检索结果-南通市图书馆

Hybrid procedures for thoracoabdominal aortic aneurysms and dissections

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第4期126卷 620-625页

作者： ZHANG Hong-peng GUO Wei LIU Xiao-ping jia xin xiong jiang MA Xiao-hui Department of Vascular Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Hybrid procedures including debranching of visceral and renal arteries followed by endovascular exclusion of the thoracoabdominal aortic aneurysm （TAAA） have recently been proposed as a less invasive alternative to conventional TAAA surgery. This study aimed to evaluate the immediate and long-term outcomes of hybrid procedures for TAAA in high-risk patients. Methods Between September 1998 and May 2012, 32 high-risk TAAA patients （five females, median age 61.5 years） underwent hybrid procedures at a single institution. Simultaneous approach and staged approach were performed on the basis of patients＇ conditions. Follow-up computed tomography angiography （CTA） was routinely performed before discharge and at 6, 12 months and annually thereafter. Results Procedural success was achieved in all cases. The median hospital stay was （21.5＋2.3） days, and the median procedure time was （420＋31） minutes. Blood loss averaged （2100_＋261） ml. A total of 124 visceral artery bypasses was performed. Two patients （6.3%） died within 30 days. One patient exhibited complete paraplegia （3.1%）. The visceral graft patency was 96.1% at 3 years. All-cause survival rates were 93.8%, 87.5%, 81.3% and 53.1% at 1, 2, 3 and 5 years, respectively. No patient died due to aortic events. The freedom rates from aortic events were 96.9%, 93.6%, 87.5%, 68.8% at 1,2, 3 and 5 years, respectively. Conclusions The results of visceral hybrid repair for high-risk patients with complex TAAAs are encouraging. However, the procedure is still a significant physiological insult to patients. Until branched and fenestrated endovascular repair become more common, hybrid procedure will continue to have a role in high-risk patients.

关键词： hybrid procedure thoraeoabdominal aortic aneurysm endovascular aortic repair," dissection," stent-grafi

Fenestrated endovascular aortic repair for juxtarenal abdominal aortic aneurysm

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第3期126卷 409-414页

作者： GUO Wei ZHANG Hong-peng LIU Xiao-ping jia xin xiong jiang MA Xiao-hui Department of Vascular Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Endovascular stent-graft with fenestration can improve proximal sealing in patients with juxtarenal abdominal aortic aneurysm （JAAA）. The purpose of this study was to describe our primary experience and evaluate the safety and efficacy of fenestrated device for JAAA in high-risk patients. Methods Between March 2011 and May 2012, nine male patients （mean age, （79.6±8.6） years） with asymptomatic JAAAs underwent elective deployment of the Zenith fenestrated stent-grafts at a single institution. All patients were treated in the hybrid operating room under general anesthesia. Follow-up computed tomography angiography （CTA） was routinely performed before discharge, at 3, 6, and 12 months and annually thereafter. Results Procedural success was achieved in all cases. Total sixteen small fenestrations, two large fenestrations and eight scallops were used. Intra-operative complications occurred in four patients, which included one proximal type I endoleak, two type II endoleaks, and one renal artery dissection. The mean hospital stay was （8.9±1.4） days, mean blood loss was （360.5±46.8） ml, and mean iodinated contrast volume was （230.6±58.3） ml. The mean follow-up time was （7.6±4.2） months. The visceral graft patency was 100% until now. One patient had an increase of serum creatinine of more than 30%, but did not require dialysis. No patients died, no stent fractured, and migration were diagnosed during the follow-up. Conclusions The early results of fenestrated device for high-risk patients with complex JAAAs are satisfactory. However, long-term fenestrated graft durability and branch vessel patency remain to be determined.

关键词： abdominal aortic aneurysm juxtarenal aneurysm endovascular aortic repair, fenestrated stent-graft

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu jia Zhao-xiong Zhang xin Liu Dao-Han Wang Yong-jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang jiayi Wen xin xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

中华民族视觉形象的文化叙事及实践——基于文化形象学的论析

在线全文

学校读者我要写书评

暂无评论

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 112-121页

作者：令小雄苗昕西北师范大学马克思主义学院教育部高校思想政治工作队伍培训研修中心(西北师范大学) 甘肃兰州730070

文本基于多维度理论系统梳理中华民族视觉形象的文化意蕴、内涵质态与构建策略,为铸牢中华民族共同体意识提供理论基础。一是运用文化符号学理论解析中华民族视觉形象的意涵及其历史演变,探赜“和合共生,合谐共美”价值理想承载的多元... 详细信息

