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Development of a prognostic model for one-year surgery risk in Crohn’s disease patients: A retrospective study

World Journal of Gastroenterology 2020年第5期26卷 524-534页

作者： jia-yin yao Yi jiang jia Ke Yi Lu Jun Hu Min Zhi Department of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Anesthesiology Guangzhou Hospital of Traditional Chinese MedicineGuangzhou 510130Guangdong ProvinceChina Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510655Guangdong ProvinceChina

BACKGROUND Accelerated therapeutic treatment should be considered in patients with progressive Crohn’s disease(CD)to prevent complications as well as ***,screening for risk factors and predicting the need for early surgery are of great importance in clinical *** To establish a model to predict CD-related early *** This was a retrospective study collecting data from CD patients diagnosed at our inflammatory bowel disease center from January 1,2012 to December 31,*** data were randomly stratified into a training set and a testing set at a ratio of 8:*** logistic regression analysis was conducted with receiver operating characteristic curves constructed and areas under the curve *** model was further validated with calibration and discrimination estimated.A nomogram was finally *** A total of 1002 eligible patients were enrolled with a mean follow-up period of 53.54±13.10 *** total,24.25%of patients received intestinal surgery within 1 year after diagnosis due to complications or disease *** behavior(B2:OR[odds ratio]=6.693,P<0.001;B3:OR=14.405,P<0.001),smoking(OR=4.135,P<0.001),body mass index(OR=0.873,P<0.001)and C-reactive protein(OR=1.022,P=0.001)at diagnosis,previous perianal(OR=9.483,P<0.001)or intestinal surgery(OR=8.887,P<0.001),maximum bowel wall thickness(OR=1.965,P<0.001),use of biologics(OR=0.264,P<0.001),and exclusive enteral nutrition(OR=0.089,P<0.001)were identified as independent significant factors associated with early intestinal surgery.A prognostic model was established and further *** receiver operating characteristic curves and calculated areas under the curves(94.7%)confirmed an ideal predictive ability of this model with a sensitivity of 75.92%and specificity of 95.81%.A nomogram was developed to simplify the use of the predictive model in clinical *** This prognostic model can effectively predict 1-year risk of CD-related intest

关键词： Crohn’s disease Prognostic model Nomogram Early surgery Inflammatory bowel disease Retrospective study

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The efficacy and safety of thalidomide in the treatment of refractory Crohn’s disease in adults:a double-center,double-blind,randomized–controlled trial

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Gastroenterology Report 2022年第1期10卷 519-525页

作者： Xiang Peng Zi-Wen Lin Min Zhang jia-yin yao Jun-Zhang Zhao Pin-Jin Hu Qian Cao Min Zhi Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology Sir Run Run Shaw Hospital Affiliated to Zhejiang UniversityHangzhouZhejiangP.R.China

Background Thalidomide is applied in therapy for refractory Crohn’s disease(CD)in adults,but systematic and rigorous clinical evidence is *** aim was to provide theoretical references for the efficacy of thalidomide in the therapy for refractory CD in *** A double-center,double-blind,placebo-controlled,randomized clinical trial of refractory CD in adults in two inflammatory bowel disease centers in *** the double-blind trial,patients were randomly assigned to 100mg of thalidomide or placebo daily for 8 *** primary outcome was considered as the clinical remission rate calculated based on the Crohn’s disease activity index at the eighth week following thalidomide or placebo *** open label,nonresponse to placebo was additionally treated with 8 weeks of thalidomide;all responders were continuously treated with thalidomide until the 48th *** Twenty-five patients were randomly assigned to each *** the eighth week,the clinical remission rate in the thalidomide group was significantly higher than that in the placebo group(68.0%[17/25]vs 16.0%[4/25];relative risk,4.2;95%confidence interval,1.8–10.9,P<0.001).After a 48-week follow-up,the continuous treatment rate of thalidomide was 46.3%(19/41).Adverse events during the whole process were reported in 58.5%of patients,mainly involving drowsiness,rash,and peripheral neuropathy that were mild and *** Thalidomide can be used in the induction and maintenance therapy of refractory CD in *** it could be one of the treatment options for refractory CD.

