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Recent progress on artificial intelligence-enhanced multimodal sensors integrated devices and systems

Journal of Semiconductors 2025年第1期46卷 179-192页

作者： Haihua wang Mingjian Zhou Xiaolong jia Hualong Wei Zhenjie Hu Wei Li Qiumeng Chen Lei wang College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China Nantong Institute of Nanjing University of Posts and Telecommunications Nantong 226021China

Multimodal sensor fusion can make full use of the advantages of various sensors,make up for the shortcomings of a single sensor,achieve information verification or information security through information redundancy,and improve the reliability and safety of the *** intelligence(AI),referring to the simulation of human intelligence in machines that are programmed to think and learn like humans,represents a pivotal frontier in modern scientific *** the continuous development and promotion of AI technology in Sensor 4.0 age,multimodal sensor fusion is becoming more and more intelligent and automated,and is expected to go further in the *** this context,this review article takes a comprehensive look at the recent progress on AI-enhanced multimodal sensors and their integrated devices and *** on the concept and principle of sensor technologies and AI algorithms,the theoretical underpinnings,technological breakthroughs,and pragmatic applications of AI-enhanced multimodal sensors in various fields such as robotics,healthcare,and environmental monitoring are *** a comparative study of the dual/tri-modal sensors with and without using AI technologies(especially machine learning and deep learning),AI-enhanced multimodal sensors highlight the potential of AI to improve sensor performance,data processing,and decision-making ***,the review analyzes the challenges and opportunities afforded by AI-enhanced multimodal sensors,and offers a prospective outlook on the forthcoming advancements.

关键词： sensor multimodal sensors machine learning deep learning intelligent system

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Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan

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Science China(Life Sciences) 2025年第2期68卷 416-430页

作者： jia-Yu Liu Yao wang Yue Guo Run-Qi Zheng Yun-Ying wang Yan-Yan Shen Yan-Hong Liu Ai-Ping Cao Rui-bo wang bo-Yang Xie Shuai jiang Qiu-Ying Han Jing Chen Fang-Ting Dong Kun He Na wang Xin Pan Tao Li Tao Zhou Ai-Ling Li Qing Xia Wei-Na Zhang Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100850China

As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly *** an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic acid(TUDCA),a natural bile acid,offers additional health benefits beyond liver ***,we show that TUDCA extends the lifespan and healthspan of ***,oral supplementation of TUDCA improves fitness in old mice,including clinically relevant phenotypes,exercise capacity and cognitive ***,TUDCA treatment drives broad transcriptional changes correlated with anti-aging ***,we discover that TUDCA targets the chaperone HSP90 to promote its protein refolding *** collaboration further alleviates aging-induced endoplasmic reticulum(ER)stress and facilitates protein homeostasis,thus offering resistance to *** summary,our findings uncover new molecular links between an endogenous metabolite and protein homeostasis,and propose a novel anti-aging strategy that could improve both lifespan and healthspan.

关键词： tauroursodeoxycholic acid lifespan healthspan protein homeostasis

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Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2025年第2期68卷 649-660页

作者： Ying-Qi Zhang Gan-Lu Qian Yun Liu jia-Hui Li Xin Hong Zhou Xu bo Zhou Long-Wu Ye State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Provinceand College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Center of Chemistry for Frontier Technologies Department of ChemistryState Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 221004China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key Laboratory of Organometallic Chemistry Chinese Academy of SciencesShanghai 200032China

Herein,we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic ***,the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high ***,the enantioselectivities of these products can be perfectly induced by Evans auxiliaries(99%ees).Significantly,this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives,but also constitutes the first asymmetric halogenation/selenation of *** calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

关键词： alkynes cyclization dearomatization Evans chiral auxiliary spirocycles

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao wang jia Zeng Donglin Gan Kun Ling Mingfang He jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Adsorption and retention of fracturing fluid and its impact on gas transport in tight sandstone with different clay minerals

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Petroleum Science 2025年第1期22卷 370-383页

作者： Yi-Jun wang Li-Jun You jian Yang Yi-Li Kang Ming-Jun Chen jia-jia Bai jian Tian State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Engineering Technology Research Institute of Southwest Oil & Gas Field Company PetroChina School of Petroleum Engineering Changzhou University State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing University

To elucidate the adsorption characteristics and retention mechanisms of fracturing fluids in diverse clay minerals, we conducted on-line nuclear magnetic resonance(NMR) and atomic force microscopy(AFM)experiments. The depth and extent of solid phase damage are determined by the ratio between the size of fine fractions in fracturing fluid residue and the pore-throat size in experiments. Poor physical properties(K 0.5 m D) combined with a scattered distribution of retained fracturing fluid is associated with high gas phase recovery permeability, whereas a continuous sheet-like distribution results in low recovery permeability. The expansive surface area and presence of filamentous illite minerals facilitate the multiple winding and adsorption of fracturing fluids, demonstrating strong hydrogen-bonding, multi-layering and multiple adsorption properties. The geological characteristics of the main gas formations exhibit significant variation, and the severity of damage caused by fracturing fluids occurs in diverse sequences. To address this issue, a differentiated strategy for optimizing fracturing fluids has been proposed.

关键词： Clay minerals Formation damage Fracturing fluid retention distribution Adsorption morphology

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Is the Gum Nebula an important interstellar scattering disk of background pulsars?

