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Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 597-610页

作者： jia, Minxuan Fan, Tingting jia, tan Liu, Xin Liu, heng Gu, Qi Chinese Acad Sci Inst Zool Key Lab Organ Regenerat & Reconstruct State Key Lab Membrane Biol Beijing 100101 Peoples R China Beijing Inst Stem Cell & Regenerat Med Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Capital Med Univ Beijing Jishuitan Hosp Dept Orthopaed Beijing 100035 Peoples R China Chinese Acad Sci State Key Lab Stem Cell & Reprod Biol Inst Zool Beijing 100101 Peoples R China

In the intricate skeletal muscle tissue, the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and nutrients. This study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization of muscle tissue. By harnessing the capabilities of three-dimensional (3D) bioprinting and modeling, we developed a novel approach involving the co-construction of endothelial and muscle cells, followed by their subsequent differentiation. Our findings highlight the importance of the interaction dynamics between these two cell types. Notably, introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube assembly. Moreover, it stimulated the development of the vascular network, paving the way for the early stages of vascularized skeletal muscle development. The methodology proposed in this study indicates the potential for constructing large-scale, physiologically aligned skeletal muscle. Additionally, it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial cells. Based on the multicell-type interaction model, we can predict promising pathways for constructing even more intricate tissues or organs. [GRAPHICS] .

关键词： Skeletal muscle Vascularization 3D bioprinting Cell interaction

Room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： jia-Min Lai Qing-Hai tan Feilong Song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-heng tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&Research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information ***,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room *** ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation *** photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock *** also develop a transition model to gain insight into the physical process behind the single defect state-phonon *** work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal

Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles

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Bio-Design and Manufacturing 2024年第05期 597-610页

作者： Minxuan jia Tingting Fan tan jia Xin Liu heng Liu Qi Gu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine University of Chinese Academy of Sciences State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Department of Orthopaedics Beijing Jishuitan HospitalCapital Medical University

In the intricate skeletal muscle tissue, the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and nutrients. This study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization of muscle tissue. By harnessing the capabilities of three-dimensional(3D) bioprinting and modeling,we developed a novel approach involving the co-construction of endothelial and muscle cells, followed by their subsequent differentiation. Our findings highlight the importance of the interaction dynamics between these two cell types. Notably,introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube assembly. Moreover,it stimulated the development of the vascular network, paving the way for the early stages of vascularized skeletal muscle development. The methodology proposed in this study indicates the potential for constructing large-scale, physiologically aligned skeletal muscle. Additionally, it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial cells. Based on the multicell-type interaction model, we can predict promising pathways for constructing even more intricate tissues or organs.

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Design of acceleration control schedule for adaptive cycle engine based on direct simulation model

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Chinese Journal of Aeronautics 2024年第6期37卷 307-318页

作者： Keran SONG Linyuan jia Yuchun CHEN Tian tan School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China

To design the optimum acceleration control schedule for the Adaptive Cycle Engine(ACE)in the full flight envelope,this paper establishes a direct simulation model of the ACE transient *** this model,geometric parameters are used to replace the component state *** corresponding relationship between geometric parameters and component state parameters is determined by sensitivity *** geometric variables are controlled when the geometric adjustment speed exceeds the limit,and at the same time the corresponding component state parameters are *** gradient optimization algorism is used to optimize the ground acceleration process of ACE,and the control schedule in terms of operating point of compression components and corrected acceleration rate is used as the full-envelope acceleration control schedule based on the similarity *** acceleration control schedules of the triple-bypass mode and the double-bypass mode are designed in this *** acceleration processes under various flight conditions are simulated using the acceleration control *** with the acceleration process with the linear geometric adjustment schedule,the acceleration performance of ACE is improved by the acceleration control schedule,with the impulse of the acceleration process of the triple-bypass mode being increased by 8.7%-12.3% and the impulse of the double-bypass mode acceleration process being increased by 11.8%-14.1%.

