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基于非靶向代谢组学研究不同炮制方法郁李仁对于小鼠肝脾代谢调节作用

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中国中药杂志 2024年第5期49卷 1225-1239页

作者：贺佳诺张阳郑雨佳徐海峰李宇健米婧璇赵雯雅杨雪郝光飞赵山山刘洪伟河北工程大学生命科学与食品工程学院河北邯郸056038 河北省科学院生物研究所河北石家庄050081

利用超高效液相色谱-四极杆-飞行时间串联质谱(UPLC-Q-TOF-MS)开展生制和炒制2种炮制方法处理的郁李仁对于小鼠肝脾代谢调节影响的研究,旨在通过代谢组学解析不同炮制方法郁李仁对于机体的分子作用机制。将24只雄性小鼠随机分为生制组... 详细信息

利用超高效液相色谱-四极杆-飞行时间串联质谱(UPLC-Q-TOF-MS)开展生制和炒制2种炮制方法处理的郁李仁对于小鼠肝脾代谢调节影响的研究,旨在通过代谢组学解析不同炮制方法郁李仁对于机体的分子作用机制。将24只雄性小鼠随机分为生制组、炒制组和对照组,以0.01 g·mL^(-1)的郁李仁水煎液经口给药1周。给药结束后取肝脏和脾脏组织,采用液相色谱质谱法(LC-MS)进行代谢组学分析,以揭示郁李仁对小鼠肝脾代谢影响。结果显示,生制组小鼠脾脏中11种差异代谢物的表达量显著上调(P<0.05),57种代谢物表达量显著下调(P<0.05);肝脏中15种差异代谢物表达量显著上调(P<0.05),58种代谢物显著下调(P<0.05)。炒制组小鼠脾脏中31种差异代谢物表达量显著上调(P<0.05),10种代谢物显著下调(P<0.05);肝脏中26种差异代谢物表达量显著上调(P<0.05),61种代谢物显著下调(P<0.05)。生制组肝脾中的代谢物主要涉及丙氨酸、天冬氨酸和谷氨酸代谢,嘌呤代谢,氨基糖和核苷酸糖代谢,D-谷氨酰胺和D-谷氨酸代谢;炒制组肝脾中的代谢物主要涉及核黄素代谢,氨基糖和核苷酸糖代谢,嘌呤代谢,丙氨酸、天冬氨酸和谷氨酸代谢,D-谷氨酰胺和D-谷氨酸代谢,谷胱甘肽代谢。由此推测,2种炮制方法处理的郁李仁均会通过影响谷氨酰胺和谷氨酸代谢进而对小鼠肝脾代谢产生影响。

关键词：郁李仁代谢组学肝脏脾脏差异代谢物差异代谢通路

肝内胆管癌细胞系ICC-X1细胞的形态学及超微结构特征的观察与分析

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中国普通外科杂志 2024年第8期33卷 1258-1263页

作者：赵振杰张波张泽亮柴长鹏骆伟苗龙王正峰徐浩兰州大学第一医院普外科四病区甘肃兰州730000 浙江省中医院肝胆胰外科浙江杭州310006

背景与目的:近年来,肝内胆管癌(ICC)发病率不断增加,因发病隐匿、早期症状不典型,ICC患者就诊时多属中晚期,预后较差。ICC细胞系是一种有价值的体外模型系统,广泛应用于ICC的基础与临床研发。通过对相关细胞系进行深入的研究及药物筛选... 详细信息

