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An approximate analytical model for unconventional reservoir considering variable matrix blocks and simultaneous matrix depletion

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Petroleum Science 2024年第1期21卷 352-365页

作者： Kai-Xuan qiu jia Li dong Feng Shi-Ming Wei Gang Lei jiangmen Laboratory of Carbon Science and Technology Jiangmen529100GuangdongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou511400GuangdongChina China University of Geosciences(Beijing) Beijing100083China China University of Petroleum(Beijing) Beijing102249China China University of Geosciences(Wuhan) Wuhan430074HubeiChina Shenzhen Research Institute China University of GeosciencesShenzhen518063GuangdongChina

In regard to unconventional oil reservoirs,the transient dual-porosity and triple-porosity models have been adopted to describe the fluid flow in the complex fracture *** has been proven to cause inaccurate production evaluations because of the absence of matrix-macrofracture *** addition,most of the existing models are solved analytically based on Laplace transform and numerical ***,an approximate analytical solution is derived directly in real-time space considering variable matrix blocks and simultaneous matrix *** simplify the derivation,the simultaneous matrix depletion is divided into two parts:one part feeding the macrofractures and the other part feeding the ***,a series of partial differential equations(PDEs)describing the transient flow and boundary conditions are constructed and solved analytically by ***,a relationship between oil rate and production time in real-time space is *** new model is verified against classical analytical *** the microfracture system and matrix-macrofracture communication is neglected,the result of the new model agrees with those obtained with the dual-porosity and triple-porosity model,***,the new model also has an excellent agreement with the numerical *** model is then applied to two actual tight oil wells completed in western Canada sedimentary *** identifying the flow regime,the solution suitably matches the field production data,and the model parameters are *** these output parameters,we can accurately forecast the production and even estimate the petrophysical properties.

关键词： Analytical solution Unconventional reservoir Variable matrix Simultaneous flow

Anti-OX40 Antibody Combined with HBc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

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Biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU jia jia SU qiu dong YI Yao SHEN Li Ping BI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(HBc VLPs)therapy using a mouse colon cancer *** Humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with HBc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with HBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that HBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with HBc *** Combination therapy of anti-h OX40 and HBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody Hepatitis B core virus-like particles Tumor Combination therapy

Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives

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Rare Metals 2024年第2期43卷 413-430页

作者： dong Wang jia-Tao Zhang Institute of Medical-Industrial Integration Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their *** therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue *** soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of ***,many sonosensitizers are studied and applied to SDT-based ***-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band *** representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is ***-gistic effects of SDT in combination with other therapeutic modalities are mainly *** the same time,the critical and potential issues and future perspectives are addressed.

关键词： Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment Antibacteria

Changes in Spring Snow Cover over the Eastern and Western Tibetan Plateau and Their Associated Mechanism

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Advances in Atmospheric Sciences 2024年第5期41卷 959-973页

作者： Fangchi LIU Xiaojing jia Wei dong Key Laboratory of Geoscience Big Data and Deep Resource of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhouZhejiang 310058China

The spring snow cover(SC)over the western Tibetan Plateau(TP)(TPSC)(W_TPSC)and eastern TPSC(E_TPSC)have displayed remarkable decreasing and increasing trends,respectively,during 1985–*** current work investigates the possible mechanisms accounting for these distinct TPSC *** results indicate that the decrease in W_TPSC is primarily attributed to rising temperatures,while the increase in E_TPSC is closely linked to enhanced *** circulation analysis shows that the essential system responsible for the TPSC changes is a significant anticyclonic system centered over the northwestern *** anomalous descending motion and adiabatic heating linked to this anticyclone leads to warmer temperatures and consequent snowmelt over the western ***,anomalous easterly winds along the southern flank of this anticyclone serve to transport additional moisture from the North Pacific,leading to an increase in snowfall over the eastern *** analysis reveals that the anomalous anticyclone is associated with an atmospheric wave pattern that originates from upstream *** warming of the subtropical North Atlantic(NA)sea surface temperature(SST)induces an atmospheric pattern resembling a wave train that travels eastward across the Eurasian continent before reaching the ***,the decline in winter sea ice(SIC)over the Barents Sea exerts a persistent warming influence on the atmosphere,inducing an anomalous atmospheric circulation that propagates southeastward and strengthens the northwest TP anticyclone in ***,an enhancement of subtropical stationary waves has resulted in significant increases in easterly moisture fluxes over the coastal areas of East Asia,which further promotes more snowfall over eastern TP.

关键词： snow cover Tibetan Plateau long-term changes spring

Distributed collaborative complete coverage path planning based on hybrid strategy

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Journal of Systems Engineering and Electronics 2024年第2期35卷 463-472页

作者： ZHANG jia DU Xin dong Qichen XIN Bin School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing Institute of TechnologyBeijing 100081China

Collaborative coverage path planning(CCPP) refers to obtaining the shortest paths passing over all places except obstacles in a certain area or space. A multi-unmanned aerial vehicle(UAV) collaborative CCPP algorithm is proposed for the urban rescue search or military search in outdoor *** to flexible control of small UAVs, it can be considered that all UAVs fly at the same altitude, that is, they perform search tasks on a two-dimensional plane. Based on the agents’ motion characteristics and environmental information, a mathematical model of CCPP problem is established. The minimum time for UAVs to complete the CCPP is the objective function, and complete coverage constraint, no-fly constraint, collision avoidance constraint, and communication constraint are considered. Four motion strategies and two communication strategies are designed. Then a distributed CCPP algorithm is designed based on hybrid strategies. Simulation results compared with patternbased genetic algorithm(PBGA) and random search method show that the proposed method has stronger real-time performance and better scalability and can complete the complete CCPP task more efficiently and stably.

