检索结果-南通市图书馆

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

改进变分自编码器的工业时序数据异常检测

计算机工程与设计 2024年第1期45卷 17-23页

作者：张志昂廖光忠武汉科技大学计算机科学与技术学院湖北武汉430065 武汉科技大学智能信息处理与实时工业系统湖北省重点实验室湖北武汉430065

为解决传统的异常检测模型对工业时序数据异常点检测方面误判率大和抗干扰性差的问题,提出一种改进的变分自编码器模型。考虑到工业时序数据的不规律性,使用变分自编码器模型作为基础架构;由于变分自编码器本身存在难以准确检测出异常... 详细信息

为解决传统的异常检测模型对工业时序数据异常点检测方面误判率大和抗干扰性差的问题,提出一种改进的变分自编码器模型。考虑到工业时序数据的不规律性,使用变分自编码器模型作为基础架构;由于变分自编码器本身存在难以准确检测出异常时序数据的问题,在编码和解码过程中分别引入时间卷积网络和通道注意力机制,实现扩大感受野和增强特征权重;对数据时序数据使用随机森林进行特征排序,提高检测的准确性。通过进行对比测试实验,验证了该模型可以有效提高对异常工业时序数据点检测的准确性和可靠性。

关键词：异常检测时间卷积网络变分自编码器通道注意力机制时序数据随机森林感受野

橡胶树胶孢炭疽菌自噬相关基因ATG20的功能

在线全文

学校读者我要写书评

暂无评论

江苏农业学报 2024年第4期40卷 636-644页

作者：黄志睿廖至雯罗红丽海南大学三亚南繁研究院海南三亚572000 海南省崖州湾种子实验室海南三亚572000

胶孢炭疽菌(Colletotrichum gloeosporioides)是引起橡胶树炭疽病的优势小种,橡胶树感染后会大量减产。自噬现象是植物病原真菌中普遍存在的生理过程,自噬过程会受到多个自噬相关基因(ATG)的调控,在病原真菌对逆境的响应、生长发育和致... 详细信息

胶孢炭疽菌(Colletotrichum gloeosporioides)是引起橡胶树炭疽病的优势小种,橡胶树感染后会大量减产。自噬现象是植物病原真菌中普遍存在的生理过程,自噬过程会受到多个自噬相关基因(ATG)的调控,在病原真菌对逆境的响应、生长发育和致病性方面具有重要作用。本研究克隆了橡胶树胶孢炭疽菌的ATG20同源基因CgATG20,构建了该基因的敲除突变株△CgATG20,并对其致病性、孢子产量、组织侵染情况和自噬情况等进行分析。结果显示,与野生型相比,△CgATG20的致病性、分生孢子产量和对植物的入侵率显著降低。在缺氮条件下,△CgATG20菌丝体中自噬小体的数量显著少于野生型。以上结果表明ATG20在胶孢炭疽菌的生长发育、致病性和自噬中发挥重要作用,这为寻找有效阻断病原真菌发育和侵染途径的防治策略提供了新的靶点。

关键词：橡胶树胶孢炭疽菌自噬 ATG20 致病力

低碳钢及其不锈钢复合钢材低周疲劳行为的对比研究

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

工程力学 2024年第11期41卷 79-87页

作者：廖小伟潘之钊班慧勇宗亮孙博浙江工业大学土木工程学院浙江杭州310023 清华大学土木工程系北京100084 天津大学建筑工程学院天津300350

不锈钢复合钢材在土木工程结构中得到了越来越多的关注和应用,但是其在循环荷载作用下的力学行为还缺乏足够的认识。通过单轴拉伸试验和不同应变幅条件下的对称应变控制加载低周疲劳试验,对比研究了2 mm+10 mm热轧304+Q235B不锈钢复合... 详细信息