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 175-186页

作者： Rui wang Zhen Yan Zhiqiang Shen Ke jia Lee Yajun Wu Rongbing Zhao Zhipeng Huang Xiaowei wang Jie Liu Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing100101China School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China Department of Astronomy School of PhysicsPeking UniversityBeijing100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing100871China Department of Physics and Astronomy Hubei University of EducationWuhan430205China

The Gum Nebula is a faint supernova remnant extending about 40°across the southern sky,potentially affecting tens of background *** the view that the Gum Nebula acts as a potential scattering screen for background pulsars has been recurrently mentioned over the past five decades,it has not been directly *** chose the strong background pulsar PSR B0740-28 as a probe and monitored its diffractive interstellar scintillation(DISS)at 2.25&8.60 GHz simultaneously for about two years using the Shanghai Tian Ma Radio Telescope(TMRT).DISS was detected at both frequencies and quantified by two-dimensional autocorrelation *** calculated their scattering spectral indexαand found that 9/21 of the observations followed the theoretical predictions,while 4/21 of them clearly showedαboth the distance(245_(-72)^(+69)pc)and transverse speed(22.4_(-4.2)^(+4.1)km s^(-1))of the scintillation screen are comparable with related parameters of the Gum *** findings indicated that anisotropic scattering provides a superior explanation for the annual modulation of scintillation arcs than isotropic ***,the orientation of its long axis was also fitted.

关键词： pulsar interstellar scintillation Gum Nebula

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Structural designs and mechanism insights into electrocatalytic oxidation of 5-hydroxymethylfurfural

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Journal of Energy Chemistry 2025年第1期100卷 792-814页

作者： Jing Lei Huijie Zhang jian Yang jia Ran Jiqiang Ning Haiyan wang Yong Hu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Department of ChemistryZhejiang Normal UniversityJinhua 321004ZhejiangChina Jinhua Advanced Research Institute Jinhua 321019ZhejiangChina Department of Optical Science and Engineering Fudan UniversityShanghai 200438China College of Chemistry and Materials Engineering Zhejiang A&F UniversityHangzhou 311300ZhejiangChina

Biomass conversion offers an efficient approach to alleviate the energy and environmental *** oxidation of 5-hydroxymethylfurfural(HMF)has attracted tremendous attention in the latest few years for the mild synthesis conditions and high conversion efficiency to obtain 2,5-furan dicarboxylic acid(FDCA),but there still remain problems such as limited yield,short cycle life,and ambiguous reaction *** many reviews highlighting a variety of electrocatalysts for electrochemical oxidation of HMF,a detailed discussion of the structural modulation of catalyst and the underlying catalytic mechanism is still *** herein provide a comprehensive summary of the recent development of electrochemical oxidation of HMF to FDCA,particularly focusing on the mechanism studies as well as the advanced strategies developed to regulate the structure and optimize the performance of the electrocatalysts,including heterointerface construction,defect engineering,single-atom engineering,and in situ *** characterization techniques and theoretical calculation methods for mechanism and active site studies are elaborated,and challenges and future directions of electrochemical oxidation of HMF are also *** review will provide guidance for designing advanced catalysts and deepening the understanding of the reaction mechanism beneath electrochemical oxidation of HMF to FDCA.

关键词： Electrochemical oxidation of 5- hydroxymethylfurfural 2,5-Furan dicarboxylic acid Structural design Mechanism Electrocatalysts

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Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang jiaNG Tian MAO Jin-Song wang Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan jia Tianfang wang National Space Science Center Chinese Academy of SciencesBeijing100090China Beijing Key Laboratory of Space Environment Exploration Beijing100090China Key Laboratory of Environmental Space Situation Awareness Technology Beijing100090China National Satellite Meteorological Center China Meteorological AdministrationBeijing100081China

The Triple Ionosphere Photo Meter(TRIPM)is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E(FY-3E),which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:(1)135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight(nighttime channel);(2)135.6 nm airglow from the OI when sunlight is present(daytime/dusk-dawn 135.6 nm channel);and(3)Airglow in the N_(2)LBH of the TRIPM(daytime/dusk-dawn N_(2)LBH channel).FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N_(2)derived from the 135.6 nm channel and N_(2)LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content(TEC)*** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N_(2)is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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Inability of recognizing offspring underlies parental errors in the selection of offspring

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Avian Research 2025年第01期 89-95页

作者： Lifang Gao Wen Zhang Wenjing Zhu Yichen Wu Ran Xu Ningning Sun Yujie wang Biyun jia bo Du College of Life Sciences Northwest Normal University School of Life Sciences Lanzhou University College of Ecology Lanzhou University

Inclusive fitness theory posits that altruistic behaviors, which are directed more likely towards relatives, should be favored by natural selection. However, the prevalence of alternative parenting behaviors in offspring selection, including rejecting their own offspring and accepting the offspring of others, remains poorly understood within the context of parental care evolution. In order to investigate the factors that prompt the occurrence of alternative parenting behaviors, we designed a series of experiments in the Azure-winged Magpie(Cyanopica cyanus). By manipulating the nest spatial position or offspring age/number and parent-offspring familiarity, we addressed how parents provided parental care for the manipulated offspring. In the nest resettlement experiment, the probability of parents rejecting their own offspring significantly increased with nest-moving distances while decreased with offspring ages. In the cross-fostering experiments, the probability of parents provisioning unrelated young significantly decreased with the age difference between cross-fostered chicks. In the nest duplication experiments, where parents were given a choice between familiar offspring and unfamiliar unrelated chicks or between unfamiliar offspring and familiar unrelated chicks, the probability of both alternative parenting behaviors was significantly influenced by the time when parental association with their offspring was deprived. We conclude that as offspring phenotypic traits become individualized and fixed at a special developmental stage, parents gradually acquire the capacity for offspring recognition by associating with them. Any factors that disrupt parent–offspring association or introduce unrelated young into the nest prior to this critical timeline can result in the occurrence of alternative parenting behaviors.

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Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

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Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU bo-yu LIU Zhi-chao ZHAO Zhen-xi HUANG Hui-ping ZHANG Na XIA jia CHEN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

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