关键词： Crohn’s disease thalidomide refractory clinical remission

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Research on Credit Regulation Mechanism of E-commerce Platform Based on Evolutionary Game Theory

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 330-359页

作者： Zeguo Qiu Yuchen yin yao Yuan Yunhao Chen School of Computer and Information Engineering Harbin University of CommerceHarbin150028China School of Management Harbin University of CommerceHarbin150028China

In the growing e-commerce industry,the problem of malicious business operations has become increasingly prominent,exposing many problems such as weak supervision of e-commerce platforms and no way for consumers to *** order to solve the problems of counterfeit and shoddy products on e-commerce platforms and promote the sustainable development of the e-commerce industry in China,this paper constructs a three-party evolutionary game model of e-commerce platforms,merchants,and consumers,investigates the influence of each influencing factor on each party’s strategy choice,and provides targeted suggestions to e-commerce platforms based on relevant ***,the impact of several important parameters on the equilibrium solution is discussed through sensitivity *** results show that:1)the smaller the cost difference between active and negative regulation,the more the e-commerce platform tends to active regulation strategy,but increasing fines for dishonest merchants and consumer complaints have little impact on the e-commerce platform;2)increasing consumer compensation,creating an honest business environment,and reducing the cost of honest business all help companies tend to operate in good faith;3)the only factor that affects the tendency of consumer complaint strategies is the cost of *** loss suffered by silence and the compensation given to consumers have little effect on consumers’tendency to complain *** results can provide theoretical guidance for participants to make useful strategic decisions in the e-commerce market.

关键词： Evolutionary game e-commerce data simulation

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Infinitely Many Solutions for a Class of Quasi-linear Elliptic Problem

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 728-743页

作者： Xiao-yao jia Zhen-luo LOU School of Economics and Management Zhongyuan University of TechnologyZhengzhou 450007China Mathematics and Statistics School Henan University of Science and TechnologyLuoyang 471023China

In this paper,we study the following quasi-linear elliptic equation:■where Ω?R^(N) is a bounded domain,λ>0 is a *** function ψ(|t|)t is the subcritical term,and φ(|t|)t is the critical Orlicz-Sobolev growth term with respect to φ.Under appropriate conditions on φ,ψ and φ,we prove the existence of infinitely many weak solutions for quasi-linear elliptic equation,for λ∈(0,λ_(0)),where λ_(0)> 0 is a fixed constant.

关键词： quasi-linear elliptic equations variational methods Orlicz-Sobolev spaces

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A Quick Calculation Method for Radiation Pattern of Submillimeter Telescope with Deformation and Displacement

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Research in Astronomy and Astrophysics 2024年第3期24卷 249-265页

作者： jia You Yi-Wei yao Zheng Wang School of Automation Southeast UniversityNanjing 210096China

Radiation pattern captures the electromagnetic performance of reflector antennas,which is significantly affected by the deformation of the primary reflector due to gravity and the displacement of the secondary *** the design process of large reflector antennas,a substantial amount of time is often dedicated to iteratively adjusting structural parameters and validating electromagnetic *** improve the efficiency of the design process,we first propose an approximate calculation method of optical path difference(OPD)for the deformation of the primary reflector under gravity and the displacement of the secondary *** an OPD fitting function based on the modified Zernike polynomials is proposed to capture the phase difference of radiation over the aperture plane,based on which the radiation pattern will be obtained quickly by the aperture field integration *** experiments demonstrate the effectiveness of the proposed quick calculation method for analyzing the radiation pattern of a 10.4 m submillimeter telescope antenna at its highest operating frequency of 856 *** comparison with the numerical simulation method based on GRASP(which is an antenna electromagnetic analysis tool combining physical optics(PO)and physical theory of diffraction(PTD)),the quick calculation method reduces the time for radiation pattern analysis from more than one hour to less than two ***,the quick calculation method exhibits excellent accuracy for the figure of merit(FOM)of the radiation ***,the proposed quick calculation method can obtain the radiation pattern with high speed and *** to the time-consuming numerical simulation method(PO and PTD),it can be employed for quick analysis of the radiation pattern for the lateral displacement of the secondary reflector and the deformation of the primary reflector under gravity in the design process of a reflector antenna.

关键词： instrumentation high angular resolution-methods data analysis-methods analytical

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A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

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Petroleum Science 2024年第3期21卷 1865-1874页

作者： Ji Wang Ning Qi Hong-yao yin Yu-Jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR.China Tianfu Yongxing Laboratory New Theory and Technology of CO_(2) Capture Research CenterChengdu610065SichuanPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well ***,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDPA),and examined comparatively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDPA for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDPA—20 wt%HCl solution maintains stable viscosity of 90 m Pa s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m Pa s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDPA remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and *** reaction rate of 2.5 wt%EDPA HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDPA to be used in the high-temperature reservoirs *** work improved the thermal tolerance of VES in highly concentrated HCl solution,paving a feasible way for the acidization of high-temperature reservoir environments(~150℃).

关键词： Viscoelastic surfactants Thermal stability Self-diverting acid Wormlike micelles Acidizing stimulation

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Global output feedback regulation of time-varying nonlinear systems via the dual-gain method

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Science China(Information Sciences) 2024年第5期67卷 333-334页

作者： Xian-Long yin Zong-yao SUN Changyun WEN Institute of Automation Qufu Normal University School of Electrical and Electronic Engineering Nanyang Technological University

Notably, owing to the limited information available, the problem of output feedback stabilization/regulation for nonlinear systems has been explored based on state *** addition, the sensors accounting for state measurement could fail to detect the system states accurately due to the limitations of manufacturing techniques and instruments.

