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Evolutionary game analysis for the strategic behavior in the provision of elderly care service

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Evolutionary game analysis for the strategic behavior in the...

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

第32届中国控制与决策会议

作者： jia-huan he Xing-gang Luo Zhong-Liang Zhang Yang Yu Department of Information Science and Engineering Northeastern University Department of Management Hangzhou Dianzi University

The paper develops an evolutionary game model to analyze the strategic behavior of government and private enterprise in the provision of elderly care *** on the replication dynamic system,the paper analyzes the evolutionary stability strategy of the two *** scenarios are given and their evolution process and results are also *** experiments are given to verify the influence of initial conditions and related parameters on the strategy selection of the private *** subsidy,fine,supervision cost,number of customers served by enterprise and other related factors will affect the strategic choice of the ***,policy recommendations are given to the government sector to promote the development of China’s elderly service industry.

关键词： Elderly care service Service provision Evolutionary Game Theory Evolutionary Stability Strategy

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-huan Zhang jia-Qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

耐甲氧西林金黄色葡萄球菌系统性感染小鼠模型的制备

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中国实验动物学报 2016年第6期24卷 596-600页

作者：邓少嫦罗银珠李航贾欢欢何丽芳龚宝勇曾业文吴玉娥广东省实验动物监测所广东省实验动物重点实验室广州510663

目的采用临床分离的耐甲氧西林金黄色葡萄球菌（MRSA）感染ICR小鼠,建立MRSA系统性感染小鼠模型。方法采用连续3 d腹腔注射环磷酰胺（100 mg/kg）进行免疫抑制后,将浓度为1×10^7cfu/m L的MRSA菌液经尾静脉接种ICR小鼠,通过生存分析、... 详细信息

目的采用临床分离的耐甲氧西林金黄色葡萄球菌（MRSA）感染ICR小鼠,建立MRSA系统性感染小鼠模型。方法采用连续3 d腹腔注射环磷酰胺（100 mg/kg）进行免疫抑制后,将浓度为1×10^7cfu/m L的MRSA菌液经尾静脉接种ICR小鼠,通过生存分析、外周血白细胞计数、组织载菌量和病理学检查对模型进行评价。结果 MRSA接种后第2天小鼠开始死亡,14 d内累积死亡率达60%;外周血白细胞总数显著升高,细菌在多个器官定植,载菌量由高到低依次是肾、关节、肺、肝和脑,肾载菌量高达10^9CFU/g,关节、肺、肝和脑的载菌量范围在10^4～10^9CFU/g。病理观察显示肾、心脏、肺、肝、脑和关节多器官感染的组织病理学改变。结论采用环磷酰胺免疫抑制后静脉接种MRSA的方法首次成功建立MRSA系统性感染小鼠模型,该模型可应用于MRSA发病机理及药物筛选等研究领域。

关键词：耐甲氧西林金黄色葡萄球菌动物模型小鼠感染

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Wavelet network based predistortion method for wideband RF power amplifiers exhibiting memory effects

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 625-630页

作者： JIN Zhe SONG Zhi-huan he jia-ming School of Information Science and Engineering Zhejiang University Hangzhou 310027 China Institute of Communication Technologies Ningbo University Ningbo 315211 China

RF power amplifiers (PAs) are usually considered as memoryless devices in most existing predistortion techniques. Nevertheless, in wideband communication systems, PA memory effects can no longer be ignored and memoryless predistortion cannot linearize PAs effectively. After analyzing PA memory effects, a novel predistortion method based on wavelet networks (WNs) is proposed to linearize wideband RF power amplifiers. A complex wavelet network with tapped delay lines is applied to construct the predistorter and then a complex backpropagation algorithm is developed to train the predistorter parameters. The simulation results show that compared with the previously published feed-forward neural network predistortion method, the proposed method provides faster convergence rate and better performance in reducing out-of-band spectral regrowth.

关键词： Power amplifiers. Predistortion. Memory effects. Wavelet networks

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Correlation of the retinopathy degree with the change of ocular surface and corneal nerve in patients with type 2 diabetes mellitus

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International Journal of Ophthalmology(English edition) 2021年第5期14卷 750-758页

作者： jia-Xin Han he Wang huan-huan Liang jian-Xin Guo Xuzhou Medical University Xuzhou 221002Jiangsu ProvinceChina Department of Ophthalmology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

AIM:To investigate the change of ocular surface and corneal nerve and their correlation in patients suffering from type 2 diabetes mellitus under different degrees of ***:Totally 129 type 2 diabetes mellitus patients(257 eyes)were *** were divided into three groups:no diabetic retinopathy(NDR)group(33 cases,66 eyes),non-proliferative diabetic retinopathy(NPDR)group(32 cases,64 eyes),and proliferative diabetic retinopathy(PDR)group(34 cases,67 eyes).healthy normal individuals were enrolled as controls(30 cases,60 eyes).Ocular Surface Disease Index(OSDI)questionnaire was completed by all subjects,and dry eye analyzer was applied to examine tear meniscus height(TMH),first tear break-up time(FTBUT),average tear break-up time(ATBUT),tear film lipid layer thickness classification,and meibomian gland loss(MGL)*** nerve fiber density(CNFD),corneal nerve branch density(CNBD),corneal nerve fiber length(CNFL),and corneal nerve fiber tortuosity(CNFT)were examined by in vivo confocal microscopy(IVCM).The differences and correlation among these parameters were ***:Total OSDI score,TMH,FTBUT,ATBUT,tear film lipid layer thickness,MGL score,CNFD,CNBD,CNFL,and CNFT were statistically different among the four groups(Phe progression of diabetic retinopathy,TMH,BUT,lipid layer thickness,CNFL,CNFD,and CNBD gradually decreased,while total OSDI score,MGL score,and CNFT *** is correlated with TMH and ATBUT in diabetic patients.

