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Plant non-coding RNAs and epigenetics

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Science China(Life Sciences) 2018年第2期61卷 135-137页

作者： jia-Wei Wang Yijun qi National Key Laboratory of Plant Molecular Genetics (NKLPMG) CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology (SIPPE) Shanghai Institutes for Biological Sciences (SIBS) Shanghai 200032 China Shanghai Tech University Shanghai 200031 China Center for Plant Biology School of Life Sciences Tsinghua University Beijing 100084 China Tsinghua-Peking Center for Life Sciences Beijing 100084 China

Epigenetics plays a large role in various aspects of plant biology,including development,response to biotic and abiotic stresses,silencing of transposable elements,and maintenance of genome *** plants,epigenetic regulation involves histone and DNA modifications and noncoding RNAs including small RNAs（s RNAs）and long noncoding RNAs（lnc RNAs）.This issue of Science China Life Sciences includes five review articles and eight research

关键词： SDG Plant non-coding RNAs and epigenetics RNA EFS DNA

Tumor-microenvironment activated programmable synergistic cancer therapy by bioresponsive rare-earth nanocomposite

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Journal of Rare Earths 2022年第9期40卷 1399-1406,I0003页

作者： qi jia Xin Han Yuxin Liu Xianquan Liao Jing Zhou Capital Normal University Beijing 100048China

Synergistic chemotherapy-photothermal therapy(CT-PTT)can improve the cancer treatment efficacy,but its treatment effect is still limited by factors such as targeting efficiency and treatment ***,a H_(2)S-responsive metal organic frameworks(MOFs)coated rare-earth nanocomposite(csEr@-MOF)was constructed and loaded with a chemotherapeutic drug(DOX)and a heat shock protein(HSP)inhibitor(Shepherdin).As the drug-loaded csEr@MOF reaches the H_(2)S-riched colorectal tumor region,based on the reaction between H_(2)S and MOF,Shepherdin is released for inhibiting the function of HSPs,the generated CuS is used for PTT and DOX is released for *** being monitored by ratiometric imaging of rare-earth nanocomposite,it is possible to perform the precise treatment timing for *** the help of Shepherdin,the treatment effect of PTT was ***,programmable CT-PTT synergistic cancer therapy activated by a single H_(2)S trigger is achieved in vitro and in *** work provides new ideas for designing tumor microenvironment-responsive therapeutic agents for programmable synergistic therapy with better targeting and therapeutic efficiency.

关键词： Rare-earth nanocomposite Tumor microenvironment Hydrogen sulfide Synergistic therapy Programmable therapy

Universal origin of glassy relaxation as recognized by configuration pattern matching

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National Science Review 2024年第5期11卷 343-351页

作者： Hai-Bin Yu Liang Gao jia-qi Gao Konrad Samwer Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and Technology I.Physikalisches Institut Universit?t G?ttingen

Relaxation processes are crucial for understanding the structural rearrangements of liquids and amorphous materials. However, the overarching principle that governs these processes across vastly different materials remains an open question. Substantial analysis has been carried out based on the motions of individual particles. Here, as an alternative, we propose viewing the global configuration as a single entity. We introduce a global order parameter, namely the inherent structure minimal displacement(IS Dmin), to quantify the variability of configurations by a pattern-matching technique. Through atomic simulations of seven model glass-forming liquids, we unify the influences of temperature, pressure and perturbation time on the relaxation dissipation, via a scaling law between the mechanical damping factor and IS Dmin. Fundamentally,this scaling reflects the curvature of the local potential energy landscape. Our findings uncover a universal origin of glassy relaxation and offer an alternative approach to studying disordered systems.

关键词： glass transition metallic glass relaxation dynamics mechanical spectroscopy internal friction

Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu jia Cheng Wang Wenlong Xu Dong Ma Fangfang qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

Anti-jamming channel access in 5G ultra-dense networks: a game-theoretic learning approach

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Digital Communications and Networks 2023年第2期9卷 523-533页

作者： Yunpeng Zhang Luliang jia Nan qi Yifan Xu Meng Wang College of Communications Engineering Army Engineering University of PLANanjing210007China School of Space Information Space Engineering UniversityBeijing101416China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016China

This paper investigates the Quality of Experience(QoE)oriented channel access anti-jamming problem in 5th Generation Mobile Communication(5G)ultra-dense ***,considering that the 5G base station adopts beamforming technology,an anti-jamming model under Space Division Multiple Access(SDMA)conditions is ***,the confrontational relationship between users and the jammer is formulated as a Stackelberg ***,to achieve global optimization,we design a local cooperation mechanism for users and formulate the cooperation and competition among users as a local altruistic *** proving that the local altruistic game is an Exact Potential Game(EPG),we further prove the existence of pure strategy Nash Equilibrium(NE)among users and Stackelberg Equilibrium(SE)between users and ***,to obtain the equilibrium solutions of the proposed games,we propose an anti-jamming channel selection algorithm and improve its convergence speed through heterogeneous learning *** simulation results validate the convergence and effectiveness of the proposed *** with the throughput optimization scheme,our proposed scheme obtain a greater network satisfaction ***,we also analyze user fairness changes during the algorithm convergence process and get some interesting conclusions.

