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Efficacy and Safety of COX-2 Inhibitor Parecoxib for Rigid Cystoscopyrelated Pain Management in Male Patients:A Prospective,Randomized and Controlled Study

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Current Medical Science 2019年第1期39卷 94-98页

作者： jia-yin sun Zheng-shuai SONG Xiao-ping ZHANG Xing-yuan XIAO Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Using anesthetic gel may not sufficiently exclude pain perception during and after cystoscopy in male *** evaluate the analgesic efficacy and safety of intramuscular parecoxib(40 mg)for outpatient-based rigid cystoscopy,we performed a prospective,randomized and controlled *** male patients requiring diagnostic cystoscopy in our hospital were divided into group A(1%tetracaine gel,n=50)and group B(parecoxib,n^5l)at *** received intramuscular injections of either 2 mL sterile saline in group A or 40 mg parecoxib in group B 30 min before the *** gel was injected into the urethra 3 min before the procedure in group A,with patients receiving plain lubricant gel in group B at the same ***-associated pain levels were evaluated using the Visual Analog Score(VAS)during the ***-procedure urethral pain and complications were recorded and *** results showed that male patients experienced significantly less pain in group B than in group A(2.70±1.36 V5.3.56±1.74,P=0.008).The percentage of patients with dysuria pain was not significantly different between the two *** addition,24 h after cystoscopy,the patients with no previous experience of cystoscopy were more likely to declare urethral pain(59.2%vs.33.3%,P=0.012,relative risk=1.78).No difference was observed in analgesic-related complications between the two *** conclude that intramuscular injection of 40 mg parecoxib may improve comfort for male patients undergoing rigid cystoscopy.

关键词： cystoscopy parecoxib tetracaine gel analgesia

Feasibility and clinical benefits of the double-ProGlide technique for hemostasis after cryoballoon atrial fibrillation ablation with uninterrupted oral anticoagulants

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Journal of Geriatric Cardiology 2023年第4期20卷 268-275页

作者： jia-yin sun Chang-Bo XUAN Hai-Liang YU Hai-Yang WANG Hong-Ya HAN Zhi-Ming ZHOU De-An jia Dong-Mei SHI Yu-Jie ZHOU Shi-Wei YANG Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel Diseasethe Key Laboratory of Remodeling-Related Cardiovascular DiseaseMinistry of EducationBeijingChina Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Department of Cardiology Tangshan Fengrun District Second People’s HospitalHebeiChina Department of Cardiology Qingdao Municipal HospitalQingdaoChina

OBJECTIVE To access the efficacy and safety of the double-ProGlide technique for the femoral vein access-site closure in cryoballoon ablation with uninterrupted oral anticoagulants(OAC),and its impact on the electrophysiology laboratory time as well as hospital stay after the procedure in this observational *** Patients with atrial fibrillation undergoing cryoballoon ablation with uninterrupted OAC at Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing,China from May 2019 to May 2021 were enrolled in this *** October 2020,double-ProGlide technique was consistently used for hemostasis(ProGlide group),and before that conventional manual compression was utilized(manual compression group).The occurrence of vascular and groin complications was accessed during the hospital stay and until the three-month *** A total of 140 participants(69.30%of male,mean age:59.21±10.29 years)were evaluated,70 participants being in each *** hemostasis was achieved in all the patients with ProGlide *** major vascular complications were found in the ProGlide group while two major vascular complications were occurred in the manual compression *** incidence of any groin complication was obviously higher in subjects with manual compression than patients with ProGlide devices(15.71%vs.2.86%,P=0.009).In addition,compared with the manual compression group,the ProGlide group was associated with significantly shorter total time in the electrophysiology laboratory[112.0(93.3–128.8)min vs.123.5(107.3–158.3)min,P=0.006],time from sheath removal until venous site hemostasis[3.8(3.4–4.2)min vs.8.0(7.6–8.5)min,P<0.001],bed rest time[8.0(7.6–8.0)h vs.14.1(12.0–17.6)h,P<0.001]and hospital stay after the procedure[13.8(12.5–17.8)h vs.38.0(21.5–41.0)h,P<0.001].CONCLUSIONS Utilization of the double-ProGlide technique for hemostasis after cryoballoon ablation with uninterrupted OAC is feasible and safe,which has the clinical

关键词： balloon interrupted closure

ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer

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Current Medical Science 2023年第3期43卷 560-571页

作者： Yang-kai jiaNG Yu-jun SHUAI Hua-min DING Hui ZHANG Chao HUANG Liang WANG jia-yin sun Wen-jie WEI Xing-yuan XIAO Guo-song jiaNG Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology Jingshan Union Hospital of Huazhong University of Science and Technology(People's Hospital of Jingshan)Jingshan 431899China

Objective Cisplatin(CDDP)-based chemotherapy is a first-line,drug regimen for muscle-invasive bladder cancer(BC)and metastatic bladder ***,resistance to CDDP restricts the clinical benefit of some bladder cancer ***-rich interaction domain 1A(ARID1A)gene mutation occurs frequently in bladder cancer;however,the role of CDDP sensitivity in BC has not been *** We established ARID1A knockout BC cell lines using CRISPR/Cas9 ***50 determination,flow cytometry analysis of apoptosis,and tumor xenograft assays were performed to verify changes in the CDDP sensitivity of BC cells losing ***-PCR,Western blotting,RNA interference,bioinformatic analysis,and ChIP-qPCR analysis were performed to further explore the potential mechanism of ARID1A inactivation in CDDP sensitivity in *** It was found that ARID1A inactivation was associated with CDDP resistance in BC ***,loss of ARID1A promoted the expression of eukaryotic translation initiation factor 4A3(EIF4A3)through epigenetic *** expression of EIF4A3 promoted the expression of hsa_circ_0008399(circ0008399),a novel circular RNA(circRNA)identified in our previous study,which,to some extent,showed that ARID1A deletion caused CDDP resistance through the inhibitory effect of circ0008399 on the apoptosis of BC ***,EIF4A3-IN-2 specifically inhibited the activity of EIF4A3 to reduce circ0008399 production and restored the sensitivity of ARID1A inactivated BC cells to *** Our research deepens the understanding of the mechanisms of CDDP resistance in BC and elucidates a potential strategy to improve the efficacy of CDDP in BC patients with ARID1A deletion through combination therapy targeting EIF4A3.

关键词： AT-rich interaction domain 1A hsa_circ_0008399 eukaryotic translation initiation factor 4A3 cisplatin resistance bladder cancer

Seed Germination and Dormancy for Iris Chrysographes （Iridaceae） from China

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Journal of Agricultural Science and Technology(A) 2013年第6期3卷 498-502页

作者： Xiaofang Yu Zhuo Huang yin jia Lingxia sun Guangli Liu Huixing Song Yonghong Zhou Landscape Architecture College Triticeae Research Institute Sichuan Agricultural University Wenjiang 611130 Chengdu SichuanChina

Several Chinese Iris species have potential for medicinal and ornamental use, but they have poor, erratic or slow seed germination. The aims of this study was to classify Iris ehrysographes dormancy type and investigate the optimum treatment for seeds germination through examining the effects of various incubation temperatures, light conditions, scarification, stratification and soil substratum. Seed viability of/. chrysographes was 74% and seeds imbibed water very fast. No seeds germinated on stratification, soil substratum, constant or alternating temperatures, light and darkness treatments. Seeds germination of different mechanical restriction treatments had significant differences. The results indicated that：（1） removal of seed coat was the most effective treatment for/. chrysographes germination; （2） physiological dormancy phenomenon was found in this species.

关键词： Dormancy germination Iris chrysographes seed.

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu jiaxin Ren yingying sun Zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： yingjie Zhao Yicheng sun Chaoxin Pei Xing yin Xinyi Li Yi Hao Mengru Zhang Meng Yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

睾丸间质细胞中睾酮合成酶及蛋白表达的调控因子

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生殖与避孕 2009年第1期29卷 42-47页

作者：孙佳音应锋韩晓冬南京大学医学院免疫与生殖生物学实验室南京210093 江苏省医学分子技术重点实验室南京210093

近年从分子机制研究睾酮的合成需要一系列酶(P450scc、P450c17、3β-HSD、17β-HSD)及蛋白(SR-B1、StAR、PBR)这些酶及蛋白的表达取得很大进展,研究显示转录因子(SF-1、Nur77、PPARγ、AhR、NFκB、CREB、GATA-4)、花生四烯酸、磷酸酯酶... 详细信息

近年从分子机制研究睾酮的合成需要一系列酶(P450scc、P450c17、3β-HSD、17β-HSD)及蛋白(SR-B1、StAR、PBR)这些酶及蛋白的表达取得很大进展,研究显示转录因子(SF-1、Nur77、PPARγ、AhR、NFκB、CREB、GATA-4)、花生四烯酸、磷酸酯酶、TGF-α、GRTH、SREBP等都可通过调控靶基因而影响相应的酶及蛋白的表达和功能。

关键词：睾酮合成酶及蛋白调控因子睾丸间质细胞

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi sun Zelong Gong Tao Zhang jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang jia-Qian Ju Jing-Cai Liu Shao-Chen sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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