关键词： type 2 diabetes retinopathy ocular surface corneal nerve in vivo confocal microscopy

Architecting Pyrenyl-graphdiyne Nanowalls for High Capacity and Long-life Lithium Storage

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Chemical Research in Chinese Universities 2021年第6期37卷 1323-1327页

作者： AN Qingqing jiaNG Yanglin he huan GAO Juan WANG Peng jia Zhiyu Key Laboratory of Cluster Science Ministry of EducationKey Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081P.R.China Department of Chemistry Renmin University of ChinaBeijing100872P.R.China

Graphdiyne,as the novel carbon allotrope,which is composed of sp^(2)-and sp-hybridized carbon,has exhibited excellent catalytic activity and *** has been applied in series of fields,such as Li-battery,catalyst and energy *** well-defined structures and useful applications of graphdiyne is still full of challenges in material ***,we optimized the synthesis condition of pyrenylgraphdiyne to obtain the nanowall *** with the typical nanosheet structure,the pyrenyl-graphdiyne nanowalls(Pyr-GDY-NWs)have more area for lithium ***-ion battery featuring Pyr-GDY-NWs-based electrode exhibits a high reversible specific capacity up to 1464 mA·h/g,which is triple than that of the commercial *** also used the theoretical calculation to investigate the mechanism of Li storage in *** experiment and theoretical data showed that Pyr-GDY-NWs had the potential application in lithium ***,Pyr-GDY with a defined structure would be applied in energy storage and energy conversion.

关键词： Graphdiyne Pyrene Nanowall Li-battery

Harvesting random embedding for high-frequency change-point detection in temporal complex systems

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National Science Review 2022年第4期9卷 92-104页

作者： jia-Wen Hou huan-Fei Ma Dake he Jie Sun Qing Nie Wei Lin Research Institute of Intelligent Complex Systems Fudan University Centre for Computational Systems Biology Institute of Science and Technology for Brain-Inspired IntelligenceFudan University School of Mathematical Sciences Soochow University Xinhua Hospital Affiliated to Shanghai jiao Tong University School of Medicine School of Mathematical Sciences and Shanghai Center for Mathematical Sciences Fudan University Department of Mathematics Department of Developmental and Cell Biologyand NSF-Simons Center for Multiscale Cell Fate ResearchUniversity of California Shanghai Key Laboratory for Contemporary Applied Mathematics LNMS (Fudan University)and LCNBI (Fudan University) State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan University

Recent investigations have revealed that dynamics of complex networks and systems are crucially dependent on the temporal structures. Accurate detection of the time instant at which a system changes its internal structures has become a tremendously significant mission, beneficial to fully understanding the underlying mechanisms of evolving systems, and adequately modeling and predicting the dynamics of the systems as well. In real-world applications, due to a lack of prior knowledge on the explicit equations of evolving systems, an open challenge is how to develop a practical and model-free method to achieve the mission based merely on the time-series data recorded from real-world systems. here, we develop such a model-free approach, named temporal change-point detection(TCD), and integrate both dynamical and statistical methods to address this important challenge in a novel way. The proposed TCD approach, basing on exploitation of spatial information of the observed time series of high dimensions, is able not only to detect the separate change points of the concerned systems without knowing, a priori, any information of the equations of the systems, but also to harvest all the change points emergent in a relatively high-frequency manner, which cannot be directly achieved by using the existing methods and *** effectiveness is comprehensively demonstrated using the data from the representative complex dynamics and real-world systems from biology to geology and even to social science.

关键词： temporal systems time series change-point detection complex dynamical systems

One step sintering of homogenized bauxite raw material and kinetic study

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International Journal of Minerals,Metallurgy and Materials 2016年第10期23卷 1231-1238页

作者： Chang-he Gao Peng jiang Yong Li jia-lin Sun Jun-jie Zhang huan-ying Yang School of Material Science and Engineering University of Science and Technology Beijing Gongyi Tongda Zhongyuan Refractory Technology Co. Ltd.

A one-step sintering process of bauxite raw material from direct mining was completed, and the kinetics of this process was analyzed thoroughly. The results show that the sintering kinetics of bauxite raw material exhibits the liquid-phase sintering behavior. A small portion of impurities existed in the raw material act as a liquid phase. After X-ray diffraction analyses, scanning electron microscopy observations, and kinetics calculations, sintering temperature and heating duration were determined as the two major factors contributing to the sintering process and densification of bauxite ore. An elevated heating temperature and longer duration favor the densification process. The major obstacle for the densification of bauxite material is attributed to the formation of the enclosed blowhole during liquid-phase sintering.

关键词： bauxite refractory materials liquid phase sintering sintering kinetic studies

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