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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong jianhong dong Ziwei Fan Mengxian jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Multi-source and multi-temporal remote sensing image classification for flood disaster monitoring

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Global Geology 2025年

作者： LI Zhu jia Zhenyang dong Jing LIU Zhenghong College of Earth Sciences Jilin University Dandong No.2 High School

Flood disasters can have a serious impact on people's production and lives, and can cause huge ***-sourceremotesensingdata,thisstudyestablished decision tree classification rules through multi-source and multi-temporal feature fusion, classified ground objects before the disaster and extracted flood information in the disaster area based on optical images during the disaster, so as to achieve rapid acquisition of the disaster situation of each disaster bearing *** the case of Qianliang Lake, which suffered from flooding in 2020, the results show that decision tree classification algorithms based on multi-temporal features can effectively integrate multi-temporal and multispectral information to overcome the shortcomings of single-temporal image classification and achieve ground-truth object classification.

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美丽中国建设的制度体系研究

生态经济 2025年第1期41卷 13-18页

作者：董战峰周佳生态环境部环境规划院北京100041

制度体系是美丽中国建设的根本保障。改革开放四十多年以来,我国基本建立了一套行之有效的生态文明制度体系,但与全面推进美丽中国建设的要求相比还存在较大差距。论文分析了美丽中国建设的制度基础和面临的关键挑战,明确了促进美丽中... 详细信息

制度体系是美丽中国建设的根本保障。改革开放四十多年以来,我国基本建立了一套行之有效的生态文明制度体系,但与全面推进美丽中国建设的要求相比还存在较大差距。论文分析了美丽中国建设的制度基础和面临的关键挑战,明确了促进美丽中国建设的制度体系思路,提出了健全生态环境空间管控、责任体系、市场体系等十大重点任务,为全面推进美丽中国建设提供坚实支撑。

关键词：美丽中国生态文明制度环境治理现代化重点任务

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制度变迁中的制度外行为

天津商业大学学报 2011年第5期31卷 61-68页

作者：贾献东南开大学经济学院天津300071 天津商业大学经济学院天津300134

通过梳理关于中国改革30年经济增长原因的解释,认为改革启动后中国经济增长和制度变迁的动力源于经济主体的制度外行为,并通过对经济理论中关于制度、行为主体行为的重新审视,尝试将制度外行为作为变量解释制度变迁的动力。

关键词：中国改革制度变迁制度内行为制度外行为

Mechanical properties and microstructure of 3D-printed high Co–Ni secondary hardening steel fabricated by laser melting deposition

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International Journal of Minerals,Metallurgy and Materials 2017年第9期24卷 1027-1033页

作者： Hui-ping Duan Xiao Liu xian-zhe Ran jia Li dong Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191China National Engineering Laboratory of Additive Manufacturing for Large Metallic Components Beijing 100191China Engineering Research Center of Ministry of Education on Laser Direct Manufacturing for Large Metallic Component Beijing 100191China

The mechanical properties and microstructure of the 3D-printed high Co–Ni secondary hardening steel fabricated by the laser melting deposition technique was investigated using a material testing machine and electron microscopy. A microstructure investigation revealed that the samples consist of martensite laths, fine dispersed precipitates, and reverted austenite films at the martensite lath boundaries. The precipitates are enriched with Co and Mo. Because the sample tempered at 486°C has smaller precipitates and a higher number of precipitates per unit area, it exhibits better mechanical properties than the sample tempered at 498°C. Although the 3D-printed samples have the same phase constituents as Aer Met 100 steel, the mechanical properties are slightly worse than those of the commercial wrought Aer Met 100 steel because of the presence of voids.

关键词： laser deposition high strength steel mechanical properties microstructure

Permeability measurement of the fracture-matrix system with 3D embedded discrete fracture model

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Petroleum Science 2022年第4期19卷 1757-1765页

作者： Bao jia Cheng-Gang xian State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China Unconventional Petroleum Research Institute China University of Petroleum(Bejing)Bejing 102249China

In this work, we performed the pulse-decay experiment on a fractured shale core and applied the 3 D embedded discrete fracture model(EDFM) to simulate the experiment process. The irregularly rough fracture surface was depicted in detail using a 3 D scanner. Then the fracture surface profile was imported in the discrete fracture network model to simulate the flow process in the fracture-matrix system realistically. History matching was efficiently performed to simultaneously obtain porosity and permeability for the matrix and fracture. Gas properties after applying nanopore confinement were obtained by modifying Sutton's viscosity correlation with sensitivity analysis on the pore diameter ranging from 2 to50 nm. Nanopore confinement results in low matched permeability due to viscosity reduction in the matrix-only porous media. The fracture-matrix system complicates the interpretation of nanopore confinement impact on flow behavior in shale reservoirs. Different scenarios of the highly fractured and matrix-dominated systems were discussed in detail by constructing the digital twin model.