关键词： Adaptive Cycle Engine(ACE) Direct simulation method Acceleration Control schedule Full flight envelope

Requirements ranking based on crowd-sourcing high-end product USs

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Journal of Systems Engineering and Electronics 2024年第1期35卷 94-104页

作者： MA Yufeng DOU Yajie XU Xiangqian jia Qingyang tan Yuejin College of Systems Engineering National University of Defense TechnologyChangsha 410003China

Based on the characteristics of high-end products,crowd-sourcing user stories can be seen as an effective means of gathering requirements,involving a large user base and generating a substantial amount of unstructured *** key challenge lies in transforming abstract user needs into specific ones,requiring integration and ***,we propose a topic mining-based approach to categorize,summarize,and rank product requirements from user ***,after determining the number of story categories based on py LDAvis,we initially classify“I want to”phrases within user ***,classic topic models are applied to each category to generate their names,defining each post-classification user story category as a ***,a weighted ranking function is devised to calculate the importance of each ***,we validate the effectiveness and feasibility of the proposed method using 2966 crowd-sourced user stories related to smart home systems.

关键词： high-end product complex system crowd-sourcing user stories topic mining requirements ranking

Chasing Sequencing Perfection: Marching Toward Higher Accuracy and Lower Costs

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GENOMICS PROTEOMICS & BIOINFORMATICS 2024年第2期22卷 qzae024页

作者： jia, Hangxing tan, Shengjun Zhang, Yong E. Chinese Acad Sci Inst Zool CAS Key Lab Zool Systemat & Evolut Beijing 100101 Peoples R China Chinese Acad Sci Inst Zool State Key Lab Integrated Management Pest Insects & Beijing 100101 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Chinese Acad Sci CAS Ctr Excellence Anim Evolut & Genet Kunming 650223 Peoples R China

Next-generation sequencing (NGS), represented by Illumina platforms, has been an essential cornerstone of basic and applied research. However, the sequencing error rate of 1 per 1000 base pairs (10-3) represents a serious hurdle for research areas focusing on rare mutations, such as somatic mosaicism or microbe heterogeneity. By examining the high-fidelity sequencing methods developed in the past decade, we summarized three major factors underlying errors and the corresponding 12 strategies mitigating these errors. We then proposed a novel framework to classify 11 preexisting representative methods according to the corresponding combinatory strategies and identified 3 trends that emerged during methodological developments. We further extended this analysis to 8 long-read sequencing methods, emphasizing error reduction strategies. Finally, we suggest 2 promising future directions that could achieve comparable or even higher accuracy with lower costs in both NGS and long-read sequencing.

关键词： Sequencing error High-fidelity sequencing Consensus sequencing Single-molecule sequencing Rare mutation RARE MUTATIONS PARALLEL QUANTIFICATION ERRORS DAMAGE

Bifunctional interstitial phosphorous doping strategy boosts platinum-zinc alloy for efficient ammonia oxidation reaction and hydrogen evolution reaction

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Nano Research 2024年第3期17卷 1182-1189页

作者： Tianqi Yu Kexin tan jia Wu Yongjin Zou Shibin Yin Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin 541004China

It is still a lack of bifunctional catalysts for ammonia oxidation reaction(AOR)and hydrogen evolution reaction(HER)due to their different reaction *** this work,P is doped into PtZn alloy by calcination with NaH_(2)PO_(2) as P source to induce the lattice tensile strain of Pt and the electronic interaction between P and Zn,which optimizes the AOR and HER activity *** sample with the optimal P content can drive the AOR peak current density of 293.6 mA·mgPt^(-1),which is almost 2.7 times of *** HER,the overpotential at^(-1)0 mA·cm^(-2) is only 23 mV with Tafel slope of 34.1 mV·dec^(-1).Furthermore,only 0.59 V is needed to obtain 50 mA·mgPt^(-1) for ammonia electrolysis under a two-electrode ***,this work shows an ingenious method to design bifunctional catalysts for ammonia electrolysis.

