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Hepaticojejunostomy for hepatolithiasis: A critical appraisal

World Journal of Gastroenterology 2006年第26期12卷 4170-4174页

作者： Shao-Qiang Li Li-jian Liang Bao-Gang Peng jia-ming lai ming-De Lu Dong-ming Li Department of Hepatobiliary Surgery the First Affiliated Hospital of Sun Yet-san University Guangzhou 510080 Guangdong Province China

AIM： To evaluate the long-term outcome and surgical indications of hepaticojejunostomy （H J） for the treatment of hepatolithiasis. METHODS- Three hundred and fourteen elective cases with hepatolithiasis but without biliary stricture or cystic dilatation treated in the past 10 years were reviewed retrospectively. The patients were divided into HJ group and T tube drainage group according to biliary drainage procedure. Furthermore, four subgroups were subdivided by hepatectomy as a balance factor, group A1： hepatectomy＋HJ; group A2： choledochoctomy＋HJ; group B1： hepatectomy ＋ choledochoctomy T tube drainage; group B2： choledochoctomy ＋ T tube drainage. The stone residual rate, surgical efficacy and long-term outcome were compared among different procedures. RESULTS： There was no surgical mortality among all patients. The total hospital mortality was 1.6%. The overall stone residual rate after surgical clearance was 25.9%. There was no statistical difference between HJ group and T tube drainage group in terms of stone residual rate after surgical clearance, however, after postoperative choledochoscopic lithotripsy, the total stone residual rate of T tube drainage group was significantly lower than that of HJ group （0.5% vs 16.7%, P 〈 0.01）. Hepatectomy ＋ choledochoctomy tube drainage achieved the optimal therapeutic effect, only 8.2% patients suffered from an attack of cholangitis postoperatively, which was significantly lower than that of hepatectomy ＋ HJ （8.2% vs 22.0%, P = 0.034）. The major reason for postoperative cholangitis was stone residual in the HJ group （16/23, 70.0%）, and stone recurrence in the T tube drainage group （34/35, 97.1%）. The operative times were significantly prolonged in those undergoing HJ, and the operative morbidity of HJ was higher than those of T tube drainage. CONCLUSION： The treatment result of HJ for hepatolithiasis is not satisfactory in this retrospective study due to high rate of stone residual and postoperative cholangi- tis. HJ cou

关键词： Hepatolithiasis Hepaticojejunostomy Outcome

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Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice

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Acta Pharmacologica Sinica 2004年第7期25卷 120-126页

作者： Zheng-hong WU, Qi-neng PING2, Yi WEI, jia-ming lai Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China Department of Pharmaceutics China Pharmaceutical University Nanjing 210009

AIM: To evaluate the hypoglycemic efficacy of insulin liposomes coated by chitosan with different molecular weights and concentrations after oral administration in mice. METHODS: Insulin-liposomes were prepared by reversed-phase evaporation. Chitosan coating was carried out by incubation of the liposomal suspensions with the chitosan solution. The hypoglycemic efficacies of chitosan-coated insulin liposomes were investigated by monitor- ing the blood glucose level using the glucose oxidase method after oral administration to healthy mice. RESULTS: In all the insulin liposomes, the insulin liposomes coated by 0.2 % chitosan (Mr 1000 kDa) showed a better hypogly- cemic efficacy as compared with the other liposomes coated by chitosan. The minimum blood glucose level was 15.1 %±6.0 % of the initial (n=6). The hypoglycemic efficacy lasted for 4 h after oral administration to mice. CONCLUSION: Chitosan-coated liposomes could reduce tryptic digestion on insulin, and enhance enteral absorp- tion of insulin. The molecular weights and concentrations of chitosan had significant effects on hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration to healthy mice.

