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Moxibustion improves experimental colitis in rats with Crohn's disease by regulating bile acid enterohepatic circulation and intestinal farnesoid X receptor

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Journal of Integrative Medicine 2023年第2期21卷 194-204页

作者： jia-cheng shen Qin Qi Dong Han Yuan Lu Rong Huang Yi Zhu Lin-shan Zhang Xiu-di Qin Fang Zhang Huan-gan Wu Hui-rong Liu Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 200030China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China

Objective:This study was conducted to explore the mechanism of intestinal inflammation and barrier repair in Crohn’s disease(CD)regulated by moxibustion through bile acid(BA)enterohepatic circulation and intestinal farnesoid X receptor(FXR).Methods:Sprague-Dawley rats were randomly divided into control group,CD model group,mild moxibustion group and herb-partitioned moxibustion *** model rats induced by 2,4,6-trinitrobenzene sulfonic acid were treated with mild moxibustion or herb-partitioned moxibustion at Tianshu(ST25)and Qihai(CV6).The changes in CD symptoms were rated according to the disease activity index score,the serum and colon tissues of rats were collected,and the pathological changes in colon tissues were observed via *** blot,immunohistochemistry(IHC)and immunofluorescence were used to evaluate the improvement of moxibustion on intestinal inflammation and mucosal barrier in CD by the BA-FXR ***:Mild moxibustion and herb-partitioned moxibustion improved the symptoms of CD,inhibited inflammation and repaired mucosal damage to the colon in CD ***,moxibustion could improve the abnormal expression of BA in the colon,liver and serum,downregulate the expression of interferon-γand upregulate the expression of FXR mRNA,and inhibit Toll-like receptor 4(TLR4)and myeloid differentiation factor 88(MyD88)*** IHC results showed that moxibustion could upregulate the expression of FXR and mucin2 and inhibit TLR4 *** blot showed that moxibustion inhibited the protein expression of TLR4 and MyD88 and upregulated the expression of *** image analysis showed that moxibustion increased the colocalization sites and intensity of FXR with TLR4 or nuclear factor-κB *** particular,herb-partitioned moxibustion has more advantages in improving BA and upregulating FXR and TLR4 in the ***:Mild moxibustion and herb-partitioned moxibustion can improve CD by regulating the enterohepatic

关键词： Crohn’s disease Moxibustion Bile acid Farnesoid X receptor Colitis Intestinal mucosal barrier

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Clinical comparison of laparoscopy vs open surgery in a radical operation for rectal cancer: A retrospective casecontrol study

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World Journal of Gastroenterology 2015年第48期21卷 13532-13541页

作者： Chen Huang jia-cheng shen Jing Zhang Tao jiang Wei-Dong Wu Jun Cao Ke-jian Huang Zheng-Jun Qiu Department of General Surgery Shanghai First People’s HospitalSchool of MedicineShanghai Jiao Tong University Department of General Surgery Yancheng Third People’s HospitalThe affiliated Yancheng hospital of Southeast University Medical College

AIM: To assess the diverse immediate and longterm clinical outcomes, a retrospective comparison between laparoscopic and conventional operation was ***: A total number of 916 clinical cases, from January 2006 to December 2013 in our hospital, were analyzed which covered 492 patients underwent the laparoscopy in radical resection(LRR) and 424 cases in open radical resection(ORR). A retrospective analysis was proceeded by comparing the general information, surgery performance, pathologic data, postoperative recovery and complications as well as long-term survival to investigate the diversity of immediate and long-term clinical outcomes of laparoscopic radical ***: There were no statistically significance differences between gender, age, height, weight, body mass index(BMI), tumor loci, tumor node metastasis stages, cell differentiation degree or American Society of Anesthesiologists scores of the patients(P > 0.05). In contrast to the ORR group, the LRR group experienced less operating time(P < 0.001), a lower blood loss(P < 0.001), and had a 2.44% probability of conversion to open surgery. Postoperative bowel function recovered more quickly, analgesic usage and the average hospital stay(P < 0.001) were reduced after LRR. Lymph node dissection during LRR appeared to be slightly more than in ORR(P = 0.338). There were no obvious differences in the lengths and margins(P = 0.182). And the occurrence rate in the two groups was similar(P = 0.081). Overall survival rate of ORR and LRR for 1, 3 and 5 years were 94.0% and 93.6%(P = 0.534), 78.1% and 80.9%(P = 0.284) and 75.2% and 77.0%(P = 0.416), ***: Laparoscopy as a radical operation for rectal cancer was safe, produced better immediate outcomes. Long-term survival of laparoscopy revealed that it was similar to the open operation.

关键词： Laparoscopic Open surgery Short-termoutcomes Long-term outcomes Rectal cancer

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上海某黄浦江原水供水系统中主要致嗅物质的迁移规律分析

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环境科学 2011年第1期32卷 120-124页

作者：白晓慧张明德贾程慎上海交通大学生命科学技术学院水质科学与工程实验室上海200240 上海市自来水市南有限公司上海200002

采用顶空固相微萃取-气相色谱质谱联用研究了上海市某黄浦江水源供水系统中2-甲基异莰醇(MIB)、土味素(GSM)和余氯的迁移变化规律.结果表明,黄浦江源水及其各级净水工艺处理水、管网水和二次供水系统末端水中均含有MIB和GSM,分别在2～18... 详细信息

采用顶空固相微萃取-气相色谱质谱联用研究了上海市某黄浦江水源供水系统中2-甲基异莰醇(MIB)、土味素(GSM)和余氯的迁移变化规律.结果表明,黄浦江源水及其各级净水工艺处理水、管网水和二次供水系统末端水中均含有MIB和GSM,分别在2～18 ng/L和2.68～5.06 ng/L之间;其浓度经水厂各级工艺处理后明显下降;在管网输送过程中总体呈下降趋势.对比2种物质嗅阈值,认为MIB是上海饮用水中的致嗅物质.经过水厂投加的余氯水平在管网中呈显著的衰减,但由于出厂水余氯较高,仍可能造成嗅味影响.

关键词：饮用水致嗅物质 2-甲基异莰醇土味素余氯

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Effect of Rice Volatiles on the Orientation Behavior of the Striped Stem Borer, Chilo suppressalis Larvae

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Rice Science 2004年第Z1期 305-308页

作者： CHEN Hua-cai, LOU Yong-gen , cheng jia-an , shen Qun-chao (Institute of Applied Entomology, Zhejiang University, Hangzhou 310029, China E-mail: huacaichen@*** College of Life. Sciences, China Jiliang University, Hangzhou 310018, China)

The orientation behavior of the 1st and the 3rd instar larvae of the striped stem borer (SSB), Chilo suppessalis, to the volatiles emitted from rice plants was studied with a Y-tube olfactometer. The treatments included healthy plants vs clean air (HP vs CA), striped stem borer damaged plants vs clean air (SSB-DP vs CA), rice leaf folder damaged plants vs clean air (RLF-DP vs CA), HP vs SSB-DP, HP vs RLF-DP and SSB-DP vs RLF-DP. Volatiles from all rice plants had significant attraction for both of the 1st and the 3rd instar larvae. The orientation selection of larvae to the volatiles from rice plants treated differentially (HP, SSB-DP, and RLF-DP) did not impose any significant influence.

关键词： rice volatile Chilo suppressalis larvae orientation behavior

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa shen Chang cheng Yu-Han Wang Wen-Chao cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Multiple parametric Marcinkiewicz integrals with mixed homogeneity along surfaces

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Applied Mathematics(A Journal of Chinese Universities) 2023年第3期38卷 413-428页

作者： shen jia-wei HE Shao-yong CHEN Jie-cheng Department of Mathematics Zhejiang Normal UniversityJinhua 321004China Department of Mathematics Huzhou UniversityHuzhou 313000China.

In this paper, the multiple parametric Marcinkiewicz integral operators with mixed homogeneity along surfaces are studied. The Lp-mapping properties for such operators are obtained under the rather weakened size conditions on the integral kernels both on the unit sphere and in the radial direction. The main results essentially improve and extend certain previous results.

