生长季提前,但新疆干旱区植被生长季开始日期在区域尺度上没有显著提前或者延迟趋势。由于物候研究方法的差异以及研究尺度的不同,在一定程度上弱化了研究结果的可比性,建议我国应基于目前的中国通量观测网以及各级生态监测网络,建立统一的物候监测平台,同时完善通量数据提取植物物候信息的方法,特别是阈值判定标准,为分析植物物候响应气候变化提供参考。

关键词：自然植被气候变化涡度相关

Breakdown Spectroscopy Induced by Nonlinear Interactionsof Femtosecond LaserFilaments and Multidimensional Plasma Gratings

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Ultrafast Science 2023年第2期3卷 1-12页

作者： Mengyun hu Shupeng Xu Shuai yuan Heping Zeng StateKey Laboratory of Precision Spectroscopy East China NormalUniverstyShanghai200062China Chongqing Key Laboratory of Precision Optics Chongqing Instute of East China Normal UniversityChongqing 401120China Shanghai Key Lab of Modern Optical System University of Shanghai for Science and TechnologyShanghai 200093China Jinan Institute of Quantum Technology Jinan China

Breakdown spectroscopy is a valuable tool for determining elements in solids,liquids,and *** materials in the breakdown region can be ionized and dissociated into highly excited fragments and emit characteristic fluorescence *** this sense,the elemental composition of materials can be evaluated by detecting the fluorescence *** paper reviews the recent developments in laser-induced breakdown *** traditional laser-induced breakdown spectroscopy,filament-induced breakdown spectroscopy,plasma grating,and multidimensional plasma grating-induced breakdown spectroscopy are *** are also some proposals for applications of plasma gratings,such as laser ablation,laser deposition,and laser catalysis of chemical reactions in conjunction with research on the properties of plasma gratings.

关键词： breakdown Femto Nonlinear

Seed Length Controlled by Same Locus in Four Different AA Genome Species of Genus Oryza

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Rice science 2014年第1期21卷 20-28页

作者： ZHANG Yu LI Jing ZHOU jia-wu XU Peng DENG Xian-neng YANG Fei DENG Wei hu Feng-yi TAO Da-yun Institute of Food and Crops Research Yunnan Academy of Agricultural Sciences Life-Sciences School Yunnan University

To broaden the genetic basis and overcome the yield plateau in Asian cultivated rice, the exploitation and utilization of favorable alleles from rice species with the AA genome has become important and urgent in modern breeding programs. Four different interspecific populations were used to detect quantitative trait locus （QTL） for seed length, including a BC4F2 population derived from Oryza glumaepatula crossed with Dianjingyou 1 （a japonica cultivar）, a BC4F2 population derived from O. nivara crossed with Dianjingyou 1, a BCzF1 population derived from a cross between O. Iongistaminata and RD23 （an indica cultivar）, and a BCsF1 population derived from a cross between O. glaberrima and Dianjingyou 1. The QTLs for seed length in four different populations were termed as SL-3a, SL-3b, SL-3c and SL-3d, respectively. They had good collinearity and accounted for 49% to 60% of the phenotypic variations. Sequencing data indicated that four QTLs were different alleles of GS3 which were responsible for the seed length variation between O. sativa and its four AA genome relatives. These results will be valuable for confirming the evolution of GS3 and also be helpful for rice breeding.

关键词： seed length O. glumaepatula O. nivara O. Iongistaminata O. glaberrima quantitative trait locus

The Graft Versus Leukemia Effect of IL-12/15/18 Preactivated Donor NK Cells in Allogeneic Hematopoietic Stem Cell Transplantation

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The Graft Versus Leukemia Effect of IL-12/15/18 Preactivated...

The Graft Versus Leukemia Effect of Donor γδT cells in Allogeneic Hematopoietic Stem Cell Transplantation

第九届全国免疫学学术大会

作者： Bo hu yuan Song Haiyan Liu Institutes of Biology and Medical Science Soochow University

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The Graft Versus Leukemia Effect of Donor γδT cells in All...

Multi-objective optimal design on vibration suppression of building structures with Active Mass Damper based on state difference feedback

第九届全国免疫学学术大会

作者： yuan Song Bo hu Haiyan Liu Institutes of Biology and Medical Science Soochow University

Allogeneic hematopoietic stem cell transplantation(HSCT)is one of the most effective way of treating leukemia and other malignant ***,disease recurrence is still the major cause of death after *** studies showed that ...

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Multi-objective optimal design on vibration suppression of b...

Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

第37届中国控制会议

作者： yuan Guang Zheng Xing Xing hu School of Mathematics and Information Science Nanchang Hangkong University

The vibration suppression of building structures with Active Mass Damper and delayed PD feedback is studied by regarding the multiple control performance *** stable region is obtained firstly by using the method of stability switch.A multi-objective optimization problem is formulated for the control design and is solved with the two-step simple cell mapping *** Pareto set and Pareto front are *** is shown the Active Mass Damper with delayed PD feedback can improve the stability of building structure significantly,and a proper small time delay is beneficial to the control *** finding is confirmed by Numerical simulations and experimental ***,it is shown the control performance is sensitive to the time delay,when the time delay deviates from the optimal value,it will deteriorate the control performance,even lead to unstable vibration.

关键词： Vibration suppression PD feedback Time delay Multi-objective optimization Pareto set

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG jia-ping CHEN Xin-wei QIAO Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong ZHAO Wei LIN Yong-de LIAO Han XIAO Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival *** suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and ***,a comprehensive analysis of their role in LUSC is *** study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of ***:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO ***,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in *** core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for *** specimens were examined by immunohistochemical analysis to confirm the diagnostic value in ***,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was ***:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for ***10 showed a significant positive correlation with immune cell infiltration and immune checkpoint ***:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice

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Stroke & Vascular Neurology 2024年第5期9卷 505-518页

作者： Lin Qi Cheng Wang Lidong Deng jia-Ji Pan Qian Suo Shengju Wu Lin Cai Xudong Shi Junfeng Sun Yongting Wang Yaohui Tang Weibao Qiu Guo-yuan Yang Jixian Wang Zhijun Zhang Shanghai jiao Tong Affiliated Sixth People's Hospital School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiShanghaiChina Department of Neurosurgery Huashan HospitalShanghai Medical CollageFudan UniversityShanghaiChina Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina Paul C.Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesBeijingChina Neuroscience and Neuroengineering Center Shanghai Jiao Tong University School of Biomedical EngineeringShanghaiChina Shanghai jiao Tong University Medical School Affiliated Ruijin Hospital ShanghaiChina

Background Low-intensity focused ultrasound stimulation(LIFUS)has been developed to enhance neurological repair and remodelling during the late acute stage of ischaemic stroke in ***,the cellular and molecular mechanisms of neurological repair and remodelling after LIFUS in ischaemic stroke are *** Ultrasound stimulation was treated in adult male mice 7 days after transient middle cerebral artery *** was measured by laser speckle imaging and histological *** and fibre photometry records were used for *** atrophy volume and neurobehaviour were assessed 0–14 days after *** proteomic analysis was performed to explore the differentially expressed ***-seq was used for subcluster analysis of *** in situ hybridisation and Western blot detected the expression of HMGB1 and *** Optimal ultrasound stimulation increased cerebral blood flow,and improved neurobehavioural outcomes in ischaemic mice(p<0.05).iTRAQ proteomic analysis revealed that the expression of HMGB1 increased and CAMK2N1 decreased in the ipsilateral hemisphere of the brain at 14 days after focal cerebral ischaemia with ultrasound treatment(p<0.05).scRNA-seq revealed that this expression pattern belonged to a subcluster of astrocytes after LIFUS in the ischaemic *** upregulated HMGB1 expression,accompanied by VEGFA elevation compared with the control group(p<0.05).Inhibition of HMGB1 expression in astrocytes decreased microvessels counts and cerebral blood flow(p<0.05).LIFUS reduced CAMK2N1 expression level,accompanied by increased extracellular calcium ions and glutamatergic synapses(p<0.05).CAMK2N1 overexpression in astrocytes decreased dendritic spines,and aggravated neurobehavioural outcomes(p<0.05).Conclusion Our results demonstrated that LIFUS promoted angiogenesis and synaptogenesis after focal cerebral ischaemia by upregulating HMGB1 and downregulating CAMK2N1 in

关键词： stimulation behaviour intensity

Snare-tip-assisted peroral endoscopic myotomy for achalasia(with video)

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Gastroenterology Report 2020年第4期8卷 329-330,I0003页

作者： Zhen-Zi huang Ren Mao Yi Cui yuan-Qi Li Ying-Lian Xiao Jin-hui Wang Min-hu Chen Xiang-Bin Xing Department of Gastroenterology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Introduction Since peroral endoscopic myotomy(POEM)for the treatment of achalasia was first introduced by Inoue et al.[1]in 2010,various endoscopic knives including the Triangular-tip knife have been used during the procedure[2].To date,the investigation on endoscopic knives with good performance and low expense is still underway for patients with *** this case,we successfully carried out POEMassisted by a snare tip in a patient with achalasia.

关键词：经口内镜下肌切开术圈套器贲门失弛缓 endoscopic