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Chinese Journal of Cancer Research 2010年第4期22卷 310-315页

作者： Guo-hong Song Jun Ren Lijun Di Jing Yu Jie Zhang Bin Shao Jun jia wei sun Key Laboratory of Carcinogenesis and Translational Research（Ministry of Education） Department of Medical Oncology Peking University Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To explore the effects of dentritic cells on the peripheral blood lymphocyte subpopulations of metastatic breast cancer patients treated with chemotherapy. Methods： The current study involved 44 metastatic breast cancer patients treated with docetaxel-based chemotherapy. Among them, 25 cases were treated with dendritic cells derived from CD34＋ hematopoietic stem cells enriched autologous peripheral mononuclear cells after chemotherapy, and 19 cases received chemotherapy alone. Peripheral blood samples were collected from each patient before and after treatment, and lymphocyte subpopulations including CD3＋, CD3＋/CD4＋, CD3＋/CD8＋, CD3-/CD16＋56＋, CD3＋/CD16＋56＋, CD4＋/CD25＋, CD8＋/CD28-, CD8＋/CD28＋, CD4/CD8, DC1, DC2 and DC1/DC2 were analysed by a 3-color flow cytometric analysis. Results： The two treatment groups were well matched with regard to demographic and baseline disease characteristics. Comparing the changes of lymphocyte subpopulations between the two groups, it showed that the difference of the change of CD8＋/CD28-lymphocyte had statistic significance. The percentage of CD8＋/CD28-lymphocyte was lower in the chemotherapy＋DC group, but higher in the chemotherapy-alone group. Conclusion： As CD8＋/CD28-lymphocyte represent a kind of suppressive T lymphocyte, we conclude that dentritic cell therapy can relieve immunosuppression to some extent.

关键词： Metastatic breast cancer Dentritic cell Lymphocyte subpopulations Regulatory T cell

Implementation of two-dimensional shear wave elastography and acoustic radiation force impulse induced strain elastography in combination with B-mode ultrasound:a method avoids unnecessary biopsies of breast lesions

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Implementation of two-dimensional shear wave elastography an...

Carbon nanostructures produced through ion irradiation

中国超声医学工程学会第五届全国介入超声医学学术交流大会

作者： jia-wei sun Xian-Li Zhou In-Patient Ultrasound Department Second Affiliated Hospital of Harbin Medical University

Purpose:To investigate the diagnostic performance of two-dimensional shear wave elastography and acoustic radiation force impulse induced strain elastography in diff erentiation benign and malignant breast *** to explore the performance in avoiding unnecessary biopsies when they combine with B(mode ***:One hundred fifty nine benign breast lesions and one hundred eleven malignant breast lesions were retrospectively *** ultrasound(CUS) features and virtual touch imaging(VTI) and virtual touch tissue imaging and quantification(VTIQ) parameters of all the lesions were *** shear wave speed(SWS) and VTI score were *** area under the receiver operating characteristic(AUCROC) curve analysis was performed to evaluate the best cut(off value of SWS and VTI *** decreased the BI-RADS grade of the lesion form 4 a to 3 when either one of the VTIQ or VTI were *** reference standard was histopathological and/or core-needle biopsy(CNB) ***:The SWS and the VTI score of malignant lesions were significantly higher than those of benign lesions(P <0.05).Among VTIQ parameters,the maximum of SWS-SWS(max) achieved the highest diagnostic performance with a cut-off value of 4.46 m/*** cut-off value of VTI score was *** to the SWS-max and VTI scores,there were 84.4%(27/32) BI-RADS 4 a lesions on B-mode ultrasound degraded to 3 which avoided unnecessary ***:Combination of VTIQ and VTI is a strong complement to B-mode ultrasound,which is a promising method in the differential diagnosis of the breast lesions as well as reduce unnecessary biopsies.

关键词： Virtual touch tissue imaging and quantification Breast lesions Virtual touch imaging Biopsy

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Nuclear Science and Techniques 2003年第2期14卷 107-114页

作者： YU Li-Ping, WANG Zhen-Xia, ZHU Zhi-Yuan, ZHANG Hu-Yong, HAN jia-Guang, ZHANG wei, sun Li-Tao,WANG Ting-Tai, MA Yu-Gang (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) Shanghai Institute of Nuclear Research the Chinese Academy of Sciences 上海 201800

Several nanostructures we produced by ion irradiation have been reviewed in this paper. By using ions to irradiate two ultrahigh molecular weight polyethylene targets respectively, it was found that small fullerenes C20 and C26 were grown, adding two members to the fullerene family. Meanwhile, crystalline diamonds also have been produced by Ar+ ions irradiation of graphite. In the experiment of double ions Ni+ and Ar+ irradiation, nanoscale argon bubbles formed. On the other side, when multi-wall carbon nanotubes were irradiated by C+, many MWCNTs evolved to amorphous carbon nanowires and amorphous carbon nanotubes. And there are possible welding in the crossed nanotubes.

