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成人高等教育课程开发导论

陕西师范大学继续教育学报 2004年第3期21卷 5-10页

作者：贾温性陕西师范大学继续教育学院院长西安710062

成人高等教育的课程体系存在着很多薄弱环节，亟待进行优化论证。现阶段成人高等教育课程开发的紧迫课题是：对学生不感兴趣的一些基础理论课程，需要整合内容，改革教学方法；对综合课程，应重视探讨“综合”的内涵，走出理解上的望文... 详细信息

成人高等教育的课程体系存在着很多薄弱环节，亟待进行优化论证。现阶段成人高等教育课程开发的紧迫课题是：对学生不感兴趣的一些基础理论课程，需要整合内容，改革教学方法；对综合课程，应重视探讨“综合”的内涵，走出理解上的望文生义和操作上的盲目性；对滞留在初级层次的信息技术教育课程，应确立科学的课程目标，循序渐进地向前推进。

关键词：成人高等教育专业基础课程综合课程信息技术课程开发

Mesenchymal stem cell therapy for liver fibrosis need“partner”:Results based on a meta-analysis of preclinical studies

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World Journal of Gastroenterology 2024年第32期30卷 3766-3782页

作者： Yan Xu Xue-Song Wang Xiao-Lei Zhou wen-Ming Lu xing-Kun Tang Yu Jin Jun-Song Ye Subcenter for Stem Cell Clinical Translation First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina School of Rehabilitation Medicine Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Medical Genetics School of MedicineTongji UniversityShanghai 200092China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of EducationGannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

BACKGROUND The efficacy of mesenchymal stem cells(MSCs)in treating liver fibrosis has been demonstrated in several clinical ***,their low survival and liver implantation rates remain *** recent years,a large number of studies in animal models of liver fibrosis have shown that MSCs combined with drugs can improve the efficacy of MSCs in the treatment of liver fibrosis alone and inhibit its progression to end-stage liver *** has inspired new ways of thinking about treating liver *** To investigate the effectiveness and mechanisms of MSCs combined with drugs in treating liver *** Data sources included four electronic databases and were constructed until January *** subjects,interventions,comparators,outcomes,and study design principle were used to screen the literature,and the quality of the literature was evaluated to assess the risk of *** randomised controlled trials were selected,and the final 13 studies were included in the final *** A total of 13 studies were included after *** analysis showed that MSCs combined with drug therapy significantly improved liver function,promoted the repair of damaged liver tissues,reduced the level of liver fibrosis-related indexes,and effectively ameliorated hepatic fibrosis by modulating the hepatic inflammatory microenvironment,promoting the homing of MSCs,and regulating the relevant signaling pathways,and the treatment efficacy was superior to MSCs ***,the combined treatment statistics showed no amelioration in serum albumin levels(standardized mean difference=0.77,95%confidence interval:-0.13 to 1.68,P=0.09).CONCLUSION In conclusion,MSCs combined with drugs for treating liver fibrosis effectively make up for the shortcomings of MSCs in their therapeutic ***,due to the different drugs,the treatment mechanism and effect also ***,more randomized controlled trials are needed to compare the therapeutic effic

关键词： drugs alone partner

Laparoscopic left hemihepatectomy guided by indocyanine green fluorescence: A cranial-dorsal approach

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 409-418页

作者： xing-Ru Wang Xiao-Ju Li Dan-Dan Wan Qian Zhang Tian-Xi Liu Zong-wen Shen Hong-xing Tong Yan Li jian-Wei Li Institute of Hepatobiliary Surgery First Affiliated HospitalArmy Medical UniversityChongqing 400038China Department of Hepatobiliary Surgery Qujing Central Hospital of Yunnan Regional Medical CenterQujing 655000Yunnan ProvinceChina School of Clinical Medicine Qujing Medical CollegeQujing 655000Yunnan ProvinceChina

