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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Fabrication and shape detection of a catheter using fiber Bragg grating

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Advances in Manufacturing 2020年第1期8卷 107-118页

作者： Xiang-Yan Chen Ya-nan Zhang Lin-Yong Shen Jin-Wu Qian jia-Ying fan Department of Mechatronics Engineering and Automation Shanghai UniversityShanghai 200444People's Republic of China

Considering the spatial position and shape detection properties of the fiber Bragg grating(FBG)curve sensor used in the human body,the positioning accuracy of the FBG curve sensor plays a major role in the pre-diagnosis and treatment of *** present a new type of shape-sensing catheter(diameter of 2.0 mm and length of 810 mm)that is integrated with an array of four optical fibers,where each contains five nodes,to track the ***,the distribution of the four orthogonal fiber gratings is wound around a nitinol wire using novel packaging technology,and the spatial curve shape is rebuilt based on the positioning of discrete points in *** experimental platform is built,and then a reconstruction algorithm for coordinate point fitting of the Frenet frame is used to perform the reconstruction experiment on millimeter *** results show that,compared with those in previous studies,in 2D test,the maximum relative error for the end position is reduced to 2.74%,and in 3D reconstruction experiment,the maximum shape error is 3.43%,which verifies both the applicability of the sensor and the feasibility of the proposed *** results reported here will provide an academic foundation and the key technologies required for navigation and positioning of noninvasive and minimally invasive surgical robots,intelligent structural health detection,and search and rescue operations in debris.

关键词： Fiber Bragg grating(FBG) Thin diameter Encapsulation positioning Shape detection

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Intrauterine cystic adenomyosis:Report of two cases

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World Journal of Clinical Cases 2019年第5期7卷 676-683页

作者： Yan-Yan fan Yi-nan Liu jia Li Yan Fu Department of Obstetrics and Gynecology the First Hospital of Jilin University Department of Otorhinolaryngology Jilin Province FAW General Hospital

BACKGROUND Cystic adenomyosis is a special type of adenomyosis. Its clinical manifestations lack specificity. Pelvic ultrasound and nuclear magnetic resonance imaging can help clarify the diagnosis. Because cystic uterine adenomyosis is rare in clinical work, it can be easily misdiagnosed or its diagnosis can be missed. Early surgical treatment and postoperative drug treatment can alleviate dysmenorrhea,menorrhagia, anemia, and other *** SUMMARY Two cases complained about abnormal vaginal bleeding and were diagnosed with intrauterine cystic adenomyosis by gynecological ultrasound and pathological examination. The clinical manifestations included dysmenorrhea,hypermenorrhea, and a history of cesarean section. Both cases underwent a surgery, and chocolate-like liquid was released from the cystic mass in the uterus and the manifestations were *** Intrauterine cystic adenomyosis could be diagnosed by pathological examination and treated by hysterectomy or hystscopy to release the liquid inside.

关键词： Cystic adenomyosis Adenomyosis Junctional zone Intrauterine Case report

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Flexible Strain Sensors with Ultra-High Sensitivity and Wide Range Enabled by Crack-Modulated Electrical Pathways

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nanO-MICRO LETTERS 2025年第1期17卷 1-19页

作者： Bai, Yunzhao Zhou, Yunlei Wu, Xuanyu Yin, Mengfei Yin, Liting Qu, Shiyuan Zhang, fan Li, Kan Huang, Yongan Huazhong Univ Sci & Technol State Key Lab Intelligent Mfg Equipment & Technol Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Flexible Elect Res Ctr Wuhan 430074 Peoples R China Xidian Univ Hangzhou Inst Technol Hangzhou 311200 Peoples R China Xidian Univ Sch Mechanoelect Engn Xian 710071 Peoples R China Univ Southern Calif Dept Aerosp & Mech Engn Los Angeles CA 90089 USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultra-high sensitivity and wide-range sensor, addressing the critical challenge of reconciling sensitivity with measurement range. Inspired by the structure of bamboo slips, we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode. The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%. The integration of patterned liquid metal enables customisable tuning of the sensor's response, while the porous fabric structure ensures superior comfort and air permeability for the wearer. Our design not only optimises the sensor's performance but also enhances the electrical stability that is essential for practical applications. Through systematic investigation, we reveal the intrinsic mechanisms governing the sensor's response, offering valuable insights for the design of wearable strain sensors. The sensor's exceptional performance across a spectrum of applications, from micro-strain to large-strain detection, highlights its potential for a wide range of real-world uses, demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

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Rac1 Signaling in Amygdala Astrocytes Regulates Fear Memory Acquisition and Retrieval

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Neuroscience Bulletin 2021年第7期37卷 947-958页

