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Signal Transduction and Targeted Therapy 2024年第1期9卷 51-54页

作者： Leili jia Haihua Luo lizhong li Mingyao Wang jiangfeng liu Yuan liang Shan li Yong jiang Juntao Yang Hongbin Song Institute for Disease Control and Prevention of PLA BeijingChina Guangdong Provincial Key Laboratory of Proteomics State Key Laboratory of Organ Failure ResearchSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Science and Peking Union Medical College100005 BeijingChina

Dear Editor,Infections by the influenza virus are a significant and widespread global health threat,as these infections have an annual death toll ranging from 290,000 to 650,000.1 A significant proportion of these fatalities are attributed to secondary bacterial pneumonia,a severe complication commonly caused by ubiquitous respiratory pathogens such as Staphylococcus aureus(***).2 Of particular concern is the increased morbidity and mortality rates in individuals infected simultaneously with influenza virus and methicillin-resistant ***(MRSA).3 The concurrent presence of bacteria and influenza virus usually causes acute respiratory distress syndrome(ARDS),which is associated with acute lung injury(Ali),severe lung tissue edema,and widespread ***,determining the complex mechanisms underlying the synergistic interplay will require further investigation with a suitable coinfection mouse *** our previous study,we utilized different sequential coinfections at various time points to model influenza A virus and MRSA coinfection.

关键词： influenza pneumonia lung

Aerodynamic/control integrated optimization method for unpowered high-speed vehicle configuration design

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Chinese Journal of Aeronautics 2024年第7期37卷 153-167页

作者： Xin PAN linlin WANG li li Lulu jiang Gang CHEN State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Shannxi Key Laboratory for Environment and Control of Flight Vehicle School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Beijing Institute of Space Long March Vehicle Beijing 100076China AVIC Xi’an Aeronautics Computing Technique Research Institute Xi’an 710068China

The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large *** conventional aircraft conceptual design process follows a sequential design approach,and there is an artificial separation between the disciplines of aerodynamics and control,neglecting the coupling effects arising from their *** a result,this design process often requires extensive iterations over long periods when applied to high-speed vehicles,and may not be able to effectively achieve the desired design *** enhance the overall performance and design efficiency of high-speed vehicles,this study integrates the concept of Active Control Technology(ACT)from modern aircraft into the philosophy of aerodynamic/control integrated *** integrated optimization strategies,with differences in coupling granularity,have been ***,these strategies are put into action on a biconical vehicle that operates at Mach *** results reveal that the comprehensive performance of the synthesis optimal model derived from the aerodynamic/control integrated optimization strategy is improved by 31.76%and 28.29%respectively compared to the base model under high-speed conditions,demonstrating the feasibility and effectiveness of the method and optimization strategies ***,in comparison to the single-stage strategy,the multi-stage strategy takes into deeper consideration the impact of control *** a result,the control performance of the synthesis opti-mal model derived from the multi-stage strategy improves by 13.99%,whereas the single-stage strategy only achieves a 5.79%*** method enables a fruitful interaction between aerodynamic configuration design and control system design,leading to enhanced overall performance and design ***,it improves the controllability of high-sp

关键词： Aerodynamic/Control Integrated Optimization MDO High-speed vehicle Shape Optimization Controllability

Assessments of Data-Driven Deep Learning Models on One-Month Predictions of Pan-Arctic Sea Ice Thickness

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Advances in Atmospheric Sciences 2024年第7期41卷 1379-1390页

作者： Chentao SONG jiang ZHU Xichen li Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

In recent years,deep learning methods have gradually been applied to prediction tasks related to Arctic sea ice concentration,but relatively little research has been conducted for larger spatial and temporal scales,mainly due to the limited time coverage of observations and reanalysis ***,deep learning predictions of sea ice thickness(SIT)have yet to receive ample *** this study,two data-driven deep learning(DL)models are built based on the ConvLSTM and fully convolutional U-net(FC-Unet)algorithms and trained using CMIP6 historical simulations for transfer learning and fine-tuned using reanalysis/*** models enable monthly predictions of Arctic SIT without considering the complex physical processes *** comprehensive assessments of prediction skills by season and region,the results suggest that using a broader set of CMIP6 data for transfer learning,as well as incorporating multiple climate variables as predictors,contribute to better prediction results,although both DL models can effectively predict the spatiotemporal features of SIT *** the predicted SIT anomalies of the FC-Unet model,the spatial correlations with reanalysis reach an average level of 89%over all months,while the temporal anomaly correlation coefficients are close to unity in most *** models also demonstrate robust performances in predicting SIT and SIE during extreme *** effectiveness and reliability of the proposed deep transfer learning models in predicting Arctic SIT can facilitate more accurate pan-Arctic predictions,aiding climate change research and real-time business applications.

关键词： Arctic sea ice thickness deep learning spatiotemporal sequence prediction transfer learning

Three-channel CMOS transimpedance amplifier for liDAR sensor receiver

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Journal of Systems Engineering and Electronics 2024年第1期35卷 74-80页

作者： liU Ruqing ZHU Jingguo jiang Yan li Feng jiang Chenghao MENG Zhe Photoelectric R&D Center Academy of Opto-ElectronicsChinese Academy of SciencesBeijing 100094China

For time-of-flight(TOF)light detection and ranging(liDAR),a three-channel high-performance transimpedance amplifier(TIA)with high immunity to input load capacitance is presented.A regulated cascade(RGC)as the input stage is at the core of the complementary metal oxide semiconductor(CMOS)circuit chip,giving it more immunity to input photodiode detectors.A simple smart output interface acting as a feedback structure,which is rarely found in other designs,reduces the chip size and power consumption *** circuit is designed using a 0.5μm CMOS process technology to achieve low *** device delivers a 33.87 dB?transimpedance gain at 350 *** a higher input load capacitance,it shows a-3 dB bandwidth of 461 MHz,indicating a better detector tolerance at the front end of the *** a 3.3 V supply voltage,the device consumes 5.2 mW,and the total chip area with three channels is 402.8×597.0μm2(including the test pads).

关键词： transimpedance amplifier(TIA) three-channel regulated cascade(RGC) light detection and ranging(liDAR)

A High-linear Radio Frequency Quadrature Modulator with Improved Sideband Suppression and Carrier Leakage Performance

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Tsinghua Science and Technology 2024年第3期29卷 635-643页

作者： Yingdan jiang Zongguang Yu Shutong Wu li li Xuelian liu School of Electronic Science and Engineering Nanjing UniversityNanjing 210093China The 58th Research Institute of China Electronic Technology Group Corporation Wuxi 214072China

The quadrature modulator is a crucial block in transmitters that upconverts baseband signals to theRadio Frequency(RF)band of interest using local oscillator *** this paper,non-ideal factors thatinfluence the performance of the quadrature modulator are considered,and solutions are accordingly taken inthe quadrature modulator design.A high-linear RF quadrature modulator with improved sideband suppressionand carrier leakage performance is presented in this *** quadrature modulator implemented in the0.18-μm SiGe process uses the current bleeding technique to improve the general performance of the doublebalanced active Gilbert *** on-chip prescaler followed by two cascaded limiting amplifiers is designed toprovide accurate quadrature local oscillator *** at quadrature baseband signal input ports areproposed to eliminate DC *** measured sideband suppression achieves a performance of better than−43 dBc and carrier leakage is less than−38 dBm over the output RF frequency range of 30 MHz to 2.15 *** output 1 dB compression point equals 11.4 dBm at 800 MHz.

关键词： Radio Frequency(RF) quadrature modulator sideband suppression carrier leakage linearity

Self-assembly Induced by Complexation of Diblock Copolyelectrolytes and Oppositely Charged Homopolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1321-1332,I0006页

作者： ling Zhao Zhi-Yuan Yin jia-Di jiang Er-Qiang Chen Shuang Yang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Mater Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are *** electrostatic complexation between oppositely charged polymers drives the formation of many ordered *** microstructures and phase diagrams are calculated using self-consistent field theory(SCFT)based on an ion-pair model with an equilibrium constant K to characterize the strength of binding between positively and negatively charged *** effects of the charge ratio,representing the ratio of charges from the homopolymer over all charges from polymers in the system,on the ordered structure are systematically studied,both for hydrophobic and hydrophilic A *** charge ratio plays an important role in determining the phase boundaries in the phase diagram of salt concentration versus polymer *** also provide information about the varying tendency of the domain spacing and core size of the spherical phase when the charge ratio is changed,and the results are in good agreement with *** studies provide a deep understanding of the self-assembled microstructures of oppositely charged diblock copolymer-homopolymer systems.

关键词： Self-assembly Polyelectrolyte complexation Self-consistent field theory Ion-pair

Numerical investigation of transient gas–solid heat transfer in a packed bed:Impact of intra-particle thermal diffusion

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Particuology 2024年第7期90卷 404-411页

作者： Hanqiao Che Yuanhe Yue Zhaohua jiang Duan li School of Mechanical Engineering Guangxi UniversityNanningGuangxi530004China School of Chemical Engineering University of BirminghamBirminghamB152TTUK Hebei Engineering Research Center of Advanced Energy Storage Technology and Equipment School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China Hebei Key Laboratory of Thermal Science and Energy Clean Utilization School of Energy and Environmental EngineeringHebei University of TechnologyTianjin300401China School of Mechatronics and Vehicle Engineering Chongqing Jiaotong UniversityChongqing400074China School of Instrumentation and Opto-Electronic Engineering Beihang UniversityBeijing 100191China

The transient heat transfer behaviours in a packed bed have been studied using coupled computational fluid dynamics(CFD)and discrete element method(DEM).Intra-particle thermal diffusion,which is a crucial but rarely explored issue,is considered by introducing a one-dimensional diffusion equation in the DEM *** achieve a sufficiently long physical time of simulations,we further reduce the computational cost by applying periodic boundary condition to a small segment of the packed *** study demonstrates a shifting peak heat flow rate from the bottom to the top of the packed bed during the initial warming *** affirm that the influence of thermal diffusion within a particle is noteworthy only for particles exhibiting a high Biot number(e.g.,Bi=1.2).This insight enriches our understanding of heat transfer mechanisms in packed beds and their practical engineering applications.

关键词： Packed bed Intra-particle heat transfer CFD–DEM

Finite-time composite learning control for nonlinear teleoperation systems under networked time-varying delays

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Science China(Information Sciences) 2024年第6期67卷 279-296页

作者： Yana YANG Huixin jiang Changchun HUA Junpeng li Institute of Electrical Engineering Yanshan University

The robust finite-time synchronization control problem is investigated for master-slave networked nonlinear telerobotics systems(NNTSs) in this article. Although there have been some research achievements on finite-time control for the NNTSs, these studies are based on the strong assumptions of communication time delays or can only achieve finite-time bounded convergence even when the external forces are *** and in view of the importance of these issues, a novel robust composite learning adaptive control scheme rendering the finite-time master-slave synchronization is proposed in this paper. In particular, the influence of time delays on finite-time convergence of the system is analyzed by employing the multi-dimension finite-time small-gain framework. Meanwhile, in order to achieve accurate and fast estimation of uncertain parameters of the system, both the online historical and the instantaneous data of the estimation data are explored to derive the new parameter adaptive law under a more realizable interval-excitation(IE) ***, the convergence of the position/force synchronization errors and the adaptive parameter estimation errors is obtained in finite time, and enhanced robustness of the closed-loop system will also be ***, the superior performance of the proposed control algorithms is validated by numerical simulations and hardware experiments.

关键词： networked teleoperation systems finite-time control exact parameter estimation small-gain theorem unknown communication delays

Numerical and experimental investigation into the evolution of the shock wave when a muzzle jet impacts a constrained moving body

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Defence Technology（防务技术） 2024年第3期33卷 317-326页

作者： Zijie li Hao Wang Changshun Chen Kun jiang School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210016China

The gun-track launch system is a new special launch device that connects the track outside the *** it is constrained by the track,the characteristics of development of the muzzle jet differ from those of the traditional muzzle ***,it changes from freely developing to doing so in a constrained manner,where this results in an asymmetric direction of flow as well as spatio-temporal coupling-induced interference between various shock waves and the formation of *** this background,the authors of this article formulate and consider the development and characteristics of evolution of the muzzle jet as it impacts a constrained moving *** designed simulations to test the gun-track launch system,and established a numerical model based on the dynamic grid method to explore the development and characteristics of propagation of disturbances when the muzzle jet impacted a constrained moving *** also considered models without a constrained track for the sake of *** results showed that the muzzle jet assumed a circumferential asymmetric shape,and tended to develop in the area above the *** the test platform was close to the ground,the muzzle jet was subjected to reflections from it that enhanced the development and evolution of various forms of shock waves and vortices in the muzzle jet to exacerbate its rate of distortion and asymmetric *** in turn led to significant differences in the changes in pressure at symmetric points that would otherwise have been *** results of a comparative analysis showed that the constrained track could hinder the influence of reflections from the ground on the muzzle jet to some extent,and could reduce the velocity of the shock waves inducing the motion of the muzzle as well as the Mach number of the moving *** work here provides a theoretical basis and the requisite technical support for applications of the gun-track launch *** also sheds light on the

关键词： Shock wave/vortex interference Muzzle jet Constrained boundary Dynamic grid

Fault diagnosis of a marine power-generation diesel engine based on the Gramian angular field and a convolutional neural network

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第6期25卷 470-482页

作者： Congyue li Yihuai HU jiawei jiang Dexin CUI Merchant Marine College Shanghai Maritime UniversityShanghai 201306China School of Mechanical and Energy Engineering Shanghai Technical Institute of Electronics&InformationShanghai 201411China

Marine power-generation diesel engines operate in harsh *** vibration signals are highly complex and the feature information exhibits a non-linear *** is difficult to extract effective feature information from the network model,resulting in low fault-diagnosis *** address this problem,we propose a fault-diagnosis method that combines the Gramian angular field(GAF)with a convolutional neural network(CNN).Firstly,the vibration signals are transformed into 2D images by taking advantage of the GAF,which preserves the temporal *** raw signals can be mapped to 2D image features such as texture and *** integrate the feature information,the images of the Gramian angular summation field(GASF)and Gramian angular difference field(GADF)are fused by the weighted average fusion ***,the channel attention mechanism and temporal attention mechanism are introduced in the CNN model to optimize the CNN learning *** the concept of residuals in the attention mechanism improves the feasibility of ***,the weighted average fused images are fed into the CNN for feature extraction and fault *** validity of the proposed method is verified by experiments with abnormal valve *** average diagnostic accuracy is 98.40%.When−20 dB≤signal-to-noise ratio(SNR)≤20 dB,the diagnostic accuracy of the proposed method is higher than 94.00%.The proposed method has superior diagnostic ***,it has a certain anti-noise capability and variable-load adaptive capability.

关键词： Multi-attention mechanisms(MAM) Convolutional neural network(CNN) Gramian angular field(GAF) Image fusion Marine power-generation diesel engine Fault diagnosis