不锈钢复合钢材在土木工程结构中得到了越来越多的关注和应用,但是其在循环荷载作用下的力学行为还缺乏足够的认识。通过单轴拉伸试验和不同应变幅条件下的对称应变控制加载低周疲劳试验,对比研究了2 mm+10 mm热轧304+Q235B不锈钢复合钢材及其基层Q235B碳钢钢材的循环弹-塑性特性和低周疲劳寿命;结合数值模拟得到的疲劳试件截面应力分布,分析了复合钢材低周疲劳失效模式的力学机理。结果表明,在拉伸和循环荷载下,复层304不锈钢与基层Q235B碳钢之间均没有出现界面剥离现象;复合钢材及Q235B碳钢均表现出与加载应变幅正相关的循环硬化行为,且前者的循环应力响应大于后者;复合钢材的低周疲劳初始裂纹均出现在Q235B碳钢侧,这是由于复层不锈钢和基层碳钢不同的拉应力状态和塑性变形能力共同造成的,但是复合钢材与Q235B碳钢的低周疲劳寿命未表现出明显的区别。该批次304+Q235B不锈钢复合钢材具有良好的低周疲劳性能,可代替Q235B碳钢用于对腐蚀防护性能具有较高要求的工程构件中。

关键词：不锈钢复合钢材低周疲劳循环硬化单轴拉伸开裂机理

维普期刊数据库博看期刊

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution:Prospective single-centre trial

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第5期16卷 259-272页

作者： Yuan Gao Lian-Song Ye Xu Li Bin Yu Ke liao jia Xie jiang Du Qiong-Ying Zhang Bing Hu Department of Gastroenterology and Hepatology Digestive Endoscopy Medical Engineering Research LaboratoryWest China HospitalMed-X Center for MaterialsSichuan UniversityChengdu 610041Sichuan ProvinceChina Design Measurement and Evaluation(CBDME)Department of Clinical Research ManagementWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Institute for Disaster Management and Reconstruction Sichuan University-The Hong Kong Polytechnic UniversityChengdu 610065Sichuan ProvinceChina West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610044Sichuan ProvinceChina Precision Medicine Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Esophageal chromoendoscopy with iodine solution is important for detecting early esophageal *** effect of routine treatment for lesions lightly stained with Lugol’s iodine solution is limited,and the addition of natural substances to a regular diet is becoming increasingly *** has antitumor effects as reported in previous *** To evaluate whether vinegar supplementation could improve the prognosis of patients with lightly stained esophageal *** prospective single-centre trial included consecutive patients with lightly stained lesions between June 2020 and April *** in the experimental group received increased amounts of vinegar for 6 *** primary outcome of the study was the clinical therapeutic *** related to vinegar ingestion and adverse events were also recorded in *** A total of 166 patients were included in the final *** was no significant difference in the baseline data between the two ***-to-treat(ITT)analysis demonstrated that the rates at which endoscopic characteristics improved were 33.72%in the experimental group and 20.00%in the conventional group(P=0.007);and the rates at which biopsy pathology improved were 19.77%and 8.75%,respectively(P=0.011).Additional vinegar consumption had a statistically protective effect on the rate at which endoscopic characteristics improved[hazard ratio(HR)_(ITT)=2.183,95%CI:1.183-4.028;HR_(per-protocol(PP))=2.307,95%CI:1.202-4.426]and biopsy pathology improved(HR_(ITT)=2.931,95%CI:1.212-7.089;HR_(PP)=3.320,95%CI:1.295-8.507).No statistically significant effect of increased vinegar consumption on preventing high-grade intraepithelial neoplasia or early cancer was observed(HR_(ITT)=0.382,95%CI:0.079-1.846;HRPP=0.382,95%CI:0.079-1.846).The subgroup analyses indicated that the overall therapeutic improvement of endoscopic characteristics and biopsy pathology seemed more obvious in older(age>60)male patients w

关键词： Chromoendoscopy Esophageal squamous epithelium Vinegar Atypical hyperplasia Prognosis

A comparison of the effect of alendronate and You-Gui-Wan on osteoporosis in female rats with kidney-yang deficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第6期9卷 31-41页

作者： Mei-Mei Wu Xing-Peng He Wan-Ting Wu Wen-Jie Lu Yan-Yang Mai Kun-Cai Xu Yao-Feng zhi Hai-Xin Mo jia-Di He Xin Zhang Peng-Fei Li Clinical Experimental Center Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational ResearchJiangmen Central HospitalJiangmen 529030China Traumatic Orthopedics Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510470China Department of Intelligent Engineering Guiyang Institute of Information Science and TechnologyGuiyang 550025China