作者： Xiao-Cen fan Chao-nan Ma jia-Chen Song Zhao-Hui Liao nan Huang Xing Liu Lan Ma Department of Neurosurgery Huashan HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceSchool of Basic Medical SciencesInstitutes of Brain ScienceFudan UniversityShanghai 200032China

The importance of astrocytes in behavior control is increasingly appreciated,but little is known about the effects of their dynamic activity in regulating learning and *** the present study,we constructed AAVs of photoactivatable and photoinactivatable Ras-related C3 botulinum toxin substrate 1(Rac1)under the mGFAP promoter,which enabled the manipulation of Rac1 activity in astrocytes by optical stimulation in free-moving *** found that both up-regulation and down-regulation of astrocytic Rac1 activity in the basolateral amygdala(BLA)attenuated memory acquisition in a fear conditioning mouse ***,neuronal activation in the BLA induced by memory acquisition was inhibited under both the up-and down-regulation of astrocytic Rac1 activity during *** terms of the impact on fear memory retrieval,we found both up-and down-regulation of BLA astrocytic Rac1 activity impaired memory retrieval of fear conditioning and memory retrieval-induced neuronal ***,the effect of astrocytic Rac1 on memory retrieval was *** results demonstrate that the normal activity of astrocytic Rac1 is necessary for the activation of neurons and memory *** activation and inactivation of astrocytic Rac1 activity in the BLA reduced the excitability of neurons,and thereby impaired fear memory acquisition and retrieval.

关键词： Rac1 Astrocyte Neuron BLA Fear memory

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Transcriptome profile of Dunaliella salina in Yuncheng Salt Lake reveals salt-stress-related genes under diff erent salinity stresses

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Journal of Oceanology and Limnology 2021年第6期39卷 2336-2362页

作者： fan GAO fangru nan jia FENG Junping LÜ Qi LIU Xudong LIU Shulian XIE School of Life Science Shanxi Key Laboratory for Research and Development of Regional PlantsShanxi UniversityTaiyuan 030006China

Salt stress is an abiotic stress to plants in especially saline ***,a halophilic microalga distributed throughout salt lakes and seas,can respond to different salinity stresses by regulating the expression of some ***,these genes and their function and biological processes involved remain *** ling these salt-stress-related genes in a high-salt-tolerant Dunaliella species will help clarify the salt tolerance machinery of *** ***_YC salt-stress groups were tested under low(0.51 mol/L),moderate(1.03 mol/L),and high(3.42 mol/L)NaCl concentrations and one control group under very low(0.05 mol/L)NaCl concentration and 3 transcriptome results that were deep sequenced and de novo assembled were obtained per *** high-quality RNA-seq libraries with 46585 upregulated and 47805 downregulated unigenes were *** to the control,188 common differentially expressed genes(DEGs)were screened and divided into four clusters in expression *** of them annotated in the significant enriched Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)were validated via *** qPCR-based relative expression patterns were similar to their RNA-seq-based *** significant DEGs,the geranylgeranyl diphosphate synthase coding gene(1876-bp cDNA)and diacylglycerol O-acyltransferase coding gene(2968-bp cDNA),were cloned and analyzed in *** total lipid content,superoxide dismutase specific activity,and betacarotene content of ***_YC increased gradually with increasing *** addition,the expression of 11 validated genes involved in fatty acid biosynthesis/degradation,active oxygen or carotenoid metabolisms showed significant *** addition,algal photochemical efficiency was diminished with increasing salinity,as well as the expression of 4 photosynthesis-related *** results could help clarify the molecular mechanisms underlying *** responses to the Yuncheng Salt Lake env

关键词： Dunaliella salina transcriptome analysis de novo assembly salt stress

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Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing fan Ruimin Li Xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

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Identification of novel salt stress-responsive microRNAs through sequencing and bioinformatic analysis in a unique halophilic Dunaliella salina strain

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Journal of Oceanology and Limnology 2023年第4期41卷 1558-1574页

Dunaliella salina is a classic halophilic ***,its molecular mechanisms in response to high salinity at the post transcriptional level remain unknown.A unique halophilic alga strain,DS-CN1,was screened from four *** strains via cell biological,physiological,and biochemical ***-throughput sequencing of small RNAs(sRNAs)of DS-CN1 in culture medium containing 3.42-mol/L NaCl(SS group)or 0.05-mol/L NaCl(CO group)was performed on the BGISEQ-500 *** annotation and sequences of *** sRNAs were ***,44 novel salt stress-responsive microRNAs(miRNAs)with a relatively high C content,with the majority of them being 24 nt in length,were identified and characterized in ***-one differentially expressed miRNAs(DEMs)in SS and CO were screened via bioinformatic analysis.A total of 319 putative salt stress-related genes targeted(104 overlapping genes)by novel miRNAs in this alga were screened based on our previous transcriptome sequencing ***,these target genes were classified and enriched by GO and KEGG pathway ***,5 novel DEMs(dsa-mir3,dsa-mir16,dsa-mir17,and dsa-mir26 were significantly upregulated,and dsa-mir40 was significantly downregulated)and their corresponding 10 target genes involved in the 6 significantly enriched metabolic pathways were verified by quantitative real-time ***,their regulatory relationships were comprehensively ***,a unique salt stress response metabolic network was constructed based on the novel DEM-target gene *** together,our results suggest that 44 novel salt stress-responsive microRNAs were identified,and 4 of them might play important roles in *** upon salinity stress and contribute to clarify its distinctive halophilic *** study will shed light on the regulatory mechanisms of salt stress responses.