关键词： chitin chitosan insulin liposomes blood glucose oral administration

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EYA4 gene functions as a prognostic marker and inhibits the growth of intrahepatic cholangiocarcinoma

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Chinese Journal of Cancer 2016年第8期35卷 421-429页

作者： Xiao-Yi Hao jian-Peng Cai Xin Liu Wei Chen Xun Hou Dong Chen jia-ming lai Li-jian Liang Xiao-Yu Yin Departments of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-sen UniversityZhongshan 2nd RoadGuangzhou 510080GuangdongPR.China

Background:The molecular prognostic markers and carcinogenesis of intrahepatic cholangiocarcinoma(ICC) have not been well *** purpose of this study was to investigate the prognostic value of the eyes absent homolog 4(EYA4) gene in ICC and its biological effects on ICC growth in vitro and in ***:One hundred twelve patients with ICC who underwent hepatectomy were enrolled in the ***4 mRNA and EYA4 protein levels in ICC and adjacent non-tumoral tissues were evaluated using real-time quantitative polymerase chain reaction and immunohistochemical staining,***4 protein levels in ICC cells were determined using western blot *** associations between EYA4 expression and clinicopathologic features of ICC were *** identify independent prognostic factors,univariate and multivariate analyses were *** biological effects of EYA4 on ICC cells were evaluated by establishing stable EYA4-overexpressing transfectants in vitro,and EYA4's effects on tumor growth were evaluated by intra-tumoral injection of EVA4-expressing plasmids in a NOD/SCID murine model of xenograft ***:ICC tissues had significantly lower EYA4 mRNA and protein levels compared with adjacent non-tumoral tissues(both P < 0.001).Univariate and multivariate analyses showed that EYA4 protein level,tumor number,adjacent organ invasion,lymph node metastasis,and tumor differentiation were independent prognostic factors for diseasefree survival and overall survival(all P < 0.05).In vitro,EYA4 overexpression inhibited tumor cell growth,foci formation,and cell *** vivo,intra-tumoral injection of EYA4-expressing plasmids significantly inhibited ICC growth in the murine xenograft model compared with the control group(P < 0.05).Conclusion:EYA4 gene functioned as a molecular prognostic marker in ICC,and its overexpression inhibited tumor growth in vitro and in vivo.

关键词： EYA4 gene Intrahepatic cholangiocarcinoma Prognostic factor Surgical resection Tumor suppressor gene

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导管螺旋桨的推力、进速与诱导速度沿盘面的分布特征

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船舶工程 2016年第12期38卷 23-26,36页

作者：吴家鸣赖宇锋李江伟徐灜华南理工大学土木与交通学院广州510640

运用计算流体力学方法对不同工况下导管螺旋桨的推力、转矩以及螺旋桨周围的流场特性进行观察,对导管螺旋桨盘面处的进速、诱导速度沿盘面的分布以及螺旋桨所发出的推力与周围速度场之间的关系进行分析。计算结果表明,由于导管出口处激... 详细信息

运用计算流体力学方法对不同工况下导管螺旋桨的推力、转矩以及螺旋桨周围的流场特性进行观察,对导管螺旋桨盘面处的进速、诱导速度沿盘面的分布以及螺旋桨所发出的推力与周围速度场之间的关系进行分析。计算结果表明,由于导管出口处激发出的下游尾涡作用,螺旋桨推力、转矩、盘面的进速以及诱导速度分量的时域过程表现出了一种多次峰谷值振荡变化的动力学特征,轴向进速是影响螺旋桨推力、转矩变化的主要因素。文章结论有助于提高对导管螺旋桨推力产生机理的了解与认识,从而为设计出性能优良导管螺旋桨提供理论指导。

关键词：导管螺旋桨计算流体力学推力特性进速诱导速度

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Viscoelastic Characteristics of Fins, Muscle and Skin in Crucian Carp (Carassius Auratus) Described by the Fractional Zener Model

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Chinese Physics Letters 2011年第8期28卷 340-343页

作者： CHEN ming jia lai-Bing YIN Xie-Zhen Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027

Fish are supposed to be able to adapt to various underwater *** mechanical properties of the body of a fish is of essential importance in order to explore the source of high efficiency during fish *** investigate the viscoelastic properties of the fins,muscle and skin of Crucian carp(carassius auratus).A fractional Zener model is used to fit the relaxation force and the results show that the model can describe the relaxation process *** a Fourier transform,we discuss the response functions of the fins,muscle and skin of Crucian carp under the external excitation of a harmonic *** of these results with the cruising frequency of Crucian carp shows that the dissipation due to internal viscoelasticity during cruising is small.

