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Evaluation of the in vitro and in vivo Genotoxicity of Almond Skins

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Biomedical and Environmental Sciences 2011年第4期24卷 415-421页

作者： ZHANG XiaoPeng XIANG Qian CUI WenMing jia XuDong li ning Institute for Nutrition and Food Safety Chinese Center for Disease Control and PreventionBeijing 100021China

Objective It aims to study potential genotoxicity of almond *** A bacterial reverse mutation assay was performed on *** strains TA97,TA98,TA100,TA102,and TA1535 in the absence or presence of S-9 mixture at a dose range of 312.5 to 5 000 μg/plate.A micronucleus test and a mammalian bone marrow chromosome aberration tests were performed in Swiss Albino （CD-1） mice at doses of 625,1 250,and 2 500 mg/kg bw *** Almond skins exerted no mutagenic activity in various bacterial strains of Salmonella typhimurium in either the absence or the presence of metabolic activation at all doses *** doses of almond skins did not affect the proportions of immature to total erythrocytes,the number of micronuclei in the immature erythrocytes,or the number of structural and numerical chromosomal aberrations of Swiss albino *** Almond skins are not genotoxic under the conditions of the in vitro bacterial reverse mutation assay and two in vivo tests-micronucleus test and mammalian bone marrow chromosome aberration test,which supports the safety of almond skins for dietary consumption.

关键词： Almond skins Genotoxicity Mutagenicity Micronuclei Chromosome aberration

Assessment on Dietary Melamine Exposure from Tainted Infant Formula

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Biomedical and Environmental Sciences 2009年第2期22卷 100-103页

作者： XU-DONG jia ning li ZHU-TIAN WANG YUN-FENG ZHAO YONG-ning WU AND WEI-XING YAN Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To estimate the dietary melamine exposure in Chinese infants and young children from the consumption of melamine adulterated Sanlu infant formula. Methods Four age groups of infants and young children （3, 6, 12, and 24 months） were chosen as the assessed subjects and the maximum amount of infant formula consumption was estimated based on the recommended usage level in the package insert of Sanlu infant formula and other brands. Melamine was analyzed in 111 Sanlu infant fbrmula samples collected from the markets in Beijing and Gansu province using the LC-MS-MS with a limit of quantification of 0.05 mg/kg. Four levels of melamine concentration were chosen to estimate the dietary intakes, including the mean, median, 90th percentile, and maximum. Results The infants of 3 months had the highest intake of melamine, and with the increase of the age （inonth）, the intake decreased. Based on the median melamine concentration （1 000 mg/kg） as an example, the melamine intakes fur the infants of 3, 6, 12, and 24 months were 23.4, 21.4, 15.0, and 8.6 mg/kg bw/d, respectively. Conclusion Dietary melamine intakes from tainted Sanln infant formula significantly exceeded the TDI level （0.2 mg/kg bw/d） recommended by the WHO Expert Meeting in 2008. However, the present assessment has some limitations including the poor representative samples, the varied melamine concentrations in the adulterated Sanlu infant formula, and other brand infant formula possibly consumed by these infants.

关键词： Dietary exposure assessment Melamine Infant formula

Self-management and self-efficacy status in liver recipients

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Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 253-262页

作者： Lei Xing Qin-Yun Chen jia-ning li Zhi-Qiu Hu Ye Zhang Ran Tao Center for Organ Transplantation and Department of Surgery Ruijin Hospital Shanghai Jiaotong University School of Medicine Nursing School Shanghai Jiaotong University School of Medicine Department of General Surgery Central Hospital of Minhang District

BACKGROUND： liver transplantation （LT） is a viable treatment for patients with end-stage chronic liver diseases. The main aim of LT is to prolong life and improve life quality. However, although survival after LT continues to improve, some aspects of recipient＇s health-related quality of life such as self-man- agement and self-efficacy have been largely ignored.

