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Effect of screening colonoscopy frequency on colorectal cancer mortality in patients with a family history of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 354-363页

作者： Li Zheng Bin Li Ling Lei Li-jia Wang zhi-Ping Zeng jian-Dong Yang Department of Gastroenterology The First Hospital of NanchangNanchang 330008Jiangxi ProvinceChina Department of General Surgery The First Hospital of NanchangNanchang 330008Jiangxi ProvinceChina

BACKGROUND Colorectal cancer is a common malignant tumor in China,and its incidence in the elderly is increasing *** bowel disease is a group of chronic non-specific intestinal inflammatory diseases,including ulcerative colitis and Crohn’s *** included the clinicopathological and follow-up data of patients with colorectal cancer who underwent laparoscopic colectomy or open colectomy at our Gastrointestinal Department between January 2019 and December *** indicators,oncological indicators,and survival rates were compared between the *** results of 104 patients who met the above criteria were extracted from the database(laparoscopic colectomy group=63,open colectomy group=41),and there were no statistically significant differences in the baseline data or follow-up time between the two *** Intraoperative blood loss,time to first ambulation,and time to first fluid intake were significantly lower in the laparoscopic colectomy group than in the open colectomy *** differences in overall mortality,tumor-related mortality,and recurrence rates between the two groups were not statistically significant,and survival analysis showed that the differences in the cumulative overall survival,tumor-related survival,and cumulative recurrence-free rates between the two groups were not statistically *** In elderly patients with colorectal cancer,laparoscopic colectomy has better short-term outcomes than open colectomy,and laparoscopic colectomy has superior long-term survival outcomes compared with open colectomy.

关键词： Colorectal cancer Laparoscopic surgery Open surgery Prognosis Laparoscopic colectomy Open colectomy

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Alzheimer’s disease early diagnostic and staging biomarkers revealed by large-scale cerebrospinal fluid and serum proteomic profiling

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The Innovation 2024年第1期5卷 118-126页

作者： Qing-Qing Tao Xue Cai Yan-Yan Xue Weigang Ge Liang Yue Xiao-Yan Li Rong-Rong Lin Guo-Ping Peng Wenhao jiang Sainan Li Kun-Mu Zheng Bin jiang jian-Ping jia Tiannan Guo zhi-Ying Wu Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310009China Liangzhu Laboratory Zhejiang UniversityHangzhou 311100China Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzho 310024China Department of Neurology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Neurology First Affiliated HospitalSchool of MedicineXiamen UniversityXiamen 361009China Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijing 100053China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhou 310058China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China

Amyloid-b,tau pathology,and biomarkers of neurodegeneration make up the core diagnostic biomarkers of Alzheimer disease(AD).However,these proteins represent only a fraction of the complex biological processes underlying AD,and individuals with other brain diseases in which AD pathology is a comorbidity also test positive for these diagnostic *** ADspecific early diagnostic and disease staging biomarkers are *** this study,we performed tandem mass tag proteomic analysis of paired cerebrospinal fluid(CSF)and serum samples in a discovery cohort comprising 98 *** biomarkers were validated by parallel reaction monitoring–based targeted proteomic assays in an independent multicenter cohort comprising 288 *** quantified 3,238 CSF and 1,702 serum proteins in the discovery cohort,identifying 171 and 860 CSF proteins and 37 and 323 serum proteins as potential early diagnostic and staging biomarkers,*** the validation cohort,58 and 21 CSF proteins,as well as 12 and 18 serum proteins,were verified as early diagnostic and staging biomarkers,*** 19-protein CSF and an 8-protein serum biomarker panels were built by machine learning to accurately classify mild cognitive impairment(MCI)due to AD from normal cognition with areas under the curve of 0.984 and 0.881,*** 19-protein CSF biomarker panel also effectively discriminated patients with MCI due to AD from patients with other neurodegenerative ***,we identified 21 CSF and 18 serum stage-associated proteins re-flecting AD *** findings provide a foundation for developing bloodbased tests for AD screening and staging in clinical practice.

