检索结果-南通市图书馆

Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第5期16卷 591-603页

作者： jin-Bo Wang ming-wei Du Yan Zheng Internal Medicine of Traditional Chinese Medicine Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Institute of Cardiovascular disease Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key laboratory of Molecular Medical Mycology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Shanghai Key laboratory of Traditional Chinese Clinical Medicine Shanghai 201203China department of hepatic The Xixi Hospital of Hangzhou Affiliated to Zhejiang University of Traditional Chinese MedicineHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Aplastic anemia(AA)presents a significant clinical challenge as a life-threatening condition due to failure to produce essential blood cells,with the current the-rapeutic options being notably *** To assess the therapeutic potential of ginsenoside Rg1 on AA,specifically its protective effects,while elucidating the mechanism at *** We employed a model of myelosuppression induced by cyclophosphamide(CTX)in C57 mice,followed by administration of ginsenoside Rg1 over 13 *** invest-igation included examining the bone marrow,thymus and spleen for pathological changes via hematoxylin-eosin ***,orbital blood of mice was collected for blood routine *** cytometry was employed to identify the impact of ginsenoside Rg1 on cell apoptosis and cycle in the bone marrow of AA ***,the study further evaluated cytokine levels with enzyme-linked immunosorbent assay and analyzed the expression of key proteins in the MAPK signaling pathway via western *** Administration of CTX led to significant damage to the bone marrow’s structural integrity and a reduction in hematopoietic cells,establishing a model of *** Rg1 successfully reversed hematopoietic dysfunction in AA *** comparison to the AA group,ginsenoside Rg1 provided relief by reducing the induction of cell apoptosis and inflammation factors caused by ***,it helped alleviate the blockade in the cell *** with ginsenoside Rg1 significantly alleviated myelosuppression in mice by inhibiting the MAPK signaling *** This study suggested that ginsenoside Rg1 addresses AA by alleviating myelosuppression,primarily through modulating the MAPK signaling pathway,which paves the way for a novel therapeutic strategy in treating AA,highlighting the potential of ginsenoside Rg1 as a beneficial intervention.

关键词： Aplastic anemia Ginsenoside Rg1 Myelosuppression MAPK signaling pathway Bone marrow hematopoietic stem cells

Time-synchronous-averaging-spectrum based on super-resolution analysis and application in bearing fault signal identification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of zhejiang university-Science A(Applied Physics & Engineering) 2024年第7期25卷 573-585页

作者： Zengle REN Yuan WANG Huiyue TANG Xin'an CheN wei feng Guangdong Provincial Key laboratory of Construction Robotics and Intelligent Construction Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China Shenzhen EBORAIl Technology Co. Ltd.Shenzhen518038China National Supercomputing Center in Shenzhen Shenzhen518055China State Key lab of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing100044China university of Chinese Academy of Sciences Beijing100190China Shenzhen university of Advanced Technology Shenzhen518107China

Time-synchronous-averaging(TSA)is based on the idea of denoising by averaging,and it extracts the periodic components of a quasiperiodic signal and keeps the extracted waveform *** paper studies the mathematical properties of TSA,where three propositions are given to reveal the nature of *** paper also proposes a TSA-spectrum based on super-resolution analysis and it decomposes a signal without using any base *** contrast to discrete Fourier transform spectrum(DFT-spectrum),which is a spectrum in frequency domain,TSA-spectrum is a period-based spectrum,which can present more details of the cross effects between different periodic components of a quasiperiodic ***,a case study is carried out using bearing fault analysis to illustrate the performance of TSA-spectrum,where the rotation speed fluctuation of the shaft is estimated,which is about 0.12 ms *** extracted fault signals are presented and some insights are *** believe that this paper can provide new motivation for TSA-spectrum to be widely used in applications involving quasiperiodic signal processing(QSP).

关键词： Time-synchronous-averaging(TSA) Spectrum Quasiperiodic signal processing(QSP) Super-resolution analysis Bearingfaultdetection

Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of diabetes 2024年第7期15卷 1627-1644页

作者： jian-Ping Wen Shuan-ji Ou jia-Bao liu wei Zhang Yu-Dun Qu jia-Xuan li Chang-liang Xia Yang Yang Yong Qi Chang-Peng Xu department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were china,Shanghai jiao Tong university of china,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

Actively contractible and antibacterial hydrogel for accelerated wound healing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7394-7403页

作者： Zhaoxin ji Ting wei jiafei Zhu jiaying Hu Zhisheng Xiao Boxiong Bai Xinying lv Yu Miao Muchao Chen Cheng Wang feng Pan Yang Yang Meng li Qian Chen Institute of Functional Nano and Soft Materials Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Central laboratory Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China School of Materials Science and Engineering Tongji UniversityShanghai 201804China department of dermatology Shanghai Children’s Medical Center School of MedicineShanghai Jiao Tong UniversityShanghai 200025China

Adhesive hydrogel has drawn great attention for wide applications in wound healing owing to its excellent biocompatibility and lasting ***,traditional adhesive hydrogels only keep the wound moist to promote wound *** is still imperative to fabricate adhesive hydrogels that exhibit efficient antibacterial ability,active driving dynamic wound closure,and reactive oxygen species(ROS)scavenging together with excellent mechanical ***,a novel hydrogel based on poly(N-isopropyl acrylamide)(PNIPAAm),a thermoresponsive polymer,and tannic acid(TA)-Ag nanoparticles(TA-Ag NPs)exhibiting active contraction,tissue adhesion,anti-inflammatory and antibacterial functions was ***-Ag dispersed in the hydrogel not only functioned as the catalyst to polymerize the reaction but also provided additional anti-inflammatory and antibacterial ***,tannic acid containing catechol groups endowed the hydrogel with adhesive *** interestingly,the obtained hydrogel exhibited the thermoresponsive shrinkage ability,which could mechanically drive wound closure due to the presence of PNIPAAm *** vivo mouse full-thickness skin defect model demonstrated that this actively contractible and antibacterial hydrogel is a promising dressing to improve wound healing process by accelerating tissue regeneration and preventing bacterial ***,this multi-functional adhesive hydrogel developed here may provide a new possibility for wound healing.

