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Integrated UHPLC-MS and network pharmacology to explore the active constituents and pharmacological mechanisms of Shenzao dripping pills against coronary heart disease

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Traditional Medicine Research 2022年第3期7卷 68-80页

作者： Tao Hu Ke-Ning Zheng jia-yin liang Dan Tang Lu-Yong Zhang Ming-Hua Xian Shu-Mei Wang Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangzhou 510006China School of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Shenzao dripping pills(SZDP)is an empirical prescription of traditional Chinese medicine that is mainly used to treat coronary heart ***,the chemical composition and pharmacological mechanisms of SZDP are ***:In this study,ultra-high performance liquid chromatography-quadruple-Exactive Orbitrap mass spectrometry was used to identify the chemical components in extracts and medicated plasma of ***,we performed network pharmacology methods,including target prediction by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine,protein-protein interaction network via STRING database;further,the key targets and compounds were screened using ***,the key targets and compounds were validated by molecular ***:72 chemical constituents were identified from SZDP by high performance liquid chromatography and mass spectrometry *** the components absorbed into plasma by SZDP,24 prototype components and 9 metabolized components were *** network pharmacology analysis of the prototype components showed that there are 13 key compounds(including ginsenoside Rc,Rb1,Rb2,ferulic acid,etc.),90 proteins(including proto-oncogene tyrosine-protein kinase Src,nuclear receptor subfamily 3 group C member 1,caspase-3,etc.),and 10 pathways(including estrogen,IL-17 and VEGF signaling pathway,etc.)that play an essential role in the treatment of coronary heart disease with *** addition,the results of molecular docking revealed that ginsenosides Rc,Rb2 and Rb1 have strong binding activities to the caspase-3,as well as ginsenoside Rb2 to the nuclear receptor subfamily 3 group C member ***:This study showed that SZDP might act through multiple chemical constituents and targets against coronary heart disease.

关键词： Shenzao dripping pills coronary heart disease chemical constituents network pharmacology molecular docking

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Neuroprotective effect and mechanism of daidzein in oxygen-glucose deprivation/reperfusion injury based on experimental approaches and network pharmacology

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Traditional Medicine Research 2021年第5期6卷 10-19页

作者： Ming-Hua Xian Si-Kai Zhan Ke-Ning Zheng Qu-liu Ke-Ning Li jia-yin liang Shu-Mei Wang Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangzhou 510006China School of Traditional Chinese Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China

Background:Daidzein,phytoestrogens derived from the Pueraria lobata(Willd.)Ohwi root used in traditional Chinese medicine,has a wide range of biological activities,including antioxidant,anti-inflammatory,and ***,the neuroprotective role of daidzein in oxygen-glucose deprivation/reperfusion injury and its underlying mechanism are still ***:In this study,we used pheochromocytoma cells induced by oxygen-glucose deprivation and reperfusion to study the potential effect in the protection of the nerve ***,we used molecular docking simulation and network pharmacology to predict the possible targets and pharmacological pathways of *** blot was used to verify the expression of target proteins with or without adding the ***:After daidzein treatment,cell vitality had an upward trend(P<0.05)and the release of lactate dehydrogenase had a downward trend(P<0.01)in dose-dependent compared with the model group by exposure to oxygen-glucose deprivation and *** core targets were analyzed through network pharmacology and molecular docking including catalase,peroxisome proliferator-activated receptor gamma,vascular endothelial growth factor A,interleukin-6,tumor necrosis factor,nitric oxide synthase 3,prostaglandin-endoperoxide synthase 2,and RAC-alpha serine/threonine kinase *** results suggest that catalase may be a first-ranked target for the neuroprotective role of *** Ontology enrichment analysis indicated the pathways mainly contained molecule metabolic process,while Kyoto Encyclopedia of Genes and Genomes enrichment analysis focus on pathways in terms of inflammation such as tumor necrosis factor signal ***,Western blot results showed that daidzein had a significant increase on the expression of protein catalase(P<0.01).Daidzein reversed catalase level alterations after oxygen-glucose deprivation reperfusion injury in a dose-dependent manner which was consistent with the cata

关键词： daidzein neuroprotection catalase oxygen-glucose deprivation and reperfusion network pharmacology

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Post-Ugi反应的研究进展

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有机化学 2017年第9期37卷 2237-2249页

作者：李修明贾学顺殷亮上海大学化学系上海200444 中国科学院上海有机化学研究所中科院天然产物有机合成化学重点实验室上海200032

Ugi反应是一种高效的、原子经济性的多组分反应.Post-Ugi反应作为其拓展,是多取代杂环化合物的有效合成方法,受到人们的广泛关注.综述了post-Ugi反应的发展,重点总结了近些年来的相关报道.

