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Constructing the metabolic network of wheat kernels based on structure-guided chemical modification and multi-omics data

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Journal of Genetics and Genomics 2024年第7期51卷 714-722页

作者： Zhitao Tian Jingqi jia Bo yin Wei chen National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Metabolic network construction plays a pivotal role in unraveling the regulatory mechanism of biological activities,although it often proves to be challenging and labor-intensive,particularly with non-model *** this study,we develop a computational approach that employs reaction models based on the structure-guided chemical modification and related compounds to construct a metabolic network in *** construction results in a comprehensive structure-guided network,including 625 identified metabolites and additional 333 putative reactions compared with the Kyoto Encyclopedia of Genes and Genomes *** a combination of gene annotation,reaction classification,structure similarity,and correlations from transcriptome and metabolome analysis,a total of 229 potential genes related to these reactions are identified within this *** validate the network,the functionality of a hydroxycinnamoyltransferase(TraesCS3D01G314900)for the synthesis of polyphenols and a rhamnosyltransferase(TraesCS2D01G078700)for the modification of flavonoids are verified through in vitro enzymatic studies and wheat mutant tests,*** research thus supports the utility of structure-guided chemical modification as an effective tool in identifying causal candidate genes for constructing metabolic networks and further in metabolomic genetic studies.

关键词： Metabolic network Chemical modification Genetic study Wheat kernel Multi-omics

Towards Domain-agnostic Depth Completion

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Machine Intelligence Research 2024年第4期21卷 652-669页

作者： Guangkai Xu Wei yin jianming Zhang Oliver Wang Simon Niklaus Simon chen jia-Wang Bian Zhejiang University Hangzhou 310058China Dajiang Technology Shenzhen 518057China Adobe Research California 95110USA University of Oxford Oxford OX12JDUK

Existing depth completion methods are often targeted at a specific sparse depth type and generalize poorly across task *** present a method to complete sparse/semi-dense,noisy,and potentially low-resolution depth maps obtained by various range sensors,including those in modern mobile phones,or by multi-view reconstruction *** method leverages a data-driven prior in the form of a single image depth prediction network trained on large-scale datasets,the output of which is used as an input to our *** propose an effective training scheme where we simulate various sparsity patterns in typical task *** addition,we design two new benchmarks to evaluate the generalizability and robustness of depth completion *** simple method shows superior cross-domain generalization ability against state-of-the-art depth completion methods,introducing a practical solution to highqualitydepthcapture onamobile device.

关键词： Monocular depth estimation depth completion zero-shot generalization scene reconstruction neural network.

Numerical investigation on wheel-turnout rail dynamic interaction excited by wheel diameter difference in high-speed railway

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第8期18卷 660-676页

作者： Rong chen jia-yin chen Ping WANG Jing-mang XU Jie-ling XIAO MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong University Chengdu 610031 China School of Civil Engineering Southwest Jiaotong University Chengdu 610031 China

目的:车轮型面磨耗和加工误差导致轮对两侧车轮的轮径不同。本文旨在探讨不同幅值和分布形式的轮径差对道岔区轮轨接触几何、轮轨法向接触性能和车辆通过道岔动力响应的影响规律,提出保证车辆通过道岔时的安全性和舒适性的轮径差限值。... 详细信息

目的:车轮型面磨耗和加工误差导致轮对两侧车轮的轮径不同。本文旨在探讨不同幅值和分布形式的轮径差对道岔区轮轨接触几何、轮轨法向接触性能和车辆通过道岔动力响应的影响规律,提出保证车辆通过道岔时的安全性和舒适性的轮径差限值。创新点:通过数值仿真,分析轮径差对道岔区轮轨接触性能和轮轨动态相互作用的影响。方法:1.基于迹线法,揭示轮径差对道岔区轮轨接触几何的影响。2.通过建立轮轨接触有限元计算模型,探讨轮径差对轮轨法向接触性能的影响。3.通过建立车辆-道岔耦合动力学模型,综合考虑在不同幅值和分布形式的轮径差激励下,车辆通过道岔的轮轨动态相互作用、运行舒适性和磨耗指数评价指标,提出轮径差限值。结论:1.轮径差加剧了道岔区固有结构不平顺。2.轮径差通过改变轮载过渡位置,对尖轨上的轮轨法向接触性能有较大影响。3.可根据轮径差幅值将轮径差对道岔区轮轨动力响应的影响划分为三个区域:轮径差小于1.5 mm时,轮缘与尖轨提前接触使轮轨横向力快速增大;轮径差在1.5~2.5 mm时,等值同相轮径差使车辆通过道岔失稳;轮径差大于2.5 mm时,轮缘与尖轨的持续接触增强了车辆稳定性,但增加了轮轨磨耗。4.建议将轮径差控制在2.5 mm以内,且应控制同相分布轮径差小于2 mm。