关键词：碳纳米结构离子辐射聚乙烯

Microstructure and corrosion behavior of as-homogenized and as-extruded Mg-xLi-3Al-2Zn-0.5Y alloys(x=4,8,12)

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Transactions of Nonferrous Metals Society of China 2022年第1期32卷 134-146页

作者： Xiang PENG jia-wei sun Hong-jie LIU Guo-hua WU Wen-cai LIU National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The microstructure and corrosion behavior of the as-homogenized and as-extruded Mg-xLi-3Al-2Zn-0.5Y alloys(x=4,8,12,wt.%)were *** results show that as the Li content increases from 4%to 12%,the matrix transfers from singleα-Mg phase,(α-Mg+β-Li)dual phase to singleβ-Li phase.A mixed corrosion feature of intergranular corrosion and pitting corrosion occurs in the Mg-4Li-3Al-2Zn-0.5Y and Mg-12Li-3Al-2Zn-0.5Y *** former is related to the precipitated AlLi phase along the grain boundaries,and the latter is related to the high potential difference between the second phase and the *** corrosion resistance of the as-extruded alloys is better than that of the as-homogenized *** superior corrosion resistance of the as-extruded Mg-8Li-3Al-2Zn-0.5Y alloy with the lowest corrosion rate(P_(W)=(0.63±0.26)mm/a)is attributed to the more uniform distribution of second phases,the protectiveα-Mg phase via sacrificing theβ-Li phase and the relatively integrated oxide film.

关键词： Mg-xLi-3Al-2Zn-0.5Y alloys microstructure corrosion behavior homogenization extrusion second phase oxide film

Higher Order Cuprate Species( Ⅱ )——Stereospecific Carbocupration of Terminal Alkynes and Its Synthetic Utility for ( ± )-Ipsenol and (E)-β-Farnesene

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Chemical Research in Chinese Universities 1993年第2期9卷 104-109页

作者： PAN Yi-jun , XU Zhang-huang, CHEN jia-wei sun Dong-chen (Department of Chemistry, Hubei University, Wuhan, 430062) To whom correspondence should be addressed.

The stereospecific carbocupration of terminal alkynes via higher order cuprates to give 1,1'-disubstituted olefins with 99% configuration purity is described. Its synthetic utility as a general method for the preparation of substituted olefins is further illustrated by the direct synthesis of (±)-ipsenol and (E)-β-farnesene with highly geometric purity of the carbon-carbon double bond.

关键词： Higher order cuprate Terminal alkyne Carbocupration Stereospecific

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma jia Liu Xiang Xia Ning Xu Wen sun jianjun Du jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan Zhao Yongchun Wang Mingxi Li Li sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

Synthesis of α-Fe_2O_3@SnO_2 core-shell nanoparticles via low-temperature molten salt reaction route

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Transactions of Nonferrous Metals Society of China 2015年第11期25卷 3651-3656页

作者：刘刚孙维佳唐莎莎梁叔全刘军中南大学湘雅医院肝胆肠外科研究中心长沙410008 中南大学湘雅医院普外科长沙410008 中南大学材料科学与工程学院长沙410083

A cost-effective carbon-free nanocoating strategy was developed for the synthesis of ultra-fine SnO2 coatingα-Fe2O3 core-shell nanoparticles. This strategy only involves a two-step molten salt reaction at low temperature of 300 °C. The as-preparedα-Fe2O3@SnO2 core-shell nanocomposites show enhanced electrochemical performances than the bareα-Fe2O3 nanoparticles. This involved metal oxide nanocoating method is easy to be carried out, and the heat treatment temperature is much lower than that of other traditional solid-state annealing method and many carbon or metal oxide nanocoating methods. The molten salt method may also be used to produce other metal oxides coating nanostructures as the electrode materials for lithium-ion batteries.

关键词： nanometer materials lithium-ion batteries molten salt reaction energy materials nano-coating

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu wei sun Hongliang Zhang jianhua Chen Yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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利用小波包和SVDD的分拣机轴承故障诊断

振动．测试与诊断 2012年第5期32卷 762-766,862页

作者：陈伟贾庆轩孙汉旭北京邮电大学自动化学院北京100876

针对邮政分拣机供包台轴承故障识别精度较低问题,展开一种基于小波包结合支持向量数据描述的振动故障辨识研究。运用小波变换对检测的振动信号进行降噪,再利用统计分析、共振解调和小波包技术从预处理后的信号中提取故障特征频率和小波... 详细信息

针对邮政分拣机供包台轴承故障识别精度较低问题,展开一种基于小波包结合支持向量数据描述的振动故障辨识研究。运用小波变换对检测的振动信号进行降噪,再利用统计分析、共振解调和小波包技术从预处理后的信号中提取故障特征频率和小波包能量等时、频域特征作为输入向量。通过核参数优化选取和正常类样本集训练学习,建立描述轴承正常工作状态的最小特征超球体作为预测模型并带入轴承试验台中。试验结果表明,该方法的正确识别率可以达到98%以上。

关键词：邮政分拣机供包台系统故障诊断支持向量数据描述预测模型