背景与目的:近年来,肝内胆管癌(ICC)发病率不断增加,因发病隐匿、早期症状不典型,ICC患者就诊时多属中晚期,预后较差。ICC细胞系是一种有价值的体外模型系统,广泛应用于ICC的基础与临床研发。通过对相关细胞系进行深入的研究及药物筛选,可望改善ICC患者预后。越来越多的证据表明肿瘤细胞的形态结构对于肿瘤的发生、发展及对药物的敏感性方面有较大影响。目前国内建立的中国人源ICC细胞系数量不多,对这些细胞系的特性鉴定不充分,特别在细胞的超微结构方面。因此,本研究探讨ICC细胞系ICC-X1的形态及超微结构特征,以期为后续研究提供参考。方法:对建立的新型中国人源ICC细胞系ICC-X1进行培养及处理。分别用光学显微镜、扫描电镜和透射电镜对ICC-X1细胞的显微结构、细胞的表面形态和超微结构以及细胞膜、细胞质和细胞器等胞内超微结构进行观察及分析。结果:光学显微镜下,ICC-X1呈贴壁生长,细胞形态以多角形及短梭形为主,其中单核细胞多见,细胞核大,细胞质少,核质比增加;营养充足的情况下细胞可出现叠层生长,失去接触抑制的特性。扫描电镜下,ICC-X1细胞周围可见丰富的微绒毛,微绒毛的粗细、长短比较均匀,且细胞有较长的伪足。透射电镜下,ICC-X1细胞内核大,核偏移,染色质电子密度不均,可见丰富线粒体及核糖体。结论:本研究获得了ICC-X1细胞形态学及超微结构的详细资料,为探讨ICC细胞结构与功能的关系以及ICC耐药机制的研究提供了线索与思路。

关键词：胆管肿瘤细胞系显微镜检查超微结构

Efficient second harmonic generation by harnessing bound states in the continuum in semi-nonlinear etchless lithium niobate waveguides

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Light(Science & Applications) 2022年第11期11卷 2774-2781页

作者： Xueshi Li jiantao Ma Shunfa Liu Peinian Huang bo Chen Dunzhao wei Jin Liu State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-Sen University510275 GuangzhouChina

Integrated photonics provides unprecedented opportunities to pursue advanced nonlinear light sources with lowpower consumptions and small footprints in a scalable manner,such as microcombs,chip-scale optical parametric oscillators and integrated quantum light *** a variety of nonlinear optical processes,high-efficiency second harmonic generation(SHG)on-chip is particularly appealing and yet *** this work,we present efficient SHG in highly engineerable semi-nonlinear waveguides consisting of electron-beam resist waveguides and thin-film silicon nitride(SiN)/lithium niobate(LN).By carefully designing octave-separating bound states in the continuum(BICs)for the nonlinear interacting waves in such a hybrid structure,we have simultaneously optimized the losses for both fundamental frequency(FF)and second harmonic(SH)waves and achieved modal phasing matching and maximized the nonlinear modal overlap between the FF and SH waves,which results in an experimental conversion efficiency up to 4.05%W^(-1)cm^(-2).Our work provides a versatile and fabrication-friendly platform to explore on-chip nonlinear optical processes with high effciency in the context of nanophotonics and quantum optics.

关键词： nonlinear harmonic lithium

Occurrence,removal,and environmental risks of pharmaceuticals in wastewater treatment plants in south China

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Frontiers of Environmental Science & Engineering 2018年第6期12卷 69-79页

作者： Huang Huang Jie Wu jian Ye Tingjin Ye jia Deng Yongmei Liang wei Liu School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou 510006China Foshan Water Group Co. Ltd.Foshan 528000China

Five pharmaceuticals were detected in wastewater treatment plants in southern China. Biological treatment was the most effective process for PhACs removal. Metoprolol showed negative removal during secondary treatment... 详细信息

关键词： Pharmaceuticals Wastewater treatment Pearl River Delta Occurrence Removal Risk assessment

定量核磁共振技术在中药质量控制中的应用进展

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中国现代中药 2024年第6期26卷 1099-1110页

作者：姚佳敏孙巍熊皓舒章顺楠中国药科大学中药学院江苏南京211198 天士力医药集团股份有限公司中药先进制造技术国家地方联合工程实验室天津300410 现代中药创制全国重点实验室天津300410