关键词：轮径差道岔轮轨接触行为轮轨系统动力性能高速铁路

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Alpha-gal syndrome

Chinese Medical Journal 2024年第10期137卷 1234-1236页

作者： Mengyuan Zhan Shaohui chen Tengda Xu jia yin Hao Li Zhouxian Pan Ning Cui Liping Wen Department of Allergy Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China State Key Laboratory of Complex Severe and Rare Diseases Beijing 100730China National Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID) Beijing 100730China Department of Health Care Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Anesthesiology Chinese Academy of Medical College and Peking Union Medical College HospitalBeijing 100730China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing Key Laboratory of Vector Borne and Natural Focus Infectious DiseasesBeijing 100071China The No.154 Hospital XinyangHenan 464000China

To the Editor:Meat is an important source of protein and could be roughly classied into red and white *** meat,which encompasses poultry,seafood such assh and shrimp,and reptiles,etc.,is characterized by its pale color when *** meat is basically mammalian meat,including domestic animal meats,such as pork,beef,lamb,and wild animal meat in certain regions,such as kangaroos,seals,and *** mammalian meat appears red due to the presence of myoglobin in skeletal *** clinical presentations of mammalian meat allergy comprise two types of allergic reactions,immediatetype and delayed-type,although both are mediated by immunoglobulin E(IgE).The immediate-type hypersensitivity manifests as allergic symptoms occurring shortly after ingestion of red meat and is primarily triggered by serum albumin and immunoglobulin which are the major allergenic *** is the classic pattern of food *** delayed-type hypersensitivity is characterized by delayed onset of allergic symptoms 2-6 h after red meat ingestion and is mediated by oligosaccharideα-gal-specic IgE which is a recently discoveried pattern of food allergy.

关键词： allergic Alpha pattern

A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo Qin Yuan Lei Luo Bao You-jia Zhang Ke-yin Liu Yu-Hong chen Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China Key Laboratory of Myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China State Key Laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(P<0.01).Additionally,ONOO-levels were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,P<0.01 for AH;OR=1.004,95%CI:1.002-1.006,P<0.001 for plasma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,P<0.01 for AH;R=0.45,P<0.001 for plasma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,P<0.001).However,administering MnTMPyP to mouse eyes reversed the elevated IOP caused by SIN-1(P<0.05).CONCLUSION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG ***,ONOO-is a potential biomarker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

Rogue wave solutions and rogue-breather solutions to the focusing nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 33-41页

作者： Si-jia chen Xing Lü College of Science Tianjin University of TechnologyTianjin 300384People's Republic of China Department of Mathematics Beijing Jiaotong UniversityBeijing 100044People's Republic of China Beijing Laboratory of National Economic Security Early-warning Engineering Beijing Jiaotong UniversityBeijing 100044People's Republic of China

Based on the long wave limit method,the general form of the second-order and third-order rogue wave solutions to the focusing nonlinear Schr?dinger equation are given by introducing some arbitrary *** interaction solutions between the first-order rogue wave and one-breather wave are constructed by taking a long wave limit on the two-breather *** applying the same method to the three-breather solutions,two types of interaction solutions are obtained,namely the first-order rogue wave and two breather waves,the second-order rogue wave and one-breather wave,*** influence of the parameters related to the phase on the interaction phenomena is graphically *** occur among the rogue waves and breather *** the collisions,the shape of them remains *** abundant interaction phenomena in this paper will contribute to a better understanding of the propagation and control of nonlinear waves.

关键词： nonlinear Schrodinger equation rogue wave solutions interaction solutions

Big Theta Equals Small Theta Generically

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Acta Mathematica Sinica,English Series 2024年第3期40卷 717-730页

作者： Rui chen jia Liang ZOU Institute for Advanced Study in Mathmatics Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics University of Michigan530 Church StAnn ArborMI 48109USA

In this paper we consider the theta correspondence over a non-Archimedean local *** the homological method and the theory of derivatives,we show that under a mild condition the bigtheta lift is irreducible.

关键词： Theta correspondence derivatives

Bioinspired nanomaterials for wearable sensing and human–machine interfacing

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Nano Research 2024年第2期17卷 445-461页

作者： Vishesh Kashyap Junyi yin Xiao Xiao Jun chen Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and *** sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional *** review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical *** also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry.

关键词： bioinspired nanomaterials human–machine interface wearable sensors wearable bioelectronics

From dichotomy to diversity:deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy

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Cancer Biology & Medicine 2024年第2期21卷 132-138页

作者： Xiumei Wang Jun chen Guangshuai jia Department of Immunology and Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Jinfeng Laboratory Chongqing 401329China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510182China

Macrophages are innate immune cells that are ubiquitously distributed throughout the vertebrate *** orchestrate sophisticated processes in development,homeostasis,immunity,and *** residing in tumor tissues are commonly known as tumor-associated macrophages(TAMs)and promote or inhibit tumor growth depending on the activation state2.

关键词： immunity homeostasis tumor