Background:In traditional Chinese medicine,You-Gui-Wan(YGW)is typically used to treat osteoporosis associated with kidney-yang ***,there have been few mechanistic studies on the effectiveness of kidney-yang deficiency-type osteoporosis with *** further clarify the role of YGW in the effect of osteoporosis with kidney-yang deficiency,the study analyzed the therapeutic advantages of YGW by comparing the therapeutic effects of YGW and alendronate(ALN)on osteoporosis with kidney-yang ***:SPF female SD rats were randomly divided into control,osteoporosis,osteoporosis with kidney-yang deficiency,osteoporosis with kidney-yang deficiency+YGW and osteoporosis with kidney-yang deficiency+ALN *** for the control group,osteoporosis was induced by the removal of bilateral *** 12 weeks,rats with osteoporosis in the kidney-yang deficiency group had kidney-yang deficiency syndrome triggered by hydrocortisone for 14 *** were treated with YGW or ALN for 12 *** weights of rats were ***-eosin staining staining was used to observe pathological changes in bone trabeculae,liver,spleen,and kidneys of *** of the growth plate cartilage of rats in different groups was observed by safranine-O *** expression of osteoclast key indices(ACP)and osteoblast key indices(ALP)in the bone tissue of rats in the different groups was observed by immunohistochemical *** expression of bone resorption-related indicators(TRAP and NXT-1),bone formation-related indicators(BALP,BGP,and P1NP),and major indicators of kidney-yang deficiency(ACTH,T3,T4,cAMP,and cGMP)were observed using an ELISA detection *** expression levels of the main indices of liver function(ALT and AST)were detected in different ***:The differences between the osteoporosis with kidney-yang deficiency group and osteoporosis group were that the weight of rats and the expression of ACTH,T3,T4,and cAMP decreased significantl

关键词： osteoporosis kidney-yang deficiency You-Gui-Wan alendronate

Changes of mitochondrial dynamics during the progression of non-alcoholic fatty liver disease: a review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical Engineering Communications 2024年第1期3卷 15-20页

作者： Man-Na Li Ling Yang Huan-Tian Cui jia-Bao liao Ning Wang Jing Miao Ying Zhang Hai-Di Wang School of Nursing Yunnan University of Chinese MedicineKunming 650500China The First Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650500China Department of Chinese Medicine Tianjin Second People's HospitalTianjin 30012China

Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease closely related to metabolic disorders that pose a serious threat to human ***,no specific drugs are available for treating the aetiology of NAFLD in clinical *** have various biological functions inside the *** have found that mitochondrial fission and fusion are closely related to ***,identifying therapeutic targets for NAFLD through mitochondrial fission and fusion is *** in the field of traditional Chinese medicine,good therapeutic effects have been achieved in the treatment of NAFLD by protecting mitochondrial fusion and ***,this article reviews the relationship between mitochondrial dynamics and NAFLD as well as the treatment of NAFLD through the regulation of mitochondrial fission and fusion with traditional Chinese medicine to provide a reference for the clinical application of traditional Chinese medicine in regulating mitochondrial fission and fusion functions to treat NAFLD.

关键词： mitochondrial dynamics NAFLD traditional Chinese medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高中语文学习任务群研究的现状、特征与展望

教学与管理 2024年第12期 69-72页

作者：杨嘉惠廖兴湖南工业大学文学与新闻传播学院湖南株洲412007

近年来关于高中语文学习任务群的研究逐渐成为学界关注的焦点。梳理其研究现状可以发现,相关成果多聚焦于高中语文学习任务群的内涵、理论基础、特点、价值与核心素养关系、教学策略等维度。通过对现有研究成果展开深入分析,发现当前高... 详细信息

近年来关于高中语文学习任务群的研究逐渐成为学界关注的焦点。梳理其研究现状可以发现,相关成果多聚焦于高中语文学习任务群的内涵、理论基础、特点、价值与核心素养关系、教学策略等维度。通过对现有研究成果展开深入分析,发现当前高中语文学习任务群研究所形成的特点以及存在的不足之处。未来,语文学习任务群的研究应加深研究的学理深度、拓展研究的多学科视域、提升研究的系统性。

