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Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension

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World Journal of Gastroenterology 2024年第13期30卷 1859-1870页

作者： Rong Chen Ling Luo Yun-Zhi Zhang zhen.Liu An-Lin Liu yi-Wen Zhang Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient *** transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival *** our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on ***,the development of an innovative modeling approach is essential to address this *** To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone *** The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively *** were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for *** Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)*** on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD *** Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of *** model’s acc

关键词： Bayesian network Cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Survival prediction model

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Towards full-stack deep learning-empowered data processing pipeline for synchrotron tomography experiments

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The Innovation 2024年第1期5卷 127-138页

作者： zhen.Zhang Chun Li Wenhui Wang zhen. Dong Gongfa Liu Yuhui Dong yi Zhang National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

Synchrotron tomography experiments are transitioning into multifunctional,cross-scale,and dynamic characterizations,enabled by new-generation synchrotron light sources and fast developments in beamline ***,with the spatial and temporal resolving power entering a new era,this transition generates vast amounts of data,which imposes a significant burden on the data processing ***,as a highly accurate and efficient data processing method,deep learning shows great potential to address the big data challenge being encountered at future synchrotron *** this review,we discuss recent advances employing deep learning at different stages of the synchrotron tomography data processing *** also highlight how applications in other data-intensive fields,such as medical imaging and electron tomography,can be migrated to synchrotron ***,we provide our thoughts on possible challenges and opportunities as well as the outlook,envisioning selected deep learning methods,curated big models,and customized learning strategies,all through an intelligent scheduling solution.

关键词： processing pipeline outlook

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MicroR-9c-5p and novel-mir50 co-target Akt to regulate Lasioderma serricorne reproduction

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Insect Science 2024年第1期31卷 106-118页

作者： yi Yan Dong-Dong Qin Hong Yang Kang-Kang Xu Can Li Wen-jia Yang Provincial Key Laboratory for Agricultural Pest Management of Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

High fecundity is a common characteristic of insect pests which increases the difficulty of population ***/threonine kinase Akt is an indispensable component of the insulin signaling *** of LsAkt severely hinders reproduction in Lasioderma serricorne,a stored product insect ***,the post-transcriptional pathway of LsAkt in *** remains *** study identified 2 binding sites of miR-9c-5p and novel-mir50 in the coding sequences of *** expression profiles of 2 microRNAs(miRNAs)and LsAkt displayed an opposite pattern during the adult *** reporter assay showed that novel-mir50 and miR-9c-5p could downregulate the expression of *** of miR-9c-5p and novel-mir50 by injection of mimics inhibited the expression of LsAkt and reduced oviposition,decreased egg hatchability,and blocked ovarian *** also decreased the expression of genes involved in ovarian development(LsVg and LsVgR)and the nutritional signaling pathway(LsTOR,LsS6K,and Ls4EBP),and reduced the phosphorylation of ***,injection of miR-9c-5p and novel-mir50 inhibitors induced the expressions of LsAkt,LsVg,LsVgR,LsTOR,LsS6K,and Ls4EBP,enhanced Akt phosphorylation level,and accelerated ovarian *** of bovine insulin downregulated the expression of miR-9c-5p and novel-mir50 and upregulated the LsAkt *** also rescued the reproductive development defects associated with miR-9c-5p/novel-mir50 overexpression,forming a positive regulatory loop of insulin *** results indicate that miR-9c-5p/novel-mir50 regulates the female reproduction of *** by targeting Akt in response to insulin *** data also demonstrate the effects of the insulin/miRNA/Akt regulatory axis in insect reproduction.

关键词： Akt insulin Lasioderma serricorne microRNA reproduction

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Optical edge-to-screw singularity state conversions

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Photonics Research 2024年第8期12卷 1689-1695页

作者： HAOLIN LIN JUNHUI jia GUOHUA LIU YANWEN HU zhen.LI zhen.IANG CHEN SHENHE FU Department of Optoelectronic Engineering Jinan University Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Guangdong Provincial Engineering Research Center of Crystal and Laser Technology

Optical singularity states, which significantly affect propagation properties of light in free space or optical medium, can be geometrically classified into screw and edge types. These different types of singularity states do not exhibit direct connection, being decoupled from each other in the absence of external *** we demonstrate a novel optical process in which a higher-order edge singularity state initially nested in the propagating Gaussian light field gradually involves into a screw singularity with a new-born topological charge determined by order of the edge state. The considered edge state comprises an equal superposition of oppositely charged vortex and antivortex modes. We theoretically and experimentally realize this edge-to-screw conversion process by introducing intrinsic vortex–antivortex interaction. We also present a geometrical representation for mapping this dynamical process, based on the higher-order orbital Poincaré sphere. Within this framework, the edge-to-screw conversion is explained by a mapping of state evolution from the equator to the north or south pole of the Poincaré sphere. Our demonstration provides a novel approach for manipulating singularity state by the intrinsic vortex–antivortex interactions. The presented phenomenon can be also generalized to other wave systems such as matter wave, water wave, and acoustic wave.

关键词： Bose Einstein condensates Light beams Light propagation Optical media Optical vortices Structured light

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Monotonic mechanical behaviour of compacted completely decomposed granite with various inclusion levels of incineration bottom ash

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 670-679页

作者： Han-Lin WANG Cheng-Shuang yiN Qian-yi ZHANG Qi-Wei LIU zhen.Yu yiN Dong-Xing XUAN Askar KHASANOV Research Center for Advanced Underground Space Technologies of Hunan University Changsha 410082China Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan UniversityChangsha 410082China College of Civil Engineering Hunan UniversityChangsha 410082China School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Applied and Theoretical Mechanics Samarkand State UniversitySamarkandUzbekistan

1 Introduction Completely decomposed granite(CDG)is widely distributed in South China(Xu et al.,2022;Wang et al.,2023).The parent granite rock mass gradually loses features during the weathering process,and thus needs to be reinforced when used(Lan et al.,2003;Dassekpo et al.,2017;Alamanis et al.,2021).On the other hand,considering the huge demand for construction materials and limited natural resources,it is increasingly important to fully utilize solid waste(Gruhler et al.,2019;Anagnostopoulos et al.,2020;jiang et al.,2022,2023a,2023b).With high strength and environment-friendly characteristics,incineration bottom ash(IBA)seems to be a suitable reinforcement material for CDG(Ahmed and Khalid,2011;Alhassan and Tankó,2012;Toraldo et al.,2013;Lynn et al.,2017;Xuan et al.,2018;Tang et al.,2020).

关键词： incineration behaviour utilize

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Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1291-1298页

作者： Qi jia Jin Li Xiaofeng Guo yi Li You Wu Yuliang Peng Zongping Fang Xijing Zhang Department of Anesthesiology and Perioperative Medicine and Department of Intensive Care Unit Xijing Hospital The Fourth Military Medical University Department of Critical Care Medicine Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University

Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis, while providing nutrients and support for cell survival. Chaperone-mediated autophagy activity can be detected in almost all cells, including neurons. Owing to the extreme sensitivity of neurons to their environmental changes, maintaining neuronal homeostasis is critical for neuronal growth and survival. Chaperone-mediated autophagy dysfunction is closely related to central nervous system diseases. It has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy dysfunction. Under certain conditions, regulation of chaperone-mediated autophagy activity attenuates neurotoxicity. In this paper, we review the changes in chaperone-mediated autophagy in neurodegenerative diseases, brain injury, glioma, and autoimmune diseases. We also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases.

关键词： chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis neuroprotection

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Risk factors,prognostic factors,and nomograms for distant metastasis in patients with diagnosed duodenal cancer:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1384-1420页

作者： jia-Rong Shang Chen-yi Xu Xiao-Xue Zhai Zhe Xu Jun Qian Department of Oncology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Proctology Nanjing Hospital of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Digestive Cancer Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Duodenal cancer is one of the most common subtypes of small intestinal cancer,and distant metastasis(DM)in this type of cancer still leads to poor *** nomograms have recently been used in tumor areas,no studies have focused on the diagnostic and prognostic evaluation of DM in patients with primary duodenal *** To develop and evaluate nomograms for predicting the risk of DM and person-alized prognosis in patients with duodenal *** Data on duodenal cancer patients diagnosed between 2010 and 2019 were extracted from the Surveillance,Epidemiology,and End Results *** and multivariate logistic regression analyses were used to identify independent risk factors for DM in patients with duodenal cancer,and univariate and multivariate Cox proportional hazards regression analyses were used to determine independent prognostic factors in duodenal cancer patients with *** novel nomograms were established,and the results were evaluated by receiver operating characteristic(ROC)curves,calibration curves,and decision curve analysis(DCA).RESULTS A total of 2603 patients with duodenal cancer were included,of whom 457 cases(17.56%)had DM at the time of *** analysis revealed independent risk factors for DM in duodenal cancer patients,including gender,grade,tumor size,T stage,and N stage(P<0.05).Univariate and multivariate COX analyses further identified independent prognostic factors for duodenal cancer patients with DM,including age,histological type,T stage,tumor grade,tumor size,bone metastasis,chemotherapy,and surgery(P<0.05).The accuracy of the nomograms was validated in the training set,validation set,and expanded testing set using ROC curves,calibration curves,and DCA *** results of Kaplan-Meier survival curves(P<0.001)indicated that both nomograms accurately predicted the occurrence and prognosis of DM in patients with duodenal *** The two nomograms are expected as effective tools fo