关键词： liver transplantation self-management self-efficacy quality of life questionnaires

Prevalence of Thrombocytopenia among Chinese Adult Antiretroviral-na（i）ve HIV-positive Patients

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Chinese Medical Journal 2015年第4期128卷 459-464页

作者： Hong-Wei Fan Fu-Ping Guo Yi-jia li ning li Tai-Sheng li Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China

Background：The prevalence ofthrombocytopenia among Chinese antiretroviral therapy （ART）-na（i）ve HIV-infected adults has not been *** aim of this study was to investigate the prevalence and associated risk factors of thrombocytopenia among Chinese ART-na（i）ve HIV-infected ***：We performed a cross-sectional study of Chinese adult ART-na（i）ve HIV-infected patients from September 2005 through August ***-demographic variables and laboratory results including platelets,CD4＋ cell count,and viral load were obtained from medical *** and outcomes associated with thrombocytopenia were assessed using logistic ***：A total of 1730 adult ART-na（i）ve HIV-infected patients was *** mean age was 38 *** prevalence of thrombocytopenia was 4.5％.There were significant differences in the prevalence of thrombocytopenia between patients ＜30 years of age （2.8％） and 30-39 years （4.0％） compared with patients greater than 50 years （7.0％）（P =0.006 and P =0.044,respectively）.The prevalence of thrombocytopenia was also significantly different between patients with CD4＋ counts of 200-349 cells/mm3 （3.3％） and ＞350 cells/mm3 （2.8％） compared with patients with CD4＋ counts of50-199 cells/mm3 （7.1％）（P =0.002 and P =0.005,respectively）.The prevalence of thrombocytopenia was significantly different by hepatitis C virus antibody （HCV-Ab） seropositivity （10.2％ for HCV-Ab positive vs.3.9％ for HCV-Ab negative,P =0.001）.We observed differences in prevalence of thrombocytopenia by mode of transmission of HIV infection：Blood transmission （10.7％） versus men who have sex with men （3.9％）（P =0.002） and versus heterosexual transmission （3.9％）（P =0.001）.In binary logistic regression analyses,age ≥＞50 years,HCV-Ab positivity and having a CD4＋ cell count of 50-199 cells/mm3 were significantly associated with thrombocytopenia with adjusted odds ratio of 2.482 （95％ confidence interval [CI]：1.167,5.281,P=0.018）,2.091 （95％ CI：1.078,4.055,P =0.029）

关键词： HIV Prevalence Thrombocytopenia

Therapeutic effects of potassium sodium hydrogen citrate on melamine-induced urinary calculi in China

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Chinese Medical Journal 2010年第9期123卷 1112-1116页

作者： GAO Jie SHEN Ying SUN ning jia li-qun PAN Yue-song SUN Qiang Department of Nephrology Beijing Children's Hospital Affiliated to Capital Medical UniversityBeijing 100045China

Background In 2008, a sharp increase of the number of children diagnosed with urinary calculi was observed in China, 9433 children were diagnosed as having melamine-induced urinary calculi at outpatient clinic in Beijing Children＇s Hospital. This study examined the therapeutic efficacy of potassium sodium hydrogen citrate （PSHC） used to treat melamine-induced urinary stones in Chinese children who consumed melamine-containing infant formula. Methods Seventy-two infants and children （average age （18.2±7.7） months） who were diagnosed with urinary calculi were icuidomly divided into three treatment groups using the SAS Plan program. Group 1 was given a low dose （1 g/d） of PSHC, group 2 was given high dose of PSHC （2 g/d） and group 3 was given no PSHC （control group）. The dose of drug was adjusted according to the baseline urinary pH. This study analyzed the influence of the dose of PSHC, the age of patients, stone size and position, and urinary pH on the level of efficacy of PSHC （cured, effectively treated or not cured）.Results After 1-6 months of therapy, 19 patients from group 1, five patients from group 2 and six patients from group 3 were cured. Five patients from group 1, five patients from group 2 and four patients from group 3 were effectively treated. There were significant differences in therapeutic efficacy between the two treatment doses after 3 and 6 months as measured by the increase in the successful expulsion rate and time of melamine-induced urinary calculi. After 6 months the mean time of expulsion of urinary calculi in groups 1 and 2 was significantly shorter than in the control group. Conclusions PSHC can significantly increase the successful expulsion rate and time of melamine-induced urinary calculi. The therapeutic efficacy is affected by PSHC dose, treatment duration, calculi position, and urinary pH. There is no relationship between the therapeutic efficacy and the stone size or patient age.

关键词： melamine potassium sodium hydrogen citrate urinary calculi

Machine learning improves prediction of severity and outcomes of acute pancreatitis:a prospective multi-center cohort study

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Science China(life Sciences) 2023年第8期66卷 1934-1937页

作者： jia-ning li Dong Mu Shi-Cheng Zheng Wei Tian Zuo-Yan Wu Jie Meng Rui-Feng Wang Tian-Lei Zheng Yue-Lun Zhang John Windsor Guo-Tao Lu Dong Wu Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610083China Department of Gastroenterology West China Longquan Hospital Sichuan UniversityChengdu 610100China Department of Gastroenterology Fangshan Liangxiang Hospital of BeijingBeijing 102400China Department of Gastroenterology The Sixth Hospital of BeijingBeijing 100048China Department of Gastroenterology Affiliated Hospital of Hebei UniversityBaoding 071030China Department of Gastroenterology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Artificial Intelligence Unit Department of Medical Equipment ManagementAffiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Surgical and Translational Research Centre Faculty of Medical and Health SciencesUniversity of AucklandAuckland Auckland 1142New Zealand Department of Gastroenterology Affiliated Hospital of Yangzhou UniversityYangzhou UniversityYangzhou 225003China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Dear Editor,Acute pancreatitis(AP)is a common acute pancreatic disease of variable severity and outcomes(Mederos et al.,2021).According to systemic and local complications,patients can be classified into severe,moderately severe,and mild AP(Banks et al.,2013).About 20%of AP patients develop severe acute pancreatitis(SAP,with persistent organ failures)of whom 20%–50%die.

关键词： pancreatitis severity

Recombinant adeno-associated virus-mediated delivery of antisense angiotensin Ⅱ receptor 1 gene attenuates hypertension development

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Acta Pharmacologica Sinica 2007年第11期28卷 1737-1745页

作者： Xu-guang li~2,jiang-tao YAN~2,Xi-zheng XU,jia-ning WANG,li-ming CHENG,Tao WANG,Ping ZUO,Dao-wen WANG~3Institute of Hypertension and Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science andTechnology,Wuhan 430030,China Institute of Hypertension and Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:The renin-angiotensin system plays a crucial role in the development andestablishment of hypertension,and the pharmacological blockade of the systemresults in a reduction in blood *** the present study,we investigatedwhether the effects of a novel,double-stranded,recombinant adeno-associatedvirus vector (rAAV)-mediated antisense angiotensin Ⅱ receptor 1 (AT1R) geneefficiently prevents the development of hypertension induced by a high-salt dietin adult,male Sprague-Dawley (SD) ***:A rAAV was prepared with acassette containing a cytomegalovirus promoter and partial cDNA (660 base pairs)for the AT1R inserted in the antisense direction (rAAV-AT1-AS).A single tail veininjection of the rAAV-AT1-AS or rAAV-GFP (green fluorescent protein,a reportergene) was performed in adult,male SD *** weeks after injection,the animalswere fed a diet containing 8% NaCl,and the systolic blood pressure was measuredweekly using the tail-cuff method for 12 ***:The high-salt dietinduced a significant rise in systolic blood pressure in the rAAV-GFP-treatedanimals;however,the rAAV-AT1-AS treatment attenuated the rise in blood pres-sure (142.7±4.5 mmHg vs 117±3.8 mmHg,Plivery attenuates the development of hypertension and pro-tects against renal injury and cardiac remodeling.

关键词： hypertension gene therapy angiotensin Ⅱ receptor 1 antisense double-stranded recombinant adeno-associated virus vector