关键词：高中语文学习任务群研究现状新课标语文素养

Sorafenib plus transarterial chemoembolization vs sorafenib alone for patients with advanced hepatocellular carcinoma: A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第1期16卷 91-102页

作者： Hong-Jie Yang Bin Ye jia-Xu liao Lei Lei Kai Chen Department of Radiology The Sixth People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Department of Oncology The Sixth People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Department of Pharmacy The Affiliated Taizhou People's Hospital of Nanjing Medical UniversityTaizhou 225300Jiangsu ProvinceChina

BACKGROUND Although the past decade has seen remarkable advances in treatment options for hepatocellular carcinoma(HCC),the dismal overall prognosis still envelops HCC *** comparative trials have been conducted to study whether transarterial chemoembolization(TACE)could improve clinical outcomes in patients receiving sorafenib for advanced HCC;however,the findings have been *** To study the potential synergies and safety of sorafenib plus TACE vs sorafenib alone for treating advanced HCC,by performing a systematic review and *** This study was conducted following the PRISMA statement.A systematic literature search was conducted using the Cochrane Library,Embase,PubMed,and Web of Science *** included in the present work were collected from patients diagnosed with advanced HCC receiving sorafenib plus TACE or sorafenib *** synthesis and meta-analysis were conducted using Review Manager *** The present study included 2780 patients from five comparative clinical trials(1 was randomized control trial and 4 were retrospective studies).It was found that patients receiving sorafenib plus TACE had better prognoses in terms of overall survival(OS),with a combined hazard ratio(HR)of 0.65[95%confidence interval(95%CI):0.46–0.93,P=0.02,n=2780].Consistently,progression free survival(PFS)and time to progression(TTP)differed significantly between the sorafenib plus TACE arm and sorafenib arm(PFS:HR=0.62,95%CI:0.40–0.96,P=0.03,n=443;TTP:HR=0.73,95%CI:0.64-0.83,P<0.00001,n=2451).Disease control rate(DCR)was also significantly increased by combination therapy(risk ratio=1.36,95%CI:1.02-1.81,P=0.04,n=641).Regarding safety,the incidence of any adverse event(AE)was increased due to the addition of TACE;however,no significant difference was found in grade≥3 *** The combination of sorafenib with TACE has superior efficacy to sorafenib monotherapy,as evidenced by prolonged OS,PFS,and TTP,as well as increase

关键词： Hepatocellular carcinoma Sorafenib Transarterial chemoembolization Systematic review Meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

低速船舶微气泡减阻数值研究

船舶力学 2024年第3期28卷 368-378页

作者：赵晓杰宗智王加夏洪智超胡俊明江苏科技大学船舶与海洋工程学院江苏镇江212000 大连理工大学船舶工程学院辽宁大连116024 工业装备结构分析国家重点实验室辽宁大连116024 江苏省船舶与海洋工程装备技术创新中心江苏南通226100

为了研究船舶微气泡减阻规律,本文基于OpenFOAM中两相欧拉数值模型,对低速散货船进行微气泡减阻数值研究。对气液两相分别建立控制方程,考虑五种相间作用力及气泡聚合和破碎,采用考虑气泡影响的改进k-ε湍流模型,忽略自由面影响,采用叠... 详细信息

为了研究船舶微气泡减阻规律,本文基于OpenFOAM中两相欧拉数值模型,对低速散货船进行微气泡减阻数值研究。对气液两相分别建立控制方程,考虑五种相间作用力及气泡聚合和破碎,采用考虑气泡影响的改进k-ε湍流模型,忽略自由面影响,采用叠模模型研究喷气量、气泡直径、航速及吃水等因素对船舶微气泡减阻的影响,分析气体体积分数、湍流粘度和气泡直径分布等。结果表明:微气泡可以同时减少船舶摩擦阻力、粘压阻力和总阻力;喷气量直接影响减阻率,喷气量越大,减阻率越高;较小气泡的平均气体体积分数较大且气体分布更均匀,同时湍流运动粘度较小,可以更有效减阻;气泡沿着流向会聚并,气泡越小聚并越剧烈;较高航速和小吃水更有利于减阻。

关键词：两相欧拉模型微气泡减阻船舶摩擦阻力数值模拟