检索结果-南通市图书馆

FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： Xian-Ze Xie Lei Zuo Wei Huang Qiao-Mei Fan Ya-Yun Weng Wen-Dong Yao jia-li jiang jia-Qi Jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths *** investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by *** To explore the identification of potential biomarkers for STAD disease based on *** A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome *** for mRNA-miRNA and mRNA-transcription factor interactions were *** prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression *** was conducted with datasets GSE26942,GSE54129,and *** of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein *** Three significant genes(FDX1,liAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score *** genes were down-regulated in both risk *** and KEGG analyses highlighted their involvement mainly in the electron transport *** validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric ***,the RCircos package localized FDX1 on chromosome *** Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数字互联是否提升了国有企业的创新水平?——影响识别和机制检验

引用

内蒙古社会科学 2024年第1期45卷 168-175页

作者：何彬贾立江吉林大学中国国有经济研究中心吉林长春130012 哈尔滨工程大学经济管理学院黑龙江哈尔滨150001

促进国有企业创新对国民经济高质量发展至关重要。利用2011~2021年国有企业的微观数据,采用微观计量分析方法,检验数字互联是否对国有企业创新能力和创新效率的提升具有显著影响。实证结果表明,数字互联显著提高了国有企业的创新能力,... 详细信息

促进国有企业创新对国民经济高质量发展至关重要。利用2011~2021年国有企业的微观数据,采用微观计量分析方法,检验数字互联是否对国有企业创新能力和创新效率的提升具有显著影响。实证结果表明,数字互联显著提高了国有企业的创新能力,但是对国有企业创新效率的影响不显著。数字互联对不同技术类别国有企业创新能力和创新效率的影响存在着明显的异质性特征。进一步从企业成本、人力资本、公司治理三个方面检验了数字互联对国有企业创新影响的机制,结果表明,数字互联对企业创新能力的影响并不存在明显的所有制差异。在今后的国有企业改革中,应该广泛借助新一代信息数字化技术提升国有企业的创新能力。

关键词：数字互联国有企业创新能力创新效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A study of economic development in Tibet of China based on the ecological economic mode

引用

Ecological Economy 2006年第3期2卷 235-244页

作者： Zhao Xiaohong He jia jiang li Neijiang Teachers＇ College Neijiang 641112 P. R. China

The purpose of this paper is to study the issues on keeping the continuous development of Tibetan economy and the relative stability of its ecosystem. Hence, in order to achieve the object, the study analyzes the status quo of economic development in Tibet and the problems of resource exploitation. It especially discusses frailty of Tibetan eco-environment, and evaluates the contradictions between the traditional economic developing mode and the safety of plateau＇s ecosystem. It concludes that there is an inevitable clash between the development of Tibetan economy and the safety of plateau＇s eco-system; this problem cannot be avoided by any decision maker, Therefore, the character of Tibetan econvironment and the requirement of its economic development strategy determine that ecological economy developing mode is the only choice for Tibet. This paper suggests that it should be compensated by the national government to assure that Tibetan economy can keep a higher developing speed. In accordance with the feature of plateau eco-economy system and demand of Tibetan economic development, this paper also suggests several methods to apply the ecoeconomy developing strategy of Tibet.

关键词： Tibet Ethnic group areas Ecological economy Developing mode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unraveling the complex roles of macrophages in obese adipose tissue:an overview

引用

Frontiers of Medicine 2024年第2期18卷 205-236页

作者： Chang Peng Jun Chen Rui Wu Haowen jiang jia li Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou310000China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China

Macrophages,a heterogeneous population of innate immune cells,exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic *** activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects,inducing insulin resistance through increased inflammation,impaired thermogenesis,and adipose tissue ***,adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis,facilitating the clearance of dead adipocytes,and promoting mitochondrial *** the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic ***,the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell *** this review,we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity,as well as explore the potential of drug delivery systems targeting macrophages,aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases.

关键词： obesity inflammation adipose tissue macrophages adipose tissue homeostasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unlocking supercapacitive energy storage potential:Catalyzing electrochemically inactive manganese oxides to active MnO_(2)via heterostructure reconstruction

引用

Nano Research 2024年第7期17卷 5897-5906页

作者： Baohong Zhang Tao jiang Xinyan Zhou Xiaoyu Fan Binbin jia lidong li School of Chemistry Beihang UniversityBeijing 100191China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChinaThree Gorges UniversityYichang 443002China Chinese Academy of Sciences(CAS)Key Laboratory of Nanosystem and Hierarchy Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Shanghai GTX Semiconductor Co. Ltd.Shanghai 201806China

Advancing supercapacitor system performance hinges on the innovation of novel electrode materials seamlessly integrated within distinct ***,we introduce a direct approach for crafting nanorod arrays featuring crystalline/amorphous CuO/MnO_(2)−*** reconfigured heterostructure results in an elevated content of electrochemically active MnO_(2).The nanorod arrays serve as efficient capacitive anodes and are easily prepared via low-potential electrochemical *** resulting structure spontaneously forms a p–n heterojunction,developing a built-in electric field that dramatically facilitates the charge transport *** intrinsic electric field,in conjunction with the crystalline/amorphous architecture,enables a large capacitance of 1.0 F·cm^(−2)at 1.0 mA·cm^(−2),an ultrahigh rate capability of approximately 85.4%at 15 mA·cm^(−2),and stable cycling performance with 92.4%retention after 10,000 *** calculations reveal that the presence of heterojunctions allows for the optimization of the electronic structure of this composite,leading to improved conductivity and optimized OH−adsorption *** work provides new insights into the rational design of heterogeneous nanostructures,which hold great potential in energy storage applications.

关键词： reconfiguration active MnO_(2) crystalline/amorphous structure p-n heterojunction supercapacitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Parity-dependent skin effects and topological properties in the multilayer nonreciprocal Su−Schrieffer−Heeger structures

引用

Frontiers of physics 2024年第3期19卷 115-133页

作者： jia-Rui li Cui jiang Han Su Di Qi lian-lian Zhang Wei-jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian Su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

liquid penetration of freeze-drying and air-drying wood of plantation Chinese fir

引用

Journal of Forestry Research 2005年第4期16卷 293-295页

作者： LU jian-xiong liN Zhi-yuan jiang jia-li jiang Jing-hui Research Institute of Wood Industry Chinese Academy of Forestry Beijing 10009 P. R. China

A comparative study was conducted on liquid penetration of the freeze-drying and air-drying sapwood and heartwood lumber of plantation Chinese fir （Cunninghamia lanceolata）. The maximum amount of dyeing solution uptake by the capillary rise method was used to evaluate the liquid penetration properties of the treated wood. The pit aspiration ratio was determined by semithin section method. Changes in wood microstructure were investigated using scanning electron microscopy. The results showed that compared with air drying, the freeze drying had a significant effect on liquid penetration of sapwood and heartwood of Chinese fir. The liquid penetration of sapwood is significantly higher than that of the heartwood for both drying treatments. Low pit aspiration ratio and cracks of pits membrane of some bordered pits are the main reasons for increasing liquid penetration after freeze drying treatment.

关键词： Chinese fir Sapwood lumber Heartwood lumber Freeze drying Air drying liquid penetration Pit aspiration ratio

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel heterozygous USH1C mutation impacts hair cell mechanotransduction and causes progressive hearing loss

引用

Science Bulletin 2024年第2期69卷 167-172页

作者： Yanyan jia Gaogan jia Luo Guo Nan Song Yu-Meng Wang Luoying jiang Yilai Shu Yan Chen Shujia Zhu Huawei li Wenyan li ENT Institute and Otorhinolaryngology Department of Eye&ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200031China The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200032China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular MedicineXinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China

Hearing loss is one of the most common sensory disorders worldwide,affecting approximately 466 million people,including 34 million children[1].Genetic mutations accounts for approximately 60%of inherited hearing loss cases[2,3].These genetic changes result in a wide variety of clinical manifestations,ranging from nonsyndromic hearing loss(NSHL)to over 400 syndromes involving hearing loss and from mild adult-onset hearing loss to profound congenital deafness,covering the entire spectrum of Mendelian inheritance.

关键词： mec hearing approximate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemoselective epoxidation of electron-deficient olefins with molecular oxygen via conjugated olefins epoxidation and BHT hydroxylation

引用

Science China Chemistry 2024年第9期67卷 3012-3018页

作者： jia Nie Huanfeng jiang Chuanle Zhu School of Chemistry and Chemical Engineering Key Lab of Functional Molecular Engineering of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510640China

The chemoselective epoxidation of electron-deficient olefins in the presence of electron-rich alkene moieties is *** chemoselective epoxidation strategy undergoes a conjugated olefin epoxidation and BHT hydroxylation process to give various useful oxiranes in high yields,especially for the 2-substituted ***,this protocol features mild conditions,is transition-metal free,operationally simple,and gram-scalable,and tolerates diverse functional *** candidate HSD-16 is synthesized smoothly by this *** studies indicate molecular oxygen is the terminal oxidant and the O-source of the oxiranes.

关键词： chemoselective epoxidation alkene fluorine molecular oxygen

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Consideration on immunotherapy of liver metastases of malignant tumors

引用

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2374-2381页

作者： Chuang jiang Zhi-Hong Zhang jia-Xin li Division of liver Surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article“Analysis of the impact of immuno-therapy efficacy and safety in patients with gastric cancer and liver metastasis”by liu et al that was published in the recent issue of the World Journal of Gastroin-testinal *** has prompted us to think and summarize some thoughts on immunotherapy for malignant tumor liver *** plays a crucial role in the treatment of malignant tumors;however,the presence of liver metastases in advanced tumors may impact its *** patients with liver metastases can still benefit from immunotherapy,multiple clinical studies have indicated that,compared to other sites of metastasis,liver metastases may diminish the effectiveness of *** efficacy of immune checkpoint inhibitors in patients with liver metastases often fails to reach the ideal level,primarily due to the liver metastases exploiting the host's peripheral immune to-lerance mechanisms to promote systemic CD8(+)T cell exhaustion,resulting in a systemic immune-tolerant *** article aims to summarize the reasons for the decreased efficacy of immunotherapy following liver metastasis in various malignant tumors and propose potential clinical strategies for manage-ment.

关键词： liver metastasis Immunotherapy Immune tolerance Cancer Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：