检索结果-南通市图书馆

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li jiamin Li Hui-Yan Zhang Yilin qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Numerical analysis of shell-side flow-induced vibration of elastic tube bundle in heat exchanger

引用

Journal of Hydrodynamics 2018年第2期30卷 249-257页

作者： jia-dong Ji Pei-qi Ge Wen-bo Bi School of Mechanical Engineering Anhui University of Science and Technology Huainan 232001 China School of Mechanical Engineering Shandong University Jinan 250061 China

The responses of the flow-induced vibration of an elastic tube bundle subjected to the shell-side cross flow are investigated in this paper. The weak coupling method and the fluid solid interface are used to solve the fluid-structure interaction problem with consideration of the geometry and physical natures. The effects of the shell-side fluid flow velocity and the structural parameters on the flow-induced vibration are discussed. Numerical results demonstrate that the vibration frequency and amplitude at the monitor points increase with the increase of the shell-side water inlet velocity in all directions. The wall thickness and the external diameter of the elastic tube bundle have significant effects on the responses of the flow-induced vibration. The structural parameters affect the vibration frequency and amplitude, and the vibration equilibrium position in the water flow direction. The vibration frequency decreases with the increase of the tube external diameter. In addition, the vibration in the water flow direction has a lower equilibrium position when the elastic tube bundle has a larger wall thickness or smaller external diameter.

关键词： Flow-induced vibration heat exchanger elastic tube bundle fluid-structure interaction shell-side fluid weak coupling method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

感觉训练对痉挛型脑性瘫痪患儿步行能力的改善效果

引用

广西医学 2018年第1期40卷 31-33页

作者：贾东奇金伟李曦光徐蓉李亚娟南京大学医学院附属鼓楼医院康复医学科江苏省南京市210008 江苏省南京市社会儿童福利院南京市210000

目的探讨感觉训练对痉挛性脑性瘫痪患儿步行能力的改善效果。方法选取脑性瘫痪患儿40例,随机分为研究组和对照组各20例。两组患儿均采用常规神经生理学疗法治疗,研究组在此基础上进行感觉训练。比较治疗前和治疗6周后两组患儿的10 m最... 详细信息

目的探讨感觉训练对痉挛性脑性瘫痪患儿步行能力的改善效果。方法选取脑性瘫痪患儿40例,随机分为研究组和对照组各20例。两组患儿均采用常规神经生理学疗法治疗,研究组在此基础上进行感觉训练。比较治疗前和治疗6周后两组患儿的10 m最快步行速度(10m MWS)、步长、步频。结果研究组10m MWS、步长、步频的治疗前后差值均高于对照组(P<0.05)。结论在常规神经生理学疗法基础上进行感觉训练能更有效地提高痉挛型脑性瘫痪患儿的步行能力。

关键词：痉挛型脑性瘫痪感觉训练神经生理学疗法步行能力儿童

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geometric Constraints for Global Regularity of 3D Shear Thickening Fluids

引用

Acta Mathematicae Applicatae Sinica 2024年第1期40卷 205-210页

作者： jia-qi Yang Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing100190China

We consider the relation between the direction of the vorticity and the global regularity of 3D shear thickening *** is showed that a weak solution to the non-Newtonian incompressible fluid in the whole space is stron... 详细信息

关键词： direction of the vorticity non-Newtonian fluid global regularity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

引用

Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming qian jiashu Lian Xin Hua jianhong dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Innovative mesenchymal stem cell treatments for fatty liver disease

引用

World Journal of Stem Cells 2024年第9期16卷 846-853页

作者： Fei-qiong Gao jia-qi Zhu Xu-dong Feng Department of Endocrinology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou 310003Zhejiang ProvinceChina Laboratory Medicine Center Department of Clinical LaboratoryZhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Clinical Laboratory Ningbo Medical Center Lihuili HospitalAffiliated Lihuili Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

The incidence of non-alcoholic fatty liver disease(NAFLD)and alcohol-associated liver disease(ALD)is increasing year by year due to changes in the contemporary environment and dietary structure,and is an important public health problem *** is an urgent need to continuously improve the understanding of their disease mechanisms and develop novel therapeutic *** stem cells(MSCs)have shown promise as a potential therapeutic strategy in therapeutic studies of NAFLD and *** and ALD have different triggers and their specific mechanisms of disease progression are different,but both involve disease processes such as hepatocellular steatosis and potential fibrosis,cirrhosis,and even hepatocellular *** have metabolic regulatory,anti-apoptotic,antioxidant,and immunomodulatory effects that together promote liver injury repair and functional recovery,and have demonstrated positive results in preclinical *** editorial is a continuum of jiang et al’s review focusing on the advantages and limitations of MSCs and their derivatives as therapeutics for NAFLD and *** detail how MSCs attenuate the progression of NAFLD by modulating molecular pathways involved in glucolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** on recent advances,we discuss MSCs and their derivatives as therapeutic strategies for NAFLD and ALD,providing useful information for their clinical application.

关键词： Alcohol-associated liver disease Non-alcoholic fatty liver disease Mesenchymal stem cells Cell therapy Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pupillary capture following sutureless scleral-fixated intraocular lens in children with Marfan syndrome

引用

International Journal of Ophthalmology(English edition) 2023年第11期16卷 1789-1793页

作者： dong-Mei qi Shu-jia Huo Tao Yu Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)Chongqing 400038China

AIM:To compare the clinical outcomes between two approaches for sutureless scleral-fixated intraocular lens(SFIOL)in children with Marfan syndrome(MFS).METHODS:The study included 15 children(26 eyes)with lens subluxation due to *** children underwent lensectomy,anterior vitrectomy,and sutureless *** to the position of placement of intraocular lens(IOL)haptics,two study groups were reviewed for best corrected visual acuity(BCVA)and postoperative complications:group A,14 eyes with haptics fixated at 2.0 mm from the limbus;group B,12 eyes with the haptics fixated at 2.5 mm from the ***:The mean axial length for all patients was 25.66±2.35 *** BCVA in logMAR were significant improved in both groups(0.77±0.32 to 0.17±0.12 in group A,0.66±0.25 to 0.24±0.12 in group B,both P0.05).Pupillary capture was main postoperative complication,occurring between 3d and *** occurred in 7 eyes in group A and one eye in group B(P=0.02).CONCLUSION:Sutureless SFIOL is an effective treatment approach for lens subluxation in children with *** capture is the main postoperative *** IOL haptics at 2.5 mm from the limbus can reduce the occurrence of pupillary capture.

关键词： Marfan syndrome sutureless scleral-fixated intraocular lens pupillary capture children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oligo-lysine Induced Formation of Silica Particles in Neutral Silicate Solution

引用

Chemical Research in Chinese Universities 2006年第3期22卷 368-370页

作者： ZHANG Xiao-dong SUN Ying-ying ZHUANG jia-qi YANG Wen-sheng College of Chemistry Jilin University Changchun 130023 P.R. China

Oligo-（lysine） n （n = 1-4） containing different numbers of lysine residues was used to induce the condensation of silicic acid to form silica particles in neutral silicate solution. It was found that the condensation rate and the formation of silica particles are dependent on the number of lysine residues in an oligo-lysine. Oligo-lysine with more lysine residues can link more silicic acid together to form a matrix that promotes the effective aggregation of the condensed silica pieces to form large silica particles.

关键词： Biosilification Polylysine Silica

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation and experiment investigations on fabrication of Fe-based amorphous powders by a novel atomization process equipped with assisted gas nozzles

引用

Journal of Iron and Steel Research International 2023年第6期30卷 1142-1155页

作者： jia-qi Liu Yan-nan dong Pu Wang Huan Zhao Jing Pang Xiao-yu Li jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China qingdao Yunlu Advanced Materials Technology Co. Ltd.Qingdao 266232ShandongChina

Based on computational fluid dynamics method,the effect of atomization gas pressure on the atomization efficiency of Laval nozzle was studied,and then a discrete phase model was established and combined with industrial trials to study the effect of a new type of assisted gas nozzles(AGNs)on powder size distribution and amorphous powder *** results show that increasing the atomization pressure can effectively improve the gas velocity for the Laval nozzle;however,it will decrease the aspiration pressure,and the optimal atomization pressure is 2.0 *** with this,after the application of AGNs with the inlet velocity of 200 m s^(-1),assisted gas jet can increase the velocity of overall droplets in the break-up and solidification area by 40 m s^(-1) and the maximum cooling rate is increased from 1.9×10^(4) to 2.3×10^(4) K s^(-1).The predicted particle behavior is demonstrated by the industrial trails,that is,after the application of AGNs,the median diameter of powders d50 is decreased from 28.42 to 25.56 lm,the sphericity is increased from 0.874 to 0.927,the fraction of amorphous powders is increased from 90.4% to 99.4%,and only the coercivity is increased slightly due to the accumulation of internal *** is illustrated that the AGNs can improve the yield of fine amorphous powders,which is beneficial to providing high-performance raw powders for additive manufacturing technology.

关键词： Computational fluid dynamics Atomization Assisted gas nozzle Discrete phase model Amorphous powder

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reaction kinetics during direct alloying of manganese ore cored wire

引用

Journal of Iron and Steel Research International 2020年第3期27卷 282-294页

作者： Wei Wu qi Gao Bo Zhang Hua-dong Meng Lu Lin jia-qing Zeng Metallurgical Technology Research Department Central Iron and Steel Research InstituteBeijing 100081China State Key Laboratory of Refractory and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

In order to increase the reaction rates between the molten steel and the slag and cut down the reduction time when the top slag of manganese ore is added into the molten steel,a method of directly alloying manganese ore has been experimented in a 500-kg induction *** results show that the manganese yield is greater than 90%when the wire feeding method is *** manganese yield is 43.26%within 1 *** contrast,the manganese yield for the top-slag adding process is only 10.98%for the same *** mass transfer rate of the manganese is greater in the molten steel than in the slag,and the limiting factor is the mass transfer rate of the manganese in the slag in the period of 10-30 *** slag composition area is closer to the area of high melting point for the wire feeding method than for the top-slag adding *** the slagging process,refining slag composed of C a O and SiO:is formed after 15 min;after 25-30 min,refining slag with a high basicity is formed and consists of CaO,SiO2 and Al203.

关键词： Manganese ore Cored wire Direct alloying process Reaction kinetics Mass transfer rate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：