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China CDC weekly 2024年第31期6卷 786-792页

作者： zhaoxia jia Yongxian zhao Lei Wang Qingqing Wu Moning Guo jianpeng Zheng Lili Huang junhua Wang zhao Wang Di Zhang Minghui Wu Department of information and statistics Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Department of data resources and statistics Beijing Municipal Health Big Data and Policy Research CenterBeijingChina

Summary What is already known about this topic?With socioeconomic development,the increase of older pregnancies and multiparas has brought risks to mothers and *** is added by this report?As parities increased,the proportion of women of advanced maternal age(AMA)and non-local domicile increased,while the proportion of women with higher education levels *** with≥3 parities are more likely to have preterm birth(PTB)and *** are the implications for public health practice?A comprehensive analysis of pregnancy traits among women at different parities offers a robust foundation for tailored strategies against adverse pregnancy outcomes.

关键词： mother pregnancy likely

Epinephrine promotes tumor progression and M2 polarization of tumor-associated macrophages by regulating the TRIM2-NF-kB pathway in colorectal cancer cells

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Genes & Diseases 2024年第4期11卷 141-144页

作者： Zhengyi Liu Chenxing jian Wenzheng Yuan Guiqing jia Donghui cheng Yanzhuo Liu Yanling Zhang Bin Zhang Zili Zhou Gaoping zhao Department of Breast Surgery Henan Provincial People's HospitalThe People's Hospital of Zhengzhou UniversityThe People's Hospital of Henan UniversityZhengzhouHenan 450003China Microbiome Laboratory Henan Provincia People's Hospital Zhengzhou University People's HospitalZhengzhouHenan 450000China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Gastrointestinal Surgeryll Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Gastrointestinal Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor *** the tumor microenvironment,tumor-associated macrophages(TAMs)receive different stimuli and can be polarized into classically activated M1 macrophages and alternatively activated M2 *** studies have indicated that the polarization of TAMs is closely related to tumor progression.

关键词： nephrin tumor inflammation

Si-Wu-Tang attenuates liver fibrosis via regulating lncRNA H19-dependent pathways involving cytoskeleton remodeling and ECM deposition

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Chinese Journal of Natural Medicines 2024年第1期22卷 31-46页

作者： QU jiaorong XUE Xiaoyong WANG Zhixing MA Zhi jia Kexin LI Fanghong ZHANG Yinhao WU Ruiyu ZHOU Fei zhao Piwen LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the extracellular matrix(ECM).Si-Wu-Tang(SWT),a traditional Chinese medicine(TCM)formula,is known for treating gynecological diseases and liver *** previous studies demonstrated that long non-coding RNA H19(H19)was markedly upregulated in fibrotic livers while its deficiency markedly reversed ***,the mechanisms by which SWT influences H19 remain ***,we established a bile duct ligation(BDL)-induced liver fibrosis model to evaluate the hepatoprotective effects of SWT on various cells in the *** results showed that SWT markedly improved ECM deposition and bile duct reactions in the ***,SWT relieved liver fibrosis by regulating the transcription of genes involved in the cytoskeleton remodeling,primarily in hepatic stellate cells(HSCs),and influencing cytoskeleton-related angiogenesis and hepatocellular *** modulation collectively led to reduced ECM *** extensive bioinformatics analyses,we determined that H19 acted as a miRNA sponge and mainly inhibited miR-200,miR-211,and let7b,thereby regulating the above cellular regulatory ***,SWT reversed H19-related miRNAs and signaling pathways,diminishing ECM deposition and liver ***,these protective effects of SWT were diminished with the overexpression of H19 in *** conclusion,our study elucidates the underlying mechanisms of SWT from the perspective of H19-related signal networks and proposes a potential SWT-based therapeutic strategy for the treatment of liver fibrosis.

关键词： Liver fibrosis LncRNA H19 Si-Wu-Tang miRNAs Cytoskeleton ECM deposition

Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 463-471页

作者： Yu Nie Jin-Bo Huang Shu-jiao He Hua-Di Chen jun-jun jia Jing-Jing Li Xiao-Shun He Qiang zhao General Surgery Center Department of Hepatobiliary Surgery IIResearch Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou 510080China Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou 510080China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use

关键词： Primary non-function Early allograft failure Risk predicting model Liver transplantation

Drug delivery with Mn-doped MoO_(2) for photothermalenhanced chemotherapy in fighting cancers

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Rare Metals 2024年第5期43卷 2230-2240页

作者： Ping zhao Hai-Fa Zheng ju Peng Xing-Long Li Fazal Raziq Xiao-jun Liu Hao-Quan Yu Jin-Lu Tang Yi-Fan Kang Wen-Huan Huang School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China KAUST Catalysis Center King Abdullah University of Science and Technology23955-6900 ThuwalKingdom of Saudi Arabia Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'an 710021China

Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant *** used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing ***,Mn-doped MoO_(2)nanoparticles coated with ZrO_(2)and capped with Bi_(2)O_(3)have been designed as a DDS,namely *** possesses good magnetic properties,great photothermal conversion ability,sensitive tumor microenvironment(TME)responsiveness,and good biocompatibility in hemocompatibility in ***,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal combined ***@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in ***,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in *** contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