关键词： Duodenal cancer Distant metastasis Nomogram Risk factors Prognostic factors

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Optimizing FeCoNiCrTi high-entropy alloy with hydrogen pumping effect to boost de/hydrogenation performance of magnesium hydride

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Rare Metals 2024年第7期43卷 3273-3285页

作者： Meng-Chen Song Fu-ying Wu yi-Qun jiang Xiu-zhen.Wang Hu Zhao Li-Xin Chen Liu-Ting Zhang School of Energy and Power Instrumental Analysis CenterJiangsu University of Science and TechnologyZhenjiang 212003China Max Planck Institute for Iron Research 40237DuisseldorfGermany School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The exploration of efficient,long-lived and cost-effective transition metal catalysts is highly desirable for the practical hydrogen storage of magnesium hydride(MgH_(2)) in sustainable energy ***,FeCoNiCrTi high-entropy alloy(HEA) nanosheets were prepared via a facile wet chemical ball milling strategy and they were introduced into MgH_(2) to boost the hydrogen storage *** refined HEA exhibited superior catalytic activity on MgH_(2).In contrast to additive-free MgH_(2),the initial desorption temperature of the constructed MgH_(2)-HEA composite was reduced from 330.0 to 198.5℃ and a remarkable 51% reduction in the dehydrogenation activation energy was ***,the MgH_(2)-HEA composite only required one-twentieth time of that consumed by pure MgH_(2) to absorb 5.0 wt% of H_(2) at 225℃.The synergy between the "hydrogen pumping" effect of Mg_2Ni/Mg_2NiH_4 and Mg_2Co/Mg_2CoH_5 couples,as well as the good dispersion of Fe,Cr and Ti on the surface of MgH_(2) contributed to the enhanced de/hydrogenation performance of the MgH_(2)-HEA *** study furnishes important steering for the design and fabrication of multiple transition metal catalysts and may push the commercial application of magnesium-based hydrides one step forward.

关键词： Hydrogen storage Magnesium hydride High-entropy alloys Catalysis

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Degradation of o-dichlorobenzene by DBD-NTP co-modified titanium gel catalyst

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Journal of Environmental Sciences 2024年第9期143卷 71-84页

作者： Wenbo Zhang yi Xing Wei Su jiaqing Wang Haoqi jia Yongkang Cui Jing Chen Hui Zhang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science and Technology BeijingBeijing 100083China Guangdong Province Engineering Laboratory for Air Pollution Control Guangzhou 510530China College of Environmental and Resource Sciences Shanxi UniversityTaiyuan 030006China Sinosteel Maanshan Mine Research Institute Co.Ltd. Anhui 243071China

In order to study the degradation process of dioxins in industrial flue gas,the decomposition of o-dichlorobenzene(o-DCB)in a DBD plasma catalytic reactor was *** results showed that an NTP-catalyzed system,especially using the Cu Mn Ti Oxcatalyst,had better o-DCB degradation performance compared to plasma *** combination of the Cu Mn Ti Oxcatalyst with NTP can achieve a degradation efficiency of up to 97.2%for o-DCB;the selectivity of CO and CO_(2)and the carbon balance were 40%,45%,and 85%,*** dielectric constant and electrical property results indicated that the surface discharge capacity of the catalysts played a major role in the degradation of o-DCB,and a higher dielectric constant could suppress the plasma expansion and enhance the duration of the plasma discharge per discharge *** to the O1s XPS and O_(2)-TPD results,the conversion of CO to CO_(2)follows the M-v-K mechanism;thus,the active species on the catalyst surface play an important ***,the Cu Mn Ti Oxand NTP mixed system exhibited excellent stability,which is probably because Cu doping improved the lifetime of the *** work can provide an experimental and theoretical basis for research in the degradation of o-DCB by plasma catalyst systems.

关键词： o-dichlorobenzene(o-DCB) Non-thermal plasma catalysis Ozone concentration

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Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He Fei Wang Nan Wang yi-cheng Fu Zihao Xing Zhiyu jia Guo-Yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction

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