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ANovel Non-Isolated Cubic DC-DC Converter with High Voltage Gain for Renewable Energy Power Generation System

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Energy Engineering 2024年第1期121卷 221-241页

作者： Qin yao Yida Zeng Qingui jia School of Electrical Engineering Southwest Jiaotong UniversityChengdu610036China

In recent years,switched inductor(SL)technology,switched capacitor(SC)technology,and switched inductor-capacitor(SL-SC)technology have been widely applied to optimize and improve DC-DC boost converters,which can effectively enhance voltage gain and reduce device *** address the issue of low output voltage in current renewable energy power generation systems,this study proposes a novel non-isolated cubic high-gain DC-DC converter based on the traditional quadratic DC-DC boost converter by incorporating a SC and a SL-SC ***,the proposed converter’s details are elaborated,including its topology structure,operating mode,voltage gain,device stress,and power ***,a comparative analysis is conducted on the voltage gain and device stress between the proposed converter and other high-gain ***,a closed-loop simulation system is constructed to obtain simulation waveforms of various devices and explore the dynamic ***,an experimental prototype is built,experimental waveforms are obtained,and the experimental dynamic performance and conversion efficiency are *** theoretical analysis’s correctness is verified through simulation and experimental *** proposed converter has advantages such as high voltage gain,low device stress,high conversion efficiency,simple control,and wide input voltage range,achieving a good balance between voltage gain,device stress,and power *** proposed converter is well-suited for renewable energy systems and holds theoretical significance and practical value in renewable energy *** provides an effective solution to the issue of low output voltage in renewable energy power generation systems.

关键词： Cubic DC-DC converter high voltage gain low device stress high efficiency renewable energy

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Research on Data Tampering Prevention Method for ATC Network Based on Zero Trust

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Computers, Materials & Continua 2024年第3期78卷 4363-4377页

作者： Xiaoyan Zhu Ruchun jia Tingrui Zhang Song yao School of Computer Science Hefei University of TechnologyHefei230000China College of Computer Science Sichuan UniversityChengdu610065China Sichuan University-Pittsburgh Institute Sichuan UniversityChengdu610065China School of Information and Business Management Chengdu Neusoft UniversityChengdu610065China

The traditional air traffic control information sharing data has weak security characteristics of personal privacy data and poor effect,which is easy to leads to the problem that the data is *** from the application of the ATC(automatic train control)network,this paper focuses on the zero trust and zero trust access strategy and the tamper-proof method of information-sharing network *** the improvement of ATC’s zero trust physical layer authentication and network data distributed feature differentiation calculation,this paper reconstructs the personal privacy scope authentication structure and designs a tamper-proof method of ATC’s information sharing on the *** the single management authority to the unified management of data units,the systematic algorithm improvement of shared network data tamper prevention method is realized,and RDTP(Reliable Data Transfer Protocol)is selected in the network data of information sharing resources to realize the effectiveness of tamper prevention of air traffic control data during *** results show that this method can reasonably avoid the tampering of information sharing on the Internet,maintain the security factors of air traffic control information sharing on the Internet,and the Central Processing Unit(CPU)utilization rate is only 4.64%,which effectively increases the performance of air traffic control data comprehensive security protection system.

关键词： Zero trust access policy air traffic information sharing network privacy data tam-per-proof certification features

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Aggregation-Induced Catalysis: Asymmetric Catalysis with Chiral Aggregates

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Research 2024年第1期2023卷 525-532页

作者： yao Tang Yu Wang Qingkai Yuan Sai Zhang jia-yin Wang Shengzhou Jin Ting Xu Junyi Pan Kazimierz Surowiec Guigen Li Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79409-1061USA School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210093China School of Pharmacy Continuous Flow Engineering Laboratory of National Petroleum and Chemical IndustryChangzhou UniversityChangzhouJiangsu 213164China

So far,there have been 4 methods to control chirality including the use of chiral auxiliaries,reagents,solvents,and catalysts documented in literature and *** them,asymmetric catalysts are normally divided into homogeneous and heterogeneous *** this report,we present a new type of asymmetric control—asymmetric catalysis via chiral aggregates that would not belong to the above *** new strategy is represented by catalytic asymmetric dihydroxylation reaction of olefins in which chiral ligands are aggregated by taking advantage of typical aggregation-induced emission systems containing tetrahydrofuran and H_(2)O *** was proven that the chiral induction can be enhanced from er of 78:22 to 97:3 simply by changing the ratios of these 2 cosolvents.

关键词： chiral asymmetric Chiral

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