中药质量控制是保证中药安全有效、质量稳定的基础,是中药标准化、现代化、国际化的前提,选用合适的分析方法在中药质量控制中具有重要意义。与薄层色谱、气相色谱、高效液相色谱等常规分析方法相比,定量核磁共振技术(qNMR)样品前处理... 详细信息

中药质量控制是保证中药安全有效、质量稳定的基础,是中药标准化、现代化、国际化的前提,选用合适的分析方法在中药质量控制中具有重要意义。与薄层色谱、气相色谱、高效液相色谱等常规分析方法相比,定量核磁共振技术(qNMR)样品前处理简单、分析检测速度快、无需自身对照品,集定性鉴别和定量分析于一体,适用于中药中各类成分的检测分析,或将作为一种有力的分析技术,应用于中药质量控制。对qNMR的基本原理、定量方法和药典应用进行总结,重点介绍了qNMR在中药材、中药制剂、中药对照品及中药生产过程质量控制中的应用进展,提出了qNMR存在的若干问题并展望了其发展前景,旨在为采用qNMR控制中药质量提供参考。

关键词：中药质量控制定量核磁共振技术含量测定研究进展

Conjugated polymer-mediated synthesis of sulfur- and nitrogen-doped carbon nanotubes as efficient anode materials for sodium ion batteries

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Nano Research 2018年第5期11卷 2573-2585页

作者： Yanzhen He Xijiang Han Yunchen Du bo Song Bin Zhang wei Zhang Ping Xu MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 China Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing 400714 China

Heteroatom-doped carbon nanomaterials have attracted significant attention as anode materials for sodium-ion batteries （SIBs）. Herein, we demonstrate a conjugated polymer-mediated synthesis of sulfur and nitrogen co-doped carbon nanotubes （S/N-CT） via the carbonization of sulfur-containing polyaniline （PANI） nanotubes. It is found that the carbonization technique greatly influences the structural features and thus the Na-storage behavior of the S/N-CT materials. The carbon nanotubes developed using a two-step carbonization process （heating at 400℃ and then at 900℃） exhibit a high specific surface area, enlarged interlayer distance, small charge transfer resistance, enhanced reaction kinetics, as well as a large number of defects and active sites; further, they exhibit a high reversible capacity of 340 mAh·g^-1 at 0.1 A·g^-1 and a remarkable cycling stability with a capacity of 141 mAh·g^-1 at 5 A·g^-1 （94% retention after 3,000 cydes）. Direct carbonization of conjugated polymers with a specific morphology is an eco-friendly and low-cost technique for the synthesis of dual atom-doped carbon nanomaterials for application in energy devices. However, the carbonization process should be carefully controlled in order to better tune the structure-property relationship.

关键词： sodium ion battery conjugated polymer carbon nanotube heteroatom doping

Degradation of Populus euphratica community in the lower reaches of the Tarim River, Xinjiang, China

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Journal of Environmental Sciences 2005年第5期17卷 740-747页

作者： LIU jia-zhen CHEN Ya-ning CHEN Yong-jin ZHANG Na LI wei-hong Xinjiang Institnte of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

To investigate the relationships between the degradation of plant community and groundwater level in the lower reaches of the Tarim River, nine monitored sections were set along the main stream, where there had been no runoff for nearly 30 years. The characteristics of plant communities were analyzed. It was found that the coverage of trees gradually decreased along the groundwater depth gradient, while the coverage of shrubs slightly increased rather than decreased at first and then gradually decreased, and the coverage of herbs steadily decreased at the beginning and then quickly decreased. The species diversity and species richness of both herbs and woody plants showed obvious degrading trends, while the variations in species evenness were slight. The degrading sequences of species were related to their physiological and ecological characteristics, especially their sensitivity to changes of groundwater table. The herbs with shallow roots first degenerated or disappeared when the groundwater table fell, and then did the deep-rooted herbs, and finally the trees and shrubs with strong tolerance to drought degenerated. The Populus euphratica communities showed typical degrading characteristics, namely the dominant species Populus euphratica remained its dominant status during the degradation. Overall, the existence of strongly tolerant-drought species was the obvious indication of plant species degradation; while simplification of community structure and the decrease of species richness were the obvious indication of plant community degradation.