关键词： Permeability Fracture Pulse-decay Shale Viscosity

Impact of rock type on the pore structures and physical properties within a tight sandstone reservoir in the Ordos Basin, NW China

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Petroleum Science 2020年第4期17卷 896-911页

作者： xiang-dong Yin Shu jiang Shi-jia Chen Peng Wu Wei Gao Ji-xian Gao xian Shi State Key Laboratory of Oil and Gas Reservoir Geology and Exploration Southwest Petroleum UniversityChengdu610500SichuanChina Key Laboratory of Tectonics and Petroleum Resources of Ministry of Education and School of Earth Resources China University of GeosciencesWuhan430074HubeiChina Energy and Geoscience Institute University of UtahSalt Lake CityUT84108USA Unconventional Oil and Gas Branch CNOOC Ltd.Beijing100011China Oil and Gas Technology Research Institute Changqing Qilfield CompanyXi’an City710021ShaanxiChina School of Petroleum Engineering China University of Petroleum(Huadong)Qingdao266000ShandongChina

The pore-throat systems and physical properties of tight sandstone reservoirs are complex,and deposition is thought to be a fundamental control for *** this study,the impacts of the full ranges of rock types(from pebbly coarse sandstone to fine sandstone) on the pore structures and physical properties of the Permian tight sandstone reservoir in the eastern Ordos Basin were investigated comprehensively through a series of experiments including conventional physical testing,thin-section analysis,scanning electron microscopy,nuclear magnetic resonance analysis and high-pressure mercury injection *** results showed that the coarser-grained sandstones tend to have higher feldspar content and lower percentage of cements,leading to strong dissolution,weak cementation and improved porosity and *** medium sandstone has the highest level of quartz and the lowest average content of feldspar,resulting in strong heterogeneity of physical *** those medium sandstone reservoirs with relatively high content of feldspars have better physical ***,the coarser-grained sandstones contain relatively large dissolution pores(nearly 200 μm),whereas the finer-grained sandstones have more intercrystalline pores with a relatively more homogeneous pore *** pebbly coarse sandstone and coarse sandstone reservoirs are favorable targets with best physical properties.

关键词： Pore size distribution Pore types Physical properties Tight sandstone Ordos Basin

Spatio-temporal trends and causes of variations in runoff and sediment load of the Jinsha River in China

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Journal of Mountain Science 2019年第10期16卷 2361-2378页

作者： LU Chuan-hao dong xian-yong TANG jia-liang LIU Gang-cai Institute of Mountain Hazards and Environment Chinese Academy of Sciences and Ministry of Water ConservancyKeyLaboratory of Mountain Surface Processes and Ecological RegulationChinese Academy of SciencesChengdu610041China China Three Gorges Corporation Chengdu610041China University of Chinese Academy of Sciences Beijing100049China

The Jinsha River Basin is an important basin for hydropower in China and it is also the main runoff and sediment source area for the Yangtze River,which greatly influence the runoff and sediment in the Three Gorges *** study aims to characterize the spatial distribution,inter-annual variation of runoff and sediment load in the Jinsha River Basin,and to analyze the contribution of rainfall and human activities to the runoff and sediment load *** monitoring data on runoff,sediment load and precipitation were collected from 11hydrological stations in the Jinsha River Basin from1966 to *** data observed at the outlet of the basin showed that 71.4%of the runoff is from the upper reaches of the Jinsha River Basin and the Yalong River,while 63.3%of the sediment is from the lower reaches(excluding the Yalong River).There is no significant increase in runoff on temporal scale in the Jinsha River Basin,while it has an abrupt change in runoff in both upstream and midstream in 1985,and an abrupt change in downstream in 1980 *** sediment load demonstrated a significantincreasing trend in the upstream,no significant reducing trend in the midstream,but significant reducing trend in the *** sediment load in upstream showed abrupt change in 1987,in midstream in 1978 and 2014,in downstream in *** dominated runoff variation,contributing more than 59.0%of the total variation,while human activity,including reservoirs construction,the implementation of soil and water conservation projects,is the major factor to sediment load variation,contributing more than 87.0%of the total variation.

关键词： Jinsha River Basin Runoff Sediment load Rainfall Cascade reservoir Three Gorges Reservoir