关键词： Dunaliella salina salt stress response small RNA(sRNAs)sequencing microRNA(miRNAs)

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可降解药物洗脱消化道支架的研究进展与前景

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中国组织工程研究 2025年第22期29卷 4784-4794页

作者：李楠范慧娟刘涛涛夏时海天津中医药大学天津市301617 中国人民武装警察部队特色医学中心消化内科天津市肝脏胰腺纤维化与分子诊疗重点实验室天津市300162

背景:目前消化道支架的临床应用较为普遍,常规的自膨胀金属及塑料支架存在易移位、取出困难、术后再狭窄等问题,可降解药物洗脱消化道支架凭借生物可降解、术后再狭窄率低等优点成为消化道支架研究的热点。目的:总结可降解药物洗脱消化... 详细信息

背景:目前消化道支架的临床应用较为普遍,常规的自膨胀金属及塑料支架存在易移位、取出困难、术后再狭窄等问题,可降解药物洗脱消化道支架凭借生物可降解、术后再狭窄率低等优点成为消化道支架研究的热点。目的:总结可降解药物洗脱消化道支架的研究进展,对可降解药物洗脱消化道支架的前景作出展望。方法:检索中国知网、万方、Pub Med、Web of Science数据库中1994年1月至2024年3月发表的相关文献,中文检索词为“可降解,药物洗脱支架,食管支架,胆道支架,胰管支架,肠道支架,消化道支架”,英文检索词为“biodegradable,drug-eluting stent,esophageal stent,biliary stent,pancreatic duct stent,intestinal stent,gastrointestinal stent”,最终纳入64篇文献进行综述分析。结果与结论:(1)可降解药物洗脱消化道支架以生物可降解材料为主体,搭载并局部洗脱不同治疗目的的药物,发挥物理支撑及药物治疗双重作用。通过调整支架材料性质、改进制造工艺及辅助手段可以加快或减缓支架降解速度,满足临床需求。药物洗脱技术以药物涂层、纳米颗粒、聚合物载药膜等为载药平台,使药物精准释放,提高病变部位局部药物浓度,减少药物损耗及毒性药物的全身吸收量。(2)可降解药物洗脱消化道支架主要为一种或多种功能性药物结合可生物降解聚合物、金属或纳米纤维材料。可用的功能性药物分为抗炎抗增生类、抗肿瘤类、溶石类、酶抑制剂类。(3)维持支架机械性能稳定和精准控释药物是可降解药物洗脱消化道支架现阶段需要解决的问题,开发新型可降解消化道支架,研究新型载药及释药方式、制造工艺和辅助手段是未来研究方向。

关键词：可降解药物洗脱支架食管支架胆道支架胰管支架肠道支架消化道支架

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Endoscopy-assisted lightweight diagnosis system based on transformers for colon polyp detection

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Optoelectronics Letters 2025年第1期21卷 57-64页

作者： fan Weiming YU jiahui JU Zhaojie School of Automation and Electrical Engineering Shenyang Ligong University Department of Biomedical Engineering Zhejiang University School of Computing University of Portsmouth

The integration of endoscopy has significantly propelled the diagnosis and treatment of gastrointestinal diseases, with colonoscopy establishing itself as the primary method for early diagnosis and preventive care in colorectal cancer(CRC). Although deep learning holds promise in mitigating missed polyp rates, modern endoscopy examinations pose additional challenges, such as image blurring and atomizing. This study explores lightweight yet powerful attention mechanisms, introducing the spatial-channel transformer(SCT), an innovative approach that leverages spatial channel relationships for attention weight calculation. The method utilizes rotation operations for inter-dimensional dependencies, followed by residual transformation, encoding inter-channel and spatial information with minimal computational overhead. Extensive experiments on the CVC-Clinic DB polyp detection dataset, addressing endoscopy pitfalls, underscore the superiority of our SCT over other state-of-the-art methods. The proposed model maintains high performance, even in challenging scenarios.

关键词： Endoscopy

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