关键词： PtZn alloy phosphorous doping ammonia oxidation reaction hydrogen evolution reaction bifunctional catalyst

Evolution of microstructure and properties of a novel Ni-based superalloy during stress relief annealing

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1876-1889页

作者： Lei jia heng Cui Shufeng Yang Shaomin Lü Xingfei Xie Jinglong Qu Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Beijing GAONA Materials&Technology Co. Ltd.Beijing 100081China High-Temperature Materials Institute Central Iron and Steel Research InstituteBeijing 100081China

We discussed the decrease in residual stress,precipitation evolution,and mechanical properties of GH4151 alloy in different annealing temperatures,which were studied by the scanning electron microscope(SEM),high-resolution transmission electron microscopy(HRTEM),and electron backscatter diffraction(EBSD).The findings reveal that annealing processing has a significant impact on diminishing residual *** the annealing temperature rose from 950 to 1150℃,the majority of the residual stresses were relieved from 60.1 MPa down to 10.9 ***,the stress relaxation mechanism transitioned from being mainly controlled by dislocation slip to a combination of dislocation slip and grain boundary ***,the annealing treatment promotes the decomposition of the Laves,accompanied by the precipitation ofμ-(Mo_(6)Co_(7))starting at 950℃ and reaching a maximum value at 1050℃.The tensile strength and plasticity of the annealing alloy at 1150℃ reached the maximum(1394 MPa,56.1%)which was 131%,200%fold than those of the as-cast alloy(1060 MPa,26.6%),but the oxidation process in the alloy was accelerated at 1150℃.The enhancement in durability and flexibility is primarily due to the dissolution of the brittle phase,along with the shape and dispersal of theγ′phase.

关键词： GH4151 alloy annealing treatment residual stress precipitation evolution strength mechanical properties

Effects of thawing-induced softening on fracture behaviors of frozen rock

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 979-989页

作者： Ting Wang Hailiang jia Qiang Sun Xianjun tan Liyun tang College of Geology and Environment Xi’an University of Science and TechnologyXi’an710054China College of Architecture and Civil Engineering Xi’an University of Science and TechnologyXi’an710054China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430064China

Due to the presence of ice and unfrozen water in pores of frozen rock,the rock fracture behaviors are susceptible to *** this study,the potential thawing-induced softening effects on the fracture behaviors of frozen rock is evaluated by testing the tension fracture toughness(KIC)of frozen rock at different temperatures(i.e.-20℃,-15℃,-12℃,-10℃,-8℃,-6℃,-4℃,-2℃,and 0℃).Acoustic emission(AE)and digital image correlation(DIC)methods are utilized to analyze the microcrack propagation during *** melting of pore ice is measured using nuclear magnetic resonance(NMR)*** results indicate that:(1)The KIC of frozen rock decreases moderately between-20℃ and-4℃,and rapidly between-4℃ and 0℃.(2)At-20℃ to-4℃,the fracturing process,deduced from the DIC results at the notch tip,exhibits three stages:elastic deformation,microcrack propagation and microcrack ***,at-4℃e0℃,only the latter two stages are observed.(3)At-4℃e0℃,the AE activities during fracturing are less than that at-20℃ to-4℃,while more small events are reported.(4)The NMR results demonstrate a reverse variation trend in pore ice content with increasing temperature,that is,a moderate decrease is followed by a sharp decrease and-4℃ is exactly the critical ***,we interpret the thawing-induced softening effect by linking the evolution in microscopic structure of frozen rock with its macroscopic fracture behaviors as follow:from-20℃ to-4℃,the thickening of the unfrozen water film diminishes the cementation strength between ice and rock skeleton,leading to the decrease in fracture ***-4℃ to 0℃,the cementation effect of ice almost vanishes,and the filling effect of pore ice is reduced significantly,which facilitates microcrack propagation and thus the easier fracture of frozen rocks.

关键词： Frozen sandstone Different thawing temperature Fracture toughness Microcrack propagation process Unfrozen water content