关键词： fish relaxation Skin

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Inhibition of hepatitis B virus production by Boehmeria nivea root extract in HepG2 2.2.15 cells

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World Journal of Gastroenterology 2006年第35期12卷 5721-5725页

作者： Kai-Ling Huang Yiu-Kay lai Chih-Chien Lin jia-ming Chang Department of Life Sciences and Institute of Biotechnology National Tsing Hua University Hsinchu Taiwan 30013 China Department of Bioresources Da-Yeh University Changhua Taiwan 515 China Division of Research and Development Development Center for Biotechnology Xizhi City Taipei County Taiwan 221 China

AIM: To explore the anti-hepatitis B virus (HBV) effects of Boehmeria nivea (B. nivea) root extract (BNE) by using the HepG2 2.2.15 cell model system. METHODS: Hepatitis B surface antigen (HBsAg), hepatitis B virus e antigen (HBeAg), and HBV DNA were measured by using ELISA and real-time PCR, respectively. Viral DNA replication and RNA expression were determined by using Southern and Northern blot, respectively. RESULTS: In HepG2 2.2.15 cells, HBeAg (60%, P 99%, P < 0.01) secretion into supernatant were significantly inhibited by BNE at a dose of 100 mg/L, whereas the HBsAg was not inhibited. With different doses of BNE, the reduced HBeAg was correlated with the inhibition of HBV DNA. The anti-HBV effect of BNE was not caused by its cytotoxicity to cells or inhibition of viral DNA replication and RNA expression. CONCLUSION: BNE could effectively reduce the HBV production and its anti-HBV machinery might differ from the nucleoside analogues.

关键词： Boehmeria nivea Medicinal herb Antiviral agent Hepatitis B virus Anti-hepatitis B virus HepG2 2.2.15

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Three-dimensional antimony sulfide anode with carbon nanotube interphase modified for lithium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2021年第10期28卷 1629-1635页

作者： Qi Wang Yue-yong Du Yan-qing lai Fang-yang Liu Liang-xing jiang ming jia School of Metallurgy and Environment Central South UniversityChangsha 410083China

Antimony sulfide(Sb_(2)S_(3))is a promising anode for lithium-ion batteries due to its high capacity and vast ***,the low electronic conductivity and severe volume change during cycling hinder its *** our work,a three-dimensional(3D)Sb_(2)S_(3) thin film anode was fabricated via a simple vapor transport deposition system by using natural stibnite as raw material and stainless steel fiber-foil(SSF)as 3D current collector,and a carbon nanotube interphase was introduced onto the film surface by a simple dropping-heating process to promote the electrochemical *** 3D structure can greatly improve the initial coulombic efficiency to a record of 86.6% and high reversible rate capacity of 760.8 mAh·g^(-1) at 10 *** carbon nanotubes interphase modified,the Sb_(2)S_(3) anode cycled extremely stable with high capacity retention of 94.7% after 160 *** work sheds light on the economical preparation and performance optimization of Sb_(2)S_(3)-based anodes.

关键词： three dimensions antimony sulfide anode carbon nanotubes interphase lithium-ion batteries

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A New Feistel-Type White-Box Encryption Scheme

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Journal of Computer Science & Technology 2017年第2期32卷 386-395页

作者： Ting-Ting Lin Xue-jia lai Wei-jia Xue Yin jia Cryptography and Information Security Laboratory Department of Computer Science Shanghai Jiao Tong University Shanghai 200240 China Irdeto Canada Ottawa Ontario K2K3G5 Canada

The white-box attack is a new attack context in which it is assumed that cryptographic software is implemented on an un-trusted platform and all the implementation details are controlled by the attackers. So far, almost all white-box solutions have been broken. In this study, we propose a white-box encryption scheme that is not a variant of obfuscating existing ciphers but a completely new solution. The new scheme is based on the unbalanced Feistel network as well as the ASASASA （where ＂A＂ means affine, and ＂S＂ means substitution） structure. It has an optional input block size and is suitable for saving space compared with other solutions because the space requirement grows slowly （linearly） with the growth of block size. Moreover, our scheme not only has huge white-box diversity and white-box ambiguity but also has a particular construction to bypass public white-box cryptanalysis techniques, including attacks aimed at white-box variants of existing ciphers and attacks specific to the ASASASA structure. More precisely, we present a definition of white-box security with regard to equivalent key, and prove that our scheme satisfies such security requirement.