关键词： anti-inflammatory antibacterial active contraction hydrogel patch wound healing

Resting state brain activity and functional brain mapping

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2007年第5期17卷 511-519页

作者： Zhao Xiaohu , Wang Peijun and Tang Xiaowei (College of life Sciences in zhejiang university, hangzhou 310058, china Imaging department of Tong ji Hospital of Tong ji university, Shanghai 200065, china Bio-X lab, department of Physics, zhejiang university, hangzhou 31002., china) [a]College of life Sciences in zhejiang university Hangzhou China [b]Imaging department of Tong ji Hospital of Tong ji university Shanghai China [c]Bio-X lab Department of Physics Zhejiang University Hangzhou China

Functional brain imaging studies commonly use either resting or passive task states as their control conditions, and typically identify the activation brain region associated with a specific task by subtracting the resting from the active task conditions. Numerous studies now suggest, however, that the resting state may not reflect true mental "rest" conditions. The mental activity that occurs during "rest" might therefore greatly influence the functional neuroimaging observations that are collected through the usual subtracting analysis strategies. Exploring the ongoing mental processes that occur during resting conditions is thus of particular importance for deciphering functional brain mapping results and obtaining a more comprehensive understanding of human brain functions. In this review article, we will mainly focus on the discussion of the current research background of functional brain mapping at resting state and the physiological significance of the available neuroimaging data.

关键词： resting state brain activity default mode brain networks BOlD deactivation OEF.

Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 667-673页

作者： Yan-Wen lin Tong li Yi Zhang wei-wei Yan Xiao-ming Chen Zhi-Sen Zhang jian-Yang Wu department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

Advanced hepatocellular carcinoma in a patient with neurofibromatosis type 1 and malignant peripheral nerve sheath tumor

在线全文

学校读者我要写书评

暂无评论

hepatobiliary & Pancreatic diseases International 2024年第5期23卷 530-532页

作者： Ahmad Alhaskawi Yan-Zhao Dong Xiao-di Zou Sohaib Hasan Abdullah Ezzi Ze-wei Wang Hai-Ying Zhou Sahar Ahmed Abdalbary Hui lu department of Orthopedics the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Chinese Medicine the Second Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou 310005China department of Orthopedics the Third Xiangya HospitalCentral South UniversityChangsha 410083China zhejiang university School of Medicine Hangzhou 310000China department of Orthopedic Physical Therapy Faculty of Physical TherapyNahda University in Beni SuefBeni SuefEgypt

To the Editor: Neurofibromatosis type 1(NF-1), or Von Recklinghausen disease, is a genetic disorder inherited in an autosomal dominant pattern. It is caused by a mutation in the neurofibromin gene located on chromosome 17, accounting for 96% of all neurofibromatosis cases. This condition can affect multiple systems and often leads to the formation of tumors along the nervous system [1]. Patients with NF-1 may exhibit various symptoms, including lisch nodules, neurofibromas, scoliosis, café au lait spots, learning disabilities, vision disorders, and epilepsy.

关键词： epilepsy hepatocellular malignant

Biogenesis of Rab14-positive Endosome Buds at Golgi-endosome Contacts by the RhoBTB3-SHIP164-Vps26B Complex

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第4期44卷 864-866页

作者： jing-ru WANG Jun-yao ZHANG wei-Ke ji department of Biochemistry and Molecular Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Cell Architecture Research Center Huazhong University of Science and TechnologyWuhan430030China State Key laboratory for diagnosis and Treatment of Severe Zoonotic Infectious diseases Huazhong University of Science and TechnologyWuhan430030China Shenzhen Bay laboratory Shenzhen518132China

As one of the basic processes of cellular activity,endocytosis sorting determines the fate of many proteins on the endosomal membranes,thus affecting a variety of important cellular processes,such as nutrient uptake,c... 详细信息

关键词： homeostasis endo sorting

laparoscopic anatomical liver resection of segment 7 using a sandwich approach to the right hepatic vein (with video)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

hepatobiliary & Pancreatic diseases International 2024年第2期23卷 217-220页

作者： Song-feng Yu wei-Chen Zhang Jun Yu department of hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Full laparoscopic liver resection has been performed widely since it was introduced in the early *** has been expanded from initial for partial resection of the anterolateral segments to non-restriction of area of the liver[1–3].Anatomical liver resec-tion is considered to have potential superiority than non-anatomic resection in terms of tumor prognosis,thus it is more often rec-ommended in the treatment of hepatocellular carcinoma[4,5].Recently,laparoscopic segmental liver resection according to the Couinaud classification has been widely performed due to its ad-vantages in minimal invasiveness and tumor prognosis.

关键词： resection liver hepatic