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Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie FAN jia-qi ZHANG jia-qi ZHAN Li HU Li-li CHEN Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of Lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental health.The traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial protrusion.In recent years,an invisible orthodontic technique,without brackets,has become increasingly popular.However,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect outcome.This case report presents an adolescent patient with bimaxillary protrusion and mandibular retrognathia.Based on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular retrognathia.The patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the treatment.This case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction patients.Furthermore,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

Extensive prediction of drug response in mutation-subtype-specific LUAD with machine learning approach

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Oncology Research 2024年第2期32卷 409-419页

作者： KEganG jia YAWEI WANG qi CAO YOUYU WANG Department of Thoracic Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina School of Medicine University of Electronic Science and Technology of ChinaChengduChina Department of Assisted Reproductive Medicine Sichuan Provincial Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduChina

Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death worldwide.Therapeutic failure in lung cancer(LUAD)is heavily influenced by drug resistance.This challenge stems from the diverse cell populations within the tumor,each having unique genetic,epigenetic,and phenotypic profiles.Such variations lead to varied therapeutic responses,thereby contributing to tumor relapse and disease progression.Methods:The Genomics of Drug Sensitivity in Cancer(GDSC)database was used in this investigation to obtain the mRNA expression dataset,genomic mutation profile,and drug sensitivity information of NSCLS.Machine Learning(ML)methods,including Random Forest(RF),Artificial Neurol Network(ANN),and Support Vector Machine(SVM),were used to predict the response status of each compound based on the mRNA and mutation characteristics determined using statistical methods.The most suitable method for each drug was proposed by comparing the prediction accuracy of different ML methods,and the selected mRNA and mutation characteristics were identified as molecular features for the drug-responsive cancer subtype.Finally,the prognostic influence of molecular features on the mutational subtype of LUAD in publicly available datasets.Results:Our analyses yielded 1,564 gene features and 45 mutational features for 46 drugs.Applying the ML approach to predict the drug response for each medication revealed an upstanding performance for SVM in predicting Afuresertib drug response(area under the curve[AUC]0.875)using CIT,GAS2L3,STAG3L3,ATP2B4-mut,and IL15RA-mut as molecular features.Furthermore,the ANN algorithm using 9 mRNA characteristics demonstrated the highest prediction performance(AUC 0.780)in Gefitinib with CCL23-mut.Conclusion:This work extensively investigated the mRNA and mutation signatures associated with drug response in LUAD using a machine-learning approach and proposed a priority algorithm to predict drug response for different drugs.

关键词： Lung adenocarcinoma Drug resistance Machine learning Molecular features Personalized treatment

Research on blade tip clearance cavitation and turbulent kinetic energy characteristics of axial flow pump based on the partially-averaged Navier-Stokes model

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Journal of Hydrodynamics 2024年第1期36卷 184-201页

作者： Xiao-qi jia Shuai-kang Zhang Zu-chao Zhu Key Laboratory of Fluid Transmission Technology of Zhejiang Province Zhejiang Sci-Tech UniversityHangzhou310018China

To reveal the cavitation forms of tip leakage vortex(TLV)of the axial flow pump and the flow mechanism of the flow field,this research adopts the partially-averaged Navier-Stokes(PANS)model to simulate the cavitation values of an axial flow pump,followed by experimental validation.The experimental result shows that compared with the shear stress transport(SST)k-ωmodel,the PANS model significantly reduces the eddy viscosity of the flow field to make the vortex structure clearer and allow the turbulence scale to be more robustly analyzed.The cavitation area within the axial flow pump mainly comprises of TLV cavitation,clearance cavitation and tip leakage flows combined effect of triangular cloud cavitation formed.The formation and development of cavitation are accompanied by the formation and evolution of vortex,and variations in vortex structure also generate and promote the development of cavitation.In addition,an in-depth analysis of the relationship between the turbulent kinetic energy(TKE)transport equation and cavitation patterns was also conducted,finding that the regions with relatively high TKE are mainly distributed around gas/liquid boundaries with serious cavitation and evident gas-liquid change.This phenomenon is mainly attributed to the combined effect of the pressure action term,stress diffusion term and TKE production term.

关键词： Cavitation axial flow pump tip leakage vortex(TLV) partially-averaged Navier-Stokes(PANS)model turbulent kinetic energy(TKE)

Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency catheter ablation

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Journal of Geriatric Cardiology 2024年第2期21卷 200-210页

作者： qing YAN jia-qi LIANG Yi-De YUAN Yuan LI jia-Li FAN Wen-Huan WU Pan XU jia-Hong XUE Department of Cardiovascular Medicine the Second Affiliated Hospital of Xi’an Jiaotong UniversityShaanxiChina Department of Cardiovascular Medicine Zichang People’s HospitalShaanxiChina Department of Ultrasound Xijing HospitalAir Force Military Medical UniversityShaanxiChina

BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin resistance.This study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency catheter ablation(RFCA).METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an jiaotong University were included in this study.The participants were grouped based on cumulative TyG index values tertiles within 3 months after ablation.Cox regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF recurrence.The predictive value of all risk factors was assessed by receiver operating curve analysis.RESULTS There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence increased with increasing cumulative TyG index values tertiles.After adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)=4.949,95%CI:1.778–13.778,P=0.002]and the high cumulative TyG index group(HR=8.716,95%CI:3.371–22.536,P<0.001)had a higher risk of AF recurrence than those in the low cumulative TyG index group.The restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulative TyG index values.When considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)=0.847,95%CI:0.797–0.897,P<0.001].CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after RFCA.Monitoring longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.

关键词： atrial fibrillation index

On a Flexible Loan Repayment Method Depending on Borrower's Asset with an Early Termination Clause

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 557-567页

作者： Jin LIANG jia-qi MAO Zhao-ya LIU School of Mathematical Sciences Tongji UniversityShanghai 200092China

Aiming at the problem that the asset’s fluctuation influences the borrower’s repayment ability,a loan with a new and flexible repayment method is designed,which depends on the asset value of the borrower.The repayment method can reduce the loan default probability,but it causes the uncertainty of the pay off time.Because the repayment term is related to the regular repayment amount in this method,a boundary for the regular repayment amount is set up in order to avoid too long repayment term.This will balance the benefit of borrowers and lenders and improve the applicability of this method.By establishing a mathematical model of the residual value of the loan,this model can be transformed into an initial-boundary problem of a partial differential equation.The analytic solution and the expected time to pay off the loan are obtained.Finally,numerical analysis are shown.

关键词： flexible repayment method repayment ratio early termination clause expected pay off time

Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method

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Journal of Earth Science 2024年第2期35卷 583-596页

作者： Xing-Yu Long Yu-Xiang Hu Bin-Rui gan jia-Wen Zhou State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China College of Water Resource and Hydropower Sichuan UniversityChengdu610065China

In the context of global warming and intensified human activities,glacier instability in plateau regions has increased,and glacier debris flows have become active,which poses a significant threat to the lives and property of people and socioeconomic development.The mass movement process of glacier debris flows is extremely complex,so this paper uses the 2018 Sedongpu glacier debris flow event on the qinghai-Tibet Plateau as an example and applies a numerical simulation method to invert the whole process of mass movement.In view of the interaction between phases in the process of motion,we use the fluid-solid coupling method to describe the mass movement.The granular-flow model and drift-flux model are employed in FLOW3D software to study the mass movement process of glacier debris flows and explore their dynamic characteristics.The results indicate that the glacier debris flow lasted for 700 s,and the movement process was roughly divided into four stages,including initiation,scraping,surging and deposition;the depositional characteristics calculated by the fluid-solid coupling model are consistent with the actual survey results and have good reliability;strong erosion occurs during the mass movement,the clear volume amplification effect,and the first wave climbs 17.8 m across the slope.The fluid-solid coupling method can better simulate glacier debris flows in plateau regions,which is helpful for the study of the mechanism and dynamic characteristics of such disasters.

关键词： glacial debris flow qinghai-Tibet Plateau fluid-solid coupling FLOW3D mass movement depositional characteristics disasters engineering geology

Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu jia Cheng Wang Wenlong Xu Dong Ma Fangfang qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting consequences.To investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual protection.Experimental results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not damaged.The shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic characteristics.The overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample thickness.For the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three materials.In this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are designed.Different layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective performance.Within the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm respectively.The overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of single-layer polyurea and polyurethane foam with

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： qian-Yun Guo jia-qi Yang Xun-Xun Feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

Postpartum quality of life and mental health in women with heart disease:Integrated clinical communication and treatment

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World Journal of Psychiatry 2024年第1期14卷 63-75页

作者： jia-Lin Liu qi Wang Dong-Ying Qu Department of Obstetrics and Gynecology China Medical UniversityShenyang 110122Liaoning ProvinceChina Department of Psychiatry General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina Department of Obstetrics and Gynecology General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina

BACKGROUND Postpartum quality of life(QoL)in women with heart disease has been neglected.AIM To improve clinical communication and treatment,we integrated medical data and subjective characteristics to study postpartum QoL concerns.METHODS The study assessed QoL 6 wk after birth using the 12-Item Short-Form Health Survey.The Edinburgh Postnatal Depression Scale,Cardiac Anxiety Questionnaire,European Heart Failure Self-Care Behavior Scale,and a self-designed questionnaire based on earlier research were also used to assess patient characteristics.Patient data were collected.Prediction models were created using multiple linear regression.RESULTS This retrospective study examined postpartum QoL in 105 cardiac patients.Postpartum QoL scores were lower(90.69±13.82)than those of women without heart disease,with physical component scores(41.09±9.91)lower than mental component scores(49.60±14.87).Postpartum depression(33.3%),moderate anxiety(37.14%),pregnancy concerns(57.14%),offspring heart problems(57.14%),and life expectancy worries(48.6%)were all prevalent.No previous cardiac surgery,multiparity,higher sadness and cardiac anxiety,and fear of unfavorable pregnancy outcomes were strongly related to lower QoL(R^(2)=0.525).CONCLUSION Postpartum QoL is linked to physical and mental health in women with heart disease.Our study emphasizes the need for healthcare workers to recognize the unique characteristics of these women while developing and implementing comprehensive management approaches during their maternity care.

关键词： Heart disease Pregnancy Postpartum Quality of life Mental health