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MicroR-9c-5p and novel-mir50 co-target Akt to regulate Lasioderma serricorne reproduction

Insect Science 2024年第1期31卷 106-118页

作者： Yi Yan Dong-Dong Qin Hong Yang Kang-Kang Xu Can Li wen-jia Yang Provincial Key Laboratory for Agricultural Pest Management of Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

High fecundity is a common characteristic of insect pests which increases the difficulty of population ***/threonine kinase Akt is an indispensable component of the insulin signaling *** of LsAkt severely hinders reproduction in Lasioderma serricorne,a stored product insect ***,the post-transcriptional pathway of LsAkt in *** remains *** study identified 2 binding sites of miR-9c-5p and novel-mir50 in the coding sequences of *** expression profiles of 2 microRNAs(miRNAs)and LsAkt displayed an opposite pattern during the adult *** reporter assay showed that novel-mir50 and miR-9c-5p could downregulate the expression of *** of miR-9c-5p and novel-mir50 by injection of mimics inhibited the expression of LsAkt and reduced oviposition,decreased egg hatchability,and blocked ovarian *** also decreased the expression of genes involved in ovarian development(LsVg and LsVgR)and the nutritional signaling pathway(LsTOR,LsS6K,and Ls4EBP),and reduced the phosphorylation of ***,injection of miR-9c-5p and novel-mir50 inhibitors induced the expressions of LsAkt,LsVg,LsVgR,LsTOR,LsS6K,and Ls4EBP,enhanced Akt phosphorylation level,and accelerated ovarian *** of bovine insulin downregulated the expression of miR-9c-5p and novel-mir50 and upregulated the LsAkt *** also rescued the reproductive development defects associated with miR-9c-5p/novel-mir50 overexpression,forming a positive regulatory loop of insulin *** results indicate that miR-9c-5p/novel-mir50 regulates the female reproduction of *** by targeting Akt in response to insulin *** data also demonstrate the effects of the insulin/miRNA/Akt regulatory axis in insect reproduction.

关键词： Akt insulin Lasioderma serricorne microRNA reproduction

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磁选粉煤灰对CFRC压敏性的影响

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功能材料 2013年第15期44卷 2166-2169页

作者：贾兴文吴洲马英汪宏涛重庆大学材料科学与工程学院重庆400045 后勤工程学院化学与材料工程系重庆400016

改善碳纤维增强水泥(CFRC)的压敏性有助于提高其感知应力应变的能力。采用两电极法研究了磁选粉煤灰部分取代水泥对CFRC压敏性的影响,分析了磁选粉煤灰掺量、铁氧化物含量等因素影响CFRC压敏性的规律及机理。结果表明,碳纤维质量掺量≤0... 详细信息

改善碳纤维增强水泥(CFRC)的压敏性有助于提高其感知应力应变的能力。采用两电极法研究了磁选粉煤灰部分取代水泥对CFRC压敏性的影响,分析了磁选粉煤灰掺量、铁氧化物含量等因素影响CFRC压敏性的规律及机理。结果表明,碳纤维质量掺量≤0.8%时,用铁氧化物含量达到30%的磁选粉煤灰取代20%～30%的水泥来制备CFRC时可以显著改善CFRC的压敏性;碳纤维质量掺量为1.2%时,掺加磁选粉煤灰不利于提高CFRC的压敏性;磁选粉煤灰对采用最大长度为3和5mm的碳纤维制备的CFRC的压敏性具有显著改善效果。掺加适量磁选粉煤灰使CFRC在碳纤维掺量较低时仍然可以获得良好压敏性,并显著降低CFRC的制备成本。

关键词：碳纤维增强水泥(CFRC) 磁选粉煤灰(MS-FA) 压敏性铁氧化物隧道效应

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Deep learning-based lung sound analysis for intelligent stethoscope

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Military Medical Research 2024年第4期11卷 567-588页

作者： Dong-Min Huang jia Huang Kun Qiao Nan-Shan Zhong Hong-Zhou Lu wen-Jin Wang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina The Third People’s Hospital of Shenzhen Shenzhen 518112GuangdongChina Guangzhou Institute of Respiratory Health China State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Auscultation is crucial for the diagnosis of respiratory system ***,traditional stethoscopes have inherent limitations,such as inter-listener variability and subjectivity,and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in *** emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and *** this basis,machine learning,particularly deep learning,enables the fully-automatic analysis of lung sounds that may pave the way for intelligent *** review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence(AI)in this *** focus on each component of deep learning-based lung sound analysis systems,including the task categories,public datasets,denoising methods,and,most importantly,existing deep learning methods,i.e.,the state-of-the-art approaches to convert lung sounds into two-dimensional(2D)spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung ***,this review highlights current challenges in this field,including the variety of devices,noise sensitivity,and poor interpretability of deep *** address the poor reproducibility and variety of deep learning in this field,this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension:https://***/contactless-healthcare/Deep-Learning-for-Lung-Sound-Analysis.

