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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen xiumin Xue Juanqing Yue Minyu Zhu Ying wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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HYDRODYNAMIC CHARACTERISTICS AND SEISMIC ANALYSIS OF OFFSHORE CYLINDRICAL STRUCTURE-FLUID-SOIL SYSTEMS

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Journal of Hydrodynamics 1991年第3期3卷 79-87页

作者： jia-ju, Bi Hong, Zhuang xiu-ling, Weng Tongi Univ Shangkai China

An analytical method is developed to solve the coupled vibration problem of a vertical elastic circular cylindrical structure founded on homogeneous elastic soil with surrounding fluid. An improved mathematical model is adopted by which not only the structure-fluid interaction but also the influence of soil are considered. The frequency-dependent radiation added mass and hydrodynamic radiation damping are expressed in closed form, and are compared with generalized mass and damping respectively. Their variations with the exciting frequency are studied as well. A discussion of the influences of structure fluid interaction and structure-soil interaction upon hydrodynamic loading is given.

关键词： Computers Applications Fluid Mechanics Foundations Soil Structure Interaction Hydrodynamics Mathematical Models

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Enhanced quality of Al_(2)O_(3)/SiC gate stack via microwave plasma annealing

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Rare Metals 2024年第10期43卷 5362-5371页

作者： Nan-Nan You Xin-Yu Liu Qian Zhang Zhen wang jia-Yi wang Yang Xu xiu-Yan Li Yu-Zheng Guo Sheng-Kai wang High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of the Chinese Academy of SciencesBeijing 100029China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China School of Electrical Engineering and Automation Wuhan UniversityWuhan430072China Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The high-quality gate dielectric on silicon carbide(SiC)surface is critical to fabricate high-performance SiC metal-oxide-semiconductor field-effect transistors(MOSFETs).This research employs microwave plasma annealing(MPA)to obtain high-quality Al_(2)O_(3)/SiC gate *** designing MPA atmosphere and optimizing the plasma power,the SiC MOS capacitor with a Al_(2)O_(3)dielectric film shows the enhanced *** interface state density is reduced by 1 order of magnitude to 6×10^(11)cm^(-2)·eV^(-1),the breakdown electric field is increased,and the voltage shift is effectively suppressed Besides,the mechanism of MPA process is discussed in terms of the thermal effect and reactant species.X-ray photoelectron spectroscopy(XPS)results unveil oxygen plasma plays the main *** plasma power during the MPA process results in defect repairs of the firstneighbor Al-O bonding and partial removal of Al-O-H bond from the interface *** study demonstrates that MPA process is an effective option to realize highquality dielectric and interface on SiC.

关键词： Silicon carbide Al_(2)O_(3) Metal-oxide-semiconductor Microwave plasma annealing Defect repairs X-ray photoelectron spectroscopy

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Relationship between hepatocellular carcinoma and hepatitis B virus genotype with spontaneous YMDD mutations

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World Journal of Gastroenterology 2013年第24期19卷 3861-3865页

作者： jia-Hong Yang Hao Zhang Xue-Bing Chen Gao Chen xiu wang Department of Infectious Diseases People's Hospital of Deyang City

AIM: To investigate the relationship between hepatitis B virus (HBV) genotype with spontaneous YMDD mu-tations and hepatocellular carcinoma (HCC) in HBV-related cirrhosis. METHODS: We investigated 264 liver cirrhosis pa-tients who were not treated with antiviral drugs, in-cluding 81 patients with HCC. YMDD mutations were detected by fluorescent hybridization bioprobe poly-merase chain reaction (PCR) and melting curve assay using the Diagnosis Kit for HBV YMDD Mutation. Serum HBV genotypes were detected by real-time PCR using genotype-specific TaqMan probes. Statistical analysis was performed according to data type using the t test, χ2 test and unconditional logistic regression analysis. RESULTS: In the HCC group, genotype C strains, spon-taneous YMDD mutations, and genotype C strains with YMDD mutations were detected in 33 (40.74%), 13 (16.05%) and 11 (13.58%) patients, respectively. In the liver cirrhosis (LC) group, HBV genotype C strains,spontaneous YMDD mutations, and genotype C strains with YMDD mutations were detected in 33 (18.03%), 7 (3.83%) and 2 (1.09%) patients, respectively. The dif-ferences in genotype C strains, spontaneous YMDD mu-tations, and genotype C strains with YMDD mutations between the two groups were statistically significant (χ2=15.441, P=0.000; χ2=11.983, P=0.001; P=0.000). In the HCC and LC groups, there were seven patients infected by genotype B strains with YMDD mutations and 13 by genotype C strains with YMDD mutations. Further research revealed that HCC oc-curred in 2 patients infected by genotype B strains with YMDD mutations and 11 infected by genotype C strains with YMDD mutations. The difference was statistically significant (P=0.000). Unconditional logistic regres-sion analysis revealed that patients infected by geno-type C strains with spontaneous YMDD mutations had a 7.775-fold higher risk for the development of HBV-related HCC than patients infected by other type HBV strains (P=0.013, 95%CI: 1.540-39.264). CONCLUSION: Genotype

关键词： Hepatitis B virus Liver cirrhosis Primary hepatocellular carcinoma Hepatitis B virus genotype YMDD mutation

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A new stabilizing method for linear aperiodic sampled-data systems with time delay inputs and uncertainties

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Science China(Information Sciences) 2020年第4期63卷 224-226页

作者： Shuangshuang GAO xiu YOU Xinchun jia Weiwei MA School of Mathematical Sciences Shanxi University