关键词： cerebrospinal Alzheimer fluid

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MPDZ variants associated with epilepsies and/or febrile seizures and the individualized genotype-phenotype correlation

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Genes & Diseases 2024年第4期11卷 124-127页

作者： Junxia Luo Yun Li Yong Lv Xin Li Bing Qin Chuanfang Cheng Xiaorong Liu Weiping liao Jie Wang Zaifen Gao Department of Epilepsy Center Children's Hospital Affiliated to Shandong UniversityJinanShandong 250022China Department of Epilepsy Center Jinan Children's HospitalJinanShandong 250022China Department of Brain Function and Neuroelectrophysiology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Pediatrics The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)HefeiAnhui 230001China Department of Pediatrics The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Epilepsy Center and Department of Neurosurgery The First Affliated Hospital of Jinan UniversityGuangzhouGuangdong 510630China Department of Cardiology The Second Afiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510260China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University GuangzhouGuangdong 510260China Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China GuangzhouGuangdong 510260China

The multiple PDZ domain crumbs cell polarity complex component gene(MPDZ;MIM:603785),is highly expressed in the brain across the whole *** encodes the multiple PDZ domain protein,which is a member of the NMDAR signaling complex that may play a role in the control of AMPAR potentiation and synaptic plasticity in excitatory synapses."Previously,MPDZ variants have been demonstrated to be associated with autosomal recessive congenital hydrocephalus-2(HYC2;MIM:615219)which is commonly complicated by brain abnormalities and developmental *** were reported in only one *** association between MPDz and epilepsy requires clarification.

关键词： epilepsy febrile congenital

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Comparison of different surrogate markers of muscle mass for the diagnosis of sarcopenia in patients with colorectal cancer

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Journal of Nutritional Oncology 2024年第1期9卷 25-36页

作者： jia-Le Li Qi Zhou Qi-WenWang De-Cheng Luo jiang-Hong Huang Xin-Long Yu Si-zhi Liang Shuang-Yi Tang jia-Liang Gan Department of Pharmacy the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Colorectal and Anal Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Grade 2020 the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina

Background:This study compared the validity of the creatinine-to-cystatin C ratio(CCR),sarcopenia index(SI),and relative skeletalmuscle index(RSMI)as predictors of sarcopenia in patients with colorectal cancer(CRC)and explored their impact on the patient ***:We retrospectively studied patients with CRC who underwent surgical intervention at the Department of Colorectal and Anal Surgery,situatedwithin the First Affiliated Hospital of GuangxiMedical *** investigation spanned from January 2015 to December 2017,encompassing a cohort of patients subject to surgical management forCRC during this ***’s correlation analysis was employed to evaluate the relationships between the CCR,SI,RSMI,and skeletal muscle index(SMI)and the patient *** operating characteristic(ROC)curves were generated to evaluate the predictive precision of these biomarkers and ascertain the optimal cutoff *** logistic regression analysis was conducted to pinpoint the independent factors linked with *** analyses,contingent on different surrogate markers of muscle mass and sarcopenia,were performed utilizing the Kaplan-Meier method alongside the log-rank ***:Weenrolled 815 patientswithCRC(522 male and 293 female patients)whowere eligible for the *** accordancewith the guidelines set forth by the International Consensus on Sarcopenia,sarcopenia was diagnosed in a collective total of 503 patients.A Pearson’s correlation coefficient(r)analysis demonstrated that the CCR,SI,and RSMI were positively correlated with the *** both male and female patients,the RSMI(male:r=0.400,P<0.001;female:r=0.640,P<0.001)was more strongly correlated with the SMI than with the CCR(male:r=0.203,P<0.001;female:r=0.192,P<0.001)or SI(male:r=0.335,P<0.001;female:r=0.285,P<0.001).In male patients,the areas under the ROC curves(AUC)for the CCR,SI,and RSMI were 0.596[(95%confidence interval(CI)=0.545-0.647)],0.648(95%CI=0.599-0.698),a

关键词： Colorectal cancer Creatinine-to-cystatin C ratio Sarcopenia index Relative skeletal muscle index Sarcopenia

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贸易协定如何影响中国进口?——基于条款深度的视角

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上海对外经贸大学学报 2024年第4期31卷 108-124页

作者：廖佳潘春阳上海对外经贸大学国际经贸学院上海201620 华东理工大学商学院上海200237

本文基于2001~2019年107个中国贸易伙伴国的面板数据,运用多维固定效应泊松伪极大似然估计方法 (PPML法)估计了贸易协定及其深度对中国进口的影响。研究发现,贸易协定显著扩大了中国从协定签署国的进口规模,且该结论在考虑贸易协定条款... 详细信息

本文基于2001~2019年107个中国贸易伙伴国的面板数据,运用多维固定效应泊松伪极大似然估计方法 (PPML法)估计了贸易协定及其深度对中国进口的影响。研究发现,贸易协定显著扩大了中国从协定签署国的进口规模,且该结论在考虑贸易协定条款的法律效力和时滞效应并使用工具变量法进行内生性处理及稳健性检验后依然成立。进一步分析发现,不同贸易协定条款对中国进口规模的影响存在异质性。“WTO-plus”条款显著促进了中国进口,其正向促进作用主要来自其中包含的十项边境条款;条款总深度对高科技含量产品和中间品进口存在较显著的正向影响,对中等科技含量产品和最终产品的进口存在较显著的负向影响,其中对中间品进口的促进作用主要来自“WTO-plus”条款,对中等科技含量产品进口的负向影响则主要来自“WTO-extra”条款。本文研究结论为我国通过签署贸易协定主动扩大进口、优化贸易结构提供了实证支撑。

关键词：贸易协定中国进口条款深度贸易模式转型

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Analysis of causal relationship between blood metabolites and prostate cancer by two-sample Mendelian randomization

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Life Research 2024年第4期7卷 42-47页

作者： Qing-Peng Jin Yang liao Rui-Yu Mou Yu-jia Du Wen Cheng Yun-Chao Zhang Wen-Hao Liu Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Graduate school of Tianjin University of Traditional Chinese Medicine Tianjin 301617China.

Objective:To investigate the causal relationship between blood metabolite levels and the occurrence of prostate cancer by using two-sample Mendelian randomization ***:Pooled data from public databases for genome-wide association analyses of blood metabolites and prostate cancer were selected,and inverse variance weighting(IVW)was used as the primary method for estimating the causal effects,while heterogeneity tests,gene multiplicity tests and sensitivity analyses were performed to assess the stability and reliability of the ***:A total of six known metabolites were found to potentially increase the risk of prostate cancer development(P<0.05),namely fructose,allantoin,5-hydroxytryptophan,potassium ketoisocaproate,glycyltryptophan,and 1-heptadecanoyl-glycerol-3-phosphorylcholine,with no heterogeneity or genetic pleiotropy ***:Six known blood metabolites may be potential risk factors for prostate cancer development in European populations.

关键词： Mendelian randomization prostate cancer blood metabolites causal association

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农户规模化经营与粮食生产外包服务转型——兼论区内服务替代跨区服务的理论逻辑

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江西财经大学学报 2024年第2期 69-81页

作者：刘家成徐志刚南京财经大学财政与税务学院江苏南京210023 南京农业大学经济管理学院江苏南京210095

近年来,中国粮食生产跨区服务逐渐萎缩而“双规模”(转入土地规模化种植的同时提供区内规模化外包服务)经营形式日益可见。在比较两类服务形式规模经济差异的基础上,分析中国粮食生产外包服务供给转型的理论逻辑,并利用来自吉林、江苏... 详细信息

近年来,中国粮食生产跨区服务逐渐萎缩而“双规模”(转入土地规模化种植的同时提供区内规模化外包服务)经营形式日益可见。在比较两类服务形式规模经济差异的基础上,分析中国粮食生产外包服务供给转型的理论逻辑,并利用来自吉林、江苏、四川3省504个外包服务组织的专题调研数据,检验农户规模化经营对不同形式外包服务作业成本、收益的差异化影响。研究结果表明:区内服务替代跨区服务是当前外包服务供给转型的基本趋势,以地块集中连片和家庭经营总面积扩大为表征的农户规模化经营是外包服务由跨区向区内转变的重要原因;从内在机制来看,农户规模化经营虽然对区内服务和跨区服务均有降本增效作用,但区内服务的边际收益程度高于跨区服务。需要进一步强化地块集中连片质量,提高外包服务发展支持政策调整的灵活度,打破地域观念的束缚以增进区域间的交流与合作,全方面为外包服务转型提供政策支持。

关键词：规模化经营相对规模经济优势区内服务跨区服务

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水泵水轮机非同步导叶启动工况三维模拟研究

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中国农村水利水电 2024年第3期 231-237页

作者：杨志炎方红弓路家廖庭庭上海勘测设计研究院有限公司上海200434

水泵水轮机低水头启动时,空载工况附近S特性明显,工况点进入后,机组宏观参数易发生振荡。为研究低水头启动工况机组快速稳定的内流机理,设置非同步导叶,引入调速器参数,通过三维模拟分析启动全过程宏观参数、压力脉动与流态的演变规律... 详细信息