关键词： Deep learning Lung sound analysis Respiratory sounds

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One-year results for myopia control of orthokeratology with different back optic zone diameters: a randomized trial using a novel multispectral-based topographer

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 324-330页

作者： wen-Ting Tang Xiang-Ning Luo wen-Jing Zhao jia Liao Xin-Yue Xu Hui-Dan Zhang Li Zhang Department of Ophthalmology the First Affiliated Hospital of Chengdu Medical CollegeChengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

AIM:To present the 1-year results of a prospective cohort study investigating the efficacy,potential mechanism,and safety of orthokeratology(ortho-k)with different back optic zone diameters(BOZD)for myopia control in ***:This randomized clinical study was performed between Dec.2020 and *** were randomly assigned to three groups wearing ortho-k:5 mm BOZD(5-MM group),5.5 mm BOZD(5.5-MM group),and 6 mm BOZD(6-MM group).The 1-year data were recorded,including axial length,relative peripheral refraction(RPR,measured by multispectral refractive topography,MRT),and visual *** contrast sensitivity(CS)was evaluated by CSV-1000 instrument with spatial frequencies of 3,6,12,and 18 cycles/degree(c/d);the corneal higher-order aberrations(HOAs)were measured by iTrace aberration *** one-way ANOVA was performed to assess the differences between the three *** correlation between the change in AL and RPR was calculated by Pearson’s correlation ***:The 1-year results of 20,21,and 21 subjects in the 5-MM,5.5-MM,and 6-MM groups,respectively,were *** were no statistical differences in baseline age,sex,or ocular parameters between the three groups(all P>0.05).At the 1-year visit,the 5-MM group had lower axial elongation than the 6-MM group(0.07±0.09 vs 0.18±0.11 mm,P=0.001).The 5-MM group had more myopic total RPR(TRPR,P=0.014),with RPR in the 15°–30°(RPR 15–30,P=0.015),30°–45°(RPR 30–45,P=0.011),temporal(RPR-T,P=0.008),and nasal area(RPR-N,P<0.001)than the 6-MM *** 15–30 in the 5.5-MM group was more myopic than that in the 6-MM group(P=0.002),and RPR-N in the 5-MM group was more myopic than that in the 5.5-MM group(P<0.001).There were positive correlations between the axial elongation and the change in TRPR(r=0.756,P<0.001),RPR 15–30(r=0.364,P=0.004),RPR 30–45(r=0.306,P=0.016),and RPR-N(r=0.253,P=0.047).The CS decreased at 3 c/d(P<0.001),and the corneal HOAs increased in the 5-MM group(P=0.030).CONCL

关键词： relative peripheral refraction orthokeratology myopia back optic zone diameter axial length multispectral refractive topography

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Impact of open hepatectomy on postoperative bile leakage in patients with biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 67-75页

作者： Gang Wu wen-Ying Li Yu-xing Gong Feng Lin Chen Sun General Surgery Department The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150000Heilongjiang ProvinceChina

BACKGROUND Bile leakage is a common and serious complication of open hepatectomy for the treatment of biliary tract *** To evaluate the incidence,risk factors,and management of bile leakage after open hepatectomy in patients with biliary tract *** We retrospectively analyzed 120 patients who underwent open hepatectomy for biliary tract cancer from February 2018 to February *** leak was defined as bile drainage from the surgical site or drain or the presence of a biloma on *** incidence,severity,timing,location,and treatment of the bile leaks were *** risk factors for bile leakage were analyzed using univariate and multivariate logistic regression *** The incidence of bile leak was 16.7%(20/120),and most cases were grade A(75%,15/20)according to the International Study Group of Liver Surgery *** median time of onset was 5 d(range,1-14 d),and the median duration was 7 d(range,2-28 d).The most common location of bile leakage was the cut surface of the liver(70%,14/20),followed by the anastomosis site(25%,5/20)and the cystic duct stump(5%,1/20).Most bile leaks were treated conservatively with drainage,antibiotics,and nutritional support(85%,17/20),whereas some required endoscopic retrograde cholangiopancreatography with stenting(10%,2/20)or percutaneous transhepatic cholangiography with drainage(5%,1/20).Risk factors for bile leakage include male sex,hepatocellular carcinoma,major hepatectomy,blood loss,and blood *** Bile leakage is a frequent complication of open hepatectomy for biliary tract ***,most cases are mild and can be conservatively *** sex,hepatocellular carcinoma,major hepatectomy,blood loss,and blood transfusion were associated with an increased risk of bile leak.

关键词： Open hepatectomy Bile leak Biliary tract cancer Risk factors Management Complication

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搅拌站污泥对混凝土力学性能和耐久性的影响

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建筑技术 2015年第1期46卷 53-56页

作者：邓斌贾兴文重庆建工第二建设有限公司重庆400030 重庆大学材料学院重庆400045

混凝土搅拌站污泥作混凝土掺合料可有效提高其利用率。通过对污泥取代粉煤灰试件进行水泥胶砂试验,评价了污泥的活性,并研究了污泥对混凝土力学性能和耐久性的影响。结果表明,搅拌站污泥活性较低,如污泥取代粉煤灰比例不超过30%,则不会... 详细信息

混凝土搅拌站污泥作混凝土掺合料可有效提高其利用率。通过对污泥取代粉煤灰试件进行水泥胶砂试验,评价了污泥的活性,并研究了污泥对混凝土力学性能和耐久性的影响。结果表明,搅拌站污泥活性较低,如污泥取代粉煤灰比例不超过30%,则不会对混凝土抗压强度和耐久性产生不利影响。

关键词：污泥活性掺合料抗压强度渗透性

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Design and Cryogenic Performance of a Hexapod Platform for a Large Ground-based Wide Field Survey Telescope

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Research in Astronomy and Astrophysics 2024年第1期24卷 178-187页

作者： Yang Yu Xue-wen Wang Yu Zhang jia-Lin Sun Zhen-Bang Xu jian-Li Wang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Chinese Academy of Sciences Key Laboratory of On-orbit Manufacturing and Integration for Space Optics System Changchun 130033China University of Chinese Academy of Sciences Beijing 100049China

The thermal gradient is an important factor that causes degradation to the image quality of telescopes. In order to ensure the accurate alignment of the primary focus unit and the primary mirror, the hexapod platform(as a corrector) is investigated in this paper. First, a ground-based telescope with 2.5 m aperture and 3.5 deg field of view is described. The telescope is under construction, and it is expected to be finished in 2023. Second, the hexapod platform with flexure hinges utilized to adjust the primary focus unit is proposed, which is applied as a ***, the inverse kinematics of the platform is established and an open-loop control system is built based on ***, the cryogenic performance test for the hexapod platform is performed. The experimental results show that the resolution and repeatability of the translation for the hexapod platform can be achieved at the micrometer *** resolution and repeatability of the rotation can be achieved at the arc-second level. Therefore, the cryogenic performance of the hexapod platform can meet the optical imaging requirements of the wide-field ground-based telescope. The kinematic analysis and cryogenic performance tests in the paper provide a technical reference for the precise alignment of the primary focus unit and the primary mirror, which can improve the imaging quality of the telescope.

关键词： methods:miscellaneous space vehicles:instruments telescopes miscellaneous

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The Crystallization Behavior of L-Poly(lactic acid)/Polypropylene Blends:The Acceleration for Both L-Poly(lactic acid)and Polypropylene

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Chinese Journal of Polymer Science 2024年第6期42卷 775-786页

作者： Shuang-Cheng Li Wei-jia Zhou wen-Jie Wu Jun Shao Shui-Liang Chen Hao-Qing Hou Sheng Xiang College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of jiangxi Province Jiangxi Normal UniversityNanchang330022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China

For a polymer/polymer dismissible blend with two crystallizable components,the crystallization behavior of different components and the reciprocal influences between different crystals are interesting and important,but did not investigate in *** this study,the L-poly(lactic acid)/polypropylene(PLLA/PP)blends with different weight ratios were prepared by melt mixing and the crystallization behavior of the blends were *** showed that the crystalline structures of PLLA and PP were not altered by the *** the crystallization of PLLA,both the diffusion of chain segments and crystallization rate were enhanced under the existence of PP *** the crystallization of PP,its crystallization rate was depressed under the existence of amorphous PLLA molecular *** the PP crystallized from the existence of PLLA crystals,although the diffusion rate of PP was reduced by PLLA crystals,the nucleation positions were obviously enhanced,which accelerated the formation of PP *** investigation would supply more basic data for the application of PLLA/PP blend.

关键词： L-poly(lactic acid) Polypropylene Blends Crystalization behavior Crystallization acceleration

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Quenching and flow of charm and bottom quarks via semi-leptonic decay of D and B mesons in Pb+Pb collisions at the LHC

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Chinese Physics C 2024年第8期48卷 190-197页

作者： Shu-Qing Li wen-Jing xing Shanshan Cao Guang-You Qin School of Physics and Electronic Engineering Jining UniversityQufu 273155China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China

Heavy flavor particles provide important probes of the microscopic structure and thermodynamic properties of the quark-gluon plasma(QGP)produced in high-energy nucleus-nucleus *** studied the energy loss and flow of charm and bottom quarks inside the QGP via the nuclear modification factor(R_(AA))and elliptic flow coefficient(v_(2))of their decayed leptons in heavy-ion collisions at the *** dynamical evolution of the QGP was performed using the CLVisc(3+1)-dimensional viscous hydrodynamics model;the evolution of heavy quarks inside the QGP was simulated with our improved Langevin model that considers both collisional and radiative energy loss of heavy quarks;the hadronization of heavy quarks was simulated via our hybrid coalescence-fragmentation model;and the semi-leptonic decay of D and B mesons was simulated via *** the same spatial diffusion coefficient for charm and bottom quarks,we obtained smaller R_(AA) and larger v_(2) of charm decayed leptons than bottom decayed leptons,indicating stronger energy loss of charm quarks than bottom quarks inside the QGP within our current model setup.

关键词： quark-gluon plasma heavy-ion collisions jet quenching anisotropic flow heavy quark heavy flavor muon

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Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li jia-Wei Tu Juan Kong Ling-Ling Yang jian-Hong jia Chuan Wang Bin Hu Zhi-Xiong Xie Dai-wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

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