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National Science Review 2023年第11期10卷 160-170页

作者： Mi Zhang jia-peng liao Run-Han Li Sheng-Nan Sun Meng Lu Long-Zhang Dong Pei Huang Shun-Li Li Yue-peng Cai Ya-Qian Lan South China Normal University School of Chemistry

Electrocatalytic CO2reduction(ECR) coupled with organic oxidation is a promising strategy to produce high value-added chemicals and improve energy efficiency. However, achieving the efficient redox coupling reaction is still challenging due to the lack of suitable electrocatalysts. Herein, we designed two bifunctional polyimides-linked covalent organic frameworks(PI-COFs) through assembling phthalocyanine(Pc) and porphyrin(Por) by non-toxic hydrothermal methods in pure water to realize the above catalytic *** to the high conductivity and well-defined active sites with different chemical environments, Ni Pc-Ni Por COF performs efficient ECR coupled with methanol oxidation reaction(MOR)(Faradaic efficiency of CO(FECO) = 98.12%, partial current densities of CO(j CO) = 6.14 m A cm-2for ECR, FEHCOOH = 93.75%,j HCOOH = 5.81 m A cm-2for MOR at low cell voltage(2.1 V) and remarkable long-term stability).Furthermore, experimental evidences and density functional theory(DFT) calculations demonstrate that the ECR process mainly conducts on Ni Pc unit with the assistance of Ni Por, meanwhile, the MOR prefers Ni Por conjugating with Ni Pc. The two units of Ni Pc-Ni Por COF collaboratively promote the coupled oxidation-reduction reaction. For the first time, this work achieves the rational design of bifunctional COFs for coupled heterogeneous catalysis, which opens a new area for crystalline material catalysts.

关键词： hydrothermal synthesis phthalocyanine-porphyrin COFs bifunctional electrocatalysts electrocatalytic CO2 reduction methanol oxidation reaction

Ultrafine Cu nanoclusters confined within covalent organic frameworks for efficient electroreduction of CO_(2) to CH_(4) by synergistic strategy

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eScience 2023年第3期3卷 96-104页

作者： Mi Zhang Meng Lu Ming-Yi Yang jia-peng liao Yu-Fei Liu Hao-Jun Yan jia-Nan Chang Tao-Yuan Yu Shun-Li Li Ya-Qian Lan School of Chemistry South China Normal UniversityGuangzhou510006PR China jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023PR China

Electrocatalytic CO_(2) reduction(ECR)to high value-added chemicals by using renewable electricity presents a promising strategy to realize“carbon neutrality”.However,the ECR system is still limited by its low current density and poor CO_(2) utilization ***,by using the confinement effect of covalent organic frame-works(COFs)to confine the in-situ growth of metal nanoclusters(NCs),we develop a series of Cu NCs encap-sulated on COF catalysts(Cu-NC@COF)for *** them,Cu-NC@CuPc-COF as a gas diffusion electrode(GDE)achieves a maximum CO_(2)-to-CH_(4) Faradaic efficiency of 74±3%(at-1.0 V *** Hydrogen Electrode(RHE))with a current density of 538±31 mA cm^(-2)(at-1.2 V ***)in a flow cell,making it one of the best among reported *** importantly,the current density is much higher than the relevant industrial current density(200 mA cm^(-2)),indicating the potential for industrial *** work opens up new possibilities for the design of ECR catalysts that utilize synergistic strategy.

关键词： Covalent organic frameworks Metal nanoclusters CO_(2)electroreduction

Photochromic radical states in 3D covalent organic frameworks with zyg topology for enhanced photocatalysis

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National Science Review 2024年第7期11卷 177-188页

作者： Tian-Tian Ma Guo-Zhang Huang Xiao-Han Wang Yan Liang Run-Han Li Bin Wang Su-Juan Yao jia-peng liao Shun-Li Li Yong Yan Ya-Qian Lan School of Chemistry South China Normal University Department of Chemistry Guangdong Provincial Key Laboratory of Catalytic Chemistry Southern University of Science and Technology

Covalent-organic frameworks（COFs） with photoinduced donor-acceptor（D-A） radical pairs show enhanced photocatalytic activity in principle. However, achieving long-lived charge separation in COFs proves challenging due to the rapid charge recombination. Here, we develop a novel strategy by combining[6 + 4] nodes to construct zyg-type 3D COFs, first reported in COF chemistry. This structure type exhibits a fused Olympic-rings-like shape, which provides a platform for stabilizing the photoinduced D-A radical pairs. The zyg-type COFs containing catalytically active moieties such as triphenylamine and phenothiazine（PTZ） show superior photocatalytic production rates of hydrogen peroxide（H2O2）. Significantly, the photochromic radical states of these COFs show up to 400% enhancement in photocatalytic activity compared to the parent states, achieving a remarkable H2O2synthesis rate of 3324 μmol g-1h-1, which makes the PTZ-COF one of the best crystalline porous photocatalysts in H2O2production. This work will shed light on the synthesis of efficient 3D COF photocatalysts built on topologies that can facilitate photogenerating D-A radical pairs for enhanced photocatalysis.

关键词： 3D covalent-organic frameworks photochromic radical states donor and acceptor hydrogen peroxide photocatalysis

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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N-双嘧啶取代芳胺的合成及其抗氧化损伤研究

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化学试剂 2017年第10期39卷 1035-1038页

作者：杨飞陈俊李琪琪李佳鹏廖兴华叶龙武汉科技大学化学与化工学院湖北武汉430081 武汉科技大学生物医学研究院湖北武汉430081

报道了一种N-双嘧啶取代芳胺衍生物2-(3-氯苯基)-N-(2-(3-氯苯基)-6-甲基嘧啶-4-基)-N-(2-甲氧苯基)-6-甲基嘧啶-4-胺的合成、表征及其抗氧化生物活性,该N-双嘧啶取代芳胺衍生物是以3-氯苄腈为原料经4步反应合成而得到,其结构通过1HNMR... 详细信息

报道了一种N-双嘧啶取代芳胺衍生物2-(3-氯苯基)-N-(2-(3-氯苯基)-6-甲基嘧啶-4-基)-N-(2-甲氧苯基)-6-甲基嘧啶-4-胺的合成、表征及其抗氧化生物活性,该N-双嘧啶取代芳胺衍生物是以3-氯苄腈为原料经4步反应合成而得到,其结构通过1HNMR、13CNMR、HR-MS进行了表征和确认。化合物的抗氧化作用与细胞毒作用分别通过是否进行双氧水处理的SH-SY5Y细胞与CCK-8试剂盒进行检测,通过荧光探针DCFH-DA标记检测细胞内ROS含量。结果表明,该化合物具有抗双氧水氧化损伤的可能,能够显著提高细胞存活率且没有明显的细胞毒性。

关键词： N-双嘧啶取代芳胺衍生物双氧水抗氧化活性 SH-SY5Y细胞

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He Match: A redundancy layout placement scheme for erasure-coded storages in practical heterogeneous failure patterns

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Science China(Information Sciences) 2015年第6期58卷 171-181页

作者： ZHANG Jing LI ShanShan liao XiangKe peng ShaoLiang LIU XiaoDong jia ZhouYang School of Computer Science and Technology National University of Defence Technology

Erasure codes are widely used in storage systems for providing data reliability due to the advantage of high storage efficiency, while the access efficiency becomes the main shortcoming because of the extra data retrieve and decoding for accessing unavailable data. Most existing work designs erasure codes based on the ideal failure pattern where all storage nodes fail at the same rate. However in practice, the physical storage nodes fail at different rates due to the heterogeneous hardware, topologies and application behaviors. In this paper,we consider the heterogeneous failure pattern and analyze how the failure pattern impacts the overall access efficiency and reliability of erasure-coded storage systems. We propose He Match, a redundancy layout placement scheme in practical heterogeneous failure pattern for erasure-coded storage access efficiency. Specifically, we first study how the heterogeneous failure pattern impacts the access efficiency and propose a general model based on the Tanner graph to evaluate and predict the access efficiency in specific failure pattern and redundancy ***, we propose the redundancy layout placement scheme, which matches the redundancy layout with the physical storage nodes in practical heterogeneous failure patterns based on the evaluation and prediction from our model. The experimental results demonstrate that the model we propose accurately evaluates the access efficiency, and He Match saves unavailable data access cost by up to 20% and improves the system reliability as well.

关键词： network storage erasure-coded storage access efficiency redundancy placement heterogeneous failure pattern

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第01期 426-457页

作者： Chong peng Xinyi Huang Mingwei Zhao Shuling liao Quanhong Yang Nianjun Yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Nano-scale pore distribution characterisation of coal using small angle X-ray scattering

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Particuology 2023年第10期81卷 73-85页

作者： peng jia Jinzhang jia Sadegh Nadimi College of Safety Science and Engineering Liaoning Technical UniversityFuxinLiaoning123000China School of Engineering Newcastle UniversityNE17RUUK

In the process of coal seam fracturing with liquid nitrogen(LN_(2)),the change of coal pore structure has an important influence on the efficiency of coalbed methane(CBM)*** nano-scale pore size distribution(PSD)in coal particles before and after freezing with LN_(2) are experimentally studied in this *** samples are collected from four coal mines,where coal and gas outburst accidents have *** angle X-ray scattering technology(SAXS)and scanning electron microscopy(SEM)are used to study the pore structure changes of coal samples quantitatively and *** is found that the scattering intensity of coal samples increases after *** PSD of all samples significantly changes in the range of 0.8–7 nm,showing new pore spaces in 0.8–4 nm and fewer pores in the 4–7 nm *** the pore fractal dimension and the radius of gyration of coal samples increase after freezing and are mainly affected by the changes in pores and the anisotropy of the coal *** expansion and pore connections are observed in the surface structure of the coal sample using *** study provides a better understanding of the nano-scale mechanism of coal seam fracturing with LN_(2) for the prevention of coal and gas outbursts.

关键词： Coalbed methane Small angle X-ray scattering LN2 freezing Pore size distribution(PSD) Particle characterisation Fractal dimension