文本基于多维度理论系统梳理中华民族视觉形象的文化意蕴、内涵质态与构建策略,为铸牢中华民族共同体意识提供理论基础。一是运用文化符号学理论解析中华民族视觉形象的意涵及其历史演变,探赜“和合共生,合谐共美”价值理想承载的多元一体文化格局,通过提炼核心符号,揭示视觉形象塑造在铸牢中华民族共同体意识中的重要作用。二是采用历史唯物主义方法论考察中华民族视觉形象在不同历史时期的构建与传播路径,通过文化形象考古学和文献学剖析视觉形象文化功能转变与价值重塑过程,探讨其在凝聚民族力量、强化国家认同中的重要意义。三是引入文化哲学、文化心理学视角分析视觉形象在增强社会凝聚力和心理认同中的内在机制,探究视觉符号通过激活集体记忆和情感共鸣、唤起民族自豪感和共同体意识成为社会整合的重要媒介。四是基于文化形象学视角提出构建中华民族视觉形象的策略:从中华文化形象本体论和认识论出发,提炼具有代表性的符号,利用现代数智科技和新媒体创新视觉形象的表达与传播,注重文化形象多样性的辩证统一,发掘整合各民族形象文化元素的共同意识。

关键词：中华民族视觉形象国家形象文化形象认同文化传播

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Localized high-concentration electrolytes for lithium metal batteries:progress and prospect

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2023年第10期17卷 1354-1371页

作者： jia-xin Guo Wen-Bo Tang Xiaosong xiong He Liu Tao Wang Yuping Wu xin-Bing Cheng School of Energy and Environment Southeast UniversityNanjing 211189China School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjing 210044China

With the increasing development of digital devices and electric vehicles,high energy-density rechargeable batteries are strongly *** one of the most promising anode materials with an ultrahigh specific capacity and extremely low electrode potential,lithium metal is greatly considered an ideal candidate for nextgeneration battery ***,limited Coulombic efficiency and potential safety risks severely hinder the practical applications of lithium metal batteries due to the inevitable growth of lithium dendrites and poor interface *** efforts have been explored to address these challenges,mainly focusing on the design of novel ***,we provide an overview of the recent developments of localized high-concentration electrolytes in lithium metal ***,the solvation structures and physicochemical properties of localized high-concentration electrolytes are ***,the developments of localized high-concentration electrolytes to suppress the formation of dendritic lithium,broaden the voltage window of electrolytes,enhance safety,and render low-temperature operation for robust lithium metal batteries are ***,the remaining challenges and further possible research directions for localized highconcentration electrolytes are outlined,which can promisingly render the practical applications of lithium metal batteries.

关键词： high-concentration electrolyte localized high-concentration electrolyte lithium metal battery solid electrolyte interphase dendrite

Temporal and spatial variations in extreme temperatures in the Qilian Mountains-Hexi Corridor over the period 1960-2013

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2016年第12期13卷 2224-2236页

作者： jia Wen-xiong College of Geography and Environment Science Northwest Normal University

Based on daily maximum and minimum temperatures at 18 meteorological stations in the Qilian Mountains and Hexi Corridor between 1960 and 2013,temporal and spatial variations in extreme temperatures were analysed using linear trends,tenpoint moving averages and the Mann-Kendall *** results are as follows:The trends in the majority of the extreme temperature indices were statistically significant,and the changes in the extreme temperatures were more obvious than the changes in the extreme *** trends were different for each season,and the changes in rates and intensities in summer and autumn were larger than those in spring and *** the cold indices,the magnitudes and trends of the changes in the warm indices were larger and more significant in the Hexi Corridor than in the Qilian *** changes were detected in the majority of the extreme temperature indices,and the extreme cold indices usually occurred earlier than the changes in the extreme warm *** abrupt changes in the extreme temperatures in winter were the earliest among the four seasons,indicating that these temperature changes were the most sensitive to global climate *** timing of the abrupt changes in certain indices was consistent throughout the study area,but the changes in the cold indices in the Hexi Corridor occurred approximately four years before those in the Qilian ***,the changes in the warm indices in the western Hexi Corridor preceded those of the other regions.

关键词： Extreme temperature Interannual change Climate change Qilian Mountains Hexi Corridor