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Pickering emulsion transport in skeletal muscle tissue:A dissipative particle dynamics simulation approach

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Chinese Journal of Chemical Engineering 2024年第4期68卷 65-75页

作者： Xuwei Liu wei Chen Yufei Xia Guanghui ma Reiji Noda wei Ge State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Division of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1 Tenjin-choKiryuGunma 376-8515Japan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green manufacture Chinese Academy of SciencesBeijing 100190China

Lymph node targeting is a commonly used strategy for particulate vaccines,particularly for Pickering ***,extensive research on the internal delivery mechanisms of these emulsions,especially the complex intercellular interactions of deformable Pickering emulsions,has been surprisingly *** gap in knowledge holds significant potential for enhancing vaccine *** study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell *** transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case *** factors impacting the transport process are explored,including local cellular tissue environmental factors and the properties of the Pickering emulsion *** simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport ***,larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single *** study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering *** insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug ***,the desired transport efficiency varies depending on the specific *** instance,while a more rapid transport might be crucial for lymph-node-targeted drug delivery,certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词： Pickering emulsion Skeletal muscular cells Transport phenomena Dissipative particle dynamics Drug delivery

Inner-shell ionization cross sections of atoms by positron impact

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Communications in Theoretical Physics 2024年第6期76卷 142-147页

作者： Yuan-Cheng Wang jia ma Li-Guang jiao Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China Helmholtz-Institut Jena D-07743 JenaGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH D-64291 DarmstadtGermany College of Science Shenyang Aerospace UniversityShenyang 110136China College of Physics Jilin UniversityChangchun 130012China Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena07743 JenaGermany

The relativistic binary-encounter-Bethe model with Wannier-type threshold law is employed to obtain the inner-shell ionization cross sections of multi-electron atoms(Ni,Cu,Y,Ag,Au,Yb,Ta,and Pb)for positron impact energies from the thresholds up to 105ke *** is good agreement between the present calculations and the experimental *** constant in the acceleration term derived from the Wannier law is determined to be 0.2 and 0.5 for the K-and L-shells,respectively.

关键词： positron scattering ionization cross section binary-encounter-Bethe model

Characteristics and Influencing Factors of Microplastics in Snow in the Inner Mongolia Plateau, China

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Engineering 2024年第6期37卷 69-77页

作者： Hongwei Yu Junrong Shao Huawei jia Diga Gang Baiwen ma Chengzhi Hu State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Changjiang Survey PlanningDesign and Research Co.Ltd.Wuhan 430010China

Microplastics(MPs;<5 mm)have become one of the most prominent global environmental pollution *** can spread to high altitudes through atmospheric transport and can be deposited by rainfall or snowfall,potentially thre... 详细信息

Microplastics(MPs;mate *** collected from surface snow in the Inner Mongolia Plateau,China,were used for quantitative analysis and *** results showed that MPs were easily detected,and the related concentration was approximately(68±10)–(199±22)MPsL1 in snow *** were the most common morphology,the polymer composition was largely varied,and the abundance and composition of MPs were linked to human activity to a great ***-throughput sequencing results showed that the composition and abundance of microorganisms also differed in snow samples from areas with different MP pollution characteristics,indicating a considerable difference in microbial functional *** may have an interference effect on the individual growth and functional expression of microorganisms in *** addition,the results showed that functional living areas(e.g.,landfills and suburban areas)in cities play an important role in the properties of *** instance,the highest abundance of MPs was found in thermal power plants,whereas the abundance of polymers per sample was significantly lower in the suburban *** MP contaminants hidden in snow can alter microbial structure and function and are therefore a potential threat to ecosystem health.

关键词： Human activities Snow Microplastics Microbial community Urban function Environmental effect

Cross-linkedα-amylase aggregates on Fe3O4 magnetic nanoparticles modified with polydopamine/polyethyleneimine for efficient hydrolysis of starch

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Particuology 2024年第7期90卷 98-105页

作者： jiandong Cui Xiuming Tang Qingqing ma Yuyan Chang Qunli Zhang Shiru jia State Key Laboratory of Food Nutrition and Safety Laboratory of Industrial Fermentation MicrobiologyMinistry of EducationTianjin University of Science and TechnologyTianjin 300457China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China

In this workα-amylase was immobilized on magnetic Fe3O4 nanoparticles with polyethylenimine(PEI)/polydopamine(PDA)coating or 3-aminopropyl triethoxysilane(APTES)for the first time via adsorption–precipitation–*** with the freeα-amylase,the resultant magnetic cross-linkedα-amylase aggregates(PEI/PDA-M-CLEAs and N-M-CLEAs)exhibited excellent thermal and storage stability as well as pH *** storage at 25°C for 60 days,freeα-amylase only retained 60%of its initial activity,while PEI/PDA-M-CLEAs and N-M-CLEAs retained 80%and 78%of their initial activities,***,N-M-CLEAs and PEI/PDA-M-CLEAs showed good *** 6 repeated uses,PEI/PDA-M-CLEAs and N-M-CLEAs still maintained 65%and 62%of their initial activities,***,PEI/PDA-M-CLEAs and N-M-CLEAs exhibited higher starch hydrolysis efficiency than freeα-*** maximum dextrose equivalent(DE)values of starch hydrolysis by PEI/PDA-M-CLEAs and N-M-CLEAs reached 29.24%and 28.79%within 90 min,***,the maximum DE values of starch hydrolysis by the freeα-amylase was only 27.89%even in 150 *** magnetic cross-linkedα-amylase aggregates could be introduced as effective biocatalyst for industrial applications in production of maltose syrups.

关键词： α-amylase magnetic nanoparticles Functional modification magnetic cross-linked enzyme aggregates Hydrolysis of starch

Extreme precipitation detection ability of four high-resolution precipitation product datasets in hilly area:a case study in Nepal

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Advances in Climate Change Research 2024年第3期15卷 390-405页

作者： Sunil Subba Yao-Ming ma wei-Qiang ma Cun-Bo Han Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakista

Given Nepal's vulnerability to extreme precipitation(EP),it is imperative to conduct a comprehensive analysis to comprehend the historical trends of such ***,acquiring precise precipitation data for EP remains challenging in mountainous countries like Nepal owing to the scarcity of densely gauged *** limitation impedes the dissemination of knowledge pertaining to EP variability events in *** current research on this topic is deficient for two main reasons:1)there is a lack of studies leveraging recently released high-resolution precipitation products to identify their EP detection capabilities,which further hinders the usability of those products in data-scarce regions like Nepal,and 2)most studies have focused on the characterisation of EP events in Nepal rather than their spatial and temporal *** address these issues,this study evaluated the EP detection capabilities of four high-resolution precipitation product datasets(PPDs)across Nepal from 1985 to *** datasets include the ERA5 Land reanalysis data,satellite-based precipitation data(PERSIANN_CCS_CDR and CHIRPS_V2.0)and a merged dataset(TPHiPr).We used various statistical and categorical indices to assess their ability to capture the spatial and temporal variability of EP *** annual EP events were characterised by 11 indices divided into frequency and intensity *** TPHiPr merged dataset offered a robust depiction of monthly precipitation estimates,achieving the highest critical success index,accuracy,probability of detection and a low false alarm ratio for daily precipitation detection of 0.1 mm in ***,the PERSIANN_CCS_CDR dataset exhibited poor *** PPDs showed increasing trends in EP ***,the TPHiPr dataset showcased those trends with fewer errors and stronger correlations for many frequency(R10mm,R20mm and R25mm)and intensity(RX1day,RX5day,PRCPTOT and R99p)*** results indicate that TPHiPr outperformed ot

关键词： Extreme precipitation Precipitation product Nepal TPHiPr ERA5 land PERSIANN_CCS_CDR CHIRPS_V2.0

Synthesis,Characterization of Polyethylene Ionomers and Their Antibacterial Properties

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Chinese Journal of Polymer Science 2024年第8期42卷 1077-1084页

作者： jia-jia Wu Fei Wang Peng-Qi Wan Li Pan Chun-Sheng Xiao Zhe ma Yue-Sheng Li Tianjin Key Lab Composite&Functional materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Key Lab Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Owing to its high production volume and wide range of application s,polyethylene has gained a great deal of attention,but its low surface energy and non-polar nature have limited its application in some important *** this study,ethylene/11-iodo-1-undecene copolymers were prepared and used as the intermediates to afford a series of imidazolium-based ionomers bearing methanesulfonate(CH_(3)SO_(3)^(-)),trifluoromethanesulfonate(CF_(3)SO_(3)^(-)),or bis(trifluoromethane)sulfonimide(Tf_(2)N^(-))*** tensile test results showed that the stress-at-break(7.8-25.6 MPa)and the elongation-at-break(445%-847%)of the ionomers could be adjusted by changing the counterion species and the ionic group *** importantly,the ionomers exhibited marvelous antibacterial activities against Staphylococcus aureus(***)and Escherichia coli(***).The ionomers bearing Tf_(2)N^(-)exhibited antibacterial activities>99%against both *** and *** when ionic content reached 9.1%.The imidazolium-based ionomers prepared in this work demonstrated excellent comprehensive properties,especially highefficient and broad-spectrum antibacterial ability,exhibiting the potential fo r the application as the antibacterial materials in packaging,medical,and other fields.

关键词： Polyethylene Ionomer Polymerization catalysis Imidazolium Antibacterial material

Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

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Nano-Micro Letters 2024年第12期16卷 59-80页

作者： Qing Chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun ma Chao jia Dihan Su Biao Kong wei Hong Libo jiang jian Dong Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai 200032People’s Republic of China Department of Chemistry Fudan UniversityShanghai 200438People’s Republic of China Department of Surgery Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore Department of Geriatrics and Gerontology Huadong HospitalFudan UniversityShanghai 200438People’s Republic of China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Department of Orthopaedic Surgery Zhongshan Hospital Wusong Branch Fudan UniversityShanghai 200940People’s Republic of China

Surgery remains the standard treatment for spinal ***,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical *** this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril *** superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse *** near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled ***-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal *** minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

关键词： Silk fibroin Nanofibril hydrogels Nanorobots Thrombin Spinal metastasis

Future Changes in Various Cold Surges over China in CMIP6 Projections

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Advances in Atmospheric Sciences 2024年第9期41卷 1751-1768页

作者： Li ma Zhigang wei Xianru LI Shuting WU Key Laboratory of Environmental Change and Natural Disasters of Chinese Ministry of Education Beijing Normal UniversityBeijing 100875China State Key Laboratory of Earth Surface Processes and Resource Ecology(ESPRE) Beijing Normal UniversityBeijing 100875China Academy of Disaster Reduction and Emergency management Ministry of Emergency Management and Ministry of EducationBeijing 100875China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Cold surges(CSs)often occur in the mid-latitude regions of the Northern Hemisphere and have enormous effects on socioeconomic *** report that the occurrences of CSs and persistent CSs(PCSs)have rebounded since the 1990s,but the trends related to the frequencies of strong CSs(SCSs)and extreme CSs(ECSs)changed from increasing to decreasing after *** highest-ranked model ensemble approach was used to project the occurrences of various CSs under the SSP1-2.6,SSP2-4.5,and SSP5-8.5 *** frequencies of the total CSs show overall decreasing ***,under the SSP1-2.6 scenario,slight increasing trends are noted for SCSs and ECSs in *** circulations that are characterized by an anomalous anticyclonic circulation with a significantly positive 500-hPa geopotential height(Z500)anomaly at high latitudes along with significant negative anomalies in China were favorable for cold air intrusions into *** addition,the frequencies of all CS types under the SPP5-8.5 scenario greatly decreased in the long term(2071-2100),a finding which is thought to be related to negative SST anomalies in the central and western North Pacific,differences in sea level pressure(SLP)between high-and mid-latitude regions,and a weaker East Asian *** terms of ECSs,the decreasing trends observed during the historical period were maintained until 2024 under the SSP1-2.6 *** to the SSP1-2.6 scenario,the Z500 pattern showed a trend of strengthened ridges over the Ural region and northern East Asia and weakened troughs over Siberia(60°-90°E)under the SSP2-4.5 and SSP5-8.5 scenarios,contributing to the shift to increasing trends of ECSs after 2014.

关键词： cold surge “highest-ranked”model ensemble anticyclonic circulation geopotential height China

Reduced-order modeling and vibration transfer analysis of a fluid-delivering branch pipeline that consider fluid–solid interactions

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Frontiers of Mechanical Engineering 2024年第2期19卷 75-97页

作者： Wenhao JI Hongwei ma wei SUN Yinhang CAO School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero-Propulsion Systems(Ministry of Education) Northeastern UniversityShenyang 110819China College of Power and Energy Engineering Harbin Engineering UniversityHarbin 150001China

The efficient dynamic modeling and vibration transfer analysis of a fluid-delivering branch pipeline(FDBP)are essential for analyzing vibration coupling effects and implementing vibration reduction ***,this study proposes a reduced-order dynamic modeling method suitable for FDBPs and then analyzes the vibration transfer *** the modeling method,the finite element method and absorbing transfer matrix method(ATMM)are integrated,considering the fluid–structure coupling effect and fluid *** dual-domain dynamic substructure method is developed to perform the reduced-order modeling of FDBP,and ATMM is adopted to reduce the matrix order when solving fluid ***,the modeling method is validated by experiments on an H-shaped branch ***,transient and steady-state vibration transfer analyses of FDBP are performed,and the effects of branch locations on natural characteristics and vibration transfer behavior are *** show that transient vibration transfer represents the transfer and conversion of the kinematic,strain,and damping energies,while steady-state vibration transfer characteristics are related to the vibration *** addition,multiple-order mode exchanges are triggered when branch locations vary in frequency-shift regions,and the mode-exchange regions are also the transformation ones for vibration transfer patterns.

关键词： fluid-delivering branch pipeline vibration transfer analysis reduced-order modeling fluid-solid interactions finite element method absorbing transfer matrix method