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Spillover of international crude oil prices on China's refined oil wholesale prices and price forecasting:daily-frequency data of private enterprises and local refineries

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Petroleum Science 2022年第3期19卷 1433-1442页

作者： Xun-Zhang Pan Xi-Ran Ma Li-Ning Wang Ya-Chen Lu jia-quan dai Xiang Li School of Economics and Management China University of PetroleumBeijing 102249China Economics&Technology Research Institute China National Petroleum CorporationBeijing 100724China Key Laboratory of Oil and Gas Market Simulation and Price Forecasting China National Petroleum CorporationBeijing 100724China Institue of Energy Peking UniversityBeijing 100080China

Compared with retail prices of state-owned companies used in almost all existing studies,China’s refined oil wholesale prices of private enterprises and local refineries are more affected by the market and better reflect the real supply-demand *** the first time,this paper applies own-monitored dailyfrequency wholesale prices of China’s private enterprises and local refineries during 2013-2020 to derive spillover effects of international crude oil prices on China’s refined oil prices through the VAR-BEKKGARCH(vector autoregression-Baba,Engle,Kraft,and Kroner-generalized autoregressive conditional heteroscedasticity)model,and then tries to forecast wholesale prices through the PCA-BP(principal component analysis-back propagation)neural network *** show that international crude oil prices have significant mean spillover and volatility spillover effects on China’s refined oil wholesale *** in crude oil prices are the Granger cause of changes in refined oil wholesale *** the improvement of China’s oil-pricing mechanism in 2016,the volatility spillover from the international crude oil market to China’s refined oil market gradually increases,and the BRENT price variation has an increasing impact on the refined oil wholesale price *** PCA-BP model could serve as a candidate tool for forecasting China’s refined oil wholesale prices.

关键词： Own-monitored daily-frequency data Refined oil wholesale prices Spillover effects VAR-BEKK-GARCH PCA-BP neural Network

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从食品安全问题看技术异化

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江苏海洋大学学报（人文社会科学版） 2011年第16期9卷 85-87页

作者：权嘉黛中国矿业大学马克思主义学院江苏徐州221008

人类在享受技术带来的物质文明和精神文明的同时,也遭受了技术负面价值带来的影响。技术已经渗入我们生活的各个领域,食品行业也不例外。食品行业近期内接连出现的食品安全问题在一定程度上则是技术异化的结果。针对这种现象分析了食品... 详细信息

人类在享受技术带来的物质文明和精神文明的同时,也遭受了技术负面价值带来的影响。技术已经渗入我们生活的各个领域,食品行业也不例外。食品行业近期内接连出现的食品安全问题在一定程度上则是技术异化的结果。针对这种现象分析了食品行业相关技术的形成、技术异化的原因、影响及相应对策。

关键词：技术价值异化食品安全

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin dai Lei Ye Tao Song Shuai Huang jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Modeling and simulation of bow wave effect in probe and drogue aerial refueling

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Chinese Journal of Aeronautics 2016年第2期29卷 448-461页

作者： dai Xunhua Wei Zibo quan quan School of Automation Science and Electrical Engineering Beihang University

In a probe and drogue aerial refueling system, the bow wave of the receiver aircraft will produce a strong aerodynamic effect on the drogue once the receiver follows the drogue at a close distance. It is a major difficulty of docking control in the probe and drogue refueling. This paper analyses the bow wave effect and presents a simple method to model it. Firstly, the inviscid flow around the receiver is modeled based on the stream function defined by basic stream singularities. Secondly, a correction function is developed to eliminate the error caused by the absence of air vis- cosity. Then, the aerodynamic coefficients are used to calculate the induced aerodynamic force on the drogue. The obtained model is in an analytical form that can be easily applied to the controller design and the real-time simulations. In the verification part, computational fluid dynamics （CFD） simulation tests are conducted to validate the obtained flow fields and aerodynamic forces. Finally, the modeling method is applied to an F-16 receiver aircraft in a previously developed autonomous aerial refueling simulation system. The simulations results are analyzed and compared with the NASA flight-test data, which demonstrates the effectiveness of the proposed method.

关键词： Aerial refueling Aerodynamic Bow wave Modeling Probe and drogueUAV

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Shear-induced Precursors of Fibrillar Crystals of Poly(butene-1):A Rheological Study

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Chinese Journal of Polymer Science 2022年第6期40卷 618-623页

作者： jia-Qi Zhang quan Chen State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China

Strong preshear flow stretches poly(butene-1)chains to form flow-induced precursors of fibrillar *** formation leads to further growth of shear/normal stress after the stress reaches the steady *** this study,stress relaxation measurements are performed after intervals of a strong flow during which the precursors *** small-angle X-ray scattering(SAXS)and wide-angle X-ray diffraction(WAXD)measurements are conducted to characterize the crystalline structure formed after the preshear and relaxation processes,each of different periods.A combination of the stress relaxation and scattering results reveal that for the precursors formed within 5 s,the stress can fully relax and the orientation of the subsequent crystals(formed upon quenching the sample at different stress levels)decays gradually with the *** comparison,for those precursors formed after 5 s,the stress hardly relaxes during~10^(4) s,and the orientation of the subsequent crystals hardly decays,suggesting that the precursors have been somehow stabilized during the *** features have been discussed with respect to the percolation of the precursors to form a reversible network.

关键词： PB-1 Rheology Precursor Fibrillar crystal

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Is hand sewing comparable with stapling for anastomotic leakage after esophagectomy? A meta-analysis

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World Journal of Gastroenterology 2014年第45期20卷 17218-17226页

作者： quan-Xing Liu jia-Xin Min Xu-Feng Deng Ji-Gang dai Department of Thoracic Surgery Xinqiao Hospital Third Military Medical University

AIM: To compare the outcome of hand sewing and stapling for anastomotic leakage after esophagectomy.

关键词： Anastomotic leakage Esophagectomy Hand-sewn sutures Mechanical sutures Meta-analysis

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Reversible Plasticity Shape Memory Effect in SEBS/Crystallizable Paraffin: Influence of Paraffin Content

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Chinese Journal of Polymer Science 2022年第12期40卷 1697-1705,I0011页

作者： Shao-quan Zhao jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University Yiwu 322000China

Polymers with reversible plasticity shape memory effect(RPSME)have attracted considerable attention due to their simple programming and large ***,the exact mechanisms of RPSME are still not thoroughly *** this work,the RPSME of SEBS/crystallizable paraffin was investigated by comparatively analyzing the performances and microstructures of samples with different paraffin *** was found the shape fixing ratios(Rfs)of samples increased with the paraffin content,and interestingly,a significant improvement in Rf was observed when the paraffin content exceeded 60 wt%.Tensile test results showed that the deformation characteristics of samples changed from elastic to plastic as the paraffin content increased above 60 wt%.By exploring the crystallization behaviors of paraffin in various SEBS/paraffin samples,it was revealed that the microstructures of SEBS/paraffin were different when the paraffin content was below 50 wt%and above 60 wt%.In samples with low paraffin content(below 50 wt%),nearly all paraffin was co-crystallized with ethylene-co-butylene(EB)chains and its crystallization was severely restricted;while in samples with high paraffin content(above 60 wt%),“excess”paraffin appeared and this part of paraffin crystallized on the template of the EB/paraffin co-crystals,which might be responsible for the elastic-to-plastic transition and the sharp increase in *** on the above results,a possible structural model was proposed to explain the exact mechanism of RPSME in SEBS/paraffin.

关键词： Reversible plasticity shape memory effect Poly(styrene-b-(ethylene-co-butylene)-b-styrene) Crystallizable paraffin Paraffin content

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C–C formation mediated by photoinduced electrons from crystallized carbon nitride nanobelts under visible light irradiation

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Journal of Energy Chemistry 2019年第3期28卷 152-161页

作者： Qiaohui jia Sufen Zhang quan Gu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University

Crystal structure and crystallinity of carbon nitride support, size and dispersity of active-metal nanoparticles(NPs), and surface engineering of composites have great roles in generation and separation of photogenerated charge carries and photocatalyzed organic reactions for the conversion of solar energy into chemical energy. Herein, we deposited well-dispersed Pd NPs with small size on crystallized carbon nitride(CN–C) to construct a Schottky-type Pd/CN–C hybrid for photocatalyzed Ullmann C–C homocoupling of aryl halides under visible light irradiation at room temperature. Compared to Pd NPs supported g-C_3N_4(Pd/g-C_3N_4), Pd/CN–C exhibits excellent visible light photocatalytic activity for Ullmann C–C coupling of aryl halides due to high crystallinity of CN–C support, high dispersion and smaller size of Pd NPs, and the interfacial heterojunction of Pd/CN–C. Upon visible light irradiation, more photogenerated electrons from CN–C flow across the Schottky junction to metallic Pd and trigger the Ullmann C–C coupling of aryl halides. The photogenerated holes on CN–C surface are captured by a protic solvent(such as EtOH). In the presence of base K_2CO_3, the solvent undergoes dissociation, dehydrogenation, and finally can be oxidized by captured photogenerated holes. Moreover, Pd/CN–C has general applicability for various substrates and shows excellent stability and reusability for more than nine cycles.

关键词： Crystallized carbon nitride Pd nanoparticles Photocatalyst C–C coupling Ullmann reaction

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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-Feng jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-quan jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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