关键词： multi-agent cooperation unmanned aerial vehicles(UAV) distributed algorithm complete coverage path planning(CCPP)

Suppress oxygen evolution of lithium-rich manganese-based cathode materials via an integrated strategy

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Green Energy & Environment 2024年第1期9卷 138-151页

作者： Wenhua Yu Yanyan Wang Aimin Wu Aikui Li Zhiwen qiu Xufeng dong Chuang dong Hao Huang Key Laboratory of Energy Materials and Devices(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian116024Liaoning ProvinceChina Dalian Engineering Research Center for New Electric Power Systerms School of Electrical EngineeringDalian University of TechnologyDalian116024Liaoning ProvinceChina

Improving the reversibility of anionic redox and inhibiting irreversible oxygen evolution are the main challenges in the application of high reversible capacity Li-rich Mn-based cathode materials.A facile synchronous lithiation strategy combining the advantages of yttrium doping and LiYO_(2) surface coating is *** doping effectively suppresses the oxygen evolution during the delithiation process by increasing the energy barrier of oxygen evolution reaction through strong Y–O bond ***_(2) nanocoating has the function of structural constraint and protection,that protecting the lattice oxygen exposed to the surface,thus avoiding irreversible *** an Li^(+) conductor,LiYO_(2) nano-coating can provide a fast Li^(+) transfer channel,which enables the sample to have excellent rate *** synergistic effect of Y doping and nano-LiYO_(2) coating integration suppresses the oxygen release from the surface,accelerates the diffusion of Li^(+)from electrolyte to electrode and decreases the interfacial side reactions,enabling the lithium ion batteries to obtain good electrochemical *** lithium-ion full cell employing the Y-1 sample(cathode)and commercial graphite(anode)exhibit an excellent specific energy density of 442.9 Wh kg^(-1) at a current density of 0.1C,with very stable safety performance,which can be used in a wide temperature range(60 to-15℃)stable *** result illustrates a new integration strategy for advanced cathode materials to achieve high specific energy density.

关键词： Lithium-rich manganese-based cathodes Lithium ion batteries Oxygen redox Oxygen evolution Integrated strategy

Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu jia Cheng Wang Wenlong Xu dong Ma Fangfang Qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

Investigating the Absorption and Desorption Behavior of Methylene Chloride in the Poly(aryl ether ketone) Film with Different Crystallinities

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Chinese Journal of Polymer Science 2024年第2期42卷 239-246,I0009页

作者： Hong-Ru Yang Jin-dong Zhang dong-Ting Gao Gang Liu Chun-Hai Chen jia-Nan Yao Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai201620China

Poly(aryl ether keton e)(PAEK) films with different crystallinities were obtained by controlling the cooling rate,which were subjected to the absorption and desorption of methylene chloride(CH_(2)Cl_(2)).We employed attenuated total reflection Fourier transform infrared(ATR-FTIR)spectroscopy analyses to investigate the diffusion behavior of CH_(2)Cl_(2) in PAEK films with different *** to the Fickian diffusion model,the calculated diffu sion coefficients of CH_(2)Cl_(2) in PAEK films were observed to decrease with increasing *** effect of CH_(2)Cl_(2)absorption and desorption on the mechanical properties of PAEK films with different crystallinity was further analyzed using tensile *** tensile tests exhibited that CH_(2)Cl_(2) has two concurrent effects:plasticization and solvent-induced *** scanning calorimetry(DSC) and wide-angle X-ray diffraction(WXRD) techniques further confirmed solvent-induced crystallization *** results would be beneficial to understand the solvent resistance of PAEK materials and consequently provide the practical application conditions of PAEK with a theoretical basis.

关键词： Poly(aryl ether ketone) Diffusion behavior Infrared spectra Solvent-induced crystallization Mechanical properties

Colorimetric Detection of Acid Phosphatase and Malathion Using NiCo_(2)O_(4)Nanosheets as Peroxidase-Mimicking Activity

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Journal of Analysis and Testing 2024年第2期8卷 170-179页

作者： jia Chen Zerong Long Yan Li Hongdeng qiu Xinjiang Uygur Autonomous Product Quality Supervision and Inspection Institute Urumqi830000China CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

The establishment of a low-cost and facile approach for the assay of acid phosphatase(ACP)and its inhibitor is a research *** this paper,we successfully synthesized NiCo_(2)O_(4)nanosheets with peroxidase-mimicking activity in alkaline deep eutectic solvents(DESs)composed of NaOH and PEG-200,which can catalyze 3,3',5,5'-tetramethylbenzidine(TMB)to the oxidation state TMB(ox-TMB)in the presence of *** to L-ascorbic acid-2-phosphate can be hydrolyzed into ascorbic acid by ACP,the peroxidase-like activity of NiCo_(2)O_(4)nanosheets is ***,the addition of malathion,an inhibitor of ACP,can inhibit the activity of ACP and thus limit the production of ascorbic acid(AA).Therefore,a colorimetric approach can be established for highly sensitive and selective detection of ACP and malathion with detection limits of 0.032 U/L and 0.65 nmol/L,*** importantly,this method can be successfully applied to malathion detection in environmental samples tap water and food cucumber juice,indicating that it has potential application prospects in environmental and agricultural fields.

关键词： NiCo_(2)O_(4)nanosheets Acid phosphatase Malathion Peroxidase-mimicking activity Colorimetric