关键词： Mn-doped MoO_(2) Bi_(2)O_(3) Nanocarrier Photothermal Chemotherapy

Graphite recycling from spent lithium-ion batteries for fabrication of high-performance aluminum-ion batteries

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Rare Metals 2024年第5期43卷 2161-2171页

作者： Li Wang Chao Wang Jing-Yi Zhang jia-Cheng Qiu Xu-Wang Fu Zi-Rui Zhang jian-Min Feng Lei Dong Cong-Lai Long De-jun Li Xiao-Wei Wang Bao Zhang jia-Feng Zhang Rui-Rui zhao College of Physics and Materials Science Tianjin Normal UniversityTianjin300387China National Engineering Laboratory for High Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China School of Chemistry South China Normal UniversityGuangzhou510631China

Efficient extraction of electrode components from recycled lithium-ion batteries(LIBs)and their highvalue applications are critical for the sustainable and ecofriendly utilization of *** work demonstrates a novel approach to stripping graphite anodes embedded with Li^(+)from spent LIBs directly in anhydrous ethanol which can be utilized as high efficiency cathodes for aluminum-ion batteries(AIBs).Recycled graphite(RG)with foam morphology and crystal structure defects was obtained under the action of ultrasonic peeling and gas generation reaction between residual lithium-graphite interlayer compound and *** inherent open structure of RG facilitates the intercalation/deintercalation of chloralum anions(AlCl_(4)^(-))and enhances its AIB cathode *** electrochemical measurements revea that the RG cathode has a specific capacity of 123 m Ah·g^(-1)at a current of 5 A·g^(-1),which is 1.55 times higher than tha of unprocessed natural graphite and 1.25 times higher than that of commercial artificial ***,the RG cathode demonstrated remarkable stability,retaining its high particular capacity of 138.15 mAh·g^(-1)even through2000 times at 10 A·g^(-1)in a low-cost electrolyte consisting of an ionic liquid/urea/AlCl_(3)*** work offers a novel approach to reusing of graphite anode waste materials from LIBs.

关键词： Aluminum ion batteries Lithium-ion batteries Graphite anode Recycling

Improving hydrogen evolution reaction efficiency through lattice tuning

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Nano Research 2024年第7期17卷 5907-5913页

作者： Zipeng zhao Haotian Liu Wenpei Gao Praveen Kolla Wang Xue Zeyan Liu Jinghua Guo Sanjeev Mukerjee Xiaoqing Pan Qingying jia Xiangfeng Duan Yu Huang Department of Materials Science and Engineering University of CaliforniaLos AngelesCalifornia 90095USA Department of Chemical Engineering and Materials Science University of CaliforniaIrvineCalifornia 92697USA Materials Science and Engineering North Carolina State UniversityRaleighNorth Carolina 27695USA Department of Chemistry and Chemical Biology Northeastern UniversityBostonMassachusetts 02115USA Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCalifornia 90095USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCalifornia 95064USA Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697USA California Nanosystems Institute University of CaliforniaLos AngelesCalifornia 90095USA

The intermittent nature of renewable energy sources sets a requirement for efficient energy storage to mitigate the conflict between energy supply and *** is a promising choice for energy storage due to its high energy ***,the conversion of electrical energy to chemical energy stored in hydrogen through water electrolysis suffers from low efficiency,and the electricity cost dominates the total cost of hydrogen ***,we report the study of improving the hydrogen evolution reaction activity of Pt-based catalysts by building a nanoscale surface NiO and Pt interface,further optimizing the performance via tuning the lattice parameter of the core of nanoparticles,which can be achieved by varying the dealloying annealing *** optimized PtCuNi-O/C and PtNi-O/C catalysts are demonstrated to be one of the best catalysts,with a mass activity(MA)of 9.1 and 8.7 mA/μgPt,which is 9.9-fold and 9.5-fold of that of Pt/C,respectively.

关键词： lattice tuning Pt-based catalyst hydrogen evolution reaction electrocatalysis

Support design method for deep soft-rock tunnels in non-hydrostatic high in-situ stress field

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Journal of Central South University 2024年第7期31卷 2431-2445页

作者： ZHENG Ke-yue SHI Cheng-hua zhao Qian-jin LEI Ming-feng jia Chao-jun PENG Zhu National Engineering Research Center of High-speed Railway Construction Technology Changsha 410075China School of Civil Engineering Central South UniversityChangsha 410075China China Railway Group Co. Ltd.Beijing 100039China

Due to the long-term plate tectonic movements in southwestern China,the in-situ stress field in deep formations is *** passing through deep soft-rock mass under non-hydrostatic high in-situ stress field,tunnels will suffer serious asymmetric *** is no available support design method for tunnels under such a situation in existing studies to clarify the support time and support *** study first analyzed the mechanical behavior of tunnels in non-hydrostatic in-situ stress field and derived the theoretical equations of the ground squeezing curve(GSC)and ground loosening curve(GLC).Then,based on the convergence confinement theory,the support design method of deep soft-rock tunnels under non-hydrostatic high in-situ stress field was established considering both squeezing and loosening *** addition,this method can provide the clear support time and support stiffness of the second layer of initial *** proposed design method was applied to the Wanhe tunnel of the China-Laos railway in *** data indicated that the optimal support scheme had a good effect on controlling the tunnel deformation in non-hydrostatic high in-situ stress *** applications showed that the secondary lining could be constructed properly.