关键词： parametric Marcinkiewicz integrals rough kernels mixed homogeneity product spaces

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Real-time observation of bainite formation at heterogeneous phases in a high-strength weathering steel

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Journal of Iron and Steel Research International 2019年第3期26卷 301-309页

作者： jian cheng jia-sheng Qing Yue-hua Guo Hou-fa shen Key Laboratory for Advanced Materials Processing Technology Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Pangang Group Research Institute Co. Ltd.State Key Laboratory of Vanadium and Titanium Comprehensive UtilizationPanzhihua 617000SichuanChina

Due to the excellent comprehensive mechanical properties and toughness of bainite steels,bainite is regarded as a most desirable microstructure for the new generation of high-strength weathering *** formation of bainite was observed in real time in a high-strength weathering steel,and the results showed that bainite laths show impingement during phase *** preferred regions of nucleation sites were identified,and the growth rate of bainite was *** growth mechanism of bainite was demonstrated to exhibit growth rate contributions from both the diffusion mechanism and the shear ***,the heterogeneous phases that form preferred sites for bainite nucleation were quantitatively identified by scanning electron microscopy(SEM),energy-dispersive X-ray spectrometry(EDS),and calculation of phase diagram(CALPHAD).The austenite grain sizes in crease with increasing austenite temperature,which leads to longer bainite *** influence of a small lattice disregistry between the heterogeneous phases and bainite on the bainite nucleation was *** disregistries between the favorable heterogeneous phases of VN,VC,TiN,or TiC and the ot-Fe in bainite are 2.9,3.1,3.9,and 4.6%,***,VN,VC,TiN,and TiC can act as highly effective nuclei for bainite during the bainite transformation.

关键词： Bainite Real-time observation Plasticity Phase transformation Weathering steel

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Structural design and optimization for vent holes of an industrial turbine sealing disk

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Chinese Journal of Aeronautics 2021年第5期34卷 265-277页

作者： cheng YAN jianfeng ZHU Xiuli shen Jun FAN Zhigang jia Tiefeng CHEN School of Aerospace Engineering Xiamen UniversityXiamen 361005China School of Energy and Power Engineering Beihang UniversityBeijing 100083China Army Aviation Institute Beijing 100000China Aero Engine Academy of China Beijing 101300China AECC Commercial Aircraft Engine Co LtdShanghai 200241China

Severe stress concentration occurs around circular vent holes of an industrial turbine sealing *** paper investigates the structural design and optimization for the vent holes to effectively reduce the maximum von Mises stress and improve the fatigue life of the turbine sealing *** efficient integrated design optimization method is presented based on a novel non-circular vent hole design method in combination with a variable dimension sub-model method,a self-developed modeling and meshing tool,and the Multi-Island Genetic *** proposed non-circular vent hole is biaxial symmetric and consists of four smoothly connected *** variable dimension sub-model method is utilized to obtain accurate results in the fields around the vent holes within the computationally acceptable *** modeling and meshing tool is developed by using the Tcl/Tk Scripts to rebuild the geometry and generate the high-quality hexahedral mesh *** Multi-Island Genetic Algorithm is adopted to solve the studied constrained optimization *** optimization,the maximum von Mises stress is reduced from 1305.644 MPa to 963.435 MPa,and the fatigue life is increased from 3091 cycles to 30,297 *** results show that the proposed design and optimization methods can significantly improve the performance of the turbine sealing disk along with the remarkable drop in stress concentration.

关键词： Multi Island Genetic Algorithm Stress concentration Structural optimization Sub-model method Vent hole

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： jiantao Cui Yueru shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Development of liquid-nitrogen-cooling friction stir spot welding for AZ31 magnesium alloy joints

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1169-1176页

作者： Dong Wu Jun shen Meng-bing Zhou Liang cheng jia-xing Sang State Key Laboratory of Mechanical Transmission College of Materials Science & Engineering Chongqing University Chongqing 400044 China

A liquid-nitrogen-cooling friction stir spot welding(C-FSSW) technology was developed for welding AZ31 magnesium alloy sheets. The liquid-nitrogen cooling degraded the deformability of the welded materials such that the width of interfacial cracks increased with increasing cooling time. The grain size of the stirred zone(SZ) and the heat-affected zone(HAZ) of the C-FSSW-welded joints decreased, whereas that of the thermomechanically affected zone(TMAZ) increased with increasing cooling time. The maximum tensile shear load of the C-FSSW-welded joints welded with a cooling time of 5 or 7 s was larger than that of the friction stir spot welding(FSSW)-welded joint, and the tensile shear load decreased with increasing cooling time. The microhardness of the C-FSSW-welded joints was greater than that of the FSSW-welded joint. Moreover, the microhardness of the SZ and the HAZ of the C-FSSW-welded joints increased, whereas that of the TMAZ decreased, with increasing cooling time.

关键词： magnesium alloy liquid nitrogen cooling friction stir spot welding microstructure mechanical property

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