关键词： white-box equivalent key Feistel network cryptography ASASASA

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典型人工景观池塘水体甲烷释放特征及其对富营养化的响应

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湖泊科学 2025年第1期37卷 122-131,I0003-I0010页

作者：赖世平刘佳肖尚斌陈敏张博文孟江槐李元正三峡大学水利与环境学院宜昌443002 三峡库区生态环境教育部工程研究中心宜昌443002 三峡水库生态系统湖北省野外科学观测研究站宜昌443002 三峡大学水利工程博士后科研流动站宜昌443002

富营养化水体的碳通量过程是全球水域生态系统中的前沿和热点问题。本研究以三峡大学校园内景观池塘(莲心湖)为研究对象,开展为期一年的水气界面CH_(4)通量监测,并在此基础上进一步探讨水体富营养化水平对CH_(4)释放的影响。结果表明,... 详细信息

富营养化水体的碳通量过程是全球水域生态系统中的前沿和热点问题。本研究以三峡大学校园内景观池塘(莲心湖)为研究对象,开展为期一年的水气界面CH_(4)通量监测,并在此基础上进一步探讨水体富营养化水平对CH_(4)释放的影响。结果表明,莲心湖水气界面CH_(4)平均排放通量为5.06 mg/(m^(2)·h),整体表现为CH_(4)的源,且以冒泡释放为主导(占比为88.56%)。CH_(4)排放通量呈现时间异质性,表现为夏季(8.70 mg/(m^(2)·h))>冬季(4.80 mg/(m^(2)·h))>春季(3.88 mg/(m^(2)·h))>秋季(2.87 mg/(m^(2)·h)),白天(0.11 mg/(m^(2)·h))略高于夜晚(0.09 mg/(m^(2)·h))。CH_(4)排放通量在各个季节及昼夜的差异与温度、风速和叶绿素a等环境因素变化有关。随着水体富营养化水平的提高,CH_(4)排放通量呈现非线性增加的趋势,重度富营养化水体的CH_(4)排放通量是中度富营养化水体的2倍,这表明降低水体富营养化水平可有效减少水体的CH_(4)排放。研究结果可为其他同类型水体的温室气体减排提供参考。

关键词：富营养化甲烷释放池塘冒泡通量叶绿素a

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Detection of electron-phonon coupling in two-dimensional materials by light scattering

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Nano Research 2021年第6期14卷 1711-1733页

作者： jia-Min lai Ya-Ru Xie Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China CAS Center of Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing101408China Beijing Academy of Quantum Information Science Beijing100193China

Electron-phonon coupling affects the properties of two-dimensional(2D)materials significantly,leading to a series of novel *** light scattering provides a powerful experimental tool to explore electron-phonon interaction in 2D *** review gives an overview of the basic theory and experimental advances of electron-phonon coupling in 2D materials detected by Raman and Brillouin scattering,*** the Raman scattering part,we review Raman spectroscopy studies of electron-phonon coupling in graphene,transition metal disulfide compounds,van der Waals heterostructures,strongly correlated systems,and 2D magnetic *** the Brillouin scattering part,we extensively introduce Brillouin spectroscopy in non-van der Waals 2D structures,including temperature sensors for phonons and magnons,interfacial Dzyaloshinsky-Moriya interaction and spin torque in multilayer magnetic structures,as well as exciton-polariton in semiconductor quantum well.

关键词： electron-phonon coupling Raman scattering Brillouin scattering two-dimensional(2D)materials

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