关键词： non-hydrostatic stress field high in-situ stress deep soft-rock tunnel squeezing pressure loosening pressure support design method

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Chinese Chemical Letters 2024年第8期35卷 25-35页

作者： Yatian Deng Dao Wang Jinglan Cheng Yunkun zhao Zongbao Li Chunyan Zang jian Li Lichao jia School of Materials Science and Engineering State Key Lab of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074China College of Science Qiongtai Normal UniversityHaikou 571127China Kunming Sino-Platinum Metals Catalyst Co. Ltd.Kunming 650106China State Key Laboratory of Advanced Electromagnetic Technology Huazhong University of Science and TechnologyWuhan 430074China

Catalyst with high performance has drawn increasing attention recently due to its significant advantages in chemical reactions such as speeding up the reaction,lowering the reaction temperature or pressure,and proceeding without itself being *** the superior catalytic performance of precious metal catalysts,transition metal oxides offer a promising route for substitution of precious metals in catalysis arising from their low cost,intrinsic activity and sufficient ***-type oxide SmMn_(2)O_(5) exhibits a unique crystal structure containing double crystalline fields,and nowadays is used widely as the catalyst in different chemical reactions,including the reactions of vehicle emissions reduction and oxygen evolution reaction,gas sensors,and metal-air batteries,promoting attention in catalytic perfor-mance *** our knowledge,there is no review article covering the comprehensive informa-tion of SmMn2 O 5 and its *** we review the recent progress in understanding of the crys-tal structure of SmMn_(2)O_(5) and its basic physical *** then summarize the catalytic sources of SmMn_(2)O_(5) and reaction mechanisms,while the strategies to improve catalytic performance of SmMn_(2)O_(5) are further ***,we provide a perspective on how to make further progress in catalytic applications.

关键词： Catalyst SmMn_(2)O_(5) Mullite-type oxide Catalytic oxidation Oxygen reduction reaction Oxygen evolution reaction Reaction mechanisms

One-year results for myopia control of orthokeratology with different back optic zone diameters: a randomized trial using a novel multispectral-based topographer

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 324-330页

作者： Wen-Ting Tang Xiang-Ning Luo Wen-Jing zhao jia Liao Xin-Yue Xu Hui-Dan Zhang Li Zhang Department of Ophthalmology the First Affiliated Hospital of Chengdu Medical CollegeChengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

AIM:To present the 1-year results of a prospective cohort study investigating the efficacy,potential mechanism,and safety of orthokeratology(ortho-k)with different back optic zone diameters(BOZD)for myopia control in ***:This randomized clinical study was performed between Dec.2020 and *** were randomly assigned to three groups wearing ortho-k:5 mm BOZD(5-MM group),5.5 mm BOZD(5.5-MM group),and 6 mm BOZD(6-MM group).The 1-year data were recorded,including axial length,relative peripheral refraction(RPR,measured by multispectral refractive topography,MRT),and visual *** contrast sensitivity(CS)was evaluated by CSV-1000 instrument with spatial frequencies of 3,6,12,and 18 cycles/degree(c/d);the corneal higher-order aberrations(HOAs)were measured by iTrace aberration *** one-way ANOVA was performed to assess the differences between the three *** correlation between the change in AL and RPR was calculated by Pearson’s correlation ***:The 1-year results of 20,21,and 21 subjects in the 5-MM,5.5-MM,and 6-MM groups,respectively,were *** were no statistical differences in baseline age,sex,or ocular parameters between the three groups(all P>0.05).At the 1-year visit,the 5-MM group had lower axial elongation than the 6-MM group(0.07±0.09 vs 0.18±0.11 mm,P=0.001).The 5-MM group had more myopic total RPR(TRPR,P=0.014),with RPR in the 15°–30°(RPR 15–30,P=0.015),30°–45°(RPR 30–45,P=0.011),temporal(RPR-T,P=0.008),and nasal area(RPR-N,P<0.001)than the 6-MM *** 15–30 in the 5.5-MM group was more myopic than that in the 6-MM group(P=0.002),and RPR-N in the 5-MM group was more myopic than that in the 5.5-MM group(P<0.001).There were positive correlations between the axial elongation and the change in TRPR(r=0.756,P<0.001),RPR 15–30(r=0.364,P=0.004),RPR 30–45(r=0.306,P=0.016),and RPR-N(r=0.253,P=0.047).The CS decreased at 3 c/d(P<0.001),and the corneal HOAs increased in the 5-MM group(P=0.030).CONCL

关键词： relative peripheral refraction orthokeratology myopia back optic zone diameter axial length multispectral refractive topography