关键词： post-Ugi反应杂环加成偶联

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

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Bresenham直线生成算法的改进

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中国图象图形学报 2008年第1期13卷 158-161页

作者：贾银亮张焕春经亚枝南京航空航天大学自动化学院南京210016

直线是图形的基本元素,研究其生成算法具有重要意义。由于经典的Bresenham直线生成算法一次计算只能生成一个像素点,效率较低。为了提高直线生成效率,通过对其进行改进,提出了一种利用直线前两行像素行的像素点数目来计算其余各像素行... 详细信息

直线是图形的基本元素,研究其生成算法具有重要意义。由于经典的Bresenham直线生成算法一次计算只能生成一个像素点,效率较低。为了提高直线生成效率,通过对其进行改进,提出了一种利用直线前两行像素行的像素点数目来计算其余各像素行的像素点数目的算法。该算法在保持Bresenham算法不使用取整和小数运算的优点下,还提高了直线生成效率,一次计算可以生成一个像素行。

关键词：计算机图形学 Bresenham算法判定变量

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Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao yin Yanting Li Zhiying Tian Qichao Li Chenhui jiang Enfu liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi liang Wenbo Ji jianhua Zhuang Yan Liu Jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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机载全姿态指示仪的图形变换

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应用科学学报 2009年第3期27卷 294-298页

作者：贾银亮张焕春经亚枝刘晶南京航空航天大学自动化学院南京210016 金陵科技学院信息技术学院南京210001

针对机载显示系统中图形变换最为耗时的全姿态指示仪画面,提出一种新的算法.该算法预测地平线各行的像素数,用水平线或竖直线作为扫描线进行填充,并在填充过程中实时计算地平线上各像素点的坐标,避免了建立地平线数组.与原有算法相比,... 详细信息

针对机载显示系统中图形变换最为耗时的全姿态指示仪画面,提出一种新的算法.该算法预测地平线各行的像素数,用水平线或竖直线作为扫描线进行填充,并在填充过程中实时计算地平线上各像素点的坐标,避免了建立地平线数组.与原有算法相比,减少了存储空间和计算量,提高了全姿态指示仪画面的图形变换速度.

关键词：填充算法全姿态指示仪电子综合显示

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基于多重竞争的无线传感器网络簇头选择算法

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传感器与微系统 2018年第2期37卷 140-142,146页

作者：贾银亮张驰宇梁康武南京航空航天大学自动化学院江苏南京210016

无线传感器网络(WSNs)需要简单而有效的算法提高网络的生存周期。在经典的分簇算法LEACH基础上,根据节点剩余能量进行竞争,剩余能量大于阈值的节点可以选为簇头。在选择簇头时,各节点设置延时时间,根据邻节点数、到已选定簇头的距离2个... 详细信息

无线传感器网络(WSNs)需要简单而有效的算法提高网络的生存周期。在经典的分簇算法LEACH基础上,根据节点剩余能量进行竞争,剩余能量大于阈值的节点可以选为簇头。在选择簇头时,各节点设置延时时间,根据邻节点数、到已选定簇头的距离2个因素进行竞争,选择合适的节点成为簇头。算法稳定了簇头数量,并使簇头分布更合理。仿真和数据分析表明:算法能显著提高网络的生存周期。

关键词：无线传感器网络能量均衡分簇网络生存周期

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快速直线生成算法

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金陵科技学院学报 2007年第3期23卷 9-12页

作者：刘晶李俊孙涵贾银亮金陵科技学院信息技术学院江苏南京210001 南京航空航天大学信息科学与技术学院江苏南京210016 南京航空航天大学自动化学院江苏南京210016

经典的Bresenham算法一次运算只能生成1个像素点,而双步直线生成算法一次能生成2个像素点,这些算法在计算时没有充分利用像素点之间的相关性因而效率不高。为了提高直线生成效率而对Bresenham算法和双步直线生成算法进行改进,提出一种... 详细信息

经典的Bresenham算法一次运算只能生成1个像素点,而双步直线生成算法一次能生成2个像素点,这些算法在计算时没有充分利用像素点之间的相关性因而效率不高。为了提高直线生成效率而对Bresenham算法和双步直线生成算法进行改进,提出一种快速直线生成算法。新算法利用直线的斜率来预测其像素行组合。生成直线时只在那些可能出现的像素行组合中进行选取,一次选取可以生成两个像素行,从而减少了计算量和循环次数,提高了直线生成效率。

关键词：计算机图形学 Bresenham算法快速算法判定变量

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