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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 543-548页

作者： Li-ping wang Xu-dong Xu jia-xing wang Department of Materials Physics and Chemistry School of Materials Science and Engineering University of Science and Technology Beijing

Oil-soluble In2O3 nanoparticles and In2O3-SnO2 nanocomposites were prepared in oleylamine via decomposition of metal acety- lacetonate precursors. Thin films of In2O3 and In2O3-SnO2 were obtained by spin-coating solutions of the oil-soluble In2O3 nanoparticles and In2O3-SnO2 nanocomposites onto substrates and then calcining them. Transmission electron microspectroscopy, scanning electron mi- crospectroscopy, atomic force microspectroscopy, X-ray diffraction, ultraviolet-visible absorption, and photoluminescence spectroscopy were used to investigate the properties of the nanoparticles and thin films. The In2O3 nanoparticles were cubic-phased spheres with a diame- ter of-8 nm; their spectra exhibited a broad emission peak centered at 348 nm. The In2O3-SnO2 nanocomposites were co-particles composed of smaller In2O3 particles and larger SnO2 particles; their spectra exhibited a broad emission peak at 355 nm. After the In2O3-SnO2 nano- composites were calcined at 400℃, the obtained thin films were highly transparent and conductive, with a thickness of 30-40 nm; the sur- faces of the thin films were smooth and crack-free.

关键词： indium trioxide tin dioxide nanoparficles nanocomposites thin films calcination

Photo-grafting Poly(acrylic acid) onto Poly(lactic acid) Chains in Solution

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Chinese Journal of Polymer Science 2020年第2期38卷 137-142,I0005页

作者： jia-xing wang Yan-Bin Huang Wan-Tai Yang Department of Chemical Engineering Tsinghua University

Poly(lactic acid)(PLA)is one of the most important bio-plastics,and chemical modification of the already-polymerized poly(lactic acid)chains may enable optimization of its material properties and expand its application *** this study,we demonstrated that poly(lactic acid)can be readily dissolved in acrylic acid at room temperature,and acrylic acid can be graft-polymerized onto poly(lactic acid)chains in solution with the help of photoinitiator benzophenone under 254 nm ultraviolet(UV)*** photo-grafting polymerization of acrylic acid(PAA)has only been studied before in the surface modification of polymer *** graft ratio could be controlled by various reaction parameters,including irradiation time,benzophenone content,and monomer/polymer *** photo-grafting reaction resulted in high graft ratio(graft ratio PAA/PLA up to 180%)without formation of homopolymers of acrylic *** the PAA/PLA graft ratio was higher than 100%,the resulting PLA-g-PAA polymer was found dispersible in *** pros and cons of the photo-grafting reaction were also discussed.

关键词： Photo-grafting Polymer modification Poly(acrylic acid) Poly(lactic acid)

Characteristics of central visual field defect after macular hole surgery

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 451-456页

作者： jia-Nan Li jia-xing wang Xin-Lei Zhu Hua Yan Department of Ophthalmology Tianjin Medical University General Hospital Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Department of Ophthalmology Emory University

AIM: To investigate the characteristics of postoperative central visual field defect(cVFD) in patients with macular hole(MH).METHODS: Eighteen eyes from 18 MH patients were involved in this retrospective study which reviewed square root of loss variance(sLV) and mean defect(MD) of the visual field test in all subjects. The relationship between cVFD and MH stage, as well as the postoperative ellipsoid zone disruption were evaluated using Spearman's correlation test. RESULTS: Our analysis determined Spearman coefficient is 0.705 for the correlation between sLV and MH stage(P<0.01), 0.877 for the correlation between sLV and postoperative ellipsoid zone disruption(P<0.01) and 0.721 for the correlation between MD and postoperative ellipsoid zone disruption(P<0.01). A significant relationship was also detected between postoperative ellipsoid zone disruption and MH stage(r=0.470, P<0.05). Univariate regression analysis indicated that sLV and MD were associated with postoperative ellipsoid zone disruption(P<0.01, P<0.01, respectively). CONCLUSION: Postoperative cVFD is highly correlated with MH stage and postoperative ellipsoid zone disruption in patients with MH.

关键词： central visual field defect macular hole photoreceptor regeneration ellipsoid zone

Effects of Mn and Cr contents on microstructures and mechanical properties of low temperature bainitic steel

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Journal of Iron and Steel Research International 2017年第3期24卷 290-295页

作者： Hui Guo Peng Zhou Ai-min Zhao Chao Zhi Ran Ding jia-xing wang Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing 100083 China Institute of Engineering Research University of Science and Technology Beijing Beijing 100083 China

The effects of Mn and Cr contents on bainitic transformation kinetics,microstructures and mechanical properties of high-carbon low alloy steels after austempered at 230,300 and 350 ℃ were determined by dilatometry,optical microscopy,scanning electron microscopy,X-ray diffraction and tensile tests. The results showed that Mn and Cr can extend bainitic incubation period and completion time,and with the increase of Mn and Cr content,the bainitic ferrite plate thickness decreased and the volume fraction of retained austenite increased. TRIP（ transformation induced plasticity） effect was observed during tensile testing which improved the overall mechanical property. The increase of Mn concentration can improve the strength to a certain extent,but reduce the ductility. The increase of Cr concentration can improve the ductility of bainitic steels which transformed at a low temperature. The low temperature bainitic steel austempered at 230 ℃ exhibited excellent mechanical properties with ultimate tensile strength of（ 2146 ± 11） MPa and total elongation of（ 12. 95 ± 0. 15） %.