Dear editor,With the rapid development of communication,control, and computer technologies, networked control systems (NCSs) have been widely used in various fields owing to its advantages of sharing information resources, reducing system wiring,and increasing the flexibility and reliability of systems [1–3]. In NCSs, sampling-data systems com-

关键词： A new stabilizing method for linear aperiodic sampled-data systems with time delay inputs and uncertainties

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Equilibrium Strategies in an Unobservable On-off Fluid Queue

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 324-336页

作者： xiu-li XU Shuo wang School of Science Yanshan UniversityQinhuangdao 060004China

This paper considers an on-off fluid queue *** on and off states of the system appear alternately,and the sojourn times at these two different states are independent,and each one follows an exponential *** fluid flows into the system buffer with some strategies to wait for the system service under the first-come first-served *** the system can process the fluid in the buffer only when the system is on *** given utility functions such as an expected average social profit,and an individual expected profit,the equilibrium strategies are characterized under both the fully unobservable case and the partially observable case.

关键词： fluid model on-off equilibrium strategies optimal benefit

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On the Existence of Ground State Solutions to a Quasilinear Schr?dinger Equation involving p-Laplacian

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Acta Mathematicae Applicatae Sinica 2023年第2期39卷 381-395页

作者： Ji-xiu wang Qi GAO School of Mathematics and Statistics Hubei University of Arts and ScienceXiangyang 441053China Department of Mathematics School of ScienceWuhan University of TechnologyWuhan 430070China

We consider the following quasilinear Schrodinger equation involving p-Laplacian-Δpu+V(x)|u|^(p-2)u-Δp(|u|^(2η))|u|^(2η-2)u=λ|u|^(q-2)u/|x|^(μ)+|u|^(2ηp*(v)-2)u/|x|^(v)in R^(N),where N>p>1,η≥p/2(p-1),p0,μ,ν∈[0,p).Via the Mountain Pass Theorem and the Concentration Compactness Principle,we establish the existence of nontrivial ground state solutions for the above problem.

关键词： quasilinear Schrodinger equation critical Hardy-Sobolev exponent ground state solutions singularities

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中国式现代化对西方式现代化的历史性超越

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哈尔滨市委党校学报 2025年第01期 8-13+20页

作者：李包庚王佳宁波大学马克思主义学院

西方式现代化受资本逻辑支配，颠倒了人与物的关系，造成了社会两极分化与人的单向度发展、全球生态危机与全球生态治理困境、欺凌剥削他国、逆全球化思潮、西方中心主义等“西方现代性问题”。中国式现代化坚持人民至上原则，追求全体... 详细信息

西方式现代化受资本逻辑支配，颠倒了人与物的关系，造成了社会两极分化与人的单向度发展、全球生态危机与全球生态治理困境、欺凌剥削他国、逆全球化思潮、西方中心主义等“西方现代性问题”。中国式现代化坚持人民至上原则，追求全体人民共同富裕与人的自由而全面的发展，统筹物质文明与生态文明协调发展，构建人类命运共同体，提倡世界不同文明相互尊重交流互鉴，实现了对西方式现代化的全面历史性超越，创造了人类文明新形态。中国式现代化彰显了中国特色社会主义制度的优越性，以建设中华民族现代文明、创造人类文明新形态为时代旨归，破除了“现代化=西方化”的迷思，走出了一条既具有中国特色又推进世界共同发展的现代化道路。

关键词：中国式现代化西方式现代化资本逻辑人民至上人类文明新形态

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Abnormal expression of miR-331 leads to impaired heart function

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Science Bulletin 2019年第14期64卷 1011-1017页

作者： Jin-Jing Zhang Li-Peng wang Rong-Chang Li Meng wang Zeng-Hui Huang Min Zhu jia-Xing wang xiu-Jie wang Shi-Qiang wang Ming Xu Department of Cardiology Institute of Vascular Medicine Peking University Third Hospital NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing Key Laboratory of Cardiovascular Receptors Research State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China State Key Laboratory of Membrane Biology College of Life Sciences Peking University Beijing 100871 China Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

MicroRNAs (miRNAs) play important roles in maintaining normal heart function. Abnormal expression of miR-331 has been observed in the hearts of patients with atrial fibrillation and Marfan syndrome. However, whether miR-331 regulates cardiac function under physiological and pathological conditions still remains unknown. In the present study, we investigated the function and underlying mechanisms of miR-331 in a pressure overload-induced heart failure model and miR-331 transgenic rat model. First, we found that the expression of miR-331-3p exhibited a 1.7-fold increase in hypertrophy compared with that in the sham group (P<0.01), yet the expression of miR-331-5p remained unchanged. Furthermore, overexpression of miR-331 in cardiomyocytes and defective excitation-contraction (E-C) coupling efficiency were observed. Luciferase assays showed that miR-331-3p suppressed JPH2 expression by binding to the coding region of JPH2 mRNA. Finally, in the miR-331 transgenic rat model, JPH2 expression was suppressed at both the mRNA and protein levels in vivo, which resulted in impairment of both the E-C coupling efficiency of cardiomyocytes and systolic function of the heart. This finding mechanistically linked miR-331 to JPH2 downregulation and suggested an important role for the abnormal expression of miR-331 leading to the dysfunction of E-C coupling in heart failure.

关键词： MiR-331 Excitation-contraction coupling Junctophilin 2 Heart function

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Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping wang Shijun Shen jia Zhao Zhiyi Lin jiatong Sun Zhongqu Su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing Yin Hong wang Zhiyang Chen Zhenyu Ju Cizhong jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong Key Laboratory of Animal Bioengineering and Disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint Surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

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