水泵水轮机低水头启动时,空载工况附近S特性明显,工况点进入后,机组宏观参数易发生振荡。为研究低水头启动工况机组快速稳定的内流机理,设置非同步导叶,引入调速器参数,通过三维模拟分析启动全过程宏观参数、压力脉动与流态的演变规律。结果表明,启动过程初期导叶同步开启,转速较小,转轮叶道内产生大范围失速涡,压力呈低频高幅值波动;转速上升过程中,流态逐渐平顺,压力脉动逐渐降低;进入调速器调节阶段后,工况点进入S区,压力脉动呈高频高幅值,而非同步导叶破坏了无叶区产生的高速水环,促使机组快速稳定。

关键词：水泵水轮机启动过程非同步导叶流态压力脉动

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集成可编程光芯片的研究与功能验证

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电子学报 2024年第5期52卷 1524-1533页

作者：李智慧梁宇鑫范诗佳廖海军刘大鹏冯靖崔乃迪联合微电子中心有限责任公司硅基光电子中心重庆401332

随着对高速、超紧凑数据信号管理需求的日益增长,光子集成电路(Photonics Integrated Circuits,PIC)在先进的光子信号处理中受到广泛关注,其中可编程光芯片因其特有的通用性、可重构特性逐渐受到开发者的青睐.本文依托联合微电子中心有... 详细信息

随着对高速、超紧凑数据信号管理需求的日益增长,光子集成电路(Photonics Integrated Circuits,PIC)在先进的光子信号处理中受到广泛关注,其中可编程光芯片因其特有的通用性、可重构特性逐渐受到开发者的青睐.本文依托联合微电子中心有限责任公司(United MicroElectronics Center ***,CUMEC)的绝缘体上硅(Silicon-On-Insulator,SOI)自主工艺平台,设计并制备了包含9个六边形单元的3×3六边形架构可编程光芯片,利用迭代扫描法实现了消光比高达30 dB的开关电压标定,并通过扁平化版图优化设计使芯片尺寸降低了21%;采用此可编程光芯片进一步完成了典型功能验证:通过对输入输出端的可调基本单元(Tunable Basic Unit,TBU)耦合系数进行调谐,可实现消光比、谐振波长、自由光谱范围可调的马赫曾德尔干涉仪(Mach-Zehnder Interferometer,MZI)/微环谐振腔(Micro-Ring Resonator,MRR),消光比可高达42.3 dB/28 dB;可实现延时量大范围可调谐的延时线及任意输入/输出端口之间的路由.该芯片是目前世界上规模最大的六边形架构可编程光芯片,并实现了与有源单元的单片集成,在微波光子信号处理、化学生物传感、量子信息、光计算领域具有广阔的应用前景.

关键词：光子集成电路可编程光芯片可重构硅光平台功能验证

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习近平关于政治判断力论述的核心要义、生成逻辑与价值意蕴

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湘潭大学学报（哲学社会科学版） 2024年第2期48卷 120-124页

作者：张佳宁刘志东北师范大学思想政治教育研究中心吉林长春130024

政治建设是党的根本性建设,政治判断力提升是政治能力建设的关键。习近平关于政治判断力论述揭示了政治判断力的基本内涵,阐述了提高政治判断力的重大意义,指明了提高政治判断力的实践路径;其生成的理论逻辑在于它是对马克思主义从政治... 详细信息

政治建设是党的根本性建设,政治判断力提升是政治能力建设的关键。习近平关于政治判断力论述揭示了政治判断力的基本内涵,阐述了提高政治判断力的重大意义,指明了提高政治判断力的实践路径;其生成的理论逻辑在于它是对马克思主义从政治上分析问题思想方法的创新运用,历史逻辑在于它是对中国共产党注重政治能力建设宝贵经验的继承发展,实践逻辑在于它是立足“两个大局”、防范化解重大风险的现实需要;其价值意蕴在于它建构了中国共产党政治能力建设的内容体系,发扬了中国共产党善作善成的实干作风,彰显了中国共产党勇于自我革命的精神品质。

关键词：习近平政治判断力核心要义生成逻辑价值意蕴

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