关键词： Low temperature bainitic steel Kinetics Retained austenite TRIP effect

Abnormal expression of miR-331 leads to impaired heart function

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Science Bulletin 2019年第14期64卷 1011-1017页

作者： Jin-Jing Zhang Li-Peng wang Rong-Chang Li Meng wang Zeng-Hui Huang Min Zhu jia-xing wang Xiu-Jie wang Shi-Qiang wang Ming Xu Department of Cardiology Institute of Vascular Medicine Peking University Third Hospital NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing Key Laboratory of Cardiovascular Receptors Research State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China State Key Laboratory of Membrane Biology College of Life Sciences Peking University Beijing 100871 China Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

MicroRNAs (miRNAs) play important roles in maintaining normal heart function. Abnormal expression of miR-331 has been observed in the hearts of patients with atrial fibrillation and Marfan syndrome. However, whether miR-331 regulates cardiac function under physiological and pathological conditions still remains unknown. In the present study, we investigated the function and underlying mechanisms of miR-331 in a pressure overload-induced heart failure model and miR-331 transgenic rat model. First, we found that the expression of miR-331-3p exhibited a 1.7-fold increase in hypertrophy compared with that in the sham group (P<0.01), yet the expression of miR-331-5p remained unchanged. Furthermore, overexpression of miR-331 in cardiomyocytes and defective excitation-contraction (E-C) coupling efficiency were observed. Luciferase assays showed that miR-331-3p suppressed JPH2 expression by binding to the coding region of JPH2 mRNA. Finally, in the miR-331 transgenic rat model, JPH2 expression was suppressed at both the mRNA and protein levels in vivo, which resulted in impairment of both the E-C coupling efficiency of cardiomyocytes and systolic function of the heart. This finding mechanistically linked miR-331 to JPH2 downregulation and suggested an important role for the abnormal expression of miR-331 leading to the dysfunction of E-C coupling in heart failure.

关键词： MiR-331 Excitation-contraction coupling Junctophilin 2 Heart function

Effects of congenital ptosis on the refractive development of eye and vision in children

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1788-1793页

作者： Xiao-Yu Zeng jia-xing wang Xiao-Li Qi Xue-Han Qian Nan Wei Tianjin Medical University Eye Institute Tianjin Medical University Eye HospitalCollege of Optometry and OphthalmologyTianjin Medical UniversityTianjin 300384China Department of Ophthalmology Emory University School of MedicineAtlantaGeorgia 30322USA

AIM:To investigate the influence of unilateral congenital ptosis on the development of the eye and vision in ***:In this prospective observational study,41 patients with unilateral congenital ptosis were enrolled(age range 3-15y).The blepharoptosis was divided into 3 subgroups according to the margin reflex distance-1(MRD-1),including mild group(MRD-1>2 mm),moderate group(0

关键词： unilateral congenital ptosis axial length AL/CR ratio amblyopia

Progress in the study of animal models of atherosclerosis

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TMR Pharmacology Research 2021年第1期1卷 20-27页

作者： Xue-Qing He Bo-Han Qu Xiao-Hui Jin jia-xing wang Qian Xu Chengde Medical College Chengde 067000China

Atherosclerosis is corporate in clinical practice,and it can cause a series of complications such as coronary heart disease,which seriously threatens human *** to the relatively complex factors of its treatment,there is no exact etiology at *** is essential to establish an animal model of atherosclerosis that can be evaluated and reproducible to study its pathogenesis and clinical treatment *** article reviews the selection of atherosclerotic model animals and the established methods of models to explore more in-depth research and clinical practice of atherosclerosis.

关键词： Atherosclerosis Aanimal model Modeling approach

京津冀地区主要排放源减排对PM_(2.5)污染改善贡献评估

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环境科学 2017年第3期38卷 867-875页

作者：吴文景常兴邢佳王书肖郝吉明清华大学环境学院环境模拟与污染控制国家重点联合实验室北京100084 国家环境保护大气复合污染来源与控制重点实验室北京100084

研究选取2012年1月和7月作为冬夏两季代表时段,利用CMAQ/2D-VBS模型分析了冬夏两季京津冀地区主要排放源减排30%对改善区域PM_(2.5)污染的效果.结果表明,工业源对PM_(2.5)污染的贡献最大,其次是民用源,但工业源单位减排量贡献低于民用源... 详细信息

研究选取2012年1月和7月作为冬夏两季代表时段,利用CMAQ/2D-VBS模型分析了冬夏两季京津冀地区主要排放源减排30%对改善区域PM_(2.5)污染的效果.结果表明,工业源对PM_(2.5)污染的贡献最大,其次是民用源,但工业源单位减排量贡献低于民用源,交通源和电厂源的整体贡献和单位减排量贡献均较小.工业部门内贡献最大的为钢铁冶金行业,其次是水泥、工业锅炉、炼焦、石灰砖瓦和化工行业.与各部门各物种排放量的比较反映出各排放源贡献大小与其一次PM_(2.5)排放水平高度相关.因京津冀地区冬季NO_x减排对PM_(2.5)形成的促进作用,以及冬季较弱的大气垂直扩散作用,各排放源夏季减排比冬季普遍更有效,交通源、电厂源以及工业源中的水泥、工业锅炉和石灰砖瓦行业夏季减排效果相比冬季优势明显.民用源由于采暖季排放较高而冬季贡献更明显,农业源因秸秆开放燃烧量大,冬季单位减排量贡献十分显著.从同等幅度减排考虑,应将工业源作为控制重点,优先控制其一次PM_(2.5)排放,在部门内进一步重点控制钢铁冶金行业的NO_x和SO_2排放、水泥行业的夏季NO_x排放以及炼焦行业的SO_2和NMVOC排放.民用源排放应着重在冬季采暖期控制.

关键词： PM2.5 京津冀地区 CMAQ/2D-VBS 控制对策减排

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu wang Xiao Ding Huang Yunyi Yiyu Liu jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel