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A multifunctional shear apparatus for rocks subjected to true triaxial stress and high temperature in real-time

Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3524-3543页

作者： Jun Zhao Xia-Ting Feng jia-rong wang Liang Hu Yue Guo Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

Deep engineering disasters,such as rockbursts and collapses,are more related to the shear slip of rock joints.A novel multifunctional device was developed to study the shear failure mechanism in *** this device,the complete shearedeformation process and long-term shear creep tests could be performed on rocks under constant normal stiffness(CNS)or constant normal loading(CNL)conditions in real-time at high temperature and true-triaxial *** the research and development process,five key technologies were successfully broken through:(1)the ability to perform true-triaxial compressioneshear loading tests on rock samples with high stiffness;(2)a shear box with ultra-low friction throughout the entire stress space of the rock sample during loading;(3)a control system capable of maintaining high stress for a long time and responding rapidly to the brittle fracture of a rock sample as well;(4)a refined ability to measure the volumetric deformation of rock samples subjected to true triaxial shearing;and(5)a heating system capable of maintaining uniform heating of the rock sample over a long *** developing these technologies,loading under high true triaxial stress conditions was *** apparatus has a maximum normal stiffness of 1000 GPa/m and a maximum operating temperature of 300*** differences in the surface temperature of the sample are constant to within5*** types of true triaxial shear tests were conducted on homogeneous sandstone to verify that the apparatus has good performance and *** results show that temperature,lateral stress,normal stress and time influence the shear deformation,failure mode and strength of the *** novel apparatus can be reliably used to conduct true-triaxial shear tests on rocks subjected to high temperatures and stress.

关键词： True-triaxial shear apparatus Rocks Complete shear stressedeformation process Creep Real-time high-temperature

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Competitive and cooperative adsorption of arsenate and citrate on goethite

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Journal of Environmental Sciences 2009年第1期21卷 106-112页

作者： SHI rong,jia Yongfeng,wang Chengzhi Institute of Applied Ecology,Chinese Academy of Sciences,Shenyang 110016,China Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China

The fate of arsenic in natural environments is influenced by adsorption onto metal （hydr）oxides. The extent of arsenic adsorption is strongly affected by coexisting dissolved natural organic acids. Recently, some studies reported that there existed competitive adsorption between arsenate and citrate on goethite. Humic acid is known to interact strongly with arsenate by forming complexes in aqueous solution, hence it is necessary to undertake a comprehensive study of the adsorption of arsenate/citrate onto goethite in the presence of one another. The results showed that at the arsenate concentrations used in this study （0.006-0.27 mmol/L）, citrate decreased arsenate adsorption at acidic pH but no effect was observed at alkaline pH. In comparison, citrate adsorption was inhibited at acidic pH, but enhanced at alkaline pH by arsenate. This was probably due to the formation of complex between arsenate and citrate like the case of arsenate with humic acid. These results implied that the mechanism of the adsorption of arsenate and citrate onto goethite in the presence of one another involved not only competition for binding sites, but the cooperation between the two species at the watergoethite interface as well.

关键词： adsorption arsenate citrate goethite

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Successful endovascular treatment with long-term antibiotic therapy for infectious pseudoaneurysm due to Klebsiella pneumoniae:A case report

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World Journal of Clinical Cases 2020年第24期8卷 6529-6536页

作者： Tie-Hao wang Ji-Chun Zhao Bin Huang jia-rong wang Ding Yuan Department of Vascular Surgery West China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina

BACKGROUND Infectious common femoral artery pseudoaneurysm caused by Klebsiellapulmonary infection is a relatively infrequent entity but is potentially life andlimb threatening. The management of infectious pseudoaneurysm *** SUMMARY We reported a 79-year-old man with previous Klebsiella pneumoniae pulmonaryinfection and multiple comorbidities who presented with a progressive pulsatemass at the right groin and with right lower limb pain. Computed tomographyangiography showed a 6 cm × 6 cm × 9 cm pseudoaneurysm of the right commonfemoral artery accompanied by occlusion of the right superficial femoral arteryand deep femoral artery. He underwent endovascular treatment (EVT) withstent–graft, and etiology of infectious pseudoaneurysm was confirmed. Then, 3-mo antibiotic therapy was given. One-year follow-up showed the stent–graft waspatent and complete removal of surrounding *** The femoral artery pseudoaneurysm can be caused by Klebsiella pneumoniaederiving from the pulmonary infection. Moreover, this unusual case highlights theuse of EVT and prolonged antibiotic therapy for infectious pseudoaneurysm.

关键词： Infectious pseudoaneurysm Common femoral artery Klebsiella pneumoniae Antibiotic therapy Endovascular treatment Case report

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Optimized parameters of downhole all-metal PDM based on genetic algorithm

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Petroleum Science 2024年第4期21卷 2663-2676页

作者： jia-Xing Lu Ling-rong Kong Yu wang Chao Feng Yu-Lin Gao China University of Geosciences (Beijing) Key Laboratory on Deep Geo-Drilling Technology of Ministry of Natural Resources

Currently, deep drilling operates under extreme conditions of high temperature and high pressure,demanding more from subterranean power motors. The all-metal positive displacement motor, known for its robust performance, is a critical choice for such drilling. The dimensions of the PDM are crucial for its performance output. To enhance this, optimization of the motor's profile using a genetic algorithm has been undertaken. The design process begins with the computation of the initial stator and rotor curves based on the equations for a screw cycloid. These curves are then refined using the least squares method for a precise fit. Following this, the PDM's mathematical model is optimized, and motor friction is assessed. The genetic algorithm process involves encoding variations and managing crossovers to optimize objective functions, including the isometric radius coefficient, eccentricity distance parameter,overflow area, and maximum slip speed. This optimization yields the ideal profile parameters that enhance the motor's output. Comparative analyses of the initial and optimized output characteristics were conducted, focusing on the effects of the isometric radius coefficient and overflow area on the motor's performance. Results indicate that the optimized motor's overflow area increased by 6.9%, while its rotational speed reduced by 6.58%. The torque, as tested by Infocus, saw substantial improvements of38.8%. This optimization provides a theoretical foundation for improving the output characteristics of allmetal PDMs and supports the ongoing development and research of PDM technology.

关键词： Positive displacement motor Genetic algorithm Profile optimization Matlab programming Overflow area

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Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1500-1513页

作者： jian-rong Sun Dong-Mei Chen rong Huang Rui-Tao wang Li-Qun jia School of Clinical Medicine Beijing University of Chinese MedicineBeijing 100029China Integrated Chinese and Western Medicine Oncology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignancies worldwide,and its development comprises a multistep process from intraepithelial neoplasia(IN)to carcinoma(CA).However,the critical regulators and underlying molecular mechanisms remain largely *** To explore the genes and infiltrating immune cells in the microenvironment that are associated with the multistage progression of ESCC to facilitate diagnosis and early *** A mouse model mimicking the multistage development of ESCC was established by providing warter containing 4-nitroquinoline 1-oxide(4NQO)to C57BL/6 ***,we established a control group without 4NQO treatment of ***,transcriptome sequencing was performed for esophageal tissues from patients with different pathological statuses,including low-grade IN(LGIN),high-grade IN(HGIN),and CA,and controlled normal tissue(NOR)*** expressed genes(DEGs)were identified in the LGIN,HGIN,and CA groups,and the biological functions of the DEGs were analyzed via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment *** CIBERSORT algorithm was used to detect the pattern of immune cell ***(IHC)was also conducted to validate our ***,the Luminex multiplex cytokine analysis was utilized to measure the serum cytokine levels in the *** Compared with those in the NOR group,a total of 681541,and 840 DEGs were obtained in the LGIN,HGIN,and CA groups,*** the intersection of the three sets of DEGs,we identified 86 genes as key genes involved in the development of *** analysis revealed that these genes were enriched mainly in the keratinization,epidermal cell differentiation,and interleukin(IL)-17 signaling *** analysis revealed that,compared with those in the NOR group,M0 and M1 macrophages in the 4NQO group showed stronger infiltration,which was validated by *** cytok

关键词： Esophageal squamous cell carcinoma Intraepithelial neoplasia Tumorigenesis Transcriptome sequencing Biomarkers Immune cell infiltration 4-nitroquinoline 1-oxid

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Bending Failure Mode and Prediction Method of the Compressive Strain Capacity of A Submarine Pipeline with Dent Defects

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China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng jia Lu-sheng CHEN Yan-fei ZHANG Qi ZHONG rong-feng wang Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

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Emergency physicians’ occupational risks in China

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World Journal of Emergency Medicine 2024年第3期15卷 232-234页

作者： Huaying jiang jia Chang rong Huang Xiayi Liang Manning Song Hejing Yuan Shuo wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100105China Operation Room Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China School of Marxism Beijing University of Chinese MedicineBeijing 100105China Department of Infectious Diseases(Fever Clinic) Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

With the rapid development of emergency medicine,emergency physicians are working around the clock,[1]including additional workloads due to sudden public health emergencies and *** risks for emergency physicians are s... 详细信息

关键词： physician acute occupational

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Simplified liver imaging reporting and data system for the diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2439-2448页

作者： rong Lyu Wei-Juan Hu Di wang jiao wang Yu-Bing Ye Ke-Feng jia Department of Radiology Tianjin Third Central HospitalTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin 300170China

BACKGROUND The liver imaging reporting and data system(LI-RADS)diagnostic table has 15 cells and is too *** diagnostic performance of LI-RADS for hepatocellular carcinoma(HCC)is not satisfactory on gadoxetic acid-enhanced magnetic resonance imaging(EOB-MRI).AIM To evaluate the ability of the simplified LI-RADS(sLI-RADS)to diagnose HCC on *** A total of 331 patients with 356 hepatic observations were retrospectively *** diagnostic performance of sLI-RADS A-D using a single threshold was evaluated and compared with LI-RADS v2018 to determine the optimal *** algorithms of sLI-RADS A-D are as follows:The single threshold for sLI-RADS A and B was 10 mm,that is,classified observations≥10mm using an algorithm of 10-19 mm observations(sLI-RADS A)and≥20 mm observations(sLI-RADS B)in the diagnosis table of LI-RADS v2018,respectively,while the classification algorithm remained unchanged for observations0.999).With HBP hypointensity as an MF,the sensitivity of F-sLI-RADS was greater than that of LI-RADS v2018(93.0%vs 87.0%,P<0.001)and sLI-RADS D(93.0%vs 89.8%,P=0.016),without a lower specificity(86.5%vs 90.1%,P=0.062;86.5%vs 89.4%,P=0.125).Compared with that of LI-RADS v2018,the time to classif

关键词： Hepatocellular carcinoma Magnetic resonance imaging Liver Diagnosis Contrast agent

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Protein crystallization with DNA templates

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Particuology 2024年第3期86卷 262-268页

作者： Bo Zhang jia Yu Zhe Pu Wenhui Guo Ruoqi Yang Yu Wen Zhijiang rong Hui wang Xiaoli Wu Bo wang Hongyan Sun School of Environment and Resources Taiyuan University of Science and TechnologyTaiyuan030024China School of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan030024China

Protein crystallization plays a significant role in three-dimensional structural analysis and protein *** is important to increase the crystallization efficiency,which is possible by adding hetero-geneous templates in crystallization *** is biologically compatible and artificially designable polymer,which is easy to *** this study,single-and double-stranded DNA of precise sequences were designed and used as templates to promote protein crystallization of lysozyme and ***-fluence of DNA,single-stranded DNA with 10,20,40 bases and double-stranded DNA with 10,20,40 base pairs,were *** success rate of obtaining crystals of lysozyme and catalase in equal period was significantly improved with the addition of DNA comparing without templates ***-stranded DNA led to higher nucleation rate than that with single-stranded *** promotion of nucleation was more obvious at low concentration of protein solution and with longer chain DNA *** number and crystallization rate was enhanced with addition of long double-stranded DNA *** the results confirm that DNA is an effective polymer additive to enhance protein crystallization,especially for the application of the scarce protein crystallization.

关键词： DNA Polymer Additive Protein Crystallization

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Nondestructive Nonlinear Optical Microscopy Revealed the Blackening Mechanism of Ancient Chinese Jades

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Research 2024年第3期2023卷 391-399页

作者： Yaxin Chen rong wang Minbiao Ji State Key Laboratory of Surface Physics and Department of Physics Human Phenome InstituteAcademy for Engineering and TechnologyKey Laboratory of Micro and Nano Photonic Structures(Ministry of Education)Yiwu Research Institute of Fudan UniversityFudan UniversityShanghai 200433China Department of Cultural Heritage and Museology Fudan UniversityShanghaiChina

Jade is most valued in Chinese culture since ancient times. For unearthed jade artifacts, the alteration color resulting from weathering effects and human activities provides information for cultural heritage conservation, archaeology, and history. Currently, the noninvasive 3-dimensional characterization of jade artifacts with high chemical and spatial resolution remains challenging. In this work, we applied femtosecond pump–probe microscopy and second harmonic generation microscopy techniques to study the black alteration of an ancient jade artifact of the late Spring and Autumn period (546 to 476 BC). The direct cause of the “mercury alteration” phenomena was discovered to be the conversion of metacinnabar from buried cinnabar in the tomb. Furthermore, a 3-dimensional optical reconstruction of the black alteration was achieved, providing a high-resolution method for analyzing the blackening mechanism without the need of sample damage. Our approach opens up new opportunities to extract microscopic spatiochemical information for a broad range of alteration colors in jade artifacts.

关键词： pump Nonlinear buried

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