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Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

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World Journal of Diabetes 2021年第1期12卷 19-46页

作者： Yang Zhou Xiao-Yu Ma Jin-Yu Han Min Yang Chuan Lv ying Shao yi-Li Wang jia-yi kang Qiu-Yue Wang Department of Endocrinology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gerontology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Clinical Laboratory The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Endocrinology The People’s Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Endocrinology Shengjing Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is significantly increasing worldwide,and the incidence of its complications is also on the *** of the main complications of T2DM is diabetic kidney disease(DKD).The glomerular filtration rate(GFR)and urinary albumin creatinine ratio(UACR)increase in the early *** the disease progresses,UACR continue to rise and GFR begins to decline until endstage renal disease *** the same time,DKD will also increase the incidence and mortality of cardiovascular and cerebrovascular *** present,the pathogenesis of DKD is not very ***,exploration of the pathogenesis of DKD to find a treatment approach,so as to delay the development of DKD,is essential to improve the prognosis of *** To detect the expression of tenascin-C(TNC)in the serum of T2DM patients,observe the content of TNC in the glomerulus of DKD rats,and detect the expression of TNC on inflammatory and fibrotic factors in rat mesangial cells(RMCs)cultured under high glucose condition,in order to explore the specific molecular mechanism of TNC in DKD and bring a new direction for the treatment of *** The expression level of TNC in the serum of diabetic patients was detected by enzyme-linked immunosorbent assay(ELISA),the protein expression level of TNC in the glomerular area of DKD rats was detected by immunohistochemistry,and the expression level of TNC in the rat serum was detected by *** glomerular mesangial cells were *** high glucose stimulation,the expression levels of related proteins and mRNA were detected by Western blot and polymerase chain reaction,*** ELISA results revealed an increase in the serum TNC level in patients with *** UACR and hypertension significantly increased the expression of TNC(P<0.05).TNC expression was positively correlated with glycosylated haemoglobin(HbA1c)level,body mass index,systolic blood pressure,and UACR(P<0.05).Immunohistochemical staining showe

关键词： Tenascin-C miR-155-5p Metformin Type 2 diabetes mellitus Diabetic kidney disease Toll-like receptor 4

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang jia-Zhu Wen Li-kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Janus MXene film with gradient structure for highly efficient terahertz and infrared electromagnetic absorption

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Nano Research 2025年第1期18卷 434-442页

作者： Shaodian Yang Weiqiang Huang Zhiqiang Lin Zibo Chen Rongliang Yang yi jia Xuebin Liu Rui Wang Zhiping Zeng Yougen Hu Huanjun Chen Xuchun Gui11 State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China National Key Laboratory of Materials for Integrated Circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China China Academy of Aerospace Science and Innovation Beijing 100176China Guangdong Province Key Laboratory of Display Material and Technology Guangzhou 510275China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

Electromagnetic interference (EMI) shielding inhigh-frequency range, especially the rapidly growing terahertz(THz) frequency range, attracts increasing attention due tothe potential application of terahertz in 6G wirelesscommunication, and security inspection. However, traditionalconductive EMI films typically achieve high shieldingeffectiveness through strong reflection, which may causesecondary pollution to other devices. Here, a gradientstructure strategy was proposed to constructTi_(3)C_(2)Tx/hydroxypropyl methyl cellulose (HPMC) film, in whichthe content of Ti_(3)C_(2)Tx gradually increases along the thicknessdirection, resulting in different conductivity of the two surfaces(surface-M and surface-H) for the film. The obtained gradientfilmexhibits an EMI shielding efficiency of over 48.5 dB in theTHz range (0.2-1.6 THz) at a thickness of 40 μm. Especially,as the THz waves incident from the surface-H to the film, the absorption effectiveness reaches 48.2 dB (average absorbedpower loss up to 91.4%), and the reflection effectiveness is only 0.3 dB. In additions, the gradient-film also demonstrates ahigh absorption rate of 95.5% in the infrared band (2.5-16.7 μm). Moreover, the gradient-film exhibits an excellent tensilestress and Young’s modulus value of 173.1 MPa and 2.8 GPa, respectively. Therefore, the gradient-film proposed in thiswork, with excellent electromagnetic absorption in both THz and infrared band, provides a promising candidate for the nextgenerationEMI shielding applications.

关键词： electromagnetic interference shielding Janus film terahertz MXene

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Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-Yuan kang yi-Ting Chang Sheng-Yang Huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

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Science Letters:Multi-frequency proportional-resonant (MFPR) current controller for PWM VSC under unbalanced supply conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第10期8卷 1527-1531页

作者： HU jia-bing HE yi-kang Sehool of Eleetrieal Engineering Zhejiang University Hangzhou 310027 China

This letter presents a multi-frequency proportional-resonant （MFPR） current controller developed for PWM voltage source converter （VSC） under the unbalanced supply voltage conditions. The delta operator is used in place of the shift operator for the implementation of MFPR by using a low-cost fixed-point DSE The experimental results with an alternative control strategy validated the feasibility of the proposed MFPR current controller for the PWM VSC during voltage unbalance.

关键词： PWM VSC Multi-frequency proportional-resonant (MFPR) Voltage unbalance

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Dynamic modelling and robust current control of wind-turbine driven DFIG during external AC voltage dip

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第10期7卷 1757-1764页

作者： HU jia-bing HE yi-kang Department of Electrical Engineering Zhejiang University Hangzhou 310027 China

Doubly-Fed Induction Generator （DFIG）, with vector control applied, is widely used in Variable-Speed Constant- Frequency （VSCF） wind energy generation system and shows good performance in maximum wind energy capture. But in two traditional vector control schemes, the equivalent stator magnetizing current is considered invariant in order to simplify the rotor current inner-loop controller. The two schemes can perform very well when the grid is in normal condition. However, when grid disturbance such as grid voltage dip or swell fault occurs, the control performance worsens, the rotor over current occurs and the Fault Ride-Through （FRT） capability of the DFIG wind energy generation system gets seriously deteriorated. An accurate DFIG model was used to deeply investigate the deficiency of the traditional vector control. The improved control schemes of two typical traditional vector control schemes used in DFIG were proposed, and simulation study of the proposed and traditional control schemes, with robust rotor current control using Internal Model Control （IMC） method, was carded out. The validity of the proposed modified schemes to control the rotor current and to improve the FRT capability of the DFIG wind energy generation system was proved by the comparison study.

关键词： Wind energy generation Variable-Speed Constant-Frequency (VSCF) Doubly-Fed Induction Generator (DFIG) Fault Ride-Through (FRT) Internal Model Control (IMC)

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Dynamic modeling and direct power control of wind turbine driven DFIG under unbalanced network voltage conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1731-1740页

作者： jia-bing HU yi-kang HE Lie XU School of Electrical Engineering Zhejiang University Hangzhou 310027 China Department of Electronics and Electrical Engineering University of Strathclyde Glasgow G40PG UK

This paper proposes an analysis and a direct power control (DPC) design of a wind turbine driven doubly-fed induction generator (DFIG) under unbalanced network voltage conditions. A DFIG model described in the positive and negative synchronous reference frames is presented. Variations of the stator output active and reactive powers are fully deduced in the presence of negative sequence supply voltage and rotor flux. An enhanced DPC scheme is proposed to eliminate stator active power oscillation during network unbalance. The proposed control scheme removes rotor current regulators and the decomposition processing of positive and negative sequence rotor currents. Simulation results using PSCAD/EMTDC are presented on a 2-MW DFIG wind power generation system to validate the feasibility of the proposed control scheme under balanced and unbalanced network conditions.

关键词： Doubly-fed induction generator (DFIG) Wind turbine Direct power control (DPC) Stator voltage oriented (SVO) Unbalanced network

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Enhanced control of DFIG-used back-to-back PWM VSC under unbalanced grid voltage conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1330-1339页

作者： HU jia-bing HE yi-kang NIAN Heng School of Electrical Engineering Zhejiang University Hangzhou 310027 China

This paper presents a unified positive-and negative-sequence dual-dq dynamic model of wind-turbine driven doubly-fed induction generator(DFIG) under unbalanced grid voltage conditions. Strategies for enhanced control and operation of a DFIG-used back-to-back(BTB) PWM voltage source converter(VSC) are proposed. The modified control design for the grid-side converter in the stationary αβ frames diminishes the amplitude of DC-link voltage ripples of twice the grid frequency,and the two proposed control targets for the rotor-side converter are alternatively achieved,which,as a result,improve the fault-ride through(FRT) capability of the DFIG based wind power generation systems during unbalanced network supply. A complete unbalanced control scheme with both grid-and rotor-side converters included is designed. Finally,simulation was carried out on a 1.5 MW wind-turbine driven DFIG system and the validity of the developed unified model and the feasibility of the proposed control strategies are all confirmed by the simulated results.

关键词： Unbalanced grid voltage Doubly-fed induction generator (DFIG) Back-to-back (BTB) Fault-ride through (FRT) Voltage source converter (VSC)

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