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Network Pharmacology:An Approach to the Analysis of Complex Systems Underlying Traditional Chinese Medicine

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World Journal of Traditional Chinese Medicine 2018年第4期4卷 135-136页

作者： Shao Li yuan-jia hu Department of Automation Ministry of Education Key Laboratory of BioinformaticsTCM-X Center/Bioinformatics DivisionBNRISTTFIDTTsinghua University Specialty Committee on Network Pharmacology World Federation of Chinese Medicine Societies State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao

As one of the most important complementary and alternative therapies in clinical practice,traditional Chinese medicine(TCM)holds great potential in treating various complex diseases,especially in the area of chronic and non-communicable ***,in terms of the complexity of chemical and biological profiles in TCM,a traditional reductionist cannot adequately explain the scientific nature of TCM.

关键词： TCM the Analysis of Complex Systems

Methods for development of a core outcome set for clinical trials integrating traditional Chinese medicine and Western medicine

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Journal of Integrative Medicine 2021年第5期19卷 389-394页

作者： Rui-jin Qiu Min Li jia-yuan hu Jing Chen Hong-cai Shang Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China The Third Affiliated Hospital Beijing University of Chinese MedicineBeijing 100029China Dermatology Department Beijing Hospital of Traditional Chinese MedicineBeijing 100010China Department of Health Care Baokang HospitalTianjin University of Traditional Chinese MedicineTianjin 300193China

Clinical trial outcome reporting differs between studies integrating traditional Chinese medicine(TCM)and Western medicine, so that some clinical trials are not eligible for inclusion in a systematic *** excluded studies are therefore less widely disseminated, and even valid studies are less likely to yield impact. This problem may be addressed by developing core outcome sets(COSs) for integrative medicine in specific healthcare areas. The first stage of development is to define the scope of the COS for integrative medicine, the second stage is to establish the need for such a COS, and the third stage is to develop a protocol and register the COS. The final stage involves three steps:(i) development of a comprehensive list of outcomes(including efficacy outcomes and safety outcomes and TCM syndromes) using systematic review, qualitative or cross-sectional research, and reviews of package inserts and medical records;(ii) merging and grouping of outcomes within domains;(iii) conducting two rounds of Delphi survey and consensus meetings with a range of stakeholders. The final COS will include a general COS and core TCM syndrome-set. Development of COSs for clinical trials of integrative medicine may help to standardize outcome reporting and reduce publication bias in the future.

关键词： Clinical trials Outcome assessment Traditional Chinese medicine Integrative medicine Methodology

Effect of p H on the Electrochemical Behaviour and Passive FilmComposition of 316L Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2019年第5期32卷 585-598页

作者： Zhu Wang Zi-Qiang Zhou Lei Zhang jia-yuan hu Zi-Ru Zhang Min-Xu Lu Institute for Advanced Materials and Technology University of Science and Technology Beijing State Grid Zhejiang Electric Power Research Institute

The effect of pH on the electrochemical behaviour and passive film composition of 316 L stainless steel in alkaline solutions was studied using electrochemical measurements and a surface analysis method. The critical pH of 12.5 was found for the conversion from pitting corrosion to the oxygen evolution reaction(OER). OER was kinetically faster than pitting corrosion when both reactions could occur, and OER could postpone pitting corrosion. This resulted in pitting being initiated during the reversing scan in the cyclic polarization at the critical pH. According to the X-ray photoelectron spectroscopy analysis, the content of Cr and Mo decreased with pH, while Fe content increased. This induced the degradation of the passive film, which resulted in the higher passive current densities under more alkaline conditions. The selective dissolution of Mo at high p H was found, which demonstrated that the addition of Mo in austenitic stainless steels might not be beneficial to the corrosion resistance of 316L in strong alkaline solutions.

关键词： Stainless steel pH Polarization XPS Passive films

High Selective Hydrogenation of Acetophenone Catalyzed by Alumina Supported Platinum Nanoclusters

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Chinese Chemical Letters 2003年第5期14卷 533-534页

作者： Qin ZHANG Hong Xia MA hua CHEN jia yuan hu Xian Jun LI Department of Chemistry Sichuan UniversityChengdu 610064

A new preparation and reduction method of ?Al2O3 supported and PVP stabilized platinum nanoclusters was studied. The catalyst exhibited very high activity and selectivity for acetophenone hydrogenation in isopropanol... 详细信息

关键词： Platinum nanoclusters acetophenone hydrogenation.