BACKGROUND Advancements in laparoscopic technology and a deeper understanding of intra-hepatic anatomy have led to the establishment of more precise laparoscopic hepatectomy(LH)*** indocyanine green(ICG)fluorescence navi-gation technique has emerged as the most effective method for identifying hepatic regions,potentially overcoming the limitations of *** laparoscopic left hemihepatectomy(LLH)is a standardized procedure,there is a need for innova-tive strategies to enhance its *** anatomical markers,surgical skills,and ICG staining *** Thirty-seven patients who underwent ICG fluorescence-guided LLH at Qujing Second People's Hospital between January 2019 and February 2022 were retrospectively *** cranial-dorsal approach was performed which involves dissecting the left hepatic vein cephalad,isolating the Arantius ligament,exposing the middle hepatic vein,and dissecting the parenchyma from the dorsal to the foot in order to complete the anatomical *** surgical methods,as well as intra-and post-surgical data,were recorded and *** hospital’s Medical Ethics Committee approved this study(Ethical review:2022-019-01).RESULTS Intraoperative blood loss during LLH was 335.68±99.869 mL and the rates of transfusion and conversion to laparotomy were 13.5%and 0%,*** overall incidence of complications throughout the follow-up(median of 18 months;range 1-36 months)was 21.6%.No mortality or severe complications(level IV)were *** LLH has the potential to become a novel,standardized approach that can effectively,safely,and simply expose the middle hepatic vein and meet the requirements of precision surgery.

关键词： Laparoscopic left hemihepatectomy Indocyanine green Cranial-dorsal approach Laparoscopic hepatectomy Arantius ligament Glissonean pedicle

The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui jiang Dong-Xu Liang Zhi-Sen jiang Huai-Na Yu Hua Wang Cheng-wen Mao jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1)O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： jia-Qi Peng Yuan-Yuan Wei Dong-Ming Liu Yun Li Bin Hu Bin Huang jian-wen Yang Shun-Hua Xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 153.5 mAh·g^(–1) at 10.0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism

High-throughput screening system of citrus bacterial cankerassociated transcription factors and its application to the regulation of citrus canker resistance

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Journal of Integrative Agriculture 2024年第1期23卷 155-165页

作者： jia Fu Jie Fan Chenxi Zhang Yongyao Fu Baohang Xian Qiyuan Yu Xin Huang wen Yang Shanchun Chen Yongrui He Qiang Li Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China School of Advanced Agriculture and Bioengineering Yangtze Normal UniversityChongqing 408100China National Citrus Engineering Research Center Chongqing 400712China

One of the main diseases that adversely impacts the global citrus industry is citrus bacterial canker(CBC),caused by the bacteria Xanthomonas citri ***(Xcc).Response to CBC is a complex process,with both proteinDNA as well as protein–protein interactions for the regulatory *** detect such interactions in CBC resistant regulation,a citrus high-throughput screening system with 203 CBC-inducible transcription factors(TFs),were *** the upstream regulators of target by yeast-one hybrid(Y1H)methods was also performed.A regulatory module of CBC resistance was identified based on this *** TF(CsDOF5.8)was explored due to its interactions with the 1-kb promoter fragment of CsPrx25,a resistant gene of CBC involved in reactive oxygen species(ROS)homeostasis *** mobility shift assay(EMSA),dual-LUC assays,as well as transient overexpression of CsDOF5.8,further validated the interactions and transcriptional *** CsDOF5.8–CsPrx25 promoter interaction revealed a complex pathway that governs the regulation of CBC resistance via *** high-throughput Y1H/Y2H screening system could be an efficient tool for studying regulatory pathways or network of CBC resistance *** addition,it could highlight the potential of these candidate genes as targets for efforts to breed CBC-resistant citrus varieties.

关键词： citrus bacterial canker(CBC) high-throughput screening system transcription factor(TF) yeast-one hybrid(Y1H) CsPrx25

Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1614-1620页

作者： Yu-wen Liu Shu-jia Guo jia-Ni Li Yu-Ting Zhang Wei-Jie Ouyang Yu-Qian Wang Cai-Hong Huang Yi Liao jiaoyue Hu Zuguo Liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina

AIM:To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire(DEQSCHN)among Chinese patients with dry ***:This study involved 231 participants,including 191 with dry eye disease(DED)comprising the dry eye disease group,and 40 healthy participants forming the control *** were required to complete the DEQS-CHN,and Chinese dry eye questionnaire and undergo clinical tests including the fluorescein breakup time(FBUT),corneal fluorescein staining(CFS),and Schirmer I *** assess the internal consistency and retest reliability,Cronbach’sαand the intraclass correlation coefficient(ICC)were *** validity was assessed by item-level content validity index(ICV)and an average scale-level content validity index(S-CVI/Ave).Construct validity was assessed by confirmatory factor *** concurrent validity was assessed by calculating correlations between DEQS-CHN and Chinese dry eye *** validity was evaluated through nonparametric tests,with receiver operating characteristic(ROC)curve serving as conclusive indicators of the questionnaire’s distinguishing ***:The Cronbach’sαcoefficients for frequency and degree of ocular symptoms,impact on daily life,and summary score were 0.736,0.704,0.811,0.818,0.861,and 0.860,respectively,and the ICC were 0.611,0.677,0.715,0.769,0.711,and 0.779,*** I-CVI scores ranged from 0.833 to 1.000,with an S-CVI/Ave of *** factor analysis results exhibited a wellfitting model consistent with the original questionnaire[χ^(2)/df=2.653,incremental fit index(IFI)=0.924,comparative fit index(CFI)=0.924,Tucker-Lewis index(TLI)=0.909,and root mean square error of approximation(RMSEA)=0.065].There was a moderate positive correlation between the DEQS-CHN and the Chinese dry eye questionnaire(r^(2)=0.588).The dry eye group demonstrated significantly higher scores compared to the control group,and the area under

关键词： dry eye quality-of-life questionnaire

Megafossils of Betulaceae from the Oligocene of Qaidam Basin and their paleoenvironmental and phytogeographic implications

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Plant Diversity 2024年第1期46卷 101-115页

作者： Tao Yang jia-Hao Cai Yan-Zhi Dai Hong-Yu Chen Lei Han Li Zhang Wei-Yu Liang Xu-Jun Li wen-jia Li Jing-Yu Wu San-Ping Xie De-Fei Yan School of Earth Sciences and Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou UniversityLanzhou 730000China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Center for Research and Education on Biological Evolution and Environments School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China

Understanding the paleoenvironment and phytogeographical history of the Tibetan Plateau,China relies on discovering new plant *** Qaidam Basin has long been regarded as an ideal‘field laboratory’to investigate the paleoclimate and paleobiological evolution of the northern Tibetan ***,fossil angiosperms from the Qaidam Basin are rare,and our knowledge of its paleovegetation is ***,we report fossil leaves and fruits of Betulaceae found from the Oligocene Shangganchaigou Formation of northwestern Qaidam Basin(Huatugou area).Comparative morphological analysis led us to assign the fruits to the Betula subgenus Betula and the leaves to Carpinus *** findings,together with other reported fossil plants from the same locality,reveal a close floristic linkage between the Qaidam Basin and Europe during the *** northern pathway of this floristic exchange may have crossed through the Qaidam Basin during the late *** floristic linkage may have been facilitated by the continuous narrowing of the Turgai Strait and stronger westerlies,which transported moisture and provided favorable climatic ***,fossil plants collected from the Qaidam Basin suggest that during the Oligocene this region had warm and humid deciduous broad-leaf forest,which differs from the region’s modern vegetation and indicates that the Qaidam Basin may have been a suitable region for these plants to flourish and spread during the Oligocene.

关键词： Paleoenvironment Biogeography Betulaceous fossil Qaidam basin Tibetan Plateau Oligocene

Young Zhou Enlai in Tianjin

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China News Release 2024年第1期 62-65页

作者： Xu xing Tan wen the Zhou Enlai Research Center of Nankai University Nankai University's Zhou Enlai School of Government

January 8,2024,marks the 48th anniversary of the passing of Premier Zhou Enlai(1898–1976).Zhou was a great Marxist,a prominent proletarian revolutionary,politician,military strategist and diplomat.“Every time we mention Zhou’s name,we feel warm and proud,”Chinese President Xi Jinping said,praising his great contribution and lofty spirit which has been enshrined in the hearts of the Chinese people and those around the world who pursue peace and justice.

关键词： peace anniversary passing