关键词： degradation plant community coverage species diversity Tarim River

Difference of sintering performance of different types of limonitic nickel laterite

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Journal of Iron and Steel Research International 2023年第1期30卷 21-30页

作者： Yu-xiao Xue jian Pan De-qing Zhu Xin Wang bo-hua Li wei Liu School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

To achieve the more extensive utilization of limonitic nickel laterite,the difference of sintering performance of different types of limonitic nickel laterite including high-gangue and low-gangue nickel ores was investigated by sinter pot tests and relevant mechanism analyses such as thermodynamic analysis and the chemistry and mineralogy of product *** the type of limonitic nickel laterite transformed from high-gangue to low-gangue nickel ore,tumble index and productivity are improved from 45.87%and 0.97 t m^(-2) h^(-1) to 50.16%and 1.05 t m^(-2) h^(-1),respectively,and solid fuel rate is reduced from 140.52 to 131.13 kg/t,indicating that the low-gangue nickel ore possesses relatively better sintering *** is mainly due to the fact that the much lower contents of MgO and Al2O3 improve the formation ability and fluidity of liquid phase,which eventually contributes to the formation of relatively tighter sinter microstructure with the lower sinter porosity,more silico-ferrite of calcium and alumina amount and better bonding of hercynite by liquid *** addition,the metallurgical performance and nickel content of product sinter would not be reduced as different types of limonitic nickel laterite are blended for *** this basis,it is entirely feasible to more widely utilize limonitic nickel laterite and simultaneously obtain much better-quality Ni-containing product sinter via effective sintering strengthening technologies.

关键词： Limonitic nickel laterite Sintering Stainless steel High-melting component Extensive utilization

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中能段电子束离子阱真空控制系统研制

真空科学与技术学报 2024年第1期44卷 20-27页

作者：曾超赵宇红张洪明杨洋吕波符佳王福地宾斌黄世涵计华健林子超毛立宇范玉孙波胡奎南华大学电气工程学院衡阳421001 中国科学院合肥物质科学研究院等离子体物理研究所合肥230031 复旦大学现代物理研究所上海200433 中国科学技术大学研究生院科学岛分院合肥230026 安徽大学物质科学与信息技术研究院合肥230601

电子束离子阱(Electron Beam Ion Trap,EBIT)是一种用于研究高电离态离子物理过程的实验装置。中能段紧凑型EBIT实验平台能够产生30 keV的电子束能量,电子束流达到20 mA,对于研究未来聚变堆杂质离子输运行为研究具有重要意义。为了产生... 详细信息

电子束离子阱(Electron Beam Ion Trap,EBIT)是一种用于研究高电离态离子物理过程的实验装置。中能段紧凑型EBIT实验平台能够产生30 keV的电子束能量,电子束流达到20 mA,对于研究未来聚变堆杂质离子输运行为研究具有重要意义。为了产生单一高电荷态离子,中能段EBIT装置阱区需要工作在超高真空(10−8 Pa)环境下。低温超导磁体需工作在10^(−5)Pa真空环境下以维持超导状态,因此真空度直接影响着中能段EBIT的工作性能,有必要研制一套稳定高效的真空控制系统以提升中能段EBIT装置稳定性与可靠性。文章基于RS485总线结构和Python编程语言开发了一套中能段EBIT真空控制系统,实现了对中能段EBIT真空系统的远程控制、数据采集和系统联锁保护。可为中能段EBIT装置提供稳定可靠的超高真空的实验环境,对中能段EBIT装置的稳态运行具有重要意义。

关键词：电子束离子阱真空控制系统 RS485 Python