Preparation of Fe_(3)O_(4)@SW-MIL-101-NH_(2) for selective preconcentration of chlorogenic acid metabolites in rat plasma,urine,and feces samples

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Journal of Pharmaceutical Analysis 2022年第4期12卷 617-626页

作者： Shi-Jun Yin Xi Zhou Li-Jing Peng Fang Li Guo-Can Zheng Feng-Qing Yang yuan-jia hu Department of Pharmaceutical Engineering School of Chemistry and Chemical EngineeringChongqing UniversityChongqing401331China Analytical and Testing Center Chongqing UniversityChongqing401331China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao999078China

An innovative sandwich-structural Fe-based metal-organic framework magnetic material(Fe_(3)O_(4)@SWMIL-101-NH_(2))was fabricated using a facile solvothermal *** characteristic properties of the material were investigated by field emission scanning electron microscopy,transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,X-ray powder diffraction,vibrating sample magnetometry,and Brunauer-Emmett-Teller ***_(3)O_(4)@SW-MIL-101-NH_(2) is associated with advantages,such as robust magnetic properties,high specific surface area,and satisfactory storage stability,as well as good selective recognition ability for chlorogenic acid(CA)and its metabolites via chelation,hydrogen bonding,and *** results of the static adsorption experiment indicated that Fe_(3)O_(4)@SW-MIL-101-NH_(2) possessed a high adsorption capacity toward CA and its isomers,cryptochlorogenic acid(CCA)and neochlorogenic acid(NCA),and the adsorption behaviors were fitted using the Langmuir adsorption isotherm ***,a strategy using magnetic solid-phase extraction(MSPE)and ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF MS/MS)was developed and successfully employed for the selective pre-concentration and rapid identification of CA metabolites in rat plasma,urine,and feces *** work presents a prospective strategy for the synthesis of magnetic adsorbents and the high-efficiency pretreatment of CA metabolites.

关键词： Sandwich structure Metal-organic framework Chlorogenic acid Magnetic solid-phase extraction Metabolic pathway

Progress of Studies on Traditional Chinese Medicine Based on Complex Network Analysis

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World Journal of Traditional Chinese Medicine 2017年第3期3卷 28-37页

作者： Qian-Ru Zhang Xiang-Jun Kong Hai-Yu Xu Yi-Tao Wang yuan-jia hu Specialty Committee on Network Pharmacology World Federation of Chinese Medicine Societies State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Traditional Chinese medicine(TCM) is a distinct medical system that deals with the life-health-disease-environment relationship using holistic, dynamic, and dialectical thinking. However, reductionism has often restricted the conventional studies on TCM, and these studies did not investigate the central concepts of TCM theory about the multiple relationships among life, health, disease, and environment. Complex network analysis describes a wide variety of complex systems in the real world, and it has the potential to bridge the gap between TCM and modern science owing to the holism of TCM theory. This article summarizes the current research involving TCM network analysis and highlights the computational tools and analysis methods involved in this research. Finally, to inspire a new approach, the article discussed the potential problems underlying the application of TCM network analysis.

关键词： Complex network analysis formula mechanism syndrome traditional Chinese medicine

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光栅投影式三维摄影测量仪的几何标定方法

光电工程 2005年第11期32卷 43-48,67页

作者：罗剑袁家虎中国科学院光电技术研究所

光栅投影式三维摄影测量仪利用了时域结构光投影技术和立体视觉测量原理获得三维点坐标。针对传统标定方法易受镜头畸变影响和标定约束方程少导致精度下降的问题,采用了非线性的摄像机和投影机模型,并提出了二维的投影机模型;使用多平... 详细信息

光栅投影式三维摄影测量仪利用了时域结构光投影技术和立体视觉测量原理获得三维点坐标。针对传统标定方法易受镜头畸变影响和标定约束方程少导致精度下降的问题,采用了非线性的摄像机和投影机模型,并提出了二维的投影机模型;使用多平面法标定了系统测量所需的摄像机和投影机几何参数;为进一步提高参数精度,采用Levenberg-Marquardt算法优化了摄像机和投影机模型。实验结果表明,该方法操作简单,无需精确的位置和姿态调整,标定的绝对精度为0.2pixel,相对精度为1/5000。

关键词：几何标定摄影测量仪三维表面测量光栅投影

三次高斯和与Kloosterman和的线性递推公式

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数学学报（中文版） 2018年第1期61卷 67-72页

作者：陈丽呼家源西北大学数学学院

应用三角和方法以及高斯和的若干性质，研究三次高斯和与Kloosterman和的一类高次混合均值的计算问题，本文给出该混合均值的一个有趣的线性递推公式．同时，还应用该递推公式，得到三次高斯和与Kloosterman和的高次混合均值的一系列较... 详细信息

应用三角和方法以及高斯和的若干性质，研究三次高斯和与Kloosterman和的一类高次混合均值的计算问题，本文给出该混合均值的一个有趣的线性递推公式．同时，还应用该递推公式，得到三次高斯和与Kloosterman和的高次混合均值的一系列较强的渐近公式．

关键词：三次高斯和 Kloosterman和高次混合均值线性递推公式渐近公式

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian Zhang Guang-Tao Zhang Peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen yuan-jia hu Chang-Sheng Zhang hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination