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Eucommia ulmoides *** H_2O_2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3,6,7,and 9

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 47-54页

作者： jun LIN Yi-jing FAN Christian MEHL jia-jun zhu Hong CHEN Ling-yan JIN Jing-hong XU Hui-ming WANG Department of Stomatology the First Affiliated HospitaL School of Medicine Zhejiang University Hangzhou 310003 China Department of Prosthodontics Propaedeutics and Dental Materials School of Dentistry Christian-Albrechts University Kie124105 Germany Department of Plastic Surgery the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Eucommia ulmoides Oliv.(EuO),also known as Duzhong,native to China,has been reported to have antioxidative function,but its cellular mechanism is not fully examined *** investigated inhibitory effects of EuO leaf ethanol extracts on H2O2-induced apoptosis in rat osteoblastic MC3T3-E1 cells and underlying ***-grown Duzhong leaves were extracted with ***3T3-E1 cells were treated with EuO (6.25,12.5,25,50,and 100 μg/ml) for 24 h,and then H2O2 (800 μmol/L) for an additional 24 *** survival rate,percentage of apoptosis,and expressions of caspases 3,6,7,and 9 were examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay,microscopic analysis,Western blotting,and reverse transcription polymerase chain reaction (RT-PCR).The final EuO leaf ethanol extract powder was detected to contain caffeotannic acid at 58 mg/g and geniposide at 3.45 mg/g by high performance liquid chromatography (HPLC).EuO remarkably restrained cell oxidative damage and increased cell survival rate in a dose-dependent manner: 0 μg/ml,0.21;6.25 μg/ml,0.28;12.5 μg/ml,0.31;25 μg/ml,0.48;50 μg/ml,0.54;and 100 μg/ml,0.66 (P<0.05),with the half-effective concentration being around 25 μg/*** results were confirmed by microscopic *** blotting and RT-PCR analyses showed that the expressions of caspases 3,6,7,and 9 were significantly decreased in the EuO-treated cells compared with the control (EuOand H2O2-free) (P<0.05),with the half-effective concentration of EuO ranging from 12.5 to 25 μg/*** conclude that the ethanol-extracted EuO leaf extracts promoted the growth of MC3T3-E1 cells,and suppressed the H2O2-induced apoptosis in a rat MC3T3-E1 osteogenic cell model,likely due to the inhibition of caspases’ *** results indicate that EuO is a potent antioxidant,which may contribute to its many cellular protective functions,including the promotion of bone growth.

关键词： Eucommia ulmoides Oliv. Duzhong Oxidative damage H2O2 MC3T3-E1 cells Free radicals Apoptosis

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Samarium Diiodide-Mediated Reductive Cleavage of Se-Se Bond of Diacyl Diselenides:A New Method for Synthesis of β-Selenoesters

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Chinese Chemical Letters 1998年第5期9卷 417-420页

作者： Yong Min ZHANG Wen Ying HAO You HUANG jia jun zhu(Department of Chemistry, Hangzhou University, Hangzhou 310028) Hangzhou Univ Dept Chem Hangzhou 310028 Peoples R China

The reduction of diacyl diselenides by samarium diiodide led to the production ofsamarium acylselenolates, which reacted with a,β-unsaturated esters or nitriles to give β-selenoesters or selenonitriles under mild an... 详细信息

关键词： reductive cleavage samarium diiodide diacyl diselenide,β-selenoester

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No relationship between mode of delivery and neonatal mortality and neurodevelopment in very low birth weight infants aged two years

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World Journal of Pediatrics 2014年第3期10卷 227-231页

作者： jia-jun zhu Ying-Ying Bao Guo-Lian Zhang Li-Xin Ma Ming-Yuan Wu Department of Neonatology Women's HospitalZhejiang University School of MedicineHangzhou 310006China

Background:To compare neonatal mortality and neurodevelopmental outcomes at two years of age in very low birth weight infants(≤1500 g)born by cesarean with those by vaginal ***:In this retrospective,case-control study,we evaluated neonatal mortality,medical conditions and neurodevelopmental outcomes at two years of corrected age in 710 very low birth weight(VLBW)infants born between January 2005 and December *** the 710 infants,351 were born by the cesarean and 359/710 by vaginal ***:There were no significant differences in neonatal mortality between the cesarean delivery group and vaginal delivery group[56/351(15.9%)vs.71/359(19.8%),P=0.20].VLBW infants delivered by the cesarean procedure had a higher incidence of respiratory distress syndrome than those born by the vaginal route[221/351(63.0%)vs.178/359(49.6%),P<0.001].There were no differences in other neonatal morbidities,including intraventricular hemorrhage[126/351(35.9%)vs.134/359(37.3%),P=0.69],bronchopulmonary dysplasia[39/351(11%)vs.31/359(8.6%),P=0.38]and necrotising enterocolitis[40/351(11.4%)vs.32/359(8.9%),P=0.32]between the two *** incidence of poor neurodevelopment after cesarean delivery was similar to that after vaginal delivery[105/351(29.9)vs.104/359(29.0%),P=0.78].Conclusions:In neither neurodevelopment nor neonatal mortality did cesarean birth offered significant advantages to VLBW ***,the operation might be associated with an increased risk of respiratory distress syndrome for VLBW *** mode of delivery of VLBW infants should be largely based on obstetric indications and maternal considerations rather than perceived better outcomes for the neonate.

关键词： cesarean delivery neonatal mortality neurodevelopment outcomes vaginal delivery very low birth weight

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Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak

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World Journal of Pediatrics 2020年第3期16卷 247-250页

作者： Xiao-Lu Ma Zheng Chen jia-jun zhu Xiao-Xia Shen Ming-Yuan Wu Li-Ping Shi Li-Zhong Du jun-Fen Fu Qiang Shu Children's Hospital Zhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health National Children's Regional Medical CenterHangzhou 310052China Women's Hospital Zhejiang University School of MedicineHangzhou 310003China

The outbreak of coronavirus disease 2019 (COVID-19;formally known as 2019-nCoV) has become a most challenging health *** to rigorous quarantine and control measures taken in China,routine neonatal health surveillance and follow-up have become *** follow-up surveillance,some rapid and progressive newborn diseases,such as bilirubin encephalopathy,may be *** characteristics of onset age of kernicterus suggest that monitoring of bilirubin level at home provides a useful way to alert hospital visits and to prevent the development of extremely ***,we developed an online follow-up program for convenient monitoring of bilirubin level of newborns that is based on our practical *** aim is to make our management strategies of neonatal jaundice tailored to the infection prevention and control during the COVID-19 epidemic.

关键词： New coronavirus pneumonia Hyperbilirubinemia Newborn Follow-up Internet hospital

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An unexpected tracheal malformation with successful endotracheal intubation in the neonate :a case report

An unexpected tracheal malformation with successful endotrac...

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2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Ling Sun Ying-ying Bao jia-jun zhu Department of Neonatology Women’s Hospital Zhejiang University School of Medicine

Background : Tracheal malformation is a rare congenital condition that usually presents as an unexpected lifethreatening emergency during resuscitation of a newborn in the delivery *** presentation: A case of a patient who failed to survive after successful endotracheal intubation with antenatally unknown malformation and thereafter identified as tracheal agenesis by computerized tomography(CT) ***: This is a rare case of tracheal malformation with pulmonary agenesis. The dignosis of tracheal malformation was not able to be timely enough due to its relatively low position which had no impact on a successful procedure of intubation. We narrated the process of resuscitation and examination of this newborn, and discussed the diagnosis and management of it.

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Corrosion behavior of novel Cu-Ni-Al-Si alloy with super-high strength in 3.5% NaCl solution

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Transactions of Nonferrous Metals Society of China 2017年第5期27卷 1096-1104页

作者： jia-jun zhu San-hua LI Lei-nuo SHEN Wu-lin YANG Zhou LI College of Materials Science and Engineering Hunan University Changsha 410082 China Hunan Province Key Laboratory for Spray Deposition Technology and Application Hunan University Changsha 410082 China School of Materials Science and Engineering Central South University Changsha 410083 China

A novel Cu?6.5Ni?1Al?1Si?0.15Mg?0.15Ce alloy with super-high strength was designed and its corrosion behavior in3.5%NaCl solution at25°C was investigated by the means of SEM observation,TEM observation and XPS *** alloy after solution treatment,80%cold rolling and aging at450°C for1h had the best comprehensive properties with hardness of HV314,electrical conductivity of19.4%IACS,tensile strength of1017MPa,and average annual corrosion rate of0.028mm/*** oxides and chloride products formed at first,followed by the formation of dyroxides *** alloy showed super-high strength,good electrical conductivity and corrosion resistant because Ni2Si hindered the precipitation of large NiAl at the grain boundary and the denickelefication of the alloy.

关键词： Cu-Ni-Al-Si alloy Ni2Si precipitate corrosion behavior average annual corrosion rate corrosion product

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Risk factors and clinical significance of posterior slip of the proximal vertebral body after lower lumbar fusion

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World Journal of Clinical Cases 2024年第26期12卷 5885-5892页

作者： jia-jun zhu Yi Wang jun Zheng Sheng-Yang Du Lei Cao Yu-Ming Yang Qing-Xi Zhang Ding-Ding Xie Department of Spinal Surgery Xuzhou First People’s HospitalXuzhou 221112Jiangsu ProvinceChina Department of Spinal Surgery The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221112Jiangsu ProvinceChina Department of Spinal Surgery The Affiliated Hospital of China University of Mining and TechnologyXuzhou 221112Jiangsu ProvinceChina

BACKGROUND Adjacent segment disease(ASD)after fusion surgery is frequently manifests as a cranial segment instability,disc herniation,spinal canal stenosis,spondylolisthesis or *** risk factors and mechanisms of ASD have been widely discussed but never clearly *** To investigate the risk factors and clinical significance of retrograde movement of the proximal vertebral body after lower lumbar *** This was a retrospective analysis of the clinical data of patients who underwent transforaminal lumbar interbody fusion surgery between September 2015 and July 2021 and who were followed up for more than 2 ***-one patients with degenerative lumbar diseases were included(22 males and 69 females),with an average age of 52.3 years(40-73 years).According to whether there was retrograde movement of the adjacent vertebral body on postoperative X-rays,the patients were divided into retrograde and nonretrograde *** sagittal parameters of the spine and pelvis were evaluated before surgery,after surgery,and at the final *** the same time,the Oswestry Disability Index(ODI)and Visual Analogue Scale(VAS)were used to evaluate the patients’quality of *** Nineteen patients(20.9%)who experienced retrograde movement of proximal adjacent segments were included in this *** pelvic incidence(PI)of the patients in the retrograde group were significantly higher than those of the patients in the nonretrograde group before surgery,after surgery and at the final follow-up(P<0.05).There was no significant difference in lumbar lordosis(LL)between the two groups before the operation,but LL in the retrograde group was significantly greater than that in the nonretrograde group postoperatively and at the final *** significant differences were detected in terms of the|PI–LL|,and there was no significant difference in the preoperative lordosis distribution index(LDI)between the two *** LDIs of the retrograde group were

关键词： Adjacent segment disease Posterior vertebral slip Sagittal alignment of spine-pelvis Lower lumbar fusion Quality of life

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新生儿窒息复苏首选纯氧还是空气的Meta分析

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中华儿科杂志 2007年第9期45卷 644-649页

作者：朱佳骏吴明远浙江大学医学院附属妇产科医院新生儿科杭州310006

目的收集现有比较采用空气或者纯氧复苏窒息新生儿效果的临床文献,对其进行系统评价,试图寻找比较合理的新生儿复苏气源。方法检索在美国医学索引(MEDLINE),荷兰医学文摘(EMBASE),中国生物医学文摘(CBMA)及 Cochrane 图书馆(CL)上收录的... 详细信息

目的收集现有比较采用空气或者纯氧复苏窒息新生儿效果的临床文献,对其进行系统评价,试图寻找比较合理的新生儿复苏气源。方法检索在美国医学索引(MEDLINE),荷兰医学文摘(EMBASE),中国生物医学文摘(CBMA)及 Cochrane 图书馆(CL)上收录的自1966年1月至2005年6月,有关窒息新生儿复苏气源比较的文献,对符合纳入要求的文献进行系统评价,比较空气或者纯氧作为复苏气源在塞息新生儿病死率,缺氧缺血性脑病发生率,以及复苏失败率等方面内容。结果 6篇文献符合纳入标准,共包括1940个窒息新生儿,其中采用空气复苏窒息新生儿988个,采用纯氧复苏窒息新生儿952个。对上述内容进行系统评价,得出采用空气复苏窒息新生儿病死率8.7%,与采用纯氧复苏窒息新生儿病死率13.4%比较,两者差异有显著统计学意义(P0.05)。结论进行窒息新生儿复苏,空气和纯氧比,空气能降低窒息新生儿病死率,且不增加新生儿2～3度的 HIE 发生率和复苏失败率。但研究纳入文献的数量有限,对此结论的运用和推广仍应谨慎。

关键词：窒息,新生儿复苏氧吸入疗法综合分析

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现代厨房家具的无障碍设计

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西北林学院学报 2012年第3期27卷 218-223页

作者：申黎明贾祝军南京林业大学家具与工业设计学院江苏南京210037

在介绍现代厨房家具的功能、类型及无障碍设计概念的基础上,对无障碍家具使用对象及其生理特性进行了分析,探讨了厨房家具无障碍设计的影响因素及设计原则,并结合厨房家具的功能要求及其组成对无障碍设计提出了针对性建议。

关键词：厨房家具无障碍设计生理特性

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan Yang Han jia Tuo Liu Yuzhen Yang jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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