关键词： Anti-jamming 5G Ultra-dense networks Stackelberg game Exact potential game Channel selection algorithm

Associations of land use around rail transit stations with jobs-housing distribution of rail commuters from smart-card data

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Geo-Spatial Information Science 2023年第3期26卷 346-361页

作者： qingming Zhan Yuqiu jia Zhenhua Zheng qi Zhang Lei Luo School of Urban Design Wuhan UniversityWuhanChina College of Tourism and Geographic Sciences Jilin Normal UniversitySipingChina Department of Technology Management Wuhan Land Use and Urban Spatial Planning Research CenterWuhanChina College of Architecture and Urban Planning Tongji UniversityShanghaiChina Faculty of Resources and Environmental Science Hubei UniversityWuhanChina

Previous studies generally used land use and travel flow to investigate the efficiency of the railway system in Transit-Oriented Development(TOD)***,to study the association of land use and jobs-housing distribution of commuters,we can find out the potential development of rail *** this research,four railway lines in Wuhan,China,were selected to explore the land use in promoting practical commuting population according to the smart-card data *** land use issues,except the road density and building density,a Normalized Location-Weighted Landscape Index(NLWLI)based on the source-sink theory in landscape ecology was established to assess the jobs-housing land use around rail transit ***,employment and housing details of commuters around rail transit stations were identified using smart-card *** found that the generation of commuting flow was affected by building density and the land use of employment in the immediate vicinity of rail transit *** distribution of building density and commuters in a mature rail line was roughly a normal ***,due to the inconsistency of land use and jobs-housing distribution around stations,the requirement of the balance of land use and jobs-housing distribution should be reduced at the scale of rail stations in the TOD planning *** study is the application of massive smart-card data in the field of urban *** identifies land use issues that affect rail transit commuting flow,and can help urban planners improve the efficiency of rail transit through planning and design.

关键词： Commuter jobs-housing ratio source-sink landscape TOD

Design,modeling,and control of morphing aircraft:A review

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Chinese Journal of Aeronautics 2022年第5期35卷 220-246页

作者： Lingling chu qi LI Feng GU Xintian DU Yuqing HE Yangchen DENG State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang 110169China University of Chinese Academy of Sciences Beijing 100049China Shenyang Aircraft Design&Research Institute Shenyang 110034China

A morphing aircraft can adapt its configuration to suit different types of tasks,which is also an important requirement of Unmanned Aerial Vehicles(UAV).The successful development of an unmanned morphing aircraft involves three steps that determine its ability and intelligent:configuration design,dynamic modeling and flight *** study conducts a comprehensive survey of morphing ***,the methods to design the configuration of a morphing aircraft are presented and ***,the nonlinear dynamic characteristics and aerodynamic interference caused by a morphing wing are ***,the dynamic modeling and flight control methods for solving the flight control problems are summarized with respect to these ***,the general as well as special challenges ahead of the development of intelligent morphing aircraft are *** findings can provide a theoretical and technical reference for designing future morphing aircraft or morphing-wing UAVs.

关键词： Aircraft design Dynamic modeling Fault tolerance Flight control Intelligent material Morphing aircraft Unmanned Aerial Vehicles(UAV)

Unbalanced classification method using least squares support vector machine with sparse strategy for steel surface defects with label noise

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Journal of Iron and Steel Research International 2020年第12期27卷 1407-1419页

作者： Li-ming Liu Mao-xiang chu Rong-fen Gong Xin-yu qi School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan 114051LiaoningChina

Least squares support vector machine (LS-SVM) plays an important role in steel surface defects classification because of its high speed. However, the defect samples obtained from the real production line may be noise. LS-SVM suffers from the poor classification performance in the classification stage when there are noise samples. Thus, in the classification stage, it is necessary to design an effective algorithm to process the defects dataset obtained from the real production line. To this end, an adaptive weight function was employed to reduce the adverse effect of noise samples. Moreover, although LSSVM offers fast speed, it still suffers from a high computational complexity if the number of training samples is large. The time for steel surface defects classification should be as short as possible. Therefore, a sparse strategy was adopted to prune the training samples. Finally, since the steel surface defects classification belongs to unbalanced data classification, LSSVM algorithm is not applicable. Hence, the unbalanced data information was introduced to improve the classification performance. Comprehensively considering above-mentioned factors, an improved LS-SVM classification model was proposed, termed as ILS-SVM. Experimental results show that the new algorithm has the advantages of high speed and great anti-noise ability.

关键词： Steel surface defect Least squares support vector machine Anti-noise Sparseness Unbalanced data

Childhood obesity and food intake

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World Journal of Pediatrics 2015年第2期11卷 101-107页

作者： jia-Yi Huang Sui-jian qi College of Light Industry and Food Sciences South China University of TechnologyGuangzhou 510640China

Background:The prevalence of obesity among children is growing in China at *** obesity reflects complex interactions of genetic,environmental,social and behavioral ***,nutritional components,and food intake patterns may be associated with the increasing obesity rate in *** sources:Articles about the relationship between childhood obesity and food intake were collected from the databases including Web of Knowledge,PubMed,Elsevier and Google ***:Foods and nutritional components such as calcium,dietary fiber are inversely related to obesity,whereas others such as vitamin B and sugar-sweeten beverages play a positive role in obesity *** differences in food intake pattern also influence the risk of ***:Food intake is an important factor influencing childhood *** strategy to prevent childhood obesity is to take foods of moderate amount